Mert R Sabuncu

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. pmc The association between a polygenic Alzheimer score and cortical thickness in clinically normal subjects
    Mert R Sabuncu
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Cereb Cortex 22:2653-61. 2012
  2. pmc The dynamics of cortical and hippocampal atrophy in Alzheimer disease
    Mert R Sabuncu
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, 02129, USA
    Arch Neurol 68:1040-8. 2011
  3. doi request reprint Using spanning graphs for efficient image registration
    Mert R Sabuncu
    CSAIL, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    IEEE Trans Image Process 17:788-97. 2008
  4. pmc Image-driven population analysis through mixture modeling
    Mert R Sabuncu
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    IEEE Trans Med Imaging 28:1473-87. 2009
  5. pmc Learning task-optimal registration cost functions for localizing cytoarchitecture and function in the cerebral cortex
    B T Thomas Yeo
    Computer Science and Artificial Intelligence Laboratory, Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    IEEE Trans Med Imaging 29:1424-41. 2010
  6. pmc Individual variability in functional connectivity architecture of the human brain
    Sophia Mueller
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neuron 77:586-95. 2013
  7. pmc Discovering modes of an image population through mixture modeling
    Mert R Sabuncu
    Computer Science and Artificial Intelligence Laboratory, MIT, USA
    Med Image Comput Comput Assist Interv 11:381-9. 2008
  8. pmc In vivo characterization of the early states of the amyloid-beta network
    Jorge Sepulcre
    Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Brain 136:2239-52. 2013
  9. pmc The relevance voxel machine (RVoxM): a self-tuning Bayesian model for informative image-based prediction
    Mert R Sabuncu
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    IEEE Trans Med Imaging 31:2290-306. 2012
  10. pmc Effects of registration regularization and atlas sharpness on segmentation accuracy
    B T Thomas Yeo
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA
    Med Image Anal 12:603-15. 2008

Detail Information

Publications23

  1. pmc The association between a polygenic Alzheimer score and cortical thickness in clinically normal subjects
    Mert R Sabuncu
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Cereb Cortex 22:2653-61. 2012
    ....
  2. pmc The dynamics of cortical and hippocampal atrophy in Alzheimer disease
    Mert R Sabuncu
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, 02129, USA
    Arch Neurol 68:1040-8. 2011
    ..To characterize rates of regional Alzheimer disease (AD)-specific brain atrophy across the presymptomatic, mild cognitive impairment, and dementia stages...
  3. doi request reprint Using spanning graphs for efficient image registration
    Mert R Sabuncu
    CSAIL, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    IEEE Trans Image Process 17:788-97. 2008
    ..Our analysis gives additional insight into the tradeoffs the graph-based algorithm is making and how these will manifest themselves in the registration algorithm's performance...
  4. pmc Image-driven population analysis through mixture modeling
    Mert R Sabuncu
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    IEEE Trans Med Imaging 28:1473-87. 2009
    ..The algorithm produces two modes, one of which contains dementia patients only. These results suggest that the algorithm can be used to discover subpopulations that correspond to interesting structural or functional "modes."..
  5. pmc Learning task-optimal registration cost functions for localizing cytoarchitecture and function in the cerebral cortex
    B T Thomas Yeo
    Computer Science and Artificial Intelligence Laboratory, Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    IEEE Trans Med Imaging 29:1424-41. 2010
    ..We demonstrate state-of-the-art localization results in both histological and functional magnetic resonance imaging data sets...
  6. pmc Individual variability in functional connectivity architecture of the human brain
    Sophia Mueller
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neuron 77:586-95. 2013
    ..Our findings have potential implications for understanding brain evolution and development, guiding intervention, and interpreting statistical maps in neuroimaging...
  7. pmc Discovering modes of an image population through mixture modeling
    Mert R Sabuncu
    Computer Science and Artificial Intelligence Laboratory, MIT, USA
    Med Image Comput Comput Assist Interv 11:381-9. 2008
    ..These results suggest that the algorithm can be used to discover sub-populations that correspond to interesting structural or functional "modes"...
  8. pmc In vivo characterization of the early states of the amyloid-beta network
    Jorge Sepulcre
    Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Brain 136:2239-52. 2013
    ....
  9. pmc The relevance voxel machine (RVoxM): a self-tuning Bayesian model for informative image-based prediction
    Mert R Sabuncu
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    IEEE Trans Med Imaging 31:2290-306. 2012
    ..Our results indicate that RVoxM yields biologically meaningful models, while providing state-of-the-art predictive accuracy...
  10. pmc Effects of registration regularization and atlas sharpness on segmentation accuracy
    B T Thomas Yeo
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA
    Med Image Anal 12:603-15. 2008
    ..Our experiments also suggest that segmentation accuracy is tolerant up to a small mismatch between atlas sharpness and warp smoothness...
  11. pmc A generative model for image segmentation based on label fusion
    Mert R Sabuncu
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    IEEE Trans Med Imaging 29:1714-29. 2010
    ..In a second experiment, we use brain MRI scans of 282 subjects to demonstrate that the proposed segmentation tool is sufficiently sensitive to robustly detect hippocampal volume changes in a study of aging and Alzheimer's Disease...
  12. pmc Stepwise connectivity of the modal cortex reveals the multimodal organization of the human brain
    Jorge Sepulcre
    Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 32:10649-61. 2012
    ..We identify the large-scale multimodal integration network and essential connectivity axes for perceptual integration in the human brain...
  13. pmc Selective disruption of the cerebral neocortex in Alzheimer's disease
    Rahul S Desikan
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
    PLoS ONE 5:e12853. 2010
    ..However, the precise relationship between pathologic changes in neocortical regions and hippocampal atrophy is largely unknown...
  14. pmc Spherical demons: fast diffeomorphic landmark-free surface registration
    B T Thomas Yeo
    Computer Science and Artificial Intelligence Laboratory, Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    IEEE Trans Med Imaging 29:650-68. 2010
    ..We validate the technique in two different applications that use registration to transfer segmentation labels onto a new image 1) parcellation of in vivo cortical surfaces and 2) Brodmann area localization in ex vivo cortical surfaces...
  15. pmc The organization of the human cerebral cortex estimated by intrinsic functional connectivity
    B T Thomas Yeo
    Harvard University, Department of Psychology, Center for Brain Science, Cambridge, MA 02138, USA
    J Neurophysiol 106:1125-65. 2011
    ..We conclude by discussing the organization of these large-scale cerebral networks in relation to monkey anatomy and their potential evolutionary expansion in humans to support cognition...
  16. ncbi request reprint Nonlinear registration of diffusion MR images based on fiber bundles
    Ulas Ziyan
    MIT Computer Science and Artificial Intelligence Lab, Cambridge MA, USA
    Med Image Comput Comput Assist Interv 10:351-8. 2007
    ..We demonstrate our algorithm on a group of subjects and show that it performs comparable to a higher dimensional nonrigid registration algorithm...
  17. pmc On removing interpolation and resampling artifacts in rigid image registration
    Iman Aganj
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    IEEE Trans Image Process 22:816-27. 2013
    ....
  18. pmc Network assemblies in the functional brain
    Jorge Sepulcre
    Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Curr Opin Neurol 25:384-91. 2012
    ..This review focuses on recent advances in functional connectivity MRI and renewed interest in studying the large-scale functional network assemblies in the brain. We also consider some methodological aspects of graph theoretical analysis...
  19. pmc The Relevance Voxel Machine (RVoxM): a Bayesian method for image-based prediction
    Mert R Sabuncu
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, MGH, Harvard Medical School, USA
    Med Image Comput Comput Assist Interv 14:99-106. 2011
    ..Experiments on age prediction from structural brain MRI indicate that RVoxM yields biologically meaningful models that provide excellent predictive accuracy...
  20. pmc A surface-based analysis of language lateralization and cortical asymmetry
    Douglas N Greve
    The Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Room 2301, 149 13th Street, Charlestown, MA 02129, USA
    J Cogn Neurosci 25:1477-92. 2013
    ..Overall, there were surprisingly few differences in GM volume asymmetry between LLD and RLD indicating that gross morphometric asymmetry is only subtly related to functional language laterality. ..
  21. pmc Spatiotemporal linear mixed effects modeling for the mass-univariate analysis of longitudinal neuroimage data
    Jorge L Bernal-Rusiel
    Athinoula A Martinos Center for Biomedical Imaging, Harvard Medical School Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neuroimage 81:358-70. 2013
    ..Our experiments revealed that ST-LME offers a dramatic gain in statistical power and repeatability of findings, while providing good control of the false positive rate. ..
  22. pmc The influence of head motion on intrinsic functional connectivity MRI
    Koene R A van Dijk
    Harvard University Department of Psychology, Center for Brain Science, Cambridge, MA 02138, USA
    Neuroimage 59:431-8. 2012
    ..These effects are important to consider when interpreting variation between groups and across individuals...
  23. pmc Effects of registration regularization and atlas sharpness on segmentation accuracy
    B T Thomas Yeo
    Computer Science and Artificial Intelligence Lab, MIT, USA
    Med Image Comput Comput Assist Interv 10:683-91. 2007
    ..The optimal parcellation in all three cases corresponds to a unique balance of atlas "sharpness" and warp regularization that yield statistically significant improvements over the previously demonstrated parcellation results...