David Sabatini

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. ncbi request reprint Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
    Dos D Sarbassov
    Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Mol Cell 22:159-68. 2006
  2. pmc Tumours with PI3K activation are resistant to dietary restriction
    Nada Y Kalaany
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 458:725-31. 2009
  3. pmc MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors
    Kivanc Birsoy
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
    Nat Genet 45:104-8. 2013
  4. pmc Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
    Richard Possemato
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 476:346-50. 2011
  5. pmc mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake
    Omer H Yilmaz
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 486:490-5. 2012
  6. pmc CellProfiler: image analysis software for identifying and quantifying cell phenotypes
    Anne E Carpenter
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Genome Biol 7:R100. 2006
  7. pmc CellProfiler Analyst: data exploration and analysis software for complex image-based screens
    Thouis R Jones
    Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
    BMC Bioinformatics 9:482. 2008
  8. ncbi request reprint mTOR and cancer: insights into a complex relationship
    David M Sabatini
    Whitehead Institute for Biomedical Research, MIT Department of Biology, 9 Cambridge Center, Cambridge, Massachusetts 02142 1479, USA
    Nat Rev Cancer 6:729-34. 2006
  9. ncbi request reprint Microarrays of lentiviruses for gene function screens in immortalized and primary cells
    Steve N Bailey
    Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology Department of Biology, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Methods 3:117-22. 2006
  10. pmc Lentivirus-delivered stable gene silencing by RNAi in primary cells
    Sheila A Stewart
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    RNA 9:493-501. 2003

Research Grants

  1. Rapamycin-Insensitive Signaling by Rictor-mTOR
    David Sabatini; Fiscal Year: 2005
  2. Regulation of the mTOR growth pathway by nutrients
    David Sabatini; Fiscal Year: 2005
  3. TRANSLATIONAL CONTROL BY RAPAMYCIN-SENSITIVE SIGNALING
    David Sabatini; Fiscal Year: 2001
  4. Rapamycin-Insensitive Signaling by Rictor-mTOR
    David Sabatini; Fiscal Year: 2009
  5. Cell Growth Signaling in Cancer Development
    David Sabatini; Fiscal Year: 2009
  6. Regulation of the mTOR Pathway By Nutrients
    David Sabatini; Fiscal Year: 2009
  7. Cell Growth Signaling in Cancer Development
    David M Sabatini; Fiscal Year: 2010
  8. Rapamycin-Insensitive Signaling by Rictor-mTOR
    David Sabatini; Fiscal Year: 2007
  9. Metabolism and Phosphatase Regulation of the TOR Pathway
    David Sabatini; Fiscal Year: 2007
  10. TRANSLATIONAL CONTROL BY RAPAMYCIN-SENSITIVE SIGNALING
    David Sabatini; Fiscal Year: 2002

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
    Dos D Sarbassov
    Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Mol Cell 22:159-68. 2006
    ..Our work describes an unforeseen mechanism of action for rapamycin that suggests it can be used to inhibit Akt/PKB in certain cell types...
  2. pmc Tumours with PI3K activation are resistant to dietary restriction
    Nada Y Kalaany
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 458:725-31. 2009
    ..Thus, the PI3K pathway is an important determinant of the sensitivity of tumours to dietary restriction, and activating mutations in the pathway may influence the response of cancers to dietary restriction-mimetic therapies...
  3. pmc MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors
    Kivanc Birsoy
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
    Nat Genet 45:104-8. 2013
    ..Our results identify a potential biomarker for 3-BrPA sensitivity and provide proof of concept that the selectivity of cancer-expressed transporters can be exploited for delivering toxic molecules to tumors...
  4. pmc Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
    Richard Possemato
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 476:346-50. 2011
    ....
  5. pmc mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake
    Omer H Yilmaz
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 486:490-5. 2012
    ..Our findings establish that mTORC1 non-cell-autonomously regulates stem-cell self-renewal, and highlight a significant role of the mammalian intestinal niche in coupling stem-cell function to organismal physiology...
  6. pmc CellProfiler: image analysis software for identifying and quantifying cell phenotypes
    Anne E Carpenter
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Genome Biol 7:R100. 2006
    ....
  7. pmc CellProfiler Analyst: data exploration and analysis software for complex image-based screens
    Thouis R Jones
    Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
    BMC Bioinformatics 9:482. 2008
    ..Image-based screens can produce hundreds of measured features for each of hundreds of millions of individual cells in a single experiment...
  8. ncbi request reprint mTOR and cancer: insights into a complex relationship
    David M Sabatini
    Whitehead Institute for Biomedical Research, MIT Department of Biology, 9 Cambridge Center, Cambridge, Massachusetts 02142 1479, USA
    Nat Rev Cancer 6:729-34. 2006
    ..The purpose is not to cover all aspects of mTOR history and signalling, but rather to foster discussion by presenting some occasionally provocative ideas...
  9. ncbi request reprint Microarrays of lentiviruses for gene function screens in immortalized and primary cells
    Steve N Bailey
    Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology Department of Biology, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Methods 3:117-22. 2006
    ..Because lentiviruses have a wide cellular tropism, including primary cells, lentivirus-infected cell microarrays can be used as a platform for high-throughput screening in a variety of cell types...
  10. pmc Lentivirus-delivered stable gene silencing by RNAi in primary cells
    Sheila A Stewart
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    RNA 9:493-501. 2003
    ....
  11. ncbi request reprint Genome-scale loss-of-function screening with a lentiviral RNAi library
    David E Root
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Nat Methods 3:715-9. 2006
    ..Initial screening efforts have demonstrated that these libraries and methods are practical and powerful tools for high-throughput lentivirus RNAi screens...
  12. pmc Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning
    Thouis R Jones
    The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 106:1826-31. 2009
    ..By using this approach, we successfully scored images in RNA interference screens in 2 organisms for the prevalence of 15 diverse cellular morphologies, some of which were previously intractable...
  13. ncbi request reprint Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
    D D Sarbassov
    Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, MA 02142, USA
    Curr Biol 14:1296-302. 2004
    ..We find that the rictor-mTOR complex modulates the phosphorylation of Protein Kinase C alpha (PKCalpha) and the actin cytoskeleton, suggesting that this aspect of TOR signaling is conserved between yeast and mammals...
  14. ncbi request reprint A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen
    Jason Moffat
    Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA
    Cell 124:1283-98. 2006
    ..This work provides a widely applicable resource for loss-of-function screens, as well as a roadmap for its application to biological discovery...
  15. pmc mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice
    David A Guertin
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cancer Cell 15:148-59. 2009
    ..The selective requirement for mTORC2 in tumor development suggests that mTORC2 inhibitors may be of substantial clinical utility...
  16. pmc Highly parallel identification of essential genes in cancer cells
    Biao Luo
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 105:20380-5. 2008
    ....
  17. ncbi request reprint Systematic genome-wide screens of gene function
    Anne E Carpenter
    Whitehead Institute for Biomedical Research, MIT Department of Biology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Rev Genet 5:11-22. 2004
  18. ncbi request reprint Defining the role of mTOR in cancer
    David A Guertin
    Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, Cambridge, MA 02141, USA
    Cancer Cell 12:9-22. 2007
    ..We further discuss the use of rapamycin in oncology and conclude with a discussion on the future of mTOR-targeted therapy...
  19. ncbi request reprint The pharmacology of mTOR inhibition
    David A Guertin
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02141, USA
    Sci Signal 2:pe24. 2009
    ..Here, we summarize exciting findings regarding mTOR signaling and the outlook for mTOR inhibitors as tools to study the mTOR pathway and as drugs in the clinic...
  20. ncbi request reprint Off-target effects associated with long dsRNAs in Drosophila RNAi screens
    Jason Moffat
    Whitehead Institute, 9 Cambridge Center, Cambridge, MA 02142, USA
    Trends Pharmacol Sci 28:149-51. 2007
    ..Discovering multiple potent siRNAs with minimal off-target profiles for each target transcript will be invaluable for genome-based studies of gene function and for personalized RNAi therapeutics...
  21. ncbi request reprint CellProfiler: free, versatile software for automated biological image analysis
    Michael R Lamprecht
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Biotechniques 42:71-5. 2007
    ....
  22. pmc Microarrays of small molecules embedded in biodegradable polymers for use in mammalian cell-based screens
    Steve N Bailey
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 101:16144-9. 2004
    ..This method will be useful to those performing small-molecule screens to discover new chemical tools and potential therapeutic agents...
  23. ncbi request reprint Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    D D Sarbassov
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, MA 02142, USA
    Science 307:1098-101. 2005
    ..Rictor-mTOR may serve as a drug target in tumors that have lost the expression of PTEN, a tumor suppressor that opposes Akt/PKB activation...
  24. ncbi request reprint RNAi living-cell microarrays for loss-of-function screens in Drosophila melanogaster cells
    Douglas B Wheeler
    Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology Department of Biology, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Methods 1:127-32. 2004
    ....
  25. ncbi request reprint Cell microarrays and RNA interference chip away at gene function
    Douglas B Wheeler
    Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Genet 37:S25-30. 2005
    ..Though still a budding technology, RNAi cell microarrays promise to increase the efficiency, economy and ease of genome-wide RNAi screens in metazoan cells...
  26. ncbi request reprint An expanding role for mTOR in cancer
    David A Guertin
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02141, USA
    Trends Mol Med 11:353-61. 2005
    ..In this article, we re-evaluate mTOR signaling, suggesting a more central role for mTOR in cancers with defective PtdIns3K-PTEN signaling and conceptually discuss these implications in the context of drug discovery...
  27. pmc mTOR and cancer: many loops in one pathway
    Alejo Efeyan
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, United States
    Curr Opin Cell Biol 22:169-76. 2010
    ..Extensive research on mTOR has also uncovered a complex network of regulatory loops that impact the therapeutic approaches aimed at targeting mTOR...
  28. ncbi request reprint Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex
    Dos D Sarbassov
    Department of Biology, Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    J Biol Chem 280:39505-9. 2005
    ..Our findings suggest that a redox-based signaling mechanism may participate in regulating the nutrient-sensitive raptor-mTOR complex and pathway...
  29. ncbi request reprint Growing roles for the mTOR pathway
    Dos D Sarbassov
    Whitehead Institute, MIT Department of Biology, 9 Cambridge Center, Cambridge, Massachussetts 02142, USA
    Curr Opin Cell Biol 17:596-603. 2005
    ....
  30. ncbi request reprint Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site
    Siraj M Ali
    Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, Cambridge, 02142, USA
    J Biol Chem 280:19445-8. 2005
    ..Because many members of the AGC family of kinases lack an analogous domain, rictor-mTOR may phosphorylate the hydrophobic motifs of other kinases...
  31. ncbi request reprint mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
    Do Hyung Kim
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Cell 110:163-75. 2002
    ..We propose that raptor is a missing component of the mTOR pathway that through its association with mTOR regulates cell size in response to nutrient levels...
  32. pmc Growth signaling at the nexus of stem cell life and death
    Kris C Wood
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Cell Stem Cell 5:232-4. 2009
    ..In this issue of Cell Stem Cell and in Nature, Castilho et al. (2009) and Harrison et al. (2009) highlight the importance of mTOR signaling in stem cell exhaustion and mammalian aging, respectively...
  33. pmc DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival
    Timothy R Peterson
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Cell 137:873-86. 2009
    ..Thus, we identify a novel mTOR-interacting protein whose deregulated overexpression in multiple myeloma cells represents a mechanism for activating PI3K/Akt signaling and promoting cell survival...
  34. doi request reprint Cancer cell metabolism: Warburg and beyond
    Peggy P Hsu
    Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology Department of Biology, Cambridge, MA 02142, USA
    Cell 134:703-7. 2008
    ..In this Essay, we re-examine the Warburg effect and establish a framework for understanding its contribution to the altered metabolism of cancer cells...
  35. pmc The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
    Yasemin Sancak
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology MIT, Nine Cambridge Center, Cambridge, MA 02142, USA
    Science 320:1496-501. 2008
    ..The Rag proteins do not directly stimulate the kinase activity of mTORC1, but, like amino acids, promote the intracellular localization of mTOR to a compartment that also contains its activator Rheb...
  36. doi request reprint Increased mTORC1 signaling UPRegulates stress
    Jan H Reiling
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Mol Cell 29:533-5. 2008
    ..2008) show that the loss of the tuberous sclerosis tumor suppressor complex induces endoplasmic reticulum stress, leading to attenuation of insulin receptor signaling activity via the unfolded protein response...
  37. ncbi request reprint AMPK and p53 help cells through lean times
    Carson C Thoreen
    The Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Cell Metab 1:287-8. 2005
    ..Recent work by Jones and colleagues (Jones et al.,2005) reveals how the AMP-activated kinase mediates this process by phosphorylating and activating the tumor suppressor p53...
  38. ncbi request reprint eIF3: a connecTOR of S6K1 to the translation preinitiation complex
    Tim R Peterson
    The Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Mol Cell 20:655-7. 2005
    ....
  39. ncbi request reprint Functional genomics identifies TOR-regulated genes that control growth and division
    David A Guertin
    Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Curr Biol 16:958-70. 2006
    ..Recent efforts have identified at least two multiprotein complexes that contain TOR, but little is known in higher eukaryotes about the genes downstream of TOR that control growth...
  40. ncbi request reprint mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s
    Maria A Frias
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Curr Biol 16:1865-70. 2006
    ..Even though all mTORC2s can phosphorylate Akt/PKB in vitro, insulin regulates the activity of only two of them. Thus, we propose that cells contain several mTORC2 flavors that may phosphorylate Akt/PKB in response to different signals...
  41. ncbi request reprint Building mammalian signalling pathways with RNAi screens
    Jason Moffat
    Whitehead Institute, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Rev Mol Cell Biol 7:177-87. 2006
    ..We are now at the brink of being able to harness the power of RNAi for large-scale functional discovery in mammalian cells...
  42. ncbi request reprint PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
    Yasemin Sancak
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, MA 02142, USA
    Mol Cell 25:903-15. 2007
    ..We propose that the relative strengths of the rheb- and PRAS40-mediated inputs to mTORC1 set overall pathway activity and that insulin activates mTORC1 through the coordinated regulation of both...
  43. ncbi request reprint Minimizing the risk of reporting false positives in large-scale RNAi screens
    Christophe J Echeverri
    Cenix BioScience GmbH, Tatzberg 47, Dresden, 10307, Germany
    Nat Methods 3:777-9. 2006
    ....
  44. pmc Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML
    Zhihong Zeng
    Section of Molecular Hematology and Therapy, Department of Stem Cell Transplantation, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 109:3509-12. 2007
    ..Our study provides the first evidence that rapamycin derivatives inhibit AKT signaling in primary AML cells both in vitro and in vivo, and supports the therapeutic potential of mTOR inhibition strategies in leukemias...
  45. ncbi request reprint Huntingtin aggregates ask to be eaten
    Carson C Thoreen
    Nat Genet 36:553-4. 2004
  46. ncbi request reprint TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function
    Stefanie S Schalm
    The Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Biol 13:797-806. 2003
    ..However, it is unclear how the TOS motif in S6K1 and 4E-BP1 mediates mTOR signaling...
  47. ncbi request reprint GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
    Do Hyung Kim
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, 02142, USA
    Mol Cell 11:895-904. 2003
    ..Thus, we propose that the opposing effects on mTOR activity of the GbetaL- and raptor-mediated interactions regulate the mTOR pathway...

Research Grants22

  1. Rapamycin-Insensitive Signaling by Rictor-mTOR
    David Sabatini; Fiscal Year: 2005
    ..abstract_text> ..
  2. Regulation of the mTOR growth pathway by nutrients
    David Sabatini; Fiscal Year: 2005
    ....
  3. TRANSLATIONAL CONTROL BY RAPAMYCIN-SENSITIVE SIGNALING
    David Sabatini; Fiscal Year: 2001
    ..Thus, our study of the RAFT1 signaling pathway will not only elucidate the workings of a critical regulator of cell division, but also explain how a clinically useful drug exerts its effects. ..
  4. Rapamycin-Insensitive Signaling by Rictor-mTOR
    David Sabatini; Fiscal Year: 2009
    ..abstract_text> ..
  5. Cell Growth Signaling in Cancer Development
    David Sabatini; Fiscal Year: 2009
    ....
  6. Regulation of the mTOR Pathway By Nutrients
    David Sabatini; Fiscal Year: 2009
    ..We anticipate that our work will elucidate molecular mechanisms that may be deranged in human cancers and thus may serve as targets for future drug development. ..
  7. Cell Growth Signaling in Cancer Development
    David M Sabatini; Fiscal Year: 2010
    ....
  8. Rapamycin-Insensitive Signaling by Rictor-mTOR
    David Sabatini; Fiscal Year: 2007
    ..abstract_text> ..
  9. Metabolism and Phosphatase Regulation of the TOR Pathway
    David Sabatini; Fiscal Year: 2007
    ....
  10. TRANSLATIONAL CONTROL BY RAPAMYCIN-SENSITIVE SIGNALING
    David Sabatini; Fiscal Year: 2002
    ..Thus, our study of the RAFT1 signaling pathway will not only elucidate the workings of a critical regulator of cell division, but also explain how a clinically useful drug exerts its effects. ..
  11. TRANSLATIONAL CONTROL BY RAPAMYCIN-SENSITIVE SIGNALING
    David Sabatini; Fiscal Year: 2003
    ..Thus, our study of the RAFT1 signaling pathway will not only elucidate the workings of a critical regulator of cell division, but also explain how a clinically useful drug exerts its effects. ..
  12. Regulation of the mTOR growth pathway by nutrients
    David Sabatini; Fiscal Year: 2004
    ....
  13. TRANSLATIONAL CONTROL BY RAPAMYCIN-SENSITIVE SIGNALING
    David Sabatini; Fiscal Year: 2004
    ..Thus, our study of the RAFT1 signaling pathway will not only elucidate the workings of a critical regulator of cell division, but also explain how a clinically useful drug exerts its effects. ..
  14. Metabolism and Phosphatase Regulation of the TOR Pathway
    David Sabatini; Fiscal Year: 2006
    ....
  15. Regulation of the mTOR growth pathway by nutrients
    David Sabatini; Fiscal Year: 2006
    ....
  16. Regulation of the mTOR growth pathway by nutrients
    David Sabatini; Fiscal Year: 2007
    ....
  17. Regulation of the mTOR Pathway By Nutrients
    David M Sabatini; Fiscal Year: 2010
    ..Furthermore, some of the signaling mechanisms we uncover may serve in the future as targets for drug development. ..
  18. Rapamycin-Insensitive Signaling by Rictor-mTOR
    David Sabatini; Fiscal Year: 2006
    ..abstract_text> ..