J L Rudolph

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Atherosclerosis is associated with delirium after coronary artery bypass graft surgery
    James L Rudolph
    Geriatric Research, Education, and Clinical Center, Division of Aging, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Am Geriatr Soc 53:462-6. 2005
  2. pmc Cerebral hemodynamics during coronary artery bypass graft surgery: the effect of carotid stenosis
    James L Rudolph
    Geriatric Research, Education, and Clinical Center, Boston, MA 02130, USA
    Ultrasound Med Biol 35:1235-41. 2009
  3. pmc Review articles: postoperative delirium: acute change with long-term implications
    James L Rudolph
    Geriatric Research, Education, and Clinical Center, VA Boston Healthcare System GRECC, 150 South Huntington Ave, Boston, MA 02130, USA
    Anesth Analg 112:1202-11. 2011
  4. doi request reprint Validation of a medical record-based delirium risk assessment
    James L Rudolph
    Geriatric Research, Education, and Clinical Center, VA Boston Healthcare System, Boston, MA 02130, USA
    J Am Geriatr Soc 59:S289-94. 2011
  5. pmc Selecting optimal screening items for delirium: an application of item response theory
    Frances M Yang
    Harvard Medical School, Beth Israel Deaconess Medical Center, Division of Gerontology, Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131, USA
    BMC Med Res Methodol 13:8. 2013
  6. doi request reprint Antipsychotics and oropharyngeal dysphagia in hospitalized older patients
    James L Rudolph
    Geriatric Research Education and Clinical Center, VA Boston Healthcare System, 150 South Huntington Ave, Boston, MA 02130, USA
    J Clin Psychopharmacol 28:532-5. 2008
  7. pmc Derivation and validation of a preoperative prediction rule for delirium after cardiac surgery
    James L Rudolph
    VA Boston Healthcare System, Geriatric Research, Education, and Clinical Center, 150 S Huntington Ave, Boston, MA 02130, USA
    Circulation 119:229-36. 2009
  8. pmc Microemboli are not associated with delirium after coronary artery bypass graft surgery
    James L Rudolph
    Geriatric Research, Education, and Clinical Center, Boston VA Healthcare System, Boston, MA 02130, USA
    Perfusion 24:409-15. 2009
  9. pmc Delirium: an independent predictor of functional decline after cardiac surgery
    James L Rudolph
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Boston Healthcare System, Boston, Massachusetts 02130, USA
    J Am Geriatr Soc 58:643-9. 2010
  10. pmc Measurement of post-operative cognitive dysfunction after cardiac surgery: a systematic review
    J L Rudolph
    Geriatric Research Education and Clinical Center, VA Boston Healthcare System, Division of Aging, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02130, USA
    Acta Anaesthesiol Scand 54:663-77. 2010

Research Grants

Detail Information

Publications25

  1. ncbi request reprint Atherosclerosis is associated with delirium after coronary artery bypass graft surgery
    James L Rudolph
    Geriatric Research, Education, and Clinical Center, Division of Aging, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Am Geriatr Soc 53:462-6. 2005
    ..To investigate whether atherosclerosis of the ascending aorta, internal carotid arteries, and coronary arteries is predictive of postoperative delirium in subjects undergoing coronary artery bypass graft (CABG) surgery...
  2. pmc Cerebral hemodynamics during coronary artery bypass graft surgery: the effect of carotid stenosis
    James L Rudolph
    Geriatric Research, Education, and Clinical Center, Boston, MA 02130, USA
    Ultrasound Med Biol 35:1235-41. 2009
    ..Carotid stenosis did not impact mean cerebral blood flow velocity during CABG. The cerebrovascular regulatory process appears to be largely intact during CABG...
  3. pmc Review articles: postoperative delirium: acute change with long-term implications
    James L Rudolph
    Geriatric Research, Education, and Clinical Center, VA Boston Healthcare System GRECC, 150 South Huntington Ave, Boston, MA 02130, USA
    Anesth Analg 112:1202-11. 2011
    ....
  4. doi request reprint Validation of a medical record-based delirium risk assessment
    James L Rudolph
    Geriatric Research, Education, and Clinical Center, VA Boston Healthcare System, Boston, MA 02130, USA
    J Am Geriatr Soc 59:S289-94. 2011
    ..To improve identification of patients at high risk for delirium, this study developed a chart abstraction tool for delirium risk and validated the tool against clinical expert diagnosis of delirium...
  5. pmc Selecting optimal screening items for delirium: an application of item response theory
    Frances M Yang
    Harvard Medical School, Beth Israel Deaconess Medical Center, Division of Gerontology, Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131, USA
    BMC Med Res Methodol 13:8. 2013
    ..This study utilizes IRT to identify a reduced set of optimally performing screening indicators for the four CAM features of delirium...
  6. doi request reprint Antipsychotics and oropharyngeal dysphagia in hospitalized older patients
    James L Rudolph
    Geriatric Research Education and Clinical Center, VA Boston Healthcare System, 150 South Huntington Ave, Boston, MA 02130, USA
    J Clin Psychopharmacol 28:532-5. 2008
    ..Higher doses of antipsychotic medication were associated with worse swallowing function (P = 0.04). Thus, the potential impact on swallow functions should be considered when prescribing antipsychotic medications in older patients...
  7. pmc Derivation and validation of a preoperative prediction rule for delirium after cardiac surgery
    James L Rudolph
    VA Boston Healthcare System, Geriatric Research, Education, and Clinical Center, 150 S Huntington Ave, Boston, MA 02130, USA
    Circulation 119:229-36. 2009
    ..The purpose of the present prospective study was to develop a prediction rule for delirium in a cardiac surgery cohort and to validate it in an independent cohort...
  8. pmc Microemboli are not associated with delirium after coronary artery bypass graft surgery
    James L Rudolph
    Geriatric Research, Education, and Clinical Center, Boston VA Healthcare System, Boston, MA 02130, USA
    Perfusion 24:409-15. 2009
    ..97). While intraoperative microemboli were not associated with delirium after CABG, further investigation into the source and composition of microemboli can further elucidate the long-term clinical impact of microemboli...
  9. pmc Delirium: an independent predictor of functional decline after cardiac surgery
    James L Rudolph
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Boston Healthcare System, Boston, Massachusetts 02130, USA
    J Am Geriatr Soc 58:643-9. 2010
    ..To determine whether patients who developed delirium after cardiac surgery were at risk of functional decline...
  10. pmc Measurement of post-operative cognitive dysfunction after cardiac surgery: a systematic review
    J L Rudolph
    Geriatric Research Education and Clinical Center, VA Boston Healthcare System, Division of Aging, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02130, USA
    Acta Anaesthesiol Scand 54:663-77. 2010
    ..There is marked variability in the measurement and definition of POCD. This heterogeneity may impede progress by reducing the ability to compare studies on the causes and treatment of POCD...
  11. pmc Hospitalization in community-dwelling persons with Alzheimer's disease: frequency and causes
    James L Rudolph
    Aging Brain Center, Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts, USA
    J Am Geriatr Soc 58:1542-8. 2010
    ..To examine the rates of and risk factors for acute hospitalization in a prospective cohort of older community-dwelling patients with Alzheimer's disease (AD)...
  12. pmc Delirium is associated with early postoperative cognitive dysfunction
    J L Rudolph
    VA Boston Healthcare System, Geriatric Education and Clinical Center Brigham and Women s Hospital, Division of Aging, Harvard Medical School, Boston, MA, USA
    Anaesthesia 63:941-7. 2008
    ..3, 95% CI 0.6-2.4). Delirium was associated with early postoperative cognitive dysfunction, but the relationship of delirium to long-term postoperative cognitive dysfunction remains unclear...
  13. doi request reprint The anticholinergic risk scale and anticholinergic adverse effects in older persons
    James L Rudolph
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Boston Healthcare System, Boston, MA 02130, USA
    Arch Intern Med 168:508-13. 2008
    ..The objective of this study was to determine if the ARS score could be used to predict the risk of anticholinergic adverse effects in a geriatric evaluation and management (GEM) cohort and in a primary care cohort...
  14. ncbi request reprint Use of a large bore syringe creates significantly fewer high intensity transient signals (HITS) into a cardiopulmonary bypass system than a small bore syringe
    James L Rudolph
    Geriatric Research Education and Clinical Center, VA Boston Healthcare System, Boston 02130, USA
    Perfusion 21:67-71. 2006
    ..High intensity transient signals (HITS) have been reported to occur following perfusionist intervention during cardiac surgery. This study investigates the relationship of the syringe bore, injection rate, and HITS created...
  15. pmc Impaired executive function is associated with delirium after coronary artery bypass graft surgery
    James L Rudolph
    Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Boston Healthcare System, 150 South Huntington Avenue, Boston, MA 02130, USA
    J Am Geriatr Soc 54:937-41. 2006
    ..To determine the extent to which preoperative performance on tests of executive function and memory was associated with delirium after coronary artery bypass graft (CABG) surgery...
  16. ncbi request reprint Independent vascular and cognitive risk factors for postoperative delirium
    James L Rudolph
    Geriatric Research, Education, and Clinical Center, VA Boston Healthcare System, Boston, Mass 02130, USA lt
    Am J Med 120:807-13. 2007
    ..We hypothesized that vascular risk factors and mildly impaired cognitive performance would independently predispose nondemented patients to develop delirium after noncardiac surgery...
  17. pmc Chemokines are associated with delirium after cardiac surgery
    James L Rudolph
    Geriatric Research, Education, and Clinical Center, 150 South Huntington Ave JP 182, Boston, MA 02130, USA
    J Gerontol A Biol Sci Med Sci 63:184-9. 2008
    ..The purpose of this study was to compare postoperative changes in groups of inflammatory markers in persons who developed delirium following cardiac surgery and matched controls without delirium...
  18. pmc Delirium accelerates cognitive decline in Alzheimer disease
    T G Fong
    Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131, USA
    Neurology 72:1570-5. 2009
    ..To examine the impact of delirium on the trajectory of cognitive function in a cohort of patients with Alzheimer disease (AD)...
  19. pmc Phenomenological subtypes of delirium in older persons: patterns, prevalence, and prognosis
    Frances M Yang
    Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131, USA
    Psychosomatics 50:248-54. 2009
    ..Delirium is an acute confusional state that is common, preventable, and life-threatening...
  20. pmc Telephone interview for cognitive status: Creating a crosswalk with the Mini-Mental State Examination
    Tamara G Fong
    Aging Brain Center, Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA
    Alzheimers Dement 5:492-7. 2009
    ..Screening instruments such as the Telephone Interview for Cognitive Status (TICS) were developed to provide a valid alternative, with comparable cut-point scores to rate global cognitive function...
  21. ncbi request reprint Nursing home patients in the intensive care unit: Risk factors for mortality
    Melissa L P Mattison
    Department of Medicine, Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, USA
    Crit Care Med 34:2583-7. 2006
    ..To determine intensive care unit (ICU) admission characteristics predictive of mortality among older nursing home residents...
  22. ncbi request reprint C-Reactive protein and inflammatory response associated to neurocognitive decline following cardiac surgery
    Basel Ramlawi
    Division of Cardiothoracic Surgery, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Surgery 140:221-6. 2006
    ..The early inflammatory response and C-reactive protein (CRP) was examined in relation to NCD and to a marker of axonal central nervous system (CNS) injury after cardiopulmonary bypass...
  23. ncbi request reprint Genomic expression pathways associated with brain injury after cardiopulmonary bypass
    Basel Ramlawi
    Division of Cardiothoracic Surgery, Beth Israel Deaconess Medical Center, Boston, Mass 02215, USA
    J Thorac Cardiovasc Surg 134:996-1005. 2007
    ..We studied acute variations in gene-expression profiles of patients with neurocognitive decline (NCD group) compared with those without neurocognitive decline (NORM group) after cardiopulmonary bypass...
  24. pmc Serologic markers of brain injury and cognitive function after cardiopulmonary bypass
    Basel Ramlawi
    Division of Cardiothoracic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Ann Surg 244:593-601. 2006
    ..To examine the association between biochemical markers of brain injury (MBI) and the inflammatory response in relation to neurocognitive deficiency (NCD) after cardiopulmonary bypass (CPB)...
  25. ncbi request reprint Serum biomarkers for delirium
    Edward R Marcantonio
    Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02446, USA
    J Gerontol A Biol Sci Med Sci 61:1281-6. 2006
    ..Identifying accurate biomarkers for delirium may shed further light into its pathophysiology and on the interrelationship between delirium and dementia...

Research Grants2

  1. Long-term White Matter Changes Resulting from Delirium after Surgery
    James Rudolph; Fiscal Year: 2007
    ..If the hypotheses are confirmed, this will alter our fundamental understanding of delirium as a short-term disorder and future studies can use imaging to prevent, identify, and treat delirium. ..