Research Topics
Species | Natalia S RostSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
| Collaborators
|
Detail Information
Publications
Predictors of increased intravenous tissue plasminogen activator use among hospitals participating in the Massachusetts Primary Stroke Service ProgramNatalia S Rost
Stroke Service, Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
Circ Cardiovasc Qual Outcomes 5:314-20. 2012....- White matter hyperintensity burden and susceptibility to cerebral ischemiaNatalia S Rost
Stroke Service, Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
Stroke 41:2807-11. 2010..We hypothesized that WMH would be less severe in patients with TIA as compared to those with acute ischemic stroke and completed infarct... - White matter hyperintensity volume is increased in small vessel stroke subtypesN S Rost
J Philip Kistler Stroke Research Center, Center for Human Genetics Research, Massachusetts General Hospital, 175 Cambridge St, Suite 300, Boston, MA 02114, USA
Neurology 75:1670-7. 2010..Therefore, we hypothesized that WMH would be most severe in patients with lacunar stroke and intracerebral hemorrhage (ICH), 2 types of stroke in which cerebral small vessel (SV) changes are pathophysiologically relevant... 
Unsuspected coagulopathy rarely prevents IV thrombolysis in acute ischemic strokeN S Rost
Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
Neurology 73:1957-62. 2009..We sought to identify how often blood clotting abnormalities were responsible for withholding IV tPA at our institution...- Brain natriuretic peptide predicts functional outcome in ischemic strokeNatalia S Rost
J Philip Kistler Stroke Research Center, Massachusetts General Hospital, 175 Cambridge Street, Suite 300, Boston, MA 02114, USA
Stroke 43:441-5. 2012..We sought to determine whether BNP levels were associated with functional outcome after ischemic stroke... - Prediction of functional outcome in patients with primary intracerebral hemorrhage: the FUNC scoreNatalia S Rost
Massachusetts General Hospital, Center for Human Genetic Research, Boston, MA 02114, USA
Stroke 39:2304-9. 2008..We developed an acute clinical score to predict likelihood of functional independence... - Determinants of white matter hyperintensity volume in patients with acute ischemic strokeNatalia S Rost
Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
J Stroke Cerebrovasc Dis 19:230-5. 2010..It is unclear whether WMH represents a single or multiple biological processes. We sought to investigate the extent and determinants of WMH in patients with acute ischemic stroke (AIS)... - The effect of survival bias on case-control genetic association studies of highly lethal diseasesChristopher D Anderson
Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
Circ Cardiovasc Genet 4:188-96. 2011.... - Burden of blood pressure-related alleles is associated with larger hematoma volume and worse outcome in intracerebral hemorrhageGuido J Falcone
Center for Human Genetic Research, Massachusetts General Hospital, 185 Cambridge St, CPZN 6818, Boston, MA 02114, USA
Stroke 44:321-6. 2013..As the burden of high blood pressure-related alleles is associated with both hypertension-related end-organ damage and risk of ICH, we sought to determine whether this burden influences ICH baseline hematoma volume... - Apolipoprotein E genotype predicts hematoma expansion in lobar intracerebral hemorrhageH Bart Brouwers
Center for Human Genetic Research Rosand Lab, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, CPZN 6818, Boston, MA 02114, USA
Stroke 43:1490-5. 2012..Among patients with lobar ICH, the apolipoprotein E (APOE) ε2 allele predicts larger hematoma volumes at presentation. We investigated whether the ε2 allele also identifies individuals at increased risk of hematoma expansion... - APOE genotype and extent of bleeding and outcome in lobar intracerebral haemorrhage: a genetic association studyAlessandro Biffi
Hemorrhagic Stroke Research Group, Massachusetts General Hospital, Boston, MA, USA
Lancet Neurol 10:702-9. 2011..We aimed to assess whether these variants also associate with severity of ICH, in terms of haematoma volume at presentation and subsequent outcome... - Elderly patients are at higher risk for poor outcomes after intra-arterial therapyRonil V Chandra
Department of Radiology, Divisions of Interventional, Massachusetts General Hospital, Boston, MA, USA
Stroke 43:2356-61. 2012..We compare safety and clinical outcomes of multimodal IAT in elderly versus nonelderly patients and investigate differences in baseline health and disability as possible explanatory factors... - Common mitochondrial sequence variants in ischemic strokeChristopher D Anderson
Center for Human Genetic Research, Massachusetts General Hospital, Boston, 02114, USA
Ann Neurol 69:471-80. 2011..We investigated whether common mitochondrial genetic variants influence risk of sporadic ischemic stroke and, in patients with stroke, the volume of white matter hyperintensity (WMHV)... - Variants at APOE influence risk of deep and lobar intracerebral hemorrhageAlessandro Biffi
Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
Ann Neurol 68:934-43. 2010.... - Burden of risk alleles for hypertension increases risk of intracerebral hemorrhageGuido J Falcone
Center for Human Genetic Research, Department of Neurology, Massachusetts General Hospital, and Department of Epidemiology, Harvard School of Public Health, 185 Cambridge Street CPZN 6818, Boston, MA 02114, USA
Stroke 43:2877-83. 2012..We sought to determine whether the cumulative burden of blood pressure-related SNPs is associated with risk of ICH and pre-ICH diagnosis of HTN... - Hyperlipidemia and reduced white matter hyperintensity volume in patients with ischemic strokeJordi Jimenez-Conde
Stroke Service, Department of Neurology and Center for Human Genetics Research, Massachusetts General Hospital, and Program in Medical and Population Genetics, Broad Institute of MIT and Harvard University, Boston, Mass 02114, USA
Stroke 41:437-42. 2010..We sought to determine the relation between hyperlipidemia and WMH severity in patients with acute ischemic stroke (AIS)... - Packed red blood cell transfusion and decreased mortality in intracerebral hemorrhageKevin N Sheth
Department of Neurology, Division of Stroke and Neurocritical Care, University of Maryland Medical Center, Baltimore, Maryland 21201, USA
Neurosurgery 68:1286-92. 2011..Although packed red blood cell (PRBC) transfusion appears to increase brain tissue oxygen, it is unknown whether such transfusions, which are commonly administered in patients with intracranial hemorrhage, alter outcome... - Common variants within oxidative phosphorylation genes influence risk of ischemic stroke and intracerebral hemorrhageChristopher D Anderson
Massachusetts General Hospital, Boston, MA 02114, USA
Stroke 44:612-9. 2013.... - Assessing variability in neurointerventional practice patterns for acute ischemic strokeBrijesh Mehta
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Neurointerv Surg 5:i52-i57. 2013..There are minimal data and guidelines for treatment indications and performance standards. We aimed to gain a better understanding of real-world practice patterns for IAT... - Risk of thromboembolism following acute intracerebral hemorrhageJoshua N Goldstein
Department of Emergency Medicine, Massachusetts General Hospital, Zero Emerson Place, Suite 3B, Boston, MA 02114, USA
Neurocrit Care 10:28-34. 2009..We hypothesized that TEs are relatively common following ICH, and that anticoagulated patients are at higher risk for these complications... - Anemia and hematoma volume in acute intracerebral hemorrhageMonisha A Kumar
Department of Neurology, Stroke and Neurocritical Care Division, Thomas Jefferson University Hospital Philadelphia, PA, USA
Crit Care Med 37:1442-7. 2009..In primary intracerebral hemorrhage (ICH), the most fatal type of stroke, outcome is largely dependent on the volume of hemorrhage into the brain. We investigated the relationship between anemia and clinical course of acute ICH... - Impact of acute ischemic stroke treatment in patients >80 years of age: the specialized program of translational research in acute stroke (SPOTRIAS) consortium experienceJoshua Z Willey
Department of Neurology, 710 West 168 Street, Box 30, New York, NY 10032, USA
Stroke 43:2369-75. 2012.... - Body mass index and etiology of intracerebral hemorrhageAlessandro Biffi
Center for Human Genetic Research, Massachusetts General Hospital, 185 Cambridge Street CPZN 6818, Boston, MA 02114, USA
Stroke 42:2526-30. 2011..Extremes of body mass index (BMI) are associated with increased incidence of intracerebral hemorrhage (ICH). Because ICH can result from different vessel pathologies, we investigated whether the effect of BMI depends on ICH etiology... - Principal-component analysis for assessment of population stratification in mitochondrial medical geneticsAlessandro Biffi
Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Hum Genet 86:904-17. 2010..Finally, we demonstrate, through simulation, no loss in power for detection of true associations with the use of mitochondrial PCA... - Chromosome 9p21 in ischemic stroke: population structure and meta-analysisChristopher D Anderson
Center for Human Genetic Research, Massachusetts General Hospital, 185 Cambridge Street, CPZN 6818, Boston, MA 02114, USA
Stroke 41:1123-31. 2010..We investigated whether these conflicting findings were due to false-positive studies confounded by population stratification or false-negative studies that failed to account for effects specific to certain stroke subtypes... - Statin treatment and functional outcome after ischemic stroke: case-control and meta-analysisAlessandro Biffi
J Philip Kistler Stroke Research Center, Center for Human Genetics Research, Department of Neurology, Massachusetts General Hospital, 175 Cambridge Street, Suite 300, Boston MA 02114, USA
Stroke 42:1314-9. 2011..We therefore investigated the effect of antecedent use of statins on stroke outcome by performing a meta-analysis of all results from published studies as well as our own unpublished data... - Implementation of a patient selection protocol for intra-arterial therapy increases treatment rates in patients with acute ischemic strokeNatalia S Rost
Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA
J Neurointerv Surg 5:i44-i47. 2013..The degree of protocol adoption and treatment rates associated with implementation of a service-wide patient selection IAT protocol were assessed... - The genetic architecture of intracerebral hemorrhageNatalia S Rost
Department of Neurology, and Hemorrhagic Stroke Research Program, Massachusetts General Hospital, 185 Cambridge Street, Boston MA 02114, USA
Stroke 39:2166-73. 2008..This review focuses on evidence for a genetic contribution to ICH, delineates approaches to genetic studies of ICH, and explores foundations for their future applications... - Diffusion weighted imaging reversibility in the brainstem following successful recanalization of acute basilar artery occlusionAlbert J Yoo
Department of Neuroradiology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Neurointerv Surg 2:195-7. 2010..The degree of apparent diffusion coefficient reduction on pretreatment MRI may not adequately identify which DWI abnormal brainstem tissue is potentially reversible... 
Effect of statins on intracerebral hemorrhage outcome and recurrenceEmilie FitzMaurice
Stroke 39:2151-4. 2008..82, 95% CI 0.34 to 1.99, P=0.66). CONCLUSIONS: Pre-ICH statin use is not associated with improved ICH functional outcome or mortality. Post-ICH statin use is not associated with an increased risk of ICH recurrence...