Natalia S Rost

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Clinical neurogenetics: stroke
    Natalia S Rost
    Department of Neurology, JP Kistler Stroke Research Center, Massachusetts General Hospital, 175 Cambridge Street, Suite 300, Boston, MA 02114, USA Electronic address
    Neurol Clin 31:915-28. 2013
  2. pmc Implementation of a patient selection protocol for intra-arterial therapy increases treatment rates in patients with acute ischemic stroke
    Natalia S Rost
    Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Neurointerv Surg 5:i44-7. 2013
  3. pmc Predictors of increased intravenous tissue plasminogen activator use among hospitals participating in the Massachusetts Primary Stroke Service Program
    Natalia S Rost
    Stroke Service, Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Circ Cardiovasc Qual Outcomes 5:314-20. 2012
  4. pmc Brain natriuretic peptide predicts functional outcome in ischemic stroke
    Natalia S Rost
    J Philip Kistler Stroke Research Center, Massachusetts General Hospital, 175 Cambridge Street, Suite 300, Boston, MA 02114, USA
    Stroke 43:441-5. 2012
  5. pmc White matter hyperintensity volume is increased in small vessel stroke subtypes
    N S Rost
    J Philip Kistler Stroke Research Center, Center for Human Genetics Research, Massachusetts General Hospital, 175 Cambridge St, Suite 300, Boston, MA 02114, USA
    Neurology 75:1670-7. 2010
  6. pmc White matter hyperintensity burden and susceptibility to cerebral ischemia
    Natalia S Rost
    Stroke Service, Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Stroke 41:2807-11. 2010
  7. doi request reprint Determinants of white matter hyperintensity volume in patients with acute ischemic stroke
    Natalia S Rost
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Stroke Cerebrovasc Dis 19:230-5. 2010
  8. doi request reprint Prediction of functional outcome in patients with primary intracerebral hemorrhage: the FUNC score
    Natalia S Rost
    Massachusetts General Hospital, Center for Human Genetic Research, Boston, MA 02114, USA
    Stroke 39:2304-9. 2008
  9. doi request reprint Unsuspected coagulopathy rarely prevents IV thrombolysis in acute ischemic stroke
    N S Rost
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Neurology 73:1957-62. 2009
  10. pmc Prestroke dementia is associated with poor outcomes after reperfusion therapy among elderly stroke patients
    Katharina M Busl
    Stroke Service, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Stroke Cerebrovasc Dis 22:718-24. 2013

Collaborators

Detail Information

Publications37

  1. pmc Clinical neurogenetics: stroke
    Natalia S Rost
    Department of Neurology, JP Kistler Stroke Research Center, Massachusetts General Hospital, 175 Cambridge Street, Suite 300, Boston, MA 02114, USA Electronic address
    Neurol Clin 31:915-28. 2013
    ..The recently uncovered shared genetic contribution between clinically manifest stroke syndromes and closely related intermediate cerebrovascular phenotypes offers effective and efficient approaches to complex trait analysis. ..
  2. pmc Implementation of a patient selection protocol for intra-arterial therapy increases treatment rates in patients with acute ischemic stroke
    Natalia S Rost
    Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Neurointerv Surg 5:i44-7. 2013
    ..The degree of protocol adoption and treatment rates associated with implementation of a service-wide patient selection IAT protocol were assessed...
  3. pmc Predictors of increased intravenous tissue plasminogen activator use among hospitals participating in the Massachusetts Primary Stroke Service Program
    Natalia S Rost
    Stroke Service, Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Circ Cardiovasc Qual Outcomes 5:314-20. 2012
    ....
  4. pmc Brain natriuretic peptide predicts functional outcome in ischemic stroke
    Natalia S Rost
    J Philip Kistler Stroke Research Center, Massachusetts General Hospital, 175 Cambridge Street, Suite 300, Boston, MA 02114, USA
    Stroke 43:441-5. 2012
    ..We sought to determine whether BNP levels were associated with functional outcome after ischemic stroke...
  5. pmc White matter hyperintensity volume is increased in small vessel stroke subtypes
    N S Rost
    J Philip Kistler Stroke Research Center, Center for Human Genetics Research, Massachusetts General Hospital, 175 Cambridge St, Suite 300, Boston, MA 02114, USA
    Neurology 75:1670-7. 2010
    ..Therefore, we hypothesized that WMH would be most severe in patients with lacunar stroke and intracerebral hemorrhage (ICH), 2 types of stroke in which cerebral small vessel (SV) changes are pathophysiologically relevant...
  6. pmc White matter hyperintensity burden and susceptibility to cerebral ischemia
    Natalia S Rost
    Stroke Service, Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Stroke 41:2807-11. 2010
    ..We hypothesized that WMH would be less severe in patients with TIA as compared to those with acute ischemic stroke and completed infarct...
  7. doi request reprint Determinants of white matter hyperintensity volume in patients with acute ischemic stroke
    Natalia S Rost
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Stroke Cerebrovasc Dis 19:230-5. 2010
    ..It is unclear whether WMH represents a single or multiple biological processes. We sought to investigate the extent and determinants of WMH in patients with acute ischemic stroke (AIS)...
  8. doi request reprint Prediction of functional outcome in patients with primary intracerebral hemorrhage: the FUNC score
    Natalia S Rost
    Massachusetts General Hospital, Center for Human Genetic Research, Boston, MA 02114, USA
    Stroke 39:2304-9. 2008
    ..We developed an acute clinical score to predict likelihood of functional independence...
  9. doi request reprint Unsuspected coagulopathy rarely prevents IV thrombolysis in acute ischemic stroke
    N S Rost
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Neurology 73:1957-62. 2009
    ..We sought to identify how often blood clotting abnormalities were responsible for withholding IV tPA at our institution...
  10. pmc Prestroke dementia is associated with poor outcomes after reperfusion therapy among elderly stroke patients
    Katharina M Busl
    Stroke Service, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Stroke Cerebrovasc Dis 22:718-24. 2013
    ..In elderly acute stroke patients, reperfusion therapy is often withheld. We sought to determine whether prestroke dementia contributed to poor outcomes after reperfusion therapy in these patients...
  11. pmc Heritability estimates identify a substantial genetic contribution to risk and outcome of intracerebral hemorrhage
    William J Devan
    Center for Human Genetic Research, Massachusetts General Hospital, 185 Cambridge St, CPZN 6818, Boston, MA 02114, USA
    Stroke 44:1578-83. 2013
    ..However, a novel analytic tool based on genome-wide data allows heritability estimation from unrelated subjects. We sought to apply this method to provide heritability estimates for ICH risk, severity, and outcome...
  12. pmc The effect of survival bias on case-control genetic association studies of highly lethal diseases
    Christopher D Anderson
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Circ Cardiovasc Genet 4:188-96. 2011
    ....
  13. pmc Variability in the use of intravenous thrombolysis for mild stroke: experience across the SPOTRIAS network
    Joshua Z Willey
    Department of Neurology, Columbia University, New York, New York, USA
    J Stroke Cerebrovasc Dis 22:318-22. 2013
    ..Current guidelines do not define the lower severity threshold for thrombolysis. In this study, we describe the variability of treatment of mild stroke patients across a network of academic stroke centers...
  14. pmc Predictors of hematoma volume in deep and lobar supratentorial intracerebral hemorrhage
    Guido J Falcone
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    JAMA Neurol 70:988-94. 2013
    ..Despite known differences in the underlying biology between deep and lobar ICHs, limited data are available on location specificity of factors reported to affect hematoma volume...
  15. pmc Common variants within oxidative phosphorylation genes influence risk of ischemic stroke and intracerebral hemorrhage
    Christopher D Anderson
    Massachusetts General Hospital, Boston, MA 02114, USA
    Stroke 44:612-9. 2013
    ....
  16. pmc Burden of blood pressure-related alleles is associated with larger hematoma volume and worse outcome in intracerebral hemorrhage
    Guido J Falcone
    Center for Human Genetic Research, Massachusetts General Hospital, 185 Cambridge St, CPZN 6818, Boston, MA 02114, USA
    Stroke 44:321-6. 2013
    ..As the burden of high blood pressure-related alleles is associated with both hypertension-related end-organ damage and risk of ICH, we sought to determine whether this burden influences ICH baseline hematoma volume...
  17. pmc Apolipoprotein E genotype predicts hematoma expansion in lobar intracerebral hemorrhage
    H Bart Brouwers
    Center for Human Genetic Research Rosand Lab, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, CPZN 6818, Boston, MA 02114, USA
    Stroke 43:1490-5. 2012
    ..Among patients with lobar ICH, the apolipoprotein E (APOE) ε2 allele predicts larger hematoma volumes at presentation. We investigated whether the ε2 allele also identifies individuals at increased risk of hematoma expansion...
  18. pmc APOE genotype and extent of bleeding and outcome in lobar intracerebral haemorrhage: a genetic association study
    Alessandro Biffi
    Hemorrhagic Stroke Research Group, Massachusetts General Hospital, Boston, MA, USA
    Lancet Neurol 10:702-9. 2011
    ..We aimed to assess whether these variants also associate with severity of ICH, in terms of haematoma volume at presentation and subsequent outcome...
  19. doi request reprint Assessing variability in neurointerventional practice patterns for acute ischemic stroke
    Brijesh Mehta
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurointerv Surg 5:i52-7. 2013
    ..There are minimal data and guidelines for treatment indications and performance standards. We aimed to gain a better understanding of real-world practice patterns for IAT...
  20. doi request reprint Elderly patients are at higher risk for poor outcomes after intra-arterial therapy
    Ronil V Chandra
    Department of Radiology, Divisions of Interventional, Massachusetts General Hospital, Boston, MA, USA
    Stroke 43:2356-61. 2012
    ..We compare safety and clinical outcomes of multimodal IAT in elderly versus nonelderly patients and investigate differences in baseline health and disability as possible explanatory factors...
  21. pmc Common mitochondrial sequence variants in ischemic stroke
    Christopher D Anderson
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, 02114, USA
    Ann Neurol 69:471-80. 2011
    ..We investigated whether common mitochondrial genetic variants influence risk of sporadic ischemic stroke and, in patients with stroke, the volume of white matter hyperintensity (WMHV)...
  22. pmc Variants at APOE influence risk of deep and lobar intracerebral hemorrhage
    Alessandro Biffi
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Ann Neurol 68:934-43. 2010
    ....
  23. pmc Burden of risk alleles for hypertension increases risk of intracerebral hemorrhage
    Guido J Falcone
    Center for Human Genetic Research, Department of Neurology, Massachusetts General Hospital, and Department of Epidemiology, Harvard School of Public Health, 185 Cambridge Street CPZN 6818, Boston, MA 02114, USA
    Stroke 43:2877-83. 2012
    ..We sought to determine whether the cumulative burden of blood pressure-related SNPs is associated with risk of ICH and pre-ICH diagnosis of HTN...
  24. pmc Hyperlipidemia and reduced white matter hyperintensity volume in patients with ischemic stroke
    Jordi Jimenez-Conde
    Stroke Service, Department of Neurology and Center for Human Genetics Research, Massachusetts General Hospital, and Program in Medical and Population Genetics, Broad Institute of MIT and Harvard University, Boston, Mass 02114, USA
    Stroke 41:437-42. 2010
    ..We sought to determine the relation between hyperlipidemia and WMH severity in patients with acute ischemic stroke (AIS)...
  25. doi request reprint Packed red blood cell transfusion and decreased mortality in intracerebral hemorrhage
    Kevin N Sheth
    Department of Neurology, Division of Stroke and Neurocritical Care, University of Maryland Medical Center, Baltimore, Maryland 21201, USA
    Neurosurgery 68:1286-92. 2011
    ..Although packed red blood cell (PRBC) transfusion appears to increase brain tissue oxygen, it is unknown whether such transfusions, which are commonly administered in patients with intracranial hemorrhage, alter outcome...
  26. doi request reprint Predicting hematoma expansion after primary intracerebral hemorrhage
    H Bart Brouwers
    Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston2Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston3Hemorrhagic S
    JAMA Neurol 71:158-64. 2014
    ..The results open a path for individualized treatment and trial design in ICH aimed at patients at highest risk of hematoma expansion with maximum potential for therapeutic benefit. ..
  27. doi request reprint Anemia and hematoma volume in acute intracerebral hemorrhage
    Monisha A Kumar
    Department of Neurology, Stroke and Neurocritical Care Division, Thomas Jefferson University Hospital Philadelphia, PA, USA
    Crit Care Med 37:1442-7. 2009
    ..In primary intracerebral hemorrhage (ICH), the most fatal type of stroke, outcome is largely dependent on the volume of hemorrhage into the brain. We investigated the relationship between anemia and clinical course of acute ICH...
  28. doi request reprint Risk of thromboembolism following acute intracerebral hemorrhage
    Joshua N Goldstein
    Department of Emergency Medicine, Massachusetts General Hospital, Zero Emerson Place, Suite 3B, Boston, MA 02114, USA
    Neurocrit Care 10:28-34. 2009
    ..We hypothesized that TEs are relatively common following ICH, and that anticoagulated patients are at higher risk for these complications...
  29. pmc Impact of acute ischemic stroke treatment in patients >80 years of age: the specialized program of translational research in acute stroke (SPOTRIAS) consortium experience
    Joshua Z Willey
    Department of Neurology, 710 West 168 Street, Box 30, New York, NY 10032, USA
    Stroke 43:2369-75. 2012
    ....
  30. pmc Body mass index and etiology of intracerebral hemorrhage
    Alessandro Biffi
    Center for Human Genetic Research, Massachusetts General Hospital, 185 Cambridge Street CPZN 6818, Boston, MA 02114, USA
    Stroke 42:2526-30. 2011
    ..Extremes of body mass index (BMI) are associated with increased incidence of intracerebral hemorrhage (ICH). Because ICH can result from different vessel pathologies, we investigated whether the effect of BMI depends on ICH etiology...
  31. pmc Chromosome 9p21 in ischemic stroke: population structure and meta-analysis
    Christopher D Anderson
    Center for Human Genetic Research, Massachusetts General Hospital, 185 Cambridge Street, CPZN 6818, Boston, MA 02114, USA
    Stroke 41:1123-31. 2010
    ..We investigated whether these conflicting findings were due to false-positive studies confounded by population stratification or false-negative studies that failed to account for effects specific to certain stroke subtypes...
  32. pmc Principal-component analysis for assessment of population stratification in mitochondrial medical genetics
    Alessandro Biffi
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Hum Genet 86:904-17. 2010
    ..Finally, we demonstrate, through simulation, no loss in power for detection of true associations with the use of mitochondrial PCA...
  33. pmc Statin treatment and functional outcome after ischemic stroke: case-control and meta-analysis
    Alessandro Biffi
    J Philip Kistler Stroke Research Center, Center for Human Genetics Research, Department of Neurology, Massachusetts General Hospital, 175 Cambridge Street, Suite 300, Boston MA 02114, USA
    Stroke 42:1314-9. 2011
    ..We therefore investigated the effect of antecedent use of statins on stroke outcome by performing a meta-analysis of all results from published studies as well as our own unpublished data...
  34. doi request reprint Diffusion weighted imaging reversibility in the brainstem following successful recanalization of acute basilar artery occlusion
    Albert J Yoo
    Department of Neuroradiology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Neurointerv Surg 2:195-7. 2010
    ..The degree of apparent diffusion coefficient reduction on pretreatment MRI may not adequately identify which DWI abnormal brainstem tissue is potentially reversible...
  35. doi request reprint Improving door-to-needle times: a single center validation of the target stroke hypothesis
    Ilana M Ruff
    From the Departments of Neurology I R, S A, N R, L S, Radiology W C, M L, and Emergency Medicine J G, J M, Massachusetts General Hospital, Harvard Medical School, Boston, MA
    Stroke 45:504-8. 2014
    ..In 2007, we implemented a new institutional acute stroke care model to include 10 best practices and evaluated the effect of this intervention on improving door-to-computed tomography (CT) and door-to-needle (DTN) times at our hospital...
  36. doi request reprint The genetic architecture of intracerebral hemorrhage
    Natalia S Rost
    Department of Neurology, and Hemorrhagic Stroke Research Program, Massachusetts General Hospital, 185 Cambridge Street, Boston MA 02114, USA
    Stroke 39:2166-73. 2008
    ..This review focuses on evidence for a genetic contribution to ICH, delineates approaches to genetic studies of ICH, and explores foundations for their future applications...
  37. doi request reprint Effect of statins on intracerebral hemorrhage outcome and recurrence
    Emilie FitzMaurice
    Stroke 39:2151-4. 2008
    ..We investigated (1) whether statin use before ICH was associated with functional independence at 90 days, and (2) whether survivors exposed to statins after ICH had an increased risk of recurrence...