J F Rosenbaum

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi A controlled study of behavioral inhibition in children of parents with panic disorder and depression
    J F Rosenbaum
    Department of Psychiatry, Massachusetts General Hospital, Boston, 02114, USA
    Am J Psychiatry 157:2002-10. 2000
  2. ncbi Attitudes toward benzodiazepines over the years
    Jerrold F Rosenbaum
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 66:4-8. 2005
  3. ncbi The development of clonazepam as a psychotropic: the massachusetts general hospital experience
    Jerrold F Rosenbaum
    Department of Psychiatry, Massachusetts General Hospital, Boston, USA
    J Clin Psychiatry 65:3-6. 2004
  4. ncbi Further evidence of association between behavioral inhibition and social anxiety in children
    J Biederman
    Department of Psychiatry, Massachusetts General Hospital, Boston, 02114, USA
    Am J Psychiatry 158:1673-9. 2001
  5. ncbi Lack of association between parental alcohol or drug addiction and behavioral inhibition in children
    J Biederman
    Department of Psychiatry Unit of Clinical Psychopharmacology, Massachusetts General Hospital, Boston, 02114, USA
    Am J Psychiatry 158:1731-3. 2001
  6. ncbi Patterns of psychopathology and dysfunction in high-risk children of parents with panic disorder and major depression
    J Biederman
    Pediatric Psychopharmacology Program, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 158:49-57. 2001
  7. ncbi Hypochondriacal concerns in depressed outpatients
    C Demopulos
    Depression Research Program, Massachusetts General Hospital, Boston 02114, USA
    Psychosom Med 58:314-20. 1996
  8. ncbi Course and treatment of atypical depression
    A A Nierenberg
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston 02114, USA
    J Clin Psychiatry 59:5-9. 1998
  9. ncbi Temperamental correlates of disruptive behavior disorders in young children: preliminary findings
    Dina R Hirshfeld-Becker
    Pediatric Psychopharmacology Unit, Department of Psychiatry, Massachusetts General Hospital, Building 149, 13th Street, Boston, MA 02129, USA
    Biol Psychiatry 51:563-74. 2002
  10. ncbi Predictors of relapse during fluoxetine continuation or maintenance treatment of major depression
    P J McGrath
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, USA
    J Clin Psychiatry 61:518-24. 2000

Research Grants

  1. A LONGITUDINAL FOLLOW UP OF CHILDREN AT RISK FOR ANXIETY
    Jerrold Rosenbaum; Fiscal Year: 2003
  2. Children at Risk for Anxiety Disorders: A Follow up Study
    Jerrold Rosenbaum; Fiscal Year: 2007
  3. PSYCHOPATHOLOGY IN CHILDREN OF AGORAPHOBIC PARENTS
    Jerrold Rosenbaum; Fiscal Year: 1993

Collaborators

Detail Information

Publications85

  1. ncbi A controlled study of behavioral inhibition in children of parents with panic disorder and depression
    J F Rosenbaum
    Department of Psychiatry, Massachusetts General Hospital, Boston, 02114, USA
    Am J Psychiatry 157:2002-10. 2000
    ..Several lines of evidence suggest that behavioral inhibition is an index of anxiety proneness. The authors sought to replicate prior findings and examine the specificity of the association between behavioral inhibition and anxiety...
  2. ncbi Attitudes toward benzodiazepines over the years
    Jerrold F Rosenbaum
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 66:4-8. 2005
    ..The intent of this article is to provide a historic overview of these issues and to offer some general clinical principles to help minimize the risk of abuse and dependence with benzodiazepine use...
  3. ncbi The development of clonazepam as a psychotropic: the massachusetts general hospital experience
    Jerrold F Rosenbaum
    Department of Psychiatry, Massachusetts General Hospital, Boston, USA
    J Clin Psychiatry 65:3-6. 2004
    ..The process of exploring new uses of older agents remains a worthy effort while we await newer agents with innovative mechanisms of action...
  4. ncbi Further evidence of association between behavioral inhibition and social anxiety in children
    J Biederman
    Department of Psychiatry, Massachusetts General Hospital, Boston, 02114, USA
    Am J Psychiatry 158:1673-9. 2001
    ..1 versus 50.8). CONCLUSIONS: This study adds to the growing literature suggesting an association between behavioral inhibition and social anxiety disorder and an inverse relationship between inhibition and disruptive behavior disorders...
  5. ncbi Lack of association between parental alcohol or drug addiction and behavioral inhibition in children
    J Biederman
    Department of Psychiatry Unit of Clinical Psychopharmacology, Massachusetts General Hospital, Boston, 02114, USA
    Am J Psychiatry 158:1731-3. 2001
    ..CONCLUSIONS: These results are not consistent with the hypothesis linking behavioral inhibition to addictions...
  6. ncbi Patterns of psychopathology and dysfunction in high-risk children of parents with panic disorder and major depression
    J Biederman
    Pediatric Psychopharmacology Program, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 158:49-57. 2001
    ....
  7. ncbi Hypochondriacal concerns in depressed outpatients
    C Demopulos
    Depression Research Program, Massachusetts General Hospital, Boston 02114, USA
    Psychosom Med 58:314-20. 1996
    ....
  8. ncbi Course and treatment of atypical depression
    A A Nierenberg
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston 02114, USA
    J Clin Psychiatry 59:5-9. 1998
    ..A review and critique of the relevant literature on atypical depression will be presented...
  9. ncbi Temperamental correlates of disruptive behavior disorders in young children: preliminary findings
    Dina R Hirshfeld-Becker
    Pediatric Psychopharmacology Unit, Department of Psychiatry, Massachusetts General Hospital, Building 149, 13th Street, Boston, MA 02129, USA
    Biol Psychiatry 51:563-74. 2002
    ..Longitudinal studies using behavioral assessments of behavioral disinhibition are needed to confirm these findings...
  10. ncbi Predictors of relapse during fluoxetine continuation or maintenance treatment of major depression
    P J McGrath
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, USA
    J Clin Psychiatry 61:518-24. 2000
    ..The goal was to examine predictors of relapse during continuation/maintenance treatment of major depression that had remitted following 12 to 14 weeks of fluoxetine therapy...
  11. ncbi Timing of onset of antidepressant response with fluoxetine treatment
    A A Nierenberg
    Depression and Clinical Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 157:1423-8. 2000
    ..The purpose of this study was to assess the time until onset of antidepressant response with fluoxetine treatment...
  12. ncbi Folate, vitamin B12, and homocysteine in major depressive disorder
    M Fava
    Depression Clinical and Research Program, Clinical Psychopharmacology Unit, Massachusetts General Hospital, Boston 02114, USA
    Am J Psychiatry 154:426-8. 1997
    ..The authors examined the relationships between levels of three metabolites (folate, vitamin B12, and homocysteine) and both depressive subtype and response to fluoxetine treatment in depressed patients...
  13. ncbi Targeted genome screen of panic disorder and anxiety disorder proneness using homology to murine QTL regions
    J W Smoller
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA
    Am J Med Genet 105:195-206. 2001
    ..05, P = 0.035). While these linkage results are merely suggestive, this study illustrates the potential advantages of using mouse gene-mapping results and exploring alternative phenotype definitions in linkage studies of anxiety disorder...
  14. ncbi Genetic association analysis of behavioral inhibition using candidate loci from mouse models
    J W Smoller
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Am J Med Genet 105:226-35. 2001
    ..This study illustrates the potential utility of using candidate genes derived from mouse models to dissect the genetic basis of BI, a possible intermediate phenotype for panic and phobic disorders...
  15. ncbi Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9086, USA
    Am J Psychiatry 163:1905-17. 2006
    ..This report describes the participants and compares the acute and longer-term treatment outcomes associated with each of four successive steps in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial...
  16. ncbi Behavioral inhibition and disinhibition as hypothesized precursors to psychopathology: implications for pediatric bipolar disorder
    Dina R Hirshfeld-Becker
    Pediatric Psychopharmacology Program, Massachusetts General Hospital, Cambridge, Massacusetts 02138, USA
    Biol Psychiatry 53:985-99. 2003
    ....
  17. ncbi Fenfluramine challenge in unipolar depression with and without anger attacks
    M Fava
    Depression Clinical and Research Program, WACC 812, Massachusetts General Hospital, 15 Parkman Street, Boston, MA 02114, USA
    Psychiatry Res 94:9-18. 2000
    ....
  18. ncbi Fluoxetine versus sertraline and paroxetine in major depression: tolerability and efficacy in anxious depression
    M Fava
    Depression Clinical and Research Program, Clinical Psychopharmacology Unit, Massachusetts General Hospital, WAC 812, 15 Parkman Street, 02114, Boston, MA, USA
    J Affect Disord 59:119-26. 2000
    ..For this reason, using head-to-head acute treatment comparison, we compared efficacy and tolerability of fluoxetine, sertraline, and paroxetine among depressed patients with high levels of anxiety...
  19. ncbi Personality and bipolar disorder: dissecting state and trait associations between mood and personality
    J H Barnett
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, and Psychiatric Genetics Program in Mood and Anxiety Disorders, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
    Psychol Med 41:1593-604. 2011
    ..This study aimed to determine whether there is a characteristic personality profile in BD, and whether associations between BD and personality are best explained by state or trait effects...
  20. ncbi Sequenced treatment alternatives to relieve depression (STAR*D): rationale and design
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9086, USA
    Control Clin Trials 25:119-42. 2004
    ..Participants with an adequate symptomatic response may enter the 12-month naturalistic follow-up phase with brief monthly and more complete quarterly assessments...
  21. ncbi A preliminary open study of the tolerability and effectiveness of nefazodone in major depressive disorder: comparing patients who recently discontinued an SSRI with those on no recent antidepressant treatment
    David Mischoulon
    Depression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts
    Depress Anxiety 19:43-50. 2004
    ..Our study suggests that the rate of negative outcomes with nefazodone is no different whether patients have recently failed an SSRI...
  22. ncbi Emergence of adverse events following discontinuation of treatment with extended-release venlafaxine
    M Fava
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 154:1760-2. 1997
    ..The rate of adverse events following discontinuation of treatment with extended-release venlafaxine was compared with the rate associated with discontinuation of placebo administration...
  23. ncbi Tryptophan depletion in SSRI-recovered depressed outpatients
    M K Spillmann
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    Psychopharmacology (Berl) 155:123-7. 2001
    ..No other predicting or mediating factors were identified, although the variable "history of response pattern to medication" deserves further study...
  24. ncbi Strategies for managing depression refractory to selective serotonin reuptake inhibitor treatment: a survey of clinicians
    D Mischoulon
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston 02114, USA
    Can J Psychiatry 45:476-81. 2000
    ..To examine treatment practices in cases where selective serotonin reuptake inhibitors (SSRIs) are ineffective...
  25. ncbi Clinical and sociodemographic predictors of response to augmentation, or dose increase among depressed outpatients resistant to fluoxetine 20 mg/day
    R H Perlis
    Depression Clinical and Research Program, Massachusetts General Hospital, WACC 812, 15 Parkman Street, Boston, MA 02114, USA
    Acta Psychiatr Scand 108:432-8. 2003
    ..Factors moderating response to these next-step interventions are not well-studied...
  26. ncbi Childhood antecedents to panic disorder in referred and nonreferred adults
    Joseph Biederman
    Pediatric Psychopharmacology Clinic, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Child Adolesc Psychopharmacol 15:549-61. 2005
    ..We used a recursive partitioning method to examine antecedent childhood anxiety disorders in large samples of referred and nonreferred subjects with and without panic disorder...
  27. ncbi The corticotropin-releasing hormone gene and behavioral inhibition in children at risk for panic disorder
    Jordan W Smoller
    Department of Psychiatry, Massachusetts General Hospital, Boston 02114, USA
    Biol Psychiatry 57:1485-92. 2005
    ..To evaluate this further, we genotyped additional families for this marker and a panel of markers encompassing the CRH locus...
  28. ncbi Serum folate, vitamin B12, and homocysteine in major depressive disorder, Part 1: predictors of clinical response in fluoxetine-resistant depression
    George I Papakostas
    Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychiatry 65:1090-5. 2004
    ....
  29. ncbi The relationship between serum folate, vitamin B12, and homocysteine levels in major depressive disorder and the timing of improvement with fluoxetine
    George I Papakostas
    Department of Psychiatry, Depression Clinical and Research Program, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Int J Neuropsychopharmacol 8:523-8. 2005
    ..05). In conclusion, low serum folate levels were found to be associated with a delayed onset of clinical improvement during treatment with fluoxetine in MDD by, on average, 1.5 wk...
  30. ncbi Patterns of comorbidity in panic disorder and major depression: findings from a nonreferred sample
    Joseph Biederman
    Pediatric Psychopharmacology Unit of the Child Psychiatry Service, Massachusetts General Hospital, Boston 02114, USA
    Depress Anxiety 21:55-60. 2005
    ....
  31. ncbi A Double-blind, randomized trial of St John's wort, fluoxetine, and placebo in major depressive disorder
    Maurizio Fava
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychopharmacol 25:441-7. 2005
    ..This study looks to compare the antidepressant efficacy and safety of a standardized extract of St John's wort with both placebo and fluoxetine...
  32. ncbi Does referral bias impact findings in high-risk offspring for anxiety disorders? A controlled study of high-risk children of non-referred parents with panic disorder/agoraphobia and major depression
    Joseph Biederman
    Pediatric Psychopharmacology Program and the Department of Psychiatry, Massachusetts General Hospital, Warren 705, 15 Parkman St, Boston, MA 02114, USA
    J Affect Disord 82:209-16. 2004
    ..This study evaluated whether these patterns of transmission between parents and high-risk offspring are moderated by referral bias...
  33. ncbi Serum folate, vitamin B12, and homocysteine in major depressive disorder, Part 2: predictors of relapse during the continuation phase of pharmacotherapy
    George I Papakostas
    Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychiatry 65:1096-8. 2004
    ....
  34. ncbi Obesity among outpatients with major depressive disorder
    George I Papakostas
    Depression Clinical and Research Program, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Int J Neuropsychopharmacol 8:59-63. 2005
    ..Greater relative body weight, but not obesity, predicted non-response. In conclusion, greater relative body weight was found to place MDD outpatients at risk for fluoxetine resistance...
  35. ncbi Parental predictors of pediatric panic disorder/agoraphobia: a controlled study in high-risk offspring
    Joseph Biederman
    Pediatric Psychopharmacology Clinic, Massachusetts General Hospital, Boston, 02114, USA
    Depress Anxiety 22:114-20. 2005
    ..These findings suggest that psychiatric comorbidity with other anxiety disorders and with bipolar disorder in parents with PD and their spouses confer a particularly high risk in their offspring to develop PD/AG in childhood...
  36. ncbi Cognitive behavioral therapy for 4- to 7-year-old children with anxiety disorders: a randomized clinical trial
    Dina R Hirshfeld-Becker
    Massachusetts General Hospital, 185 Alewife Brook Parkway, Cambridge, MA 02138, USA
    J Consult Clin Psychol 78:498-510. 2010
    ..To examine the efficacy of a developmentally appropriate parent-child cognitive behavioral therapy (CBT) protocol for anxiety disorders in children ages 4-7 years...
  37. ncbi Executive functioning in offspring at risk for depression and anxiety
    Jamie A Micco
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, 85 Alewife Brook Parkway, Suite 2000, Cambridge, MA 02138, USA
    Depress Anxiety 26:780-90. 2009
    ..Studies of at-risk offspring can shed light on this question by examining whether EFDs characterize children at high risk for depression and anxiety who are not yet symptomatic...
  38. ncbi Disruptive behavior disorders in offspring of parents with major depression: associations with parental behavior disorders
    Dina R Hirshfeld-Becker
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, United States
    J Affect Disord 111:176-84. 2008
    ....
  39. ncbi Developmental trajectories of anxiety disorders in offspring at high risk for panic disorder and major depression
    Joseph Biederman
    Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Boston, MA 02114, USA
    Psychiatry Res 153:245-52. 2007
    ....
  40. ncbi Behavioral inhibition in preschool children at risk is a specific predictor of middle childhood social anxiety: a five-year follow-up
    Dina R Hirshfeld-Becker
    Harvard Medical School Massachusetts General Hospital, Boston, MA 02138, USA
    J Dev Behav Pediatr 28:225-33. 2007
    ..It has been hypothesized to be a risk factor for anxiety disorders. In this prospective longitudinal study, we compared the psychiatric outcomes in middle childhood of children evaluated at preschool age for BI...
  41. ncbi The child behavior checklist broad-band scales predict subsequent psychopathology: A 5-year follow-up
    Carter R Petty
    Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Warren 705, 15 Parkman Street, Boston, MA 02114, USA
    J Anxiety Disord 22:532-9. 2008
    ..To evaluate the utility of the Child Behavior Check list (CBCL) for identifying children of parents with panic disorder or major depression at high-risk for future psychopathology...
  42. ncbi Clinical outcomes of laboratory-observed preschool behavioral disinhibition at five-year follow-up
    Dina R Hirshfeld-Becker
    Pediatric Psychopharmacology Program, Massachusetts General Hospital, 185 Alewife Brook Parkway, Cambridge, MA 02138, USA
    Biol Psychiatry 62:565-72. 2007
    ..In the present study, our objective was to examine the diagnostic outcome in middle childhood of behavioral disinhibition assessed at preschool age among offspring at risk for anxiety and mood disorders...
  43. ncbi Early symptomatic worsening during treatment with fluoxetine in major depressive disorder: prevalence and implications
    Cristina Cusin
    Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychiatry 68:52-7. 2007
    ..While patterns of response have been examined as possible predictors of outcome, the clinical correlates and implications of early worsening per se have not been investigated...
  44. ncbi Treatment-associated suicidal ideation and adverse effects in an open, multicenter trial of fluoxetine for major depressive episodes
    Roy H Perlis
    Depression Clinical and Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Psychother Psychosom 76:40-6. 2007
    ..The time course and clinical correlates of this phenomenon have not been characterized in detail...
  45. ncbi Psychopathology in the young offspring of parents with bipolar disorder: a controlled pilot study
    Dina R Hirshfeld-Becker
    Pediatric Psychopharmacology Program, Massachusetts General Hospital, 185 Alewife Brook Parkway, Suite 2100, Cambridge, MA 02138, USA
    Psychiatry Res 145:155-67. 2006
    ..Results support the hypotheses of elevated behavior, anxiety, and mood disorders among offspring at risk for bipolar disorder, and suggest that this psychopathology is already evident in early childhood...
  46. ncbi Antecedents to panic disorder in nonreferred adults
    Joseph Biederman
    Pediatric Psychopharmacology Clinic, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychiatry 67:1179-86. 2006
    ..The current study examined both childhood and adult comorbid disorders as potential antecedent disorders to panic disorder in a large sample of nonreferred adults...
  47. ncbi Effects of parental anxiety disorders in children at high risk for panic disorder: a controlled study
    Joseph Biederman
    Massachusetts General Hospital, Pediatric Psychopharmacology Research, Boston, MA 02114, United States
    J Affect Disord 94:191-7. 2006
    ..To examine the association between anxiety disorders in parents and offspring in a sample of children at risk for panic disorder. We hypothesized that individual anxiety disorders will breed true in offspring...
  48. ncbi A controlled longitudinal 5-year follow-up study of children at high and low risk for panic disorder and major depression
    Joseph Biederman
    Pediatric Psychopharmacology Program, Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA 02114, USA
    Psychol Med 36:1141-52. 2006
    ..To evaluate the longitudinal course of psychiatric disorders in children of parents with panic disorder (PD) and major depression (MD) as they transition through the period of risk from childhood into adolescence...
  49. ncbi Laboratory-observed behavioral disinhibition in the young offspring of parents with bipolar disorder: a high-risk pilot study
    Dina R Hirshfeld-Becker
    Mass General Hospital Pediatric Psychopharmacology Program, 185 Alewife Brook Parkway, Suite 2100, Cambridge, MA 02138, USA
    Am J Psychiatry 163:265-71. 2006
    ..This study tested whether behavioral disinhibition is more prevalent among offspring of parents with bipolar disorder than among offspring of parents without bipolar disorder...
  50. ncbi Pregnancy complications associated with childhood anxiety disorders
    Dina R Hirshfeld-Becker
    Pediatric Psychopharmacology Program, Massachusetts General Hospital, Cambridge, Massachusetts 02138, USA
    Depress Anxiety 19:152-62. 2004
    ..Results suggest that prenatal stressors may increase a child's risk for anxiety disorders beyond the risk conferred by parental psychopathology alone...
  51. ncbi Body dysmorphic disorder in outpatients with major depression
    Andrew A Nierenberg
    Depression Research Program, Clinical Psychopharmacology Unit, Massachusetts General Hospital and The Consolidated Department of Psychiatry, Harvard Medical School, Boston, MA 02114, USA
    J Affect Disord 69:141-8. 2002
    ..The purpose of this study was to evaluate the rate of BDD in a cohort of consecutive outpatients with typical and atypical major depressive disorder...
  52. ncbi Rationale, design, and methods of the systematic treatment enhancement program for bipolar disorder (STEP-BD)
    Gary S Sachs
    Partners Bipolar Treatment Center, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Biol Psychiatry 53:1028-42. 2003
    ....
  53. ncbi A survey of prescribing practices in the treatment of depression
    Timothy Petersen
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston 02114, USA
    Prog Neuropsychopharmacol Biol Psychiatry 26:177-87. 2002
    ..The purpose of this study was to examine prescribing practices in a sample of psychiatrists attending a psychopharmacology review course and compare these results with empirical evidence...
  54. ncbi Comparing anxiety disorders and anxiety-related traits in bipolar disorder and unipolar depression
    Naomi M Simon
    WACC 815, Massachusetts General Hospital, 15 Parkman Street, Boston, MA 02114, USA
    J Psychiatr Res 37:187-92. 2003
    ..Further research is needed to clarify the etiologic basis of anxiety disorder/BPD comorbidity and to optimize treatment strategies for patients with these co-occurring disorders...
  55. ncbi Behavioral and emotional disturbances in the offspring of depressed parents with anger attacks
    Jonathan E Alpert
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, Mass, USA
    Psychother Psychosom 72:102-6. 2003
    ..This finding may be important in identifying and formulating intervention strategies for childhood problems in the offspring of depressed parents...
  56. ncbi Fluoxetine treatment of depressed patients with comorbid anxiety disorders
    Shamsah B Sonawalla
    Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    J Psychopharmacol 16:215-9. 2002
    ..Further double-blind, placebo-controlled trials are required in larger samples to confirm our findings...
  57. ncbi Strategies for treatment of SSRI-associated sexual dysfunction: a survey of an academic psychopharmacology practice
    Roy H Perlis
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston 02114, USA
    Harv Rev Psychiatry 10:109-14. 2002
  58. ncbi Treatment-resistant depression and Axis II comorbidity
    Timothy Petersen
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, Mass 02114, USA
    Psychother Psychosom 71:269-74. 2002
    ....
  59. ncbi Effect of abrupt change from standard to low serum levels of lithium: a reanalysis of double-blind lithium maintenance data
    Roy H Perlis
    Department of Psychiatry, Massachusetts General Hospital, 50 Staniford Street, Boston, MA 02114, USA
    Am J Psychiatry 159:1155-9. 2002
    ..To assess the effect of abrupt change in lithium dose, the authors reanalyzed data from a previously reported, randomized, double-blind trial of standard- versus low-dose lithium for maintenance therapy in bipolar disorder...
  60. ncbi Double-blind study of high-dose fluoxetine versus lithium or desipramine augmentation of fluoxetine in partial responders and nonresponders to fluoxetine
    Maurizio Fava
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Psychopharmacol 22:379-87. 2002
    ....
  61. ncbi Serum cholesterol and serotonergic function in major depressive disorder
    George I Papakostas
    Depression Clinical and Research Program, Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, 15 Parkman Street, WAC 812, Boston, MA 02114, USA
    Psychiatry Res 118:137-45. 2003
    ....
  62. ncbi Ziprasidone augmentation of selective serotonin reuptake inhibitors (SSRIs) for SSRI-resistant major depressive disorder
    George I Papakostas
    Depression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, 15 Parkman Street, WAC 812, Boston, MA 02114, USA
    J Clin Psychiatry 65:217-21. 2004
    ..The purpose of this study is to test this hypothesis in depressed outpatients who have not experienced significant clinical improvement following an adequate trial of a selective serotonin reuptake inhibitor (SSRI)...
  63. ncbi Axis III disorders in treatment-resistant major depressive disorder
    George I Papakostas
    Department of Psychiatry, Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, WAC 812, Boston, MA 02114, USA
    Psychiatry Res 118:183-8. 2003
    ..Thus, the present results cannot be generalized to such populations...
  64. ncbi Effect of medical comorbidity on response to fluoxetine augmentation or dose increase in outpatients with treatment-resistant depression
    Roy H Perlis
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston 02114, USA
    Psychosomatics 45:224-9. 2004
    ..Medical comorbidity thus does not appear to be associated with significantly poorer outcome among patients whose major depressive disorder failed initially to respond to an initial trial of 20 mg/day of fluoxetine...
  65. ncbi Moderating effects of major depression on patterns of comorbidity in patients with panic disorder
    Joseph Biederman
    Clinical Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, and Harvard Medical School, WACC 725, 15 Parkman Street, Boston, MA 02114, USA
    Psychiatry Res 126:143-9. 2004
    ..Overanxious disorder was associated with both panic disorder and major depression. Major depression has important moderating effects on patterns of comorbidity of panic disorder in referred adults...
  66. ncbi Lack of association between behavioral inhibition and psychosocial adversity factors in children at risk for anxiety disorders
    Dina R Hirshfeld-Becker
    Pediatric Psychopharmacology Unit, Department of Psychiatry, Massachusetts General Hospital, Cambridge, MA 02138, USA
    Am J Psychiatry 161:547-55. 2004
    ..To explore whether this association was mediated by environmental factors, the authors examined associations between psychosocial adversity variables and behavioral inhibition in this group of children...
  67. ncbi The prevalence and clinical correlates of anger attacks during depressive episodes in bipolar disorder
    Roy H Perlis
    Massachusetts General Hospital Department of Psychiatry, Boston, MA, USA
    J Affect Disord 79:291-5. 2004
    ..This study compared the prevalence and clinical significance of anger attacks in unipolar versus bipolar depression...
  68. ncbi Treatment resistant depression and axis I co-morbidity
    T Petersen
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston 02114, USA
    Psychol Med 31:1223-9. 2001
    ..In fact, the only statistical difference showed non-TRD patients with higher co-morbidity rates...
  69. ncbi Pramipexole augmentation in the treatment of unipolar and bipolar depression: a retrospective chart review
    J Sporn
    Department of Psychiatry, Massachusetts General Hospital, USA
    Ann Clin Psychiatry 12:137-40. 2000
    ..To assess the effectiveness and safety of pramipexole as an adjunctive medication in refractory bipolar and unipolar depression in a naturalistic setting...
  70. ncbi Childhood history of anxiety disorders among adults with social phobia: rates, correlates, and comparisons with patients with panic disorder
    M W Otto
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Depress Anxiety 14:209-13. 2001
    ....
  71. ncbi Association of a polymorphism near CREB1 with differential aversion processing in the insula of healthy participants
    Roy H Perlis
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Arch Gen Psychiatry 65:882-92. 2008
    ....
  72. ncbi Influence of RGS2 on anxiety-related temperament, personality, and brain function
    Jordan W Smoller
    Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Arch Gen Psychiatry 65:298-308. 2008
    ..The gene encoding regulator of G protein signaling 2 (Rgs2) is a quantitative trait gene that influences mouse anxiety behavior, making its human ortholog (RGS2) a compelling candidate gene for human anxiety phenotypes...
  73. ncbi Report by the ACNP Task Force on response and remission in major depressive disorder
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9086, USA
    Neuropsychopharmacology 31:1841-53. 2006
    ..Research to evaluate these recommendations empirically is needed...
  74. ncbi Association of a genetic marker at the corticotropin-releasing hormone locus with behavioral inhibition
    Jordan W Smoller
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Biol Psychiatry 54:1376-81. 2003
    ..Transgenic mice overexpressing CRH exhibit BI-like behaviors, implicating this gene in the development of the phenotype...
  75. ncbi Background and rationale for the sequenced treatment alternatives to relieve depression (STAR*D) study
    Maurizio Fava
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
    Psychiatr Clin North Am 26:457-94, x. 2003
    ..This article provides the overall rationale for STAR*D and details the rationale for key design, measurement, and analytic features of the study...
  76. ncbi Serotonin transporter polymorphisms and adverse effects with fluoxetine treatment
    Roy H Perlis
    Department of Psychiatry, Massachusetts General Hospital, Boston 02114, USA
    Biol Psychiatry 54:879-83. 2003
    ..This study investigated a possible association with treatment-emergent insomnia or agitation...
  77. ncbi Obstetrical and neonatal outcome following clonazepam use during pregnancy: a case series
    L Weinstock
    Perinatal and Reproductive Psychiatry Clinical Research Program, Center for Women's Mental Health, Department of Psychiatry, Clinical Psychopharmacology Unit, Massachusetts General Hospital, Boston, Mass, USA
    Psychother Psychosom 70:158-62. 2001
    ....
  78. ncbi It is time to take a stand for medical research and against terrorism targeting medical scientists
    John H Krystal
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 63:725-7. 2008
  79. ncbi Posttraumatic stress disorder symptoms following media exposure to tragic events: impact of 9/11 on children at risk for anxiety disorders
    Michael W Otto
    Massachusetts General Hospital and Harvard Medical School, MA, United States
    J Anxiety Disord 21:888-902. 2007
    ..Given the links between PTSD symptoms and viewing habits, parental monitoring of media exposure may be important for younger children...
  80. ncbi Hypericum extract in patients with MDD and reversed vegetative signs: re-analysis from data of a double-blind, randomized trial of hypericum extract, fluoxetine, and placebo
    Harald Murck
    Lichtwer Pharma GmbH, Berlin, Germany
    Int J Neuropsychopharmacol 8:215-21. 2005
    ..These data are based on a small sample size and must be considered tentative. A characterization of vegetative features of patients with depression could lead to an overall increased effect size in the treatment with HE...
  81. ncbi Clinical and demographic features of atypical depression in outpatients with major depressive disorder: preliminary findings from STAR*D
    Jon S Novick
    Zucker Hillside Hospital, Glen Oaks, NY, USA
    J Clin Psychiatry 66:1002-11. 2005
    ..CONCLUSION: Previously identified features of atypical depression were confirmed in this large and broadly representative, nonresearch clinical population...
  82. ncbi National Depressive and Manic-Depressive Association consensus statement on the use of placebo in clinical trials of mood disorders
    Dennis S Charney
    Division of Intramural Research Programs, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 59:262-70. 2002
    ..Research is needed on the ethical conduct of studies to limit risks of medication-free intervals and facilitate poststudy treatment. Patients must fully understand the risks and lack of individualized treatment involved in research...
  83. ncbi Fluoxetine and norfluoxetine plasma concentrations during relapse-prevention treatment
    David J Brunswick
    The Depression Research Unit, University of Pennsylvania Medical Center, University Science Center, 8th Floor, 3600 Market Street, Philadelphia, PA 19104, USA
    J Affect Disord 68:243-9. 2002
    ..The purpose of this study was to investigate the relationship between steady-state plasma drug concentrations and outcome during relapse-prevention therapy with fluoxetine...
  84. ncbi Selecting methodologies for the evaluation of differences in time to response between antidepressants
    Stuart A Montgomery
    Imperial College School of Medicine, London, United Kingdom
    J Clin Psychiatry 63:694-9. 2002
    ..The delay in the therapeutic effect of antidepressants is a considerable impediment to their successful clinical use, and attention has recently been focused on antidepressant drugs that may have a faster onset of action...
  85. ncbi Serum cholesterol in the continuation phase of pharmacotherapy with fluoxetine in remitted major depressive disorder
    George I Papakostas
    J Clin Psychopharmacol 24:467-9. 2004

Research Grants15

  1. A LONGITUDINAL FOLLOW UP OF CHILDREN AT RISK FOR ANXIETY
    Jerrold Rosenbaum; Fiscal Year: 2003
    ..Given that we are also assessing adverse features of the environment, we will also be able to determine if gene-environment interactions play a role in the genesis of anxiety disorders. ..
  2. Children at Risk for Anxiety Disorders: A Follow up Study
    Jerrold Rosenbaum; Fiscal Year: 2007
    ..abstract_text> ..
  3. PSYCHOPATHOLOGY IN CHILDREN OF AGORAPHOBIC PARENTS
    Jerrold Rosenbaum; Fiscal Year: 1993
    ..The products of this research, in addition to early identification of children at highest risk for later development of anxiety disorders, could lead to the design of protocols for primary preventive or early intervention programs...