J Rosand

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Screening for familial APP mutations in sporadic cerebral amyloid angiopathy
    Alessandro Biffi
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 5:e13949. 2010
  2. pmc Heritability estimates identify a substantial genetic contribution to risk and outcome of intracerebral hemorrhage
    William J Devan
    Center for Human Genetic Research, Massachusetts General Hospital, 185 Cambridge St, CPZN 6818, Boston, MA 02114, USA
    Stroke 44:1578-83. 2013
  3. pmc Burden of blood pressure-related alleles is associated with larger hematoma volume and worse outcome in intracerebral hemorrhage
    Guido J Falcone
    Center for Human Genetic Research, Massachusetts General Hospital, 185 Cambridge St, CPZN 6818, Boston, MA 02114, USA
    Stroke 44:321-6. 2013
  4. ncbi request reprint Human genome sequence variation and the search for genes influencing stroke
    Jonathan Rosand
    Stroke and Neurocritical Care Units, Massachusetts General Hospital, VBK 811, 32 Fruit St, Boston, Mass 02114, USA
    Stroke 34:2512-6. 2003
  5. ncbi request reprint Spatial clustering of hemorrhages in probable cerebral amyloid angiopathy
    Jonathan Rosand
    Vascular and Critical Care Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Ann Neurol 58:459-62. 2005
  6. ncbi request reprint Dynamic single-section CT demonstrates reduced cerebral blood flow in acute intracerebral hemorrhage
    Jonathan Rosand
    Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Cerebrovasc Dis 14:214-20. 2002
  7. pmc Personalized approaches to clopidogrel therapy: are we there yet?
    Christopher D Anderson
    Division of Neurocritical Care and Emergency Neurology, Stroke Service, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA
    Stroke 41:2997-3002. 2010
  8. pmc Genetic variation at CR1 increases risk of cerebral amyloid angiopathy
    A Biffi
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA
    Neurology 78:334-41. 2012
  9. pmc Aspirin and recurrent intracerebral hemorrhage in cerebral amyloid angiopathy
    A Biffi
    Department of Neurology and Hemorrhagic Stroke Research Program, Massachusetts General Hospital Stroke Research Center, Harvard Medical School, 175 Cambridge Street, Suite 300, Boston, MA 02114, USA
    Neurology 75:693-8. 2010
  10. pmc Warfarin-related intraventricular hemorrhage: imaging and outcome
    A Biffi
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA
    Neurology 77:1840-6. 2011

Research Grants

Detail Information

Publications87

  1. pmc Screening for familial APP mutations in sporadic cerebral amyloid angiopathy
    Alessandro Biffi
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 5:e13949. 2010
    ..The majority of affected families harbor mutations in the Beta amyloid Peptide (Aβ) coding region of the gene for amyloid precursor protein (APP) or have duplications of chromosomal segments containing APP...
  2. pmc Heritability estimates identify a substantial genetic contribution to risk and outcome of intracerebral hemorrhage
    William J Devan
    Center for Human Genetic Research, Massachusetts General Hospital, 185 Cambridge St, CPZN 6818, Boston, MA 02114, USA
    Stroke 44:1578-83. 2013
    ..However, a novel analytic tool based on genome-wide data allows heritability estimation from unrelated subjects. We sought to apply this method to provide heritability estimates for ICH risk, severity, and outcome...
  3. pmc Burden of blood pressure-related alleles is associated with larger hematoma volume and worse outcome in intracerebral hemorrhage
    Guido J Falcone
    Center for Human Genetic Research, Massachusetts General Hospital, 185 Cambridge St, CPZN 6818, Boston, MA 02114, USA
    Stroke 44:321-6. 2013
    ..As the burden of high blood pressure-related alleles is associated with both hypertension-related end-organ damage and risk of ICH, we sought to determine whether this burden influences ICH baseline hematoma volume...
  4. ncbi request reprint Human genome sequence variation and the search for genes influencing stroke
    Jonathan Rosand
    Stroke and Neurocritical Care Units, Massachusetts General Hospital, VBK 811, 32 Fruit St, Boston, Mass 02114, USA
    Stroke 34:2512-6. 2003
    ..Technological progress spurred by the Human Genome Project is accelerating the pace of genetic studies of common diseases, including stroke. Stroke clinicians will soon need to interpret increasingly complex genetic studies...
  5. ncbi request reprint Spatial clustering of hemorrhages in probable cerebral amyloid angiopathy
    Jonathan Rosand
    Vascular and Critical Care Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Ann Neurol 58:459-62. 2005
    ..These data suggest that regional differences within the brain play a role in the development of CAA-related hemorrhage...
  6. ncbi request reprint Dynamic single-section CT demonstrates reduced cerebral blood flow in acute intracerebral hemorrhage
    Jonathan Rosand
    Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Cerebrovasc Dis 14:214-20. 2002
    ..A gradient of hypoperfusion appears to extend at least 4 mm beyond the hematoma edge and may be time dependent. Whether reduced CBF is associated with perihematoma ischemia requires additional study...
  7. pmc Personalized approaches to clopidogrel therapy: are we there yet?
    Christopher D Anderson
    Division of Neurocritical Care and Emergency Neurology, Stroke Service, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA
    Stroke 41:2997-3002. 2010
    ....
  8. pmc Genetic variation at CR1 increases risk of cerebral amyloid angiopathy
    A Biffi
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA
    Neurology 78:334-41. 2012
    ....
  9. pmc Aspirin and recurrent intracerebral hemorrhage in cerebral amyloid angiopathy
    A Biffi
    Department of Neurology and Hemorrhagic Stroke Research Program, Massachusetts General Hospital Stroke Research Center, Harvard Medical School, 175 Cambridge Street, Suite 300, Boston, MA 02114, USA
    Neurology 75:693-8. 2010
    ..To identify and compare clinical and neuroimaging predictors of primary lobar intracerebral hemorrhage (ICH) recurrence, assessing their relative contributions to recurrent ICH...
  10. pmc Warfarin-related intraventricular hemorrhage: imaging and outcome
    A Biffi
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA
    Neurology 77:1840-6. 2011
    ..We investigated whether OAT also influences risk of development of intraventricular hemorrhage (IVH), the volume of IVH and IVH expansion, and whether IVH is a substantive mediator of the overall effect of OAT on ICH outcome...
  11. ncbi request reprint Contrast extravasation on CT angiography predicts hematoma expansion in intracerebral hemorrhage
    J N Goldstein
    Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Neurology 68:889-94. 2007
    ..However, only a minority arrive within this time frame. Therefore, alternative markers for expansion risk are needed...
  12. pmc Severity of leukoaraiosis correlates with clinical outcome after ischemic stroke
    E M Arsava
    AA Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Neurology 72:1403-10. 2009
    ..Leukoaraiosis (LA) is closely associated with aging, a major determinant of clinical outcome after ischemic stroke. In this study we sought to identify whether LA, independent of advancing age, affects outcome after acute ischemic stroke...
  13. pmc A score to predict early risk of recurrence after ischemic stroke
    H Ay
    Stroke Service, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Neurology 74:128-35. 2010
    ..There is currently no instrument to stratify patients presenting with ischemic stroke according to early risk of recurrent stroke. We sought to develop a comprehensive prognostic score to predict 90-day risk of recurrent stroke...
  14. pmc Silent ischemic infarcts are associated with hemorrhage burden in cerebral amyloid angiopathy
    W T Kimberly
    Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Neurology 72:1230-5. 2009
    ..We examined the prevalence and associated risk factors for infarcts detected by diffusion-weighted imaging (DWI)...
  15. pmc Severity of leukoaraiosis determines clinical phenotype after brain infarction
    E M Arsava
    A A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 2301, Charlestown, MA 02129, USA
    Neurology 77:55-61. 2011
    ....
  16. pmc White matter hyperintensity volume is increased in small vessel stroke subtypes
    N S Rost
    J Philip Kistler Stroke Research Center, Center for Human Genetics Research, Massachusetts General Hospital, 175 Cambridge St, Suite 300, Boston, MA 02114, USA
    Neurology 75:1670-7. 2010
    ..Therefore, we hypothesized that WMH would be most severe in patients with lacunar stroke and intracerebral hemorrhage (ICH), 2 types of stroke in which cerebral small vessel (SV) changes are pathophysiologically relevant...
  17. ncbi request reprint Course of cerebral amyloid angiopathy-related inflammation
    C Kinnecom
    Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    Neurology 68:1411-6. 2007
    ..A subset of patients with cerebral amyloid angiopathy (CAA) present with cognitive symptoms, seizures, headaches, T2-hyperintense MRI lesions, and neuropathologic evidence of CAA-associated vascular inflammation...
  18. pmc MR imaging detection of cerebral microbleeds: effect of susceptibility-weighted imaging, section thickness, and field strength
    R N K Nandigam
    Hemorrhagic Stroke Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    AJNR Am J Neuroradiol 30:338-43. 2009
    ....
  19. ncbi request reprint Plasma beta-amyloid peptide, transforming growth factor-beta 1, and risk for cerebral amyloid angiopathy
    S M Greenberg
    Massachusetts General Hospital, Boston 02114, USA
    Ann N Y Acad Sci 903:144-9. 2000
    ..While the data do not exclude important roles for these molecules as risks for CAA, they indicate that plasma measurements are not useful in its diagnosis...
  20. pmc Association of subdural hematoma with increased mortality in lobar intracerebral hemorrhage
    Pratik V Patel
    Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital, 175 Cambridge St, Ste 300, Boston, MA 02114, USA
    Arch Neurol 66:79-84. 2009
    ..To determine the prevalence of subdural hematoma (SDH) in patients presenting with primary nontraumatic lobar intracerebral hemorrhage (ICH) and characteristics associated with the presence of SDH...
  21. ncbi request reprint Imaging of amyloid burden and distribution in cerebral amyloid angiopathy
    Keith A Johnson
    Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    Ann Neurol 62:229-34. 2007
    ....
  22. ncbi request reprint Antiplatelet use after intracerebral hemorrhage
    A Viswanathan
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Neurology 66:206-9. 2006
    ..Survivors of intracerebral hemorrhage are at risk for recurrent intracerebral hemorrhage and ischemic cardiovascular and cerebrovascular disease...
  23. pmc Statin use and outcome after intracerebral hemorrhage: case-control study and meta-analysis
    A Biffi
    Center for Human Genetic Research, Massachusetts General Hospital, 185 Cambridge Street, CPZN 6818, Boston, MA 02114, USA
    Neurology 76:1581-8. 2011
    ..We therefore performed a meta-analysis of all available evidence, including unpublished data from our own institution, to determine whether statin exposure is protective for patients who develop ICH...
  24. ncbi request reprint Warfarin, hematoma expansion, and outcome of intracerebral hemorrhage
    J J Flibotte
    Stroke Service and Neurology Clinical Trials Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Neurology 63:1059-64. 2004
    ..Warfarin increases mortality of intracerebral hemorrhage (ICH). The authors investigated whether this effect reflects increased baseline ICH volume at presentation or increased ICH expansion...
  25. ncbi request reprint White matter lesions, cognition, and recurrent hemorrhage in lobar intracerebral hemorrhage
    E E Smith
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Neurology 63:1606-12. 2004
    ..The authors investigated the relationships between white matter lesions, cognitive impairment, and risk of recurrent hemorrhage in a prospectively identified cohort of patients with lobar intracerebral hemorrhage (ICH)...
  26. pmc Practical scoring system for the identification of patients with intracerebral hemorrhage at highest risk of harboring an underlying vascular etiology: the Secondary Intracerebral Hemorrhage Score
    J E Delgado Almandoz
    Division of Neuroradiology, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    AJNR Am J Neuroradiol 31:1653-60. 2010
    ..Our aim was to develop a practical scoring system to stratify patients with ICH according to their risk of harboring a vascular etiology...
  27. pmc Impaired visual evoked flow velocity response in cerebral amyloid angiopathy
    E E Smith
    Harvard Medical School, 175 Cambridge Street, Suite 300, Massachusetts General Hospital, Boston, MA 02114, USA
    Neurology 71:1424-30. 2008
    ..Animal models of cerebral amyloid angiopathy (CAA) exhibit abnormal vascular reactivity. We determined whether vascular reactivity, measured by transcranial Doppler ultrasound (TCD), is reduced in humans with CAA...
  28. ncbi request reprint Plasma beta-amyloid and white matter lesions in AD, MCI, and cerebral amyloid angiopathy
    M E Gurol
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Neurology 66:23-9. 2006
    ..Recent studies suggest a role for circulating beta-amyloid peptide in microvascular dysfunction and white matter disease...
  29. ncbi request reprint The effect of warfarin and intensity of anticoagulation on outcome of intracerebral hemorrhage
    Jonathan Rosand
    Neurology Clinical Trials Unit, Department of Neurology, Massachusetts General Hospital, 15 Parkman Street, Boston, MA 02114, USA
    Arch Intern Med 164:880-4. 2004
    ..We studied the determinants of ICH outcome to quantify the independent effect of warfarin...
  30. doi request reprint Warfarin reversal in anticoagulant-associated intracerebral hemorrhage
    Joshua N Goldstein
    Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Neurocrit Care 9:277-83. 2008
    ..At our institution, we have focused on improving the rapid and reliable delivery of a combination of intravenous vitamin K and FFP, with continued re-dosing until the desired INR lowering is achieved...
  31. ncbi request reprint Homocysteine, MTHFR 677C-->T polymorphism, and risk of ischemic stroke: results of a meta-analysis
    P J Kelly
    Stroke Service, Department of Neurology, Massachusetts General Hospital and Harvard University, Boston, MA 02114, USA
    Neurology 59:529-36. 2002
    ....
  32. ncbi request reprint Leukoaraiosis is associated with warfarin-related hemorrhage following ischemic stroke
    E E Smith
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Neurology 59:193-7. 2002
    ..This study investigates radiographic and clinical characteristics of patients with warfarin-related ICH following ischemic stroke...
  33. ncbi request reprint Outcome markers for clinical trials in cerebral amyloid angiopathy
    S M Greenberg
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Amyloid 8:56-60. 2001
    ..This analysis suggests that radiographic detection of small hemorrhages may be an efficient surrogate endpoint for pilot trials of promising therapeutic approaches to cerebral amyloid angiopathy...
  34. pmc The Causative Classification of Stroke system: an international reliability and optimization study
    E M Arsava
    A A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Neurology 75:1277-84. 2010
    ..We determined whether CCS demonstrates high interrater reliability in order to be useful for international multicenter studies...
  35. pmc Prior antiplatelet therapy and outcome following intracerebral hemorrhage: a systematic review
    B B Thompson
    Department of Neurology, Brown University, Providence, RI, USA
    Neurology 75:1333-42. 2010
    ..We performed a systematic review and meta-analysis to address the hypothesis that pre-ICH APT use is associated with mortality and poor functional outcome following ICH...
  36. pmc Microbleeds versus macrobleeds: evidence for distinct entities
    Steven M Greenberg
    MGH Stroke Research Center, Harvard Medical School, Boston, MA 02114, USA
    Stroke 40:2382-6. 2009
    ..It is unclear whether microbleeds and macrobleeds represent arbitrary categories within a single continuum versus truly distinct events with separate pathophysiologies...
  37. pmc Tissue microstructural changes are independently associated with cognitive impairment in cerebral amyloid angiopathy
    Anand Viswanathan
    Hemorrhagic Stroke Research Program, Massachusetts General Hospital, Stroke Research Center, 175 Cambridge Street, Suite 300, Boston, MA 02114, USA
    Stroke 39:1988-92. 2008
    ..We hypothesized that higher global mean apparent diffusion coefficient (mean ADC), reflecting a higher amount of chronic tissue disruption caused by CAA, would be independently associated with CAA-related cognitive impairment...
  38. pmc White matter hyperintensity burden and susceptibility to cerebral ischemia
    Natalia S Rost
    Stroke Service, Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Stroke 41:2807-11. 2010
    ..We hypothesized that WMH would be less severe in patients with TIA as compared to those with acute ischemic stroke and completed infarct...
  39. doi request reprint Prediction of functional outcome in patients with primary intracerebral hemorrhage: the FUNC score
    Natalia S Rost
    Massachusetts General Hospital, Center for Human Genetic Research, Boston, MA 02114, USA
    Stroke 39:2304-9. 2008
    ..We developed an acute clinical score to predict likelihood of functional independence...
  40. doi request reprint Risk of thromboembolism following acute intracerebral hemorrhage
    Joshua N Goldstein
    Department of Emergency Medicine, Massachusetts General Hospital, Zero Emerson Place, Suite 3B, Boston, MA 02114, USA
    Neurocrit Care 10:28-34. 2009
    ..We hypothesized that TEs are relatively common following ICH, and that anticoagulated patients are at higher risk for these complications...
  41. pmc Management of thrombolysis-associated symptomatic intracerebral hemorrhage
    Joshua N Goldstein
    Department of Emergency Medicine, Massachusetts General Hospital, Zero Emerson Place, STE 3B, Boston, MA 02114, USA
    Arch Neurol 67:965-9. 2010
    ..It is not clear whether patients with sICH continue to bleed after diagnosis, nor has the most appropriate treatment been determined...
  42. pmc Statin treatment and functional outcome after ischemic stroke: case-control and meta-analysis
    Alessandro Biffi
    J Philip Kistler Stroke Research Center, Center for Human Genetics Research, Department of Neurology, Massachusetts General Hospital, 175 Cambridge Street, Suite 300, Boston MA 02114, USA
    Stroke 42:1314-9. 2011
    ..We therefore investigated the effect of antecedent use of statins on stroke outcome by performing a meta-analysis of all results from published studies as well as our own unpublished data...
  43. doi request reprint Determinants of white matter hyperintensity volume in patients with acute ischemic stroke
    Natalia S Rost
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Stroke Cerebrovasc Dis 19:230-5. 2010
    ..It is unclear whether WMH represents a single or multiple biological processes. We sought to investigate the extent and determinants of WMH in patients with acute ischemic stroke (AIS)...
  44. doi request reprint Severity of leukoaraiosis and susceptibility to infarct growth in acute stroke
    Hakan Ay
    A A Martinos Center for Biomedical Imaging and Stroke Service, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 2301, Charlestown, MA 02129, USA
    Stroke 39:1409-13. 2008
    ..We hypothesized that the volume of LA correlated with the proportion of initially ischemic but eventually infarcted tissue in acute human stroke...
  45. pmc Detection of isolated cerebrovascular beta-amyloid with Pittsburgh compound B
    Steven M Greenberg
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Ann Neurol 64:587-91. 2008
    ..These results offer compelling evidence that Pittsburgh Compound B positron emission tomography can noninvasively detect isolated cerebral amyloid angiopathy before overt signs of tissue damage such as hemorrhage or white matter lesions...
  46. ncbi request reprint A phase 2 study of tramiprosate for cerebral amyloid angiopathy
    Steven M Greenberg
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Alzheimer Dis Assoc Disord 20:269-74. 2006
    ..Tramiprosate (3-amino-1-propanesulfonic acid) is a candidate molecule shown in preclinical studies to reduce CAA in a transgenic mouse model...
  47. ncbi request reprint Timing of fresh frozen plasma administration and rapid correction of coagulopathy in warfarin-related intracerebral hemorrhage
    Joshua N Goldstein
    Department of Emergency Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Stroke 37:151-5. 2006
    ..We sought to determine whether particular emergency department (ED) interventions are effective in reversing coagulopathy and improving outcome...
  48. ncbi request reprint Hemorrhagic stroke
    Eric E Smith
    Vascular and Critical Care Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Neuroimaging Clin N Am 15:259-72, ix. 2005
    ..New evidence suggests that MR imaging alone may be adequate to identify hemorrhagic stroke in the acute setting, and that MR imaging is superior to CT for identification of chronic microbleeds and hemorrhagic conversion of infarction...
  49. ncbi request reprint Treatment of warfarin-associated intracerebral hemorrhage: literature review and expert opinion
    Maria I Aguilar
    Department of Neurology, Mayo Clinic College of Medicine, 13400 E Shea Blvd, Scottsdale, AZ 85259, USA
    Mayo Clin Proc 82:82-92. 2007
    ..Reasonable management based on expert opinion includes a wide range of additional measures to reverse anticoagulation in the absence of solid evidence...
  50. ncbi request reprint Hypoattenuation on CT angiographic source images predicts risk of intracerebral hemorrhage and outcome after intra-arterial reperfusion therapy
    Lee H Schwamm
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    AJNR Am J Neuroradiol 26:1798-803. 2005
    ..We hypothesized that the degree of vascular insufficiency, reflected as hypoattenuation on initial CT angiography (CTA) axial source images, is predictive of HT risk in stroke patients receiving intra-arterial reperfusion therapy...
  51. ncbi request reprint Amyloid angiopathy-related vascular cognitive impairment
    Steven M Greenberg
    Neurology Clinical Trials Unit and Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Stroke 35:2616-9. 2004
    ..These data highlight the importance of elucidating the effects of vascular amyloid on cerebrovascular function and of developing therapeutic strategies for this potentially widespread form of microvascular cognitive impairment...
  52. ncbi request reprint Clinical diagnosis of cerebral amyloid angiopathy: validation of the Boston criteria
    K A Knudsen
    Clinical Trials Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Neurology 56:537-9. 2001
    ..All 13 individuals were confirmed neuropathologically as having CAA. This small pathologic series indicates that the diagnosis of probable CAA can be made during life with high accuracy...
  53. pmc Genetic variation and neuroimaging measures in Alzheimer disease
    Alessandro Biffi
    Center for Human Genetic Research, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    Arch Neurol 67:677-85. 2010
    ..To investigate whether genome-wide association study (GWAS)-validated and GWAS-promising candidate loci influence magnetic resonance imaging measures and clinical Alzheimer's disease (AD) status...
  54. ncbi request reprint Treatment and prevention of primary intracerebral hemorrhage
    Amytis Towfighi
    Vascular and Critical Care Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Semin Neurol 25:445-52. 2005
    ....
  55. pmc Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy
    Gregory A Dierksen
    Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Ann Neurol 68:545-8. 2010
    ..0001). These findings indicate that microbleeds occur preferentially in local regions of concentrated amyloid and support therapeutic strategies aimed at reducing vascular amyloid deposition...
  56. ncbi request reprint Early edema in warfarin-related intracerebral hemorrhage
    Joshua M Levine
    Department of Neurology, 3 W Gates Building, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA
    Neurocrit Care 7:58-63. 2007
    ..A leading theory proposes that early PHE results from activation of the clotting cascade. We sought to test this theory by examining the relationship between early PHE and warfarin use in ICH patients...
  57. doi request reprint Efficacy and safety of recombinant activated factor VII for acute intracerebral hemorrhage
    Stephan A Mayer
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, USA
    N Engl J Med 358:2127-37. 2008
    ..We performed this phase 3 trial to confirm a previous study in which recombinant activated factor VII (rFVIIa) reduced growth of the hematoma and improved survival and functional outcomes...
  58. ncbi request reprint Intracerebral hemorrhage
    Neeraj Badjatia
    Neurocritical Care and Acute Stroke Service, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Neurologist 11:311-24. 2005
    ..Intracerebral hemorrhage (ICH) occurs from the rupture of small vessels into the brain parenchyma and accounts for approximately 10% of all strokes in the United States, and carries with it a significantly high morbidity and mortality...
  59. pmc Hyperlipidemia and reduced white matter hyperintensity volume in patients with ischemic stroke
    Jordi Jimenez-Conde
    Stroke Service, Department of Neurology and Center for Human Genetics Research, Massachusetts General Hospital, and Program in Medical and Population Genetics, Broad Institute of MIT and Harvard University, Boston, Mass 02114, USA
    Stroke 41:437-42. 2010
    ..We sought to determine the relation between hyperlipidemia and WMH severity in patients with acute ischemic stroke (AIS)...
  60. ncbi request reprint The genetic architecture of intracerebral hemorrhage
    Natalia S Rost
    Department of Neurology, and Hemorrhagic Stroke Research Program, Massachusetts General Hospital, 185 Cambridge Street, Boston MA 02114, USA
    Stroke 39:2166-73. 2008
    ..This review focuses on evidence for a genetic contribution to ICH, delineates approaches to genetic studies of ICH, and explores foundations for their future applications...
  61. doi request reprint Anemia and hematoma volume in acute intracerebral hemorrhage
    Monisha A Kumar
    Department of Neurology, Stroke and Neurocritical Care Division, Thomas Jefferson University Hospital Philadelphia, PA, USA
    Crit Care Med 37:1442-7. 2009
    ..In primary intracerebral hemorrhage (ICH), the most fatal type of stroke, outcome is largely dependent on the volume of hemorrhage into the brain. We investigated the relationship between anemia and clinical course of acute ICH...
  62. ncbi request reprint Warfarin-associated hemorrhage and cerebral amyloid angiopathy: a genetic and pathologic study
    J Rosand
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Neurology 55:947-51. 2000
    ..The pathogenesis of this often-fatal complication remains obscure. Cerebral amyloid angiopathy (CAA) is a major cause of spontaneous lobar hemorrhage in the elderly and is associated with specific alleles of the APOE gene...
  63. pmc SCORE-IT: the Spot Sign score in restricting ICH growth─an Atach-II ancillary study
    Jn Goldstein
    Hemorrhagic Stroke Research Group, Massachusetts General Hospital, Boston, MA, USA Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA Department of Emergency Medicine, Massachusetts General Hospital, Zero Emerson Place, Suite 3B, Boston, MA 02114, USA
    J Vasc Interv Neurol 5:20-5. 2012
    ..We hypothesize that specific imaging findings on CT angiography (CTA) and MRI will mark those patients who receive the most benefit from intensive blood pressure reduction...
  64. pmc CT angiography for intracerebral hemorrhage does not increase risk of acute nephropathy
    Alexandra Oleinik
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Stroke 40:2393-7. 2009
    ..Its use is limited by the concern for contrast induced nephropathy (CIN); however, the magnitude of this risk is not known...
  65. ncbi request reprint Hemorrhage burden predicts recurrent intracerebral hemorrhage after lobar hemorrhage
    Steven M Greenberg
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Stroke 35:1415-20. 2004
    ..We sought to determine whether hemorrhages detected at the time of lobar ICH predict the major clinical complications of CAA: recurrent ICH or decline in cognition and function...
  66. pmc Longitudinal changes in white matter disease and cognition in the first year of the Alzheimer disease neuroimaging initiative
    Owen Carmichael
    Department of Neurology, School of Medicine, University of California, Davis, CA, USA
    Arch Neurol 67:1370-8. 2010
    ....
  67. pmc Systematic characterization of the computed tomography angiography spot sign in primary intracerebral hemorrhage identifies patients at highest risk for hematoma expansion: the spot sign score
    Josser E Delgado Almandoz
    Division of Neuroradiology, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Stroke 40:2994-3000. 2009
    ..We aim to systematically characterize the spot sign to identify features that are most predictive of hematoma expansion and construct a spot sign scoring system...
  68. pmc Body mass index and etiology of intracerebral hemorrhage
    Alessandro Biffi
    Center for Human Genetic Research, Massachusetts General Hospital, 185 Cambridge Street CPZN 6818, Boston, MA 02114, USA
    Stroke 42:2526-30. 2011
    ..Extremes of body mass index (BMI) are associated with increased incidence of intracerebral hemorrhage (ICH). Because ICH can result from different vessel pathologies, we investigated whether the effect of BMI depends on ICH etiology...
  69. pmc Independent susceptibility markers for atrial fibrillation on chromosome 4q25
    Steven A Lubitz
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02114, USA
    Circulation 122:976-84. 2010
    ..Genetic variants on chromosome 4q25 are associated with atrial fibrillation (AF). We sought to determine whether there is more than 1 susceptibility signal at this locus...
  70. ncbi request reprint Continuous antibiotic prophylaxis and cerebral spinal fluid infection in patients with intracranial pressure monitors
    John J Flibotte
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    Neurocrit Care 1:61-8. 2004
    ..We examined the rate, possible risk factors, causative organisms, and characteristics of infection...
  71. pmc Chromosome 9p21 in ischemic stroke: population structure and meta-analysis
    Christopher D Anderson
    Center for Human Genetic Research, Massachusetts General Hospital, 185 Cambridge Street, CPZN 6818, Boston, MA 02114, USA
    Stroke 41:1123-31. 2010
    ..We investigated whether these conflicting findings were due to false-positive studies confounded by population stratification or false-negative studies that failed to account for effects specific to certain stroke subtypes...
  72. ncbi request reprint Validation of intracranial area as a surrogate measure of intracranial volume when using clinical MRI
    R N Kaveer Nandigam
    Department of Neurology, Neurology Clinical Trials Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    J Neuroimaging 17:74-7. 2007
    ..We sought to determine whether mid-sagittal intracranial area (ICA) is a valid surrogate of intracranial volume (ICV) when using retrospective data with relatively thick (6-7 mm) sagittal slices...
  73. doi request reprint Effect of statins on intracerebral hemorrhage outcome and recurrence
    Emilie FitzMaurice
    Stroke 39:2151-4. 2008
    ..We investigated (1) whether statin use before ICH was associated with functional independence at 90 days, and (2) whether survivors exposed to statins after ICH had an increased risk of recurrence...
  74. ncbi request reprint Hypertension and the brain: stroke is just the tip of the iceberg
    Jonathan Rosand
    Neurology 63:6-7. 2004
  75. ncbi request reprint Can patients be anticoagulated after intracerebral hemorrhage? A decision analysis
    Mark H Eckman
    Division of General Internal Medicine and the Center for Clinical Effectiveness, University of Cincinnati, Cincinnati, OH, USA
    Stroke 34:1710-6. 2003
    ....
  76. ncbi request reprint Advanced age, anticoagulation intensity, and risk for intracranial hemorrhage among patients taking warfarin for atrial fibrillation
    Margaret C Fang
    Division of General Internal Medicine, Hospitalist Group, University of California, San Francisco, San Francisco 94143, USA
    Ann Intern Med 141:745-52. 2004
    ..However, higher intensities increase hemorrhage risk. Optimal use of warfarin for atrial fibrillation requires precise information on the risk for intracranial hemorrhage as a function of patient age and anticoagulation intensity...
  77. ncbi request reprint Intracerebral hemorrhage associated with oral anticoagulant therapy: current practices and unresolved questions
    Thorsten Steiner
    Department of Neurology, University of Heidelberg, Germany
    Stroke 37:256-62. 2006
    ..Early intervention focuses on rapid correction of coagulopathy in order to prevent continued bleeding...
  78. ncbi request reprint Beyond hypertension: unraveling the causes of intracerebral hemorrhage
    Jonathan Rosand
    Stroke 33:1195-6. 2002
  79. ncbi request reprint Contrast extravasation on CT angiography predicts hematoma expansion in intracerebral hemorrhage
    Yasuo Murai
    Neurology 69:617; author reply 617. 2007
  80. ncbi request reprint Fragile vessels: handle with care
    James F Meschia
    Neurology 69:1560-1. 2007
  81. ncbi request reprint White matter alterations in cerebral amyloid angiopathy measured by diffusion tensor imaging
    David H Salat
    Massachusetts General Hospital Massachusetts Institute of Technology Harvard Medical School, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, Mass 02129 2060, USA
    Stroke 37:1759-64. 2006
    ..We used diffusion tensor imaging to evaluate the anatomic distribution of white matter degeneration in participants diagnosed with advanced CAA...
  82. ncbi request reprint Many hypotheses but no replication for the association between PDE4D and stroke
    Jonathan Rosand
    Nat Genet 38:1091-2; author reply 1092-3. 2006
  83. ncbi request reprint In search of genes for stroke
    Paul I W de Bakker
    Lancet Neurol 6:383-4. 2007
  84. ncbi request reprint Reply
    Jonathan Rosand
    Ann Neurol 59:432. 2006
  85. ncbi request reprint Epistasis is coming: are we ready?
    Jonathan Rosand
    Stroke 36:1879-80. 2005
  86. ncbi request reprint Variants conferring risk of atrial fibrillation on chromosome 4q25
    Daniel F Gudbjartsson
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nature 448:353-7. 2007
    ..42 per copy. A stronger association was observed in individuals with typical atrial flutter. Both variants are adjacent to PITX2, which is known to have a critical function in left-right asymmetry of the heart...
  87. ncbi request reprint Cost-effectiveness of recombinant activated factor VII in the treatment of intracerebral hemorrhage
    Stephanie R Earnshaw
    RTI Health Solutions, Research Triangle Park, NC, USA
    Stroke 37:2751-8. 2006
    ..In the current analysis, we examine the cost-effectiveness of early treatment with rFVIIa for ICH in the United States...

Research Grants5

  1. Genetic Determinants of Hematoma Volume
    Jonathan Rosand; Fiscal Year: 2006
    ..He will be trained to conduct fundamental studies in clinical and molecular epidemiology of acute cerebrovascular disease as well as pivotal clinical trials of novel therapeutic interventions for ICH. ..
  2. Gene Discovery for Warfarin-Related Intracerebral Hemorrhage
    Jonathan Rosand; Fiscal Year: 2009
    ..It therefore offers the promise of novel biological insights, as well as immediate clinical impact through improving risk assessment for chronic antiocoagulation. ..
  3. Gene Discovery for Warfarin-Related Intracerebral Hemorrhage
    Jonathan Rosand; Fiscal Year: 2009
    ..It therefore offers the promise of novel biological insights, as well as immediate clinical impact through improving risk assessment for chronic antiocoagulation. ..
  4. Gene Discovery for Warfarin-Related Intracerebral Hemorrhage
    Jonathan Rosand; Fiscal Year: 2010
    ..It therefore offers the promise of novel biological insights, as well as immediate clinical impact through improving risk assessment for chronic antiocoagulation. ..