Arlin B Rogers

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. ncbi Polycystic kidney syndrome in New Zealand White rabbits resembling human polycystic kidney disease
    Kirk J Maurer
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Kidney Int 65:482-9. 2004
  2. ncbi Inflammation and Cancer. I. Rodent models of infectious gastrointestinal and liver cancer
    Arlin B Rogers
    Comparative Pathology Laboratory, Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Ave, Bldg 16 849, Cambridge, MA 02139, USA
    Am J Physiol Gastrointest Liver Physiol 286:G361-6. 2004
  3. ncbi Progression of chronic hepatitis and preneoplasia in Helicobacter hepaticus-infected A/JCr mice
    Arlin B Rogers
    Comparative Pathology Laboratory 16 849, Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Toxicol Pathol 32:668-77. 2004
  4. ncbi Thiol-reactive compounds prevent nonspecific antibody binding in immunohistochemistry
    Arlin B Rogers
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Lab Invest 86:526-33. 2006
  5. ncbi Hepatocellular carcinoma associated with liver-gender disruption in male mice
    Arlin B Rogers
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Cancer Res 67:11536-46. 2007
  6. ncbi Helicobacter pylori but not high salt induces gastric intraepithelial neoplasia in B6129 mice
    Arlin B Rogers
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Cancer Res 65:10709-15. 2005
  7. pmc Helicobacter hepaticus HHGI1 is a pathogenicity island associated with typhlocolitis in B6.129-IL10 tm1Cgn mice
    Zhongming Ge
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Microbes Infect 10:726-33. 2008
  8. pmc 17 β-estradiol suppresses Helicobacter pylori-induced gastric pathology in male hypergastrinemic INS-GAS mice
    Masahiro Ohtani
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Carcinogenesis 32:1244-50. 2011
  9. pmc T-cell function is critical for murine cholesterol gallstone formation
    Kirk J Maurer
    Department of Biological Engineering, Massachusetts Institute of Technology, Boston, Massachusetts, USA
    Gastroenterology 133:1304-15. 2007
  10. ncbi Helicobacter hepaticus urease is not required for intestinal colonization but promotes hepatic inflammation in male A/JCr mice
    Zhongming Ge
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Microb Pathog 45:18-24. 2008

Detail Information

Publications69

  1. ncbi Polycystic kidney syndrome in New Zealand White rabbits resembling human polycystic kidney disease
    Kirk J Maurer
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Kidney Int 65:482-9. 2004
    ..Cystic kidney diseases are an important cause of morbidity and mortality in humans. Small animal models are needed to more fully explore the complex expression patterns and pathobiology of this group of heritable diseases...
  2. ncbi Inflammation and Cancer. I. Rodent models of infectious gastrointestinal and liver cancer
    Arlin B Rogers
    Comparative Pathology Laboratory, Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Ave, Bldg 16 849, Cambridge, MA 02139, USA
    Am J Physiol Gastrointest Liver Physiol 286:G361-6. 2004
    ..Hepatitis B and C virus transgenic mice provide insights into viral hepatitis and hepatocellular carcinoma. Rodent models enhance our understanding of infectious cancer pathogenesis and suggest novel targets for intervention...
  3. ncbi Progression of chronic hepatitis and preneoplasia in Helicobacter hepaticus-infected A/JCr mice
    Arlin B Rogers
    Comparative Pathology Laboratory 16 849, Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Toxicol Pathol 32:668-77. 2004
    ..Continued study of chronic hepatitis progression may reveal therapeutic targets to reduce the risk of hepatocellular carcinoma...
  4. ncbi Thiol-reactive compounds prevent nonspecific antibody binding in immunohistochemistry
    Arlin B Rogers
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Lab Invest 86:526-33. 2006
    ..These findings provide a molecular basis to improve the specificity of IHC and other immunoassays, and hold implications for antibody-based clinical diagnostics and therapeutics...
  5. ncbi Hepatocellular carcinoma associated with liver-gender disruption in male mice
    Arlin B Rogers
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Cancer Res 67:11536-46. 2007
    ..This model introduces a novel mechanism of inflammation-associated carcinogenesis consistent with male-predominant HCC risk...
  6. ncbi Helicobacter pylori but not high salt induces gastric intraepithelial neoplasia in B6129 mice
    Arlin B Rogers
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Cancer Res 65:10709-15. 2005
    ..In summary, we report for the first time H. pylori-induced gastric intraepithelial neoplasia in a wild-type mouse model and show no additive effect of high-salt ingestion on tumor progression...
  7. pmc Helicobacter hepaticus HHGI1 is a pathogenicity island associated with typhlocolitis in B6.129-IL10 tm1Cgn mice
    Zhongming Ge
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Microbes Infect 10:726-33. 2008
    ..05) at 13 WPI. These results demonstrate that genes in the HHGI1 contribute to the pathogenicity of H. hepaticus, at least in part via up-regulation of proinflammatory mediators IFN-gamma, TNF-alpha and IL-17a...
  8. pmc 17 β-estradiol suppresses Helicobacter pylori-induced gastric pathology in male hypergastrinemic INS-GAS mice
    Masahiro Ohtani
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Carcinogenesis 32:1244-50. 2011
    ..pylori-infected male INS-GAS mice and to a lesser extent in uninfected mice, potentially by enhancing IL-10 function, which in turn decreased IFN-γ and IL-1β responses induced by H.pylori...
  9. pmc T-cell function is critical for murine cholesterol gallstone formation
    Kirk J Maurer
    Department of Biological Engineering, Massachusetts Institute of Technology, Boston, Massachusetts, USA
    Gastroenterology 133:1304-15. 2007
    ..Although gallbladder inflammation is believed to be common during cholelithogenesis, the role of immunologic factors is unknown...
  10. ncbi Helicobacter hepaticus urease is not required for intestinal colonization but promotes hepatic inflammation in male A/JCr mice
    Zhongming Ge
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Microb Pathog 45:18-24. 2008
    ..These results indicate that H. hepaticus urease activity plays a crucial role in hepatic disease but is not required for cecal colonization by H. hepaticus...
  11. pmc Genetic susceptibility to chronic hepatitis is inherited codominantly in Helicobacter hepaticus-infected AB6F1 and B6AF1 hybrid male mice, and progression to hepatocellular carcinoma is linked to hepatic expression of lipogenic genes and immune function-a
    Alexis Garcia
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Ave 16 825, Cambridge, MA 02139, USA
    Infect Immun 76:1866-76. 2008
    ..The use of AB6F1 and B6AF1 mice, as well as genetically engineered mice, on a C57BL/6 background will allow studies investigating the role of chronic microbial hepatitis and steatohepatitis in the pathogenesis of liver cancer...
  12. pmc Vitamin C supplementation does not protect L-gulono-gamma-lactone oxidase-deficient mice from Helicobacter pylori-induced gastritis and gastric premalignancy
    Chung Wei Lee
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Int J Cancer 122:1068-76. 2008
    ..pylori-induced premalignant gastric lesions. In addition, less severe gastric lesions in H.pylori infected gulo(-/-) mice supplemented with low vitamin C correlated with an attenuated Th1 inflammatory response...
  13. ncbi Helicobacter pylori and cholesterol gallstone formation in C57L/J mice: a prospective study
    Kirk J Maurer
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA
    Am J Physiol Gastrointest Liver Physiol 290:G175-82. 2006
    ..Nonetheless, the C57L mouse develops severe lesions of both the glandular and nonglandular stomach in response to H. pylori infection and the lithogenic diet, respectively...
  14. ncbi Protective role of 17 beta -estradiol against the development of Helicobacter pylori-induced gastric cancer in INS-GAS mice
    Masahiro Ohtani
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Building 16 825C, Cambridge, MA 02139, USA
    Carcinogenesis 28:2597-604. 2007
    ..These results demonstrate a protective effect of E2 in H.pylori-induced gastric cancer in a mouse model...
  15. ncbi CD4(+)CD25(+) regulatory lymphocytes require interleukin 10 to interrupt colon carcinogenesis in mice
    Susan E Erdman
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Cancer Res 63:6042-50. 2003
    ..Regulatory lymphocytes and cytokines may have implications for novel therapies for colon cancer in humans...
  16. pmc Combination of sulindac and antimicrobial eradication of Helicobacter pylori prevents progression of gastric cancer in hypergastrinemic INS-GAS mice
    Chung Wei Lee
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Cancer Res 69:8166-74. 2009
    ..pylori eradication was beneficial for reducing proinflammatory cytokine mRNA in the stomach and preventing progression from severe dysplasia to gastric cancer in H. pylori-infected INS-GAS mice...
  17. pmc Sex hormone influence on hepatitis in young male A/JCr mice infected with Helicobacter hepaticus
    Elizabeth J Theve
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Infect Immun 76:4071-8. 2008
    ..hepaticus-induced hepatitis in young male mice, whereas androgen receptor agonism does not worsen disease. This raises the possibility of targeted hormonal therapy in young male patients with childhood-acquired HBV...
  18. pmc Wild-type and interleukin-10-deficient regulatory T cells reduce effector T-cell-mediated gastroduodenitis in Rag2-/- mice, but only wild-type regulatory T cells suppress Helicobacter pylori gastritis
    Chung Wei Lee
    Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Infect Immun 75:2699-707. 2007
    ..pylori-mediated inflammation and in regulatory effects between wt T(R) and IL-10(-/-) T(R) cells suggest that IL-10 expression by wt T(R) cells is important to regulatory suppression of gastric inflammation...
  19. pmc Helicobacter pylori eradication prevents progression of gastric cancer in hypergastrinemic INS-GAS mice
    Chung Wei Lee
    Division of Comparative Medicine, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cancer Res 68:3540-8. 2008
    ..pylori eradication prevented gastric cancer to the greatest extent when antibiotics are given at an early point of infection, but that eradication therapy given at a later time point delayed the development of severe dysplastic lesions...
  20. pmc Experimental Helicobacter marmotae infection in A/J mice causes enterohepatic disease
    Mary M Patterson
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Building 16 825, Cambridge, MA 02139, USA
    J Med Microbiol 59:1235-41. 2010
    ..Such a woodchuck helicobacter-infected mouse model could be used to dissect potential mechanisms of microbial co-carcinogenesis involved in tumour development in woodchucks with WHV and in humans with hepatitis B virus...
  21. pmc Cytotoxic-T-lymphocyte-associated antigen 4 blockade abrogates protection by regulatory T cells in a mouse model of microbially induced innate immune-driven colitis
    Koichiro Watanabe
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA
    Infect Immun 76:5834-42. 2008
    ....
  22. pmc Helicobacter hepaticus infection promotes colon tumorigenesis in the BALB/c-Rag2(-/-) Apc(Min/+) mouse
    Claude M Nagamine
    Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Infect Immun 76:2758-66. 2008
    ..5% versus 1.7%, respectively). The data suggest that H. hepaticus, which is present in many research colonies, promotes colon tumorigenesis in the BALB-RagMin mouse and that it has the potential to confound colon tumorigenesis studies...
  23. pmc Concurrent Helicobacter bilis infection in C57BL/6 mice attenuates proinflammatory H. pylori-induced gastric pathology
    Laura B Lemke
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Ave, Bldg 16 825, Cambridge, MA 02139, USA
    Infect Immun 77:2147-58. 2009
    ..pylori infection, particularly in developing countries, may occur where coinfection with lower bowel helicobacters and H. pylori may be common...
  24. pmc DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice
    Lisiane B Meira
    Department of Biological Engineering and Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Clin Invest 118:2516-25. 2008
    ..These data demonstrate that the repair of DNA lesions formed by RONS during chronic inflammation is important for protection against colon carcinogenesis...
  25. doi Helicobacter-based mouse models of digestive system carcinogenesis
    Arlin B Rogers
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA
    Methods Mol Biol 511:267-95. 2009
    ....
  26. ncbi Helicobacter hepaticus promotes azoxymethane-initiated colon tumorigenesis in BALB/c-IL10-deficient mice
    Claude M Nagamine
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Int J Cancer 122:832-8. 2008
    ..The AOM-induced adenomas were predominantly exophytic and nodular or polypoid and localized to the distal colon. These results suggest that H. hepaticus promotes AOM-induced tumorigenesis in the BALB/c-IL10 null mouse...
  27. pmc Accelerated progression of gastritis to dysplasia in the pyloric antrum of TFF2 -/- C57BL6 x Sv129 Helicobacter pylori-infected mice
    James G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Am J Pathol 171:1520-8. 2007
    ..pylori-infected mice at 19 months pi. These data support a protective role for TFF2 in part by modulating levels of gastric interferon-gamma in the development of H. pylori-associated premalignancy of the distal stomach...
  28. ncbi Host and microbial constituents influence Helicobacter pylori-induced cancer in a murine model of hypergastrinemia
    James G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA
    Gastroenterology 124:1879-90. 2003
    ..We examined the effects of an H. pylori cancer-associated determinant (cagE), IL-1beta, and host gender in a transgenic hypergastrinemic (INS-GAS) murine model of gastric carcinogenesis...
  29. ncbi Bacterial cytolethal distending toxin promotes the development of dysplasia in a model of microbially induced hepatocarcinogenesis
    Zhongming Ge
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Cell Microbiol 9:2070-80. 2007
    ....
  30. pmc Different Helicobacter hepaticus strains with variable genomic content induce various degrees of hepatitis
    Samuel R Boutin
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, 16 825C, Cambridge, MA 02139, USA
    Infect Immun 73:8449-52. 2005
    ..Mice infected with HhG and HhNET developed less-severe hepatitis than male A/JCr mice infected with Hh3B1...
  31. ncbi Helicobacter bilis-associated hepatitis in outbred mice
    James G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Comp Med 54:571-7. 2004
    ..bilis-infected mice of group III seroconverted to H. bilis outer membrane antigen. Helicobacter bilis infection is associated with hepatitis in SW mice and can confound experimental results...
  32. pmc Modulation of acute diarrheal illness by persistent bacterial infection
    Megan E McBee
    Department of Biological Engineering, Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Infect Immun 76:4851-8. 2008
    ..This new model of polymicrobial infection provides insight into the mechanism by which subclinical infection can exacerbate morbidity due to an unrelated self-limiting infection...
  33. ncbi Helicobacter pylori-associated gastric cancer in INS-GAS mice is gender specific
    James G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cancer Res 63:942-50. 2003
    ..This study highlights the importance of using both genders to investigate the pathogenesis of H. pylori...
  34. pmc Gastroenteritis in NF-kappaB-deficient mice is produced with wild-type Camplyobacter jejuni but not with C. jejuni lacking cytolethal distending toxin despite persistent colonization with both strains
    James G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Infect Immun 72:1116-25. 2004
    ..jejuni to escape immune surveillance. NF-kappaB-deficient mice should be a useful model to further study the role of CDT and other aspects of C. jejuni pathogenesis...
  35. ncbi Hepatic temporal gene expression profiling in Helicobacter hepaticus-infected A/JCr mice
    Samuel R Boutin
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Toxicol Pathol 32:678-93. 2004
    ....
  36. ncbi Identification of cholelithogenic enterohepatic helicobacter species and their role in murine cholesterol gallstone formation
    Kirk J Maurer
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Gastroenterology 128:1023-33. 2005
    ..To test this, we prospectively investigated the effects of Helicobacter spp infection in cholesterol gallstone pathogenesis in the highly susceptible C57L/J mouse model...
  37. doi Intravenous Shiga toxin 2 promotes enteritis and renal injury characterized by polymorphonuclear leukocyte infiltration and thrombosis in Dutch Belted rabbits
    Alexis Garcia
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Ave 16 873, Cambridge, MA 02139, USA
    Microbes Infect 10:650-6. 2008
    ..04), and tissue plasminogen activator (P<0.05). Circulating Stx2 promoted dose-dependent enteritis and renal injury characterized by inflammation and impaired fibrinolysis leading to thrombosis...
  38. ncbi Isolation and characterization of novel Helicobacter spp. from the gastric mucosa of harp seals Phoca groenlandica
    Claudia G Harper
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Building 16, Room 825C, Cambridge, Massachusetts 02139, USA
    Dis Aquat Organ 57:1-9. 2003
    ..may play a role in the etiopathogenesis of gastrointestinal diseases in pinnipeds. To our knowledge, this represents the first isolation and characterization of a novel Helicobacter spp. from pinnipeds...
  39. ncbi Renal injury is a consistent finding in Dutch Belted rabbits experimentally infected with enterohemorrhagic Escherichia coli
    Alexis Garcia
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Infect Dis 193:1125-34. 2006
    ..Our findings indicate that DB rabbits are suitable for the study of the renal manifestations of EHEC infection in humans...
  40. pmc Cystic renal disease in the domestic ferret
    Courtnye N Jackson
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA
    Comp Med 58:161-7. 2008
    ..In addition to the clinical implications for ferrets as research subjects and pets, these findings suggest a potential value for ferrets as a model of human cystic renal diseases...
  41. pmc Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis
    Chengkai Dai
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 130:1005-18. 2007
    ..While it enhances organismal survival and longevity under most circumstances, HSF1 has the opposite effect in supporting the lethal phenomenon of cancer...
  42. pmc CD4+ CD25+ regulatory T lymphocytes inhibit microbially induced colon cancer in Rag2-deficient mice
    Susan E Erdman
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Am J Pathol 162:691-702. 2003
    ..These roles for T cells in protection against colon carcinoma may have implications for new modes of prevention and treatment of cancer in humans...
  43. ncbi Renal infarction and immune-mediated glomerulonephritis in sheep (Ovis aries) chronically implanted with indwelling catheters
    Varada P Rao
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts
    J Am Assoc Lab Anim Sci 45:14-9. 2006
    ....
  44. doi Obesity and non-insulin-dependent diabetes mellitus in Swiss-Webster mice associated with late-onset hepatocellular carcinoma
    Laura B Lemke
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Endocrinol 199:21-32. 2008
    ..The SW availability and histopathologic features represent a promising new model for the study of T2D...
  45. ncbi Applications of fluorescence for detecting rare sequence rearrangements in vivo
    Dominika M Wiktor-Brown
    Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, Massachsuttes 02139, USA
    Cell Cycle 5:2715-9. 2006
    ..The FYDR mice provide a unique tool for identifying genetic conditions and environmental exposures that induce genotoxic stress in a variety of tissues...
  46. pmc Acute respiratory distress syndrome in two rhesus macaques (Macaca mulatta)
    Jacqueline J Fremont
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA
    J Am Assoc Lab Anim Sci 47:61-6. 2008
    ..Recognition and aggressive treatment of ARDS at an early stage may improve survival rates in dyspneic nonhuman primates with underlying extrapulmonary diseases...
  47. pmc Agammaglobulinemia and Staphylococcus aureus botryomycosis in a cohort of related sentinel Swiss Webster mice
    Erin C Bridgeford
    Division of Comparative Medicine 16 825, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Clin Microbiol 46:1881-4. 2008
    ..Our experience reinforces the importance of immunocompetency validation in surveillance programs...
  48. ncbi Alopecia attributed to neoplastic ovarian tissue in two ferrets
    Mary M Patterson
    Division of Comparative Medicine, Massachuetts Institute of Technology, Cambridge 02139, USA
    Comp Med 53:213-7. 2003
    ..Immunohistochemical analysis, using an antibody against Mullerian-inhibiting substance, failed to prove definitively the source of the steroidogenic cells...
  49. ncbi No significant endothelial apoptosis in the radiation-induced gastrointestinal syndrome
    Bradley W Schuller
    Department of Nuclear Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Int J Radiat Oncol Biol Phys 68:205-10. 2007
    ..This report addresses the incidence of vascular endothelial cell apoptosis in the mouse small intestine in relation to the radiation-induced gastrointestinal (GI) syndrome...
  50. ncbi Oral papillomas and papilliform lesions in rhesus macaques (Macaca mulatta)
    Mary M Patterson
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Comp Med 55:75-9. 2005
    ..Benign tumors of the oral epithelium in macaques have not been reported previously; they appear to be rare and of variable clinical significance...
  51. ncbi Diagnostic techniques for clinical investigation of laboratory zebrafish
    Keith M Astrofsky
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Ave, Building 16 820, Cambridge, MA 02139, USA
    Lab Anim (NY) 31:41-5. 2002
    ..The authors outline the basic procedures used to diagnose disease outbreaks in laboratory zebrafish colonies, and provide a basic framework for initiating clinical investigations...
  52. ncbi p27kip1 deficiency confers susceptibility to gastric carcinogenesis in Helicobacter pylori-infected mice
    Noriyoshi Kuzushita
    Division of Gastroenterology, Department of Medicine, Rhode Island Hospital Brown University, Providence, Rhode Island 02903, USA
    Gastroenterology 129:1544-56. 2005
    ..We therefore evaluated p27-deficient mice as a model for H pylori-associated gastric cancer...
  53. pmc Activation of beta-catenin by carcinogenic Helicobacter pylori
    Aime T Franco
    Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2279, USA
    Proc Natl Acad Sci U S A 102:10646-51. 2005
    ..cag- strains or uninfected persons. These results indicate that H. pylori-induced dysregulation of beta-catenin-dependent pathways may explain in part the augmentation in the risk of gastric cancer conferred by this pathogen...
  54. ncbi Swedish moist snuff accelerates gastric cancer development in Helicobacter pylori-infected wild-type and gastrin transgenic mice
    Bjorn Stenstrom
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, NO 7006 Norway
    Carcinogenesis 28:2041-6. 2007
    ..We suggest that snus is a potential gastric carcinogen in mice. The development of CIS was associated with increased rates of the epithelial cell proliferation and apoptosis, common features of gastric carcinogenesis...
  55. pmc Trefoil family factor 2 is expressed in murine gastric and immune cells and controls both gastrointestinal inflammation and systemic immune responses
    Evelyn A Kurt-Jones
    Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Lazare Research Building Rm 226, Worcester, MA 01605, USA
    Infect Immun 75:471-80. 2007
    ..Our studies suggest that TFF2 not only controls gastrointestinal repair but also regulates mononuclear cell inflammatory responses...
  56. ncbi NF-kappa B is required within the innate immune system to inhibit microflora-induced colitis and expression of IL-12 p40
    Michal F Tomczak
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 171:1484-92. 2003
    ..These results suggest that inhibition of H. hepaticus-induced IL-12 p40 expression by NF-kappaB subunits is critical to preventing colonic inflammation in response to inflammatory microflora...
  57. pmc Critical roles for stx2, eae, and tir in enterohemorrhagic Escherichia coli-induced diarrhea and intestinal inflammation in infant rabbits
    Jennifer M Ritchie
    Division of Geographic Medicine and Infectious Diseases, Tufts New England Medical Center, and Howard Hughes Medical Institute, Boston, Massachusetts 02111, USA
    Infect Immun 71:7129-39. 2003
    ....
  58. pmc In vitro and in vivo characterization of Helicobacter hepaticus cytolethal distending toxin mutants
    Vincent B Young
    Department of Microbiology and Molecular Genetics, National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 48824, USA
    Infect Immun 72:2521-7. 2004
    ..However, a CDT-negative H. hepaticus mutant had a significantly diminished capacity to induce lesions in this murine model of inflammatory bowel disease...
  59. ncbi Coinfection modulates inflammatory responses and clinical outcome of Helicobacter felis and Toxoplasma gondii infections
    Calin Stoicov
    Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 173:3329-36. 2004
    ..These data demonstrate the profound interactions between the immune response to unrelated organisms, and suggest these types of interactions my impact clinical disease...
  60. ncbi A role for NF-kappa B subunits p50 and p65 in the inhibition of lipopolysaccharide-induced shock
    Mihaela Gadjeva
    Center for Blood Research, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 173:5786-93. 2004
    ....
  61. ncbi Synergistic inhibitory effects of gastrin and histamine receptor antagonists on Helicobacter-induced gastric cancer
    Shigeo Takaishi
    Division of Digestive and Liver Disease, Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Gastroenterology 128:1965-83. 2005
    ..We used this model to examine the role of cholecystokinin 2 (CCK2)/gastrin receptor and histamine H2-receptor signaling in the development of gastric atrophy and cancer...
  62. pmc Probiotic Lactobacillus spp. diminish Helicobacter hepaticus-induced inflammatory bowel disease in interleukin-10-deficient mice
    Jeremy A Pena
    Department of Molecular Virology and Pathology, Baylor College of Medicine, 6621 Fannin St, Houston, TX 77030, USA
    Infect Immun 73:912-20. 2005
    ..In this H. hepaticus-challenged IL-10-deficient murine colitis model, lactobacilli demonstrated probiotic effects by direct modulation of mucosal inflammatory responses...
  63. ncbi Inhibition of Helicobacter hepaticus-induced colitis by IL-10 requires the p50/p105 subunit of NF-kappa B
    Michal F Tomczak
    Immunology Research Division, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 177:7332-9. 2006
    ..These results suggest that the absence of the p50/p105 subunit of NF-kappaB within hemopoietic cells of the innate immune system interferes with the ability of IL-10 to suppress inflammatory gene expression and Hh-induced colitis...
  64. ncbi Gastric cancer originating from bone marrow-derived cells
    JeanMarie Houghton
    Department of Medicine and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 306:1568-71. 2004
    ..These findings suggest that epithelial cancers can originate from marrow-derived sources and thus have broad implications for the multistep model of cancer progression...
  65. ncbi Spontaneous expression of embryonic factors and p53 point mutations in aged mesenchymal stem cells: a model of age-related tumorigenesis in mice
    Hanchen Li
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605 2324, USA
    Cancer Res 67:10889-98. 2007
    ..These data suggest that MSCs may play a key role in age-related tumors, and fusion with host cells restores a nonmalignant phenotype, thereby providing a mechanism for regulating tumor cell activity...
  66. ncbi Overexpression of glycine-extended gastrin inhibits parietal cell loss and atrophy in the mouse stomach
    Guanglin Cui
    Division of Gastroenterology, University of Massachusetts Medical School, Worcester, Massachusetts
    Cancer Res 64:8160-6. 2004
    ..The overexpression of G-gly seems to increase the susceptibility to peptic ulcer disease and delay the development of Helicobacter-mediated gastric preneoplasia in this model...
  67. ncbi Stem cells and cancer: evidence for bone marrow stem cells in epithelial cancers
    Han chen Li
    Department of Medicine, University of Massachusetts Medical School, LRB Second Floor, Room 209, 364 Plantation Street, Worcester, MA 01605 2324, United States
    World J Gastroenterol 12:363-71. 2006
    ..Here we review the recent advances in our understanding of the contributions of circulating bone marrow-derived stem cells to the formation of tumors in animal models as well as in human beings...
  68. pmc Immunohistochemical localization of feline immunodeficiency virus using native species antibodies
    Arlin B Rogers
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80523 1674, USA
    Am J Pathol 161:1143-51. 2002
    ..Use of native species antibodies for immunohistochemical detection of infectious antigens has application to other settings in which xenotypic (eg, mouse and rabbit) antibody sources are inadequate or unavailable...
  69. ncbi Fetal feline immunodeficiency virus is prevalent and occult
    Arlin B Rogers
    Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523 1671, USA
    J Infect Dis 186:895-904. 2002
    ..In situ assays demonstrated FIV DNA but neither RNA nor antigens in placentas and fetuses. If mother-to-offspring FIV infection reflects vertical HIV-1 transmission, fetal virus exposure is common and may be occult at term...