Joshua L Roffman

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi Neuroimaging and the functional neuroanatomy of psychotherapy
    Joshua L Roffman
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Psychol Med 35:1385-98. 2005
  2. ncbi Effects of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism on executive function in schizophrenia
    Joshua L Roffman
    Schizophrenia Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, USA
    Schizophr Res 92:181-8. 2007
  3. doi MTHFR 677C>T effects on anterior cingulate structure and function during response monitoring in schizophrenia: a preliminary study
    Joshua L Roffman
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Brain Imaging Behav 5:65-75. 2011
  4. doi Randomized multicenter investigation of folate plus vitamin B12 supplementation in schizophrenia
    Joshua L Roffman
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA 02129, USA
    JAMA Psychiatry 70:481-9. 2013
  5. pmc Genetic variation throughout the folate metabolic pathway influences negative symptom severity in schizophrenia
    Joshua L Roffman
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Schizophr Bull 39:330-8. 2013
  6. pmc A hypomethylating variant of MTHFR, 677C>T, blunts the neural response to errors in patients with schizophrenia and healthy individuals
    Joshua L Roffman
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America
    PLoS ONE 6:e25253. 2011
  7. pmc MTHFR 677C --> T genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val --> Met
    Joshua L Roffman
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 105:17573-8. 2008
  8. doi Eight ball
    Joshua L Roffman
    Psychiatric Neuroscience Research Program, Rm 2656, Bldg 149, Massachusetts General Hospital, 149 13th St, Charlestown, MA 02129, USA
    Am J Psychiatry 165:956-7. 2008
  9. doi Interactive effects of COMT Val108/158Met and MTHFR C677T on executive function in schizophrenia
    Joshua L Roffman
    Schizophrenia Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Am J Med Genet B Neuropsychiatr Genet 147:990-5. 2008
  10. ncbi Neuroimaging-genetic paradigms: a new approach to investigate the pathophysiology and treatment of cognitive deficits in schizophrenia
    Joshua L Roffman
    Harvard Medical School and Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02129, USA
    Harv Rev Psychiatry 14:78-91. 2006

Detail Information

Publications18

  1. ncbi Neuroimaging and the functional neuroanatomy of psychotherapy
    Joshua L Roffman
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Psychol Med 35:1385-98. 2005
    ..This review examines initial attempts to measure directly the effects of psychotherapy on brain function in patients with depression or anxiety disorders...
  2. ncbi Effects of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism on executive function in schizophrenia
    Joshua L Roffman
    Schizophrenia Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, USA
    Schizophr Res 92:181-8. 2007
    ..This study examined whether schizophrenia patients homozygous for the risk allele (T/T) exhibit greater impairment in executive function, and determined the extent to which MTHFR's effects on negative symptoms underlie this relationship...
  3. doi MTHFR 677C>T effects on anterior cingulate structure and function during response monitoring in schizophrenia: a preliminary study
    Joshua L Roffman
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Brain Imaging Behav 5:65-75. 2011
    ..These findings suggest that the MTHFR 677T allele blunts response monitoring in schizophrenia, presumably via effects on dopamine signaling and dACC white matter microstructural integrity...
  4. doi Randomized multicenter investigation of folate plus vitamin B12 supplementation in schizophrenia
    Joshua L Roffman
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA 02129, USA
    JAMA Psychiatry 70:481-9. 2013
    ....
  5. pmc Genetic variation throughout the folate metabolic pathway influences negative symptom severity in schizophrenia
    Joshua L Roffman
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Schizophr Bull 39:330-8. 2013
    ..A relationship between folate level and negative symptom severity among patients with greater genetic vulnerability is biologically plausible and suggests the utility of folate supplementation in these patients...
  6. pmc A hypomethylating variant of MTHFR, 677C>T, blunts the neural response to errors in patients with schizophrenia and healthy individuals
    Joshua L Roffman
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America
    PLoS ONE 6:e25253. 2011
    ..MTHFR is a key regulator of the intracellular one-carbon milieu, including DNA methylation, and each copy of the 677T allele reduces MTHFR activity by 35%...
  7. pmc MTHFR 677C --> T genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val --> Met
    Joshua L Roffman
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 105:17573-8. 2008
    ..The findings also suggest the importance of weighing COMT effects on prefrontal function within the context of MTHFR genotype...
  8. doi Eight ball
    Joshua L Roffman
    Psychiatric Neuroscience Research Program, Rm 2656, Bldg 149, Massachusetts General Hospital, 149 13th St, Charlestown, MA 02129, USA
    Am J Psychiatry 165:956-7. 2008
  9. doi Interactive effects of COMT Val108/158Met and MTHFR C677T on executive function in schizophrenia
    Joshua L Roffman
    Schizophrenia Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Am J Med Genet B Neuropsychiatr Genet 147:990-5. 2008
    ..It is plausible that cumulative effects of the MTHFR T and COMT Val alleles on intracellular methylation profiles and prefrontal dopamine transmission underlie their interactive effect on perseverative errors...
  10. ncbi Neuroimaging-genetic paradigms: a new approach to investigate the pathophysiology and treatment of cognitive deficits in schizophrenia
    Joshua L Roffman
    Harvard Medical School and Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02129, USA
    Harv Rev Psychiatry 14:78-91. 2006
    ..The potential of this approach for improving patient care will depend on its ability to predict outcomes with greater accuracy and sensitivity than current clinical measures...
  11. ncbi Neuroscience in psychiatry training: how much do residents need to know?
    Joshua L Roffman
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Am J Psychiatry 163:919-26. 2006
    ..The authors sought to determine how this dilemma is currently being played out in residency training programs, in which training directors must decide how best to integrate neuroscience teaching in a rapidly changing clinical landscape...
  12. ncbi Contribution of methylenetetrahydrofolate reductase (MTHFR) polymorphisms to negative symptoms in schizophrenia
    Joshua L Roffman
    Schizophrenia Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 63:42-8. 2008
    ..We examined whether the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C functional polymorphisms contribute to negative symptoms...
  13. doi Folate supplementation in schizophrenia: a possible role for MTHFR genotype
    Michele Hill
    Schizophrenia Program, Massachusetts General Hospital, Harvard Medical School, United States
    Schizophr Res 127:41-5. 2011
    ..This study examined the effect of folate supplementation on negative symptoms overall and in relation to MTHFR 677C>T genotype...
  14. pmc DISC1 is associated with cortical thickness and neural efficiency
    Stefan Brauns
    MGH MIT HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129 2000, USA
    Neuroimage 57:1591-600. 2011
    ..Here, we investigated the effects of variation in DISC1 on cortical thickness. In a subsequent analysis we tested whether the identified DISC1 risk variant is also associated with neural activity during working memory functioning...
  15. pmc The COMT Val108/158Met polymorphism and medial temporal lobe volumetry in patients with schizophrenia and healthy adults
    Stefan Ehrlich
    MGH MIT HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129 2000, USA
    Neuroimage 53:992-1000. 2010
    ..Taken together with previous work, our data support a model in which lower COMT activity, and a resulting elevation in extracellular dopamine levels, stimulates growth of medial temporal lobe structures...
  16. pmc Aberrant frontoparietal function during recognition memory in schizophrenia: a multimodal neuroimaging investigation
    Anthony P Weiss
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Neurosci 29:11347-59. 2009
    ..Inefficient utilization of prefrontal-parietal networks, with compensatory activation in temporal regions, may thus contribute to deficient old-new item recognition in schizophrenia...
  17. pmc Distinguishing familiarity-based from source-based memory performance in patients with schizophrenia
    Anthony P Weiss
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
    Schizophr Res 99:208-17. 2008
    ..Yet the exact nature of these deficits remains a matter of some debate. This study sought to examine performance on two distinct aspects of memory performance: familiarity-based and source-based memory processes...
  18. doi Auditory stimulus repetition effects on cortical hemoglobin oxygenation: a near-infrared spectroscopy investigation
    Anthony P Weiss
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    Neuroreport 19:161-5. 2008
    ..These findings provide preliminary support for a relationship between the perceptual characteristics of auditory stimuli and modulation of cortical oxygenation as measured via an emerging neuromonitoring technique...