Research Topics
Species | Joshua L RoffmanSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Publications
Neuroimaging and the functional neuroanatomy of psychotherapyJoshua L Roffman
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Psychol Med 35:1385-98. 2005..This review examines initial attempts to measure directly the effects of psychotherapy on brain function in patients with depression or anxiety disorders...- Effects of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism on executive function in schizophreniaJoshua L Roffman
Schizophrenia Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, USA
Schizophr Res 92:181-8. 2007..This study examined whether schizophrenia patients homozygous for the risk allele (T/T) exhibit greater impairment in executive function, and determined the extent to which MTHFR's effects on negative symptoms underlie this relationship... 
Genetic variation throughout the folate metabolic pathway influences negative symptom severity in schizophreniaJoshua L Roffman
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Schizophr Bull 39:330-8. 2013..A relationship between folate level and negative symptom severity among patients with greater genetic vulnerability is biologically plausible and suggests the utility of folate supplementation in these patients...- A hypomethylating variant of MTHFR, 677C>T, blunts the neural response to errors in patients with schizophrenia and healthy individualsJoshua L Roffman
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America
PLoS ONE 6:e25253. 2011..MTHFR is a key regulator of the intracellular one-carbon milieu, including DNA methylation, and each copy of the 677T allele reduces MTHFR activity by 35%... 
MTHFR 677C>T effects on anterior cingulate structure and function during response monitoring in schizophrenia: a preliminary studyJoshua L Roffman
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Brain Imaging Behav 5:65-75. 2011..These findings suggest that the MTHFR 677T allele blunts response monitoring in schizophrenia, presumably via effects on dopamine signaling and dACC white matter microstructural integrity...- MTHFR 677C --> T genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val --> MetJoshua L Roffman
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
Proc Natl Acad Sci U S A 105:17573-8. 2008..The findings also suggest the importance of weighing COMT effects on prefrontal function within the context of MTHFR genotype... - Eight ballJoshua L Roffman
Psychiatric Neuroscience Research Program, Rm. 2656, Bldg. 149, Massachusetts General Hospital, 149 13th St, Charlestown, MA 02129, USA
Am J Psychiatry 165:956-7. 2008 - Interactive effects of COMT Val108/158Met and MTHFR C677T on executive function in schizophreniaJoshua L Roffman
Schizophrenia Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
Am J Med Genet B Neuropsychiatr Genet 147:990-5. 2008..It is plausible that cumulative effects of the MTHFR T and COMT Val alleles on intracellular methylation profiles and prefrontal dopamine transmission underlie their interactive effect on perseverative errors... - Neuroimaging-genetic paradigms: a new approach to investigate the pathophysiology and treatment of cognitive deficits in schizophreniaJoshua L Roffman
Harvard Medical School and Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02129, USA
Harv Rev Psychiatry 14:78-91. 2006..The potential of this approach for improving patient care will depend on its ability to predict outcomes with greater accuracy and sensitivity than current clinical measures... - Contribution of methylenetetrahydrofolate reductase (MTHFR) polymorphisms to negative symptoms in schizophreniaJoshua L Roffman
Schizophrenia Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Biol Psychiatry 63:42-8. 2008..We examined whether the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C functional polymorphisms contribute to negative symptoms... - Neuroscience in psychiatry training: how much do residents need to know?Joshua L Roffman
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Am J Psychiatry 163:919-26. 2006..The authors sought to determine how this dilemma is currently being played out in residency training programs, in which training directors must decide how best to integrate neuroscience teaching in a rapidly changing clinical landscape... - DISC1 is associated with cortical thickness and neural efficiencyStefan Brauns
MGH MIT HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129 2000, USA
Neuroimage 57:1591-600. 2011..Here, we investigated the effects of variation in DISC1 on cortical thickness. In a subsequent analysis we tested whether the identified DISC1 risk variant is also associated with neural activity during working memory functioning... - Folate supplementation in schizophrenia: a possible role for MTHFR genotypeMichele Hill
Schizophrenia Program, Massachusetts General Hospital, Harvard Medical School, United States
Schizophr Res 127:41-5. 2011..This study examined the effect of folate supplementation on negative symptoms overall and in relation to MTHFR 677C>T genotype... - The COMT Val108/158Met polymorphism and medial temporal lobe volumetry in patients with schizophrenia and healthy adultsStefan Ehrlich
MGH MIT HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129 2000, USA
Neuroimage 53:992-1000. 2010..Taken together with previous work, our data support a model in which lower COMT activity, and a resulting elevation in extracellular dopamine levels, stimulates growth of medial temporal lobe structures... - Aberrant frontoparietal function during recognition memory in schizophrenia: a multimodal neuroimaging investigationAnthony P Weiss
Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Neurosci 29:11347-59. 2009..Inefficient utilization of prefrontal-parietal networks, with compensatory activation in temporal regions, may thus contribute to deficient old-new item recognition in schizophrenia... - Distinguishing familiarity-based from source-based memory performance in patients with schizophreniaAnthony P Weiss
Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
Schizophr Res 99:208-17. 2008..Yet the exact nature of these deficits remains a matter of some debate. This study sought to examine performance on two distinct aspects of memory performance: familiarity-based and source-based memory processes... - Auditory stimulus repetition effects on cortical hemoglobin oxygenation: a near-infrared spectroscopy investigationAnthony P Weiss
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
Neuroreport 19:161-5. 2008..These findings provide preliminary support for a relationship between the perceptual characteristics of auditory stimuli and modulation of cortical oxygenation as measured via an emerging neuromonitoring technique...