Research Topics
Genomes and GenesSpecies | Gregory K RobbinsSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Publications
Efficacy of a clinical decision-support system in an HIV practice: a randomized trialGregory K Robbins
Massachusetts General Hospital, Division of Infectious Diseases, 55 Fruit Street, Cox 5, Boston, MA 02114, USA
Ann Intern Med 157:757-66. 2012..Data to support improved patient outcomes from clinical decision-support systems (CDSSs) are lacking in HIV care...
Comparison of four-drug regimens and pairs of sequential three-drug regimens as initial therapy for HIV-1 infectionRobert W Shafer
Stanford University Medical Center, Stanford, Calif, USA
N Engl J Med 349:2304-15. 2003..It is unclear whether therapy for human immunodeficiency virus type 1 (HIV-1) should be initiated with a four-drug or two sequential three-drug regimens...
Predictors of antiretroviral treatment failure in an urban HIV clinicGregory K Robbins
Division of Infectious Diseases, Massachusetts General Hospital, Harvard Center for AIDS Research CFAR, and Harvard Medical School, Boston, MA 02114, USA
J Acquir Immune Defic Syndr 44:30-7. 2007..Predictors of antiretroviral treatment (ART) failure are not well characterized for heterogeneous clinic populations...- Incomplete reconstitution of T cell subsets on combination antiretroviral therapy in the AIDS Clinical Trials Group protocol 384Gregory K Robbins
Infectious Diseases Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Clin Infect Dis 48:350-61. 2009..Whether the baseline CD4 cell count affects reconstitution of immune cell subsets has not been well characterized... - Comparison of sequential three-drug regimens as initial therapy for HIV-1 infectionGregory K Robbins
Harvard Medical School, Boston, USA
N Engl J Med 349:2293-303. 2003..The optimal sequencing of antiretroviral regimens for the treatment of infection with human immunodeficiency virus type 1 (HIV-1) is unknown. We compared several different antiretroviral treatment strategies... - Predicting virologic failure in an HIV clinicGregory K Robbins
Harvard Medical School, Boston, Massachusetts, USA
Clin Infect Dis 50:779-86. 2010..We sought to use data captured in the electronic health record (EHR) to develop and validate a prediction rule for virologic failure among patients being treated for infection with human immunodeficiency virus (HIV)... - Long-term body fat outcomes in antiretroviral-naive participants randomized to nelfinavir or efavirenz or both plus dual nucleosides. Dual X-ray absorptiometry results from A5005s, a substudy of Adult Clinical Trials Group 384Michael P Dube
Division of Infectious Diseases, Indiana University, Indianapolis, USA
J Acquir Immune Defic Syndr 45:508-14. 2007..Long-term regional body fat outcomes have not been well described in randomized antiretroviral drug trials... - Effects of potent antiretroviral therapy on free testosterone levels and fat-free mass in men in a prospective, randomized trial: A5005s, a substudy of AIDS Clinical Trials Group Study 384Michael P Dube
Division of Infectious Diseases, Indiana University, Indianapolis, USA
Clin Infect Dis 45:120-6. 2007..The effects of initiation of different antiretroviral regimens on testosterone levels and changes in fat-free mass have not been reported... - Hemochromatosis gene polymorphisms, mitochondrial haplogroups, and peripheral lipoatrophy during antiretroviral therapyTodd Hulgan
Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA
J Infect Dis 197:858-66. 2008..Mitochondrial haplogroups and hemochromatosis gene (HFE) polymorphisms have been associated with ART-induced neuropathy. We assessed relationships between these variants and lipoatrophy... - Fully differentiated HIV-1 specific CD8+ T effector cells are more frequently detectable in controlled than in progressive HIV-1 infectionMarylyn M Addo
Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School Division of AIDS, Boston, Massachusetts, United States of America
PLoS ONE 2:e321. 2007..Recent data suggest that impaired maturation, as defined by the lineage markers CD45RA and CCR7, may contribute to a lack of immune control by these responses... - Effect of baseline- and treatment-related factors on immunologic recovery after initiation of antiretroviral therapy in HIV-1-positive subjects: results from ACTG 384Rajesh T Gandhi
Massachusetts General Hospital, Boston, MA, USA
J Acquir Immune Defic Syndr 42:426-34. 2006..To assess the effect of baseline- and treatment-related factors on immunologic recovery after initiation of antiretroviral therapy (ART)... - Replication capacity in relation to immunologic and virologic outcomes in HIV-1-infected treatment-naive subjectsGail Skowron
Division of Infectious Diseases, Roger Williams Medical Center, Providence, RI 02908, USA
J Acquir Immune Defic Syndr 50:250-8. 2009..To evaluate the association between baseline (BL) replication capacity (RC) (RCBL) and immunologic/virologic parameters (at BL and after 48 weeks on therapy) in HIV-1-infected subjects initiating antiretroviral therapy... - Longitudinal analysis of clinical markers following antiretroviral therapy initiated during acute or early HIV type 1 infectionSigall Kassutto
Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Clin Infect Dis 42:1024-31. 2006..Protease inhibitor-based and nonnucleoside reverse-transcriptase inhibitor-based regimens show comparable performance in tolerability, time to virological suppression, and CD4+ cell count when used as a first regimen... - Impaired hepatitis C virus-specific T cell responses and recurrent hepatitis C virus in HIV coinfectionArthur Y Kim
Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS Med 3:e492. 2006..Here we examined the effect of a lymphotropic virus, HIV-1, on the ability of coinfected patients to maintain spontaneous control of HCV infection... - Ocular syphilis among HIV-infected patients: a systematic analysis of the literatureJoseph D Tucker
Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, GRJ 504, Boston 02114, USA
Sex Transm Infect 87:4-8. 2011..Objective To examine the literature on HIV-infected patients and determine the results of treatment... - High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infectionGeorg M Lauer
Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Gastroenterology 127:924-36. 2004.... - Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramersCheryl L Day
Howard Hughes Medical Institute, Partners AIDS Research Center, Boston, Massachusetts, USA
J Clin Invest 112:831-42. 2003..Moreover, they show that rare populations of memory CD4 T cells can be studied ex vivo in human diseases... - Pilot study of postexposure prophylaxis for hepatitis C virus in healthcare workersKathleen E Corey
Harvard Medical School, Boston, MA, USA
Infect Control Hosp Epidemiol 30:1000-5. 2009..We sought to determine the safety, tolerability, and acceptance of postexposure prophylaxis with peginterferon alfa-2b in healthcare workers (HCWs) exposed to blood from HCV-infected patients... - Loss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cellsMathias Lichterfeld
Partners AIDS Research Center, Massachusetts General Hospital, 149 13th St, Boston, MA 02129, USA
J Exp Med 200:701-12. 2004..This identification of a reversible defect in cell-mediated immunity in chronic HIV-1 infection has important implications for immunotherapeutic interventions... - Glucose metabolism, lipid, and body fat changes in antiretroviral-naive subjects randomized to nelfinavir or efavirenz plus dual nucleosidesMichael P Dube
Division of Infectious Diseases, Indiana University, Indianapolis, Indiana, USA
AIDS 19:1807-18. 2005..To determine if particular components of antiretroviral drug regimens are associated with greater insulin resistance, dyslipidemia, and peripheral lipoatrophy... - Spontaneous control of HCV is associated with expression of HLA-B 57 and preservation of targeted epitopesArthur Y Kim
Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, GRB 504, Boston, Massachusetts 02114, USA
Gastroenterology 140:686-696.e1. 2011..We aimed to determine the correlations between these alleles and natural outcomes of HCV and determine associated key T-cell responses... - Effect of CYP2B6, ABCB1, and CYP3A5 polymorphisms on efavirenz pharmacokinetics and treatment response: an AIDS Clinical Trials Group studyHeather J Ribaudo
Statistical Data Analysis Center, Harvard School of Public Health, Harvard University, Boston, MA, USA
J Infect Dis 202:717-22. 2010..Slow-metabolizer genotypes were associated with increased central nervous system events among white participants and decreased virologic failure among black participants... - Predictors of antiretroviral-related hepatotoxicity in the adult AIDS Clinical Trial Group (1989-1999)Julie C Servoss
Gastrointestinal Unit, Massachusetts General Hospital, Boston, 02114, USA
J Acquir Immune Defic Syndr 43:320-3. 2006..7; P < 0.003). In conclusion, this study identified known and previously unreported risk factors for severe hepatotoxicity that should be considered before the initiation of ART... - Broad specificity of virus-specific CD4+ T-helper-cell responses in resolved hepatitis C virus infectionCheryl L Day
Partners AIDS Research Center, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
J Virol 76:12584-95. 2002..Moreover, these data provide important parameters for evaluation of candidate HCV vaccines, and provide rationale for immunotherapy in chronic HCV infection... - The major genetic determinants of HIV-1 control affect HLA class I peptide presentationFlorencia Pereyra
Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology MIT and Harvard, Boston, MA, USA
Science 330:1551-7. 2010..These results implicate the nature of the HLA-viral peptide interaction as the major factor modulating durable control of HIV infection... - Sex differences in the Toll-like receptor-mediated response of plasmacytoid dendritic cells to HIV-1Angela Meier
Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, Massachusetts, USA
Nat Med 15:955-9. 2009..Modulation of the TLR7 pathway in pDCs may therefore represent a new approach to reduce HIV-1-associated pathology... - Augmentation of HIV-1-specific T helper cell responses in chronic HIV-1 infection by therapeutic immunizationGregory K Robbins
Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital, Division of AIDS Harvard Medical School, Boston, 02114, USA
AIDS 17:1121-6. 2003..Further studies will be needed to determine whether the augmentation of these responses correlate with long-term clinical benefits... - Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibilityGeorge L Melikian
Division of Infectious Diseases, Department of Medicine, Stanford University, Stanford, California, USA
Antimicrob Agents Chemother 56:2305-13. 2012.... - Effects of switching from lopinavir/ritonavir to atazanavir/ritonavir on muscle glucose uptake and visceral fat in HIV-infected patientsTakara L Stanley
Massachusetts General Hospital and Harvard Medical School, Boston, 02114, USA
AIDS 23:1349-57. 2009..To determine the effects of switching from lopinavir/ritonavir (LPV/r) to atazanavir/ritonavir (ATV/r) on muscle glucose uptake, glucose homeostasis, lipids, and body composition... - Peginterferon Alfa-2a plus ribavirin versus interferon alfa-2a plus ribavirin for chronic hepatitis C in HIV-coinfected personsRaymond T Chung
Massachusetts General Hospital, Boston, MA 02114, USA
N Engl J Med 351:451-9. 2004..We conducted a multicenter, randomized trial comparing peginterferon plus ribavirin with interferon plus ribavirin for the treatment of chronic hepatitis C in persons coinfected with HIV... - Mitochondrial haplogroups and peripheral neuropathy during antiretroviral therapy: an adult AIDS clinical trials group studyTodd Hulgan
Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA
AIDS 19:1341-9. 2005..The objective of this study was to determine if NRTI-associated peripheral neuropathy is associated with European mitochondrial haplogroups... - Long-term increase in CD4+ T-cell counts during combination antiretroviral therapy for HIV-1 infectionJudith J Lok
Center for Biostatistics in AIDS Research, Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
AIDS 24:1867-76. 2010..We estimated the long-term CD4 cell count trajectory accounting for losses-to-follow-up and treatment discontinuations... - Reactive Epstein-Barr virus-related polyclonal lymphoproliferative disorder in a patient with AIDSStanley I Martin
Division of Infectious Disease, Massachusetts General Hospital, Boston, MA 02114, USA
Clin Infect Dis 41:e76-9. 2005..We report an analogous case of posttransplantation polyclonal lymphoproliferative disorder in a patient with human immunodeficiency virus infection who was successfully treated with antiretroviral therapy... - Human immunodeficiency virus type 1-hepatitis C virus coinfection: intraindividual comparison of cellular immune responses against two persistent virusesGeorg M Lauer
Partners AIDS Research Center, Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
J Virol 76:2817-26. 2002..In addition, they show a consistent and profound impairment in cellular immune responses to HCV compared to HIV-1 in HIV-1-HCV-coinfected persons... - The effects of highly active antiretroviral therapy on albuminuria in HIV-infected persons: results from a randomized trialSamir K Gupta
Division of Infectious Diseases, Indiana University School of Medicine, Wishard Hospital, OPW 430, 1001 W 10th Street, Indianapolis, IN 46202, USA
Nephrol Dial Transplant 20:2237-42. 2005..Alternatively, albuminuria may improve with HAART as a result of treating renal parenchymal HIV infection. Longitudinal studies have not been performed previously addressing the effects of HAART on albuminuria... - Ocular syphilis among HIV-infected individualsJonathan Z Li
Division of Infectious Diseases, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Clin Infect Dis 51:468-71. 2010..5 years. In patients with HIV infection, clinicians should be vigilant for ocular syphilis despite normal cerebrospinal fluid measures and for syphilis reinfection... - BK virus-associated hemorrhagic cystitis in a Human Immunodeficiency Virus-infected patientDan H Barouch
Division of Infectious Diseases, Massachusetts General Hospital, and Division of Infectious Diseases, Brigham and Women s Hospital, Boston, MA, USA
Clin Infect Dis 35:326-9. 2002.... - Treatment of refractory Babesia microti infection with atovaquone-proguanil in an HIV-infected patient: case reportJatin M Vyas
Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
Clin Infect Dis 45:1588-90. 2007..Atovaquone-proguanil appears to have activity against babesiosis and should be studied as a potential therapy for patients with refractory babesiosis... - GB virus C (GBV-C) infection in hepatitis C virus (HCV)/HIV-coinfected patients receiving HCV treatment: importance of the GBV-C genotypeCarolynne Schwarze-Zander
Department of Internal Medicine I, University of Bonn, Bonn, Germany
J Infect Dis 194:410-9. 2006..GBV-C RNA clearance with HCV therapy was associated with neither short-term loss of HIV control nor impaired immune status. The association of GBV-C genotype 2 with higher CD4(+) cell counts merits further study... - Factors influencing medication adherence beliefs and self-efficacy in persons naive to antiretroviral therapy: a multicenter, cross-sectional studyNancy R Reynolds
Ohio State University, Columbus 43210, USA
AIDS Behav 8:141-50. 2004.... - Pharmacokinetics of nelfinavir and efavirenz in antiretroviral-naive, human immunodeficiency virus-infected subjects when administered alone or in combination with nucleoside analog reverse transcriptase inhibitorsPatrick F Smith
Adult ACTG Pharmacology Support Laboratory, Laboratory for Antiviral Research, Department of Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY 12460, USA
Antimicrob Agents Chemother 49:3558-61. 2005..There were no significant differences in efavirenz pharmacokinetics... - Multilocus genetic interactions and response to efavirenz-containing regimens: an adult AIDS clinical trials group studyAlison A Motsinger
Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA
Pharmacogenet Genomics 16:837-45. 2006..We examined whether long-term responses to efavirenz, and/or plasma efavirenz exposure, are better predicted by multilocus genetic interactions than by individual polymorphisms... - Dynamics of total, linear nonintegrated, and integrated HIV-1 DNA in vivo and in vitroKersten K Koelsch
University of California, San Diego, USA
J Infect Dis 197:411-9. 2008..Recent studies report an association between HIV-1 DNA levels, disease progression, and treatment outcome. However, HIV-1 DNA exists as distinct molecular forms that are not distinguished by conventional assays... - Hemochromatosis (HFE) gene mutations and peripheral neuropathy during antiretroviral therapyAsha R Kallianpur
Department of Medicine, Divisions of General Internal Medicine and Public Health, Nashville, TN, USA
AIDS 20:1503-13. 2006..Since iron deficiency is associated with some types of PN, and iron is essential for mitochondrial function, we tested the hypothesis that hemochromatosis (HFE) gene mutations influence susceptibility to NRTI-induced PN... - Pharmacogenetics of long-term responses to antiretroviral regimens containing Efavirenz and/or Nelfinavir: an Adult Aids Clinical Trials Group StudyDavid W Haas
Vanderbilt University School of Medicine, Nashville, TN 37203, USA
J Infect Dis 192:1931-42. 2005..Nelfinavir is a substrate for P-glycoprotein, which is encoded by MDR1. The present study examined associations between genetic variants and long-term responses to treatment... - Hematologic toxicity associated with interferon-based hepatitis C therapy in HIV type 1-coinfected subjectsCaroline M Behler
Department of Hematology and Oncology, University of California San Francisco, San Francisco, CA 94143 1270, USA
Clin Infect Dis 44:1375-83. 2007.... - Telephone support to improve antiretroviral medication adherence: a multisite, randomized controlled trialNancy R Reynolds
AIDS Clinical Trials Unit, Ohio State University, Columbus, OH, USA
J Acquir Immune Defic Syndr 47:62-8. 2008..To determine whether proactive telephone support improves adherence to antiretroviral therapy (ART) and clinical outcomes when compared to standard care... - Mixed patterns of changes in central and peripheral fat following initiation of antiretroviral therapy in a randomized trialKathleen Mulligan
Department of Medicine, Division of Endocrinology, San Francisco General Hospital, University of California at San Francisco, San Francisco, CA, USA
J Acquir Immune Defic Syndr 41:590-7. 2006..Increased waist/hip ratio was predominantly associated with increased waist circumference. There was no evidence that central fat accumulation and peripheral fat loss are linked in most subjects... - Oxidant stress and peripheral neuropathy during antiretroviral therapy: an AIDS clinical trials group studyTodd Hulgan
Vanderbilt University School of Medicine, Nashville, TN 37203, USA
J Acquir Immune Defic Syndr 42:450-4. 2006..Mitochondria play a central role in regulating oxidant stress. We explored the relationships between oxidant stress and NRTI-induced peripheral neuropathy...
Research Grants
- Bridging the Gap HIV Trials and Clinical PracticeGregory Robbins; Fiscal Year: 2007..abstract_text> ..