Miguel N Rivera

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Wilms' tumour: connecting tumorigenesis and organ development in the kidney
    Miguel N Rivera
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Nat Rev Cancer 5:699-712. 2005
  2. ncbi request reprint Vaccines for cervical cancer
    Christopher P Crum
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer J 9:368-76. 2003
  3. pmc The WTX tumor suppressor enhances p53 acetylation by CBP/p300
    Woo Jae Kim
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA
    Mol Cell 45:587-97. 2012
  4. pmc The predominant WT1 isoform (+KTS) encodes a DNA-binding protein targeting the planar cell polarity gene Scribble in renal podocytes
    Julie Wells
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts, USA
    Mol Cancer Res 8:975-85. 2010
  5. ncbi request reprint An X chromosome gene, WTX, is commonly inactivated in Wilms tumor
    Miguel N Rivera
    Massachusetts General Hospital Cancer Center, Harvard Medical Center, Boston, MA 02114, USA
    Science 315:642-5. 2007
  6. ncbi request reprint Wilms' tumor with an apparently balanced translocation t(X;18) resulting in deletion of the WTX gene
    Moonjoo Han
    Molecular Diagnostics Laboratory, Department of Pathology, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Genes Chromosomes Cancer 46:909-13. 2007

Collaborators

  • Christopher P Crum
  • Woo Jae Kim
  • Daniel A Haber
  • Julie Wells
  • Moonjoo Han
  • Erik J Coffman
  • Kristen Starbuck
  • Julie M Batten
  • Paola Dal Cin
  • A John Iafrate

Detail Information

Publications6

  1. ncbi request reprint Wilms' tumour: connecting tumorigenesis and organ development in the kidney
    Miguel N Rivera
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Nat Rev Cancer 5:699-712. 2005
    ..Our understanding of the roles of WT1 in tumour formation and organogenesis have advanced in parallel, providing a striking example of the intersection between tumour biology, cellular differentiation and normal organogenesis...
  2. ncbi request reprint Vaccines for cervical cancer
    Christopher P Crum
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer J 9:368-76. 2003
    ..However, success will require identifying and circumventing the mechanisms by which tumor cells evade the immune system...
  3. pmc The WTX tumor suppressor enhances p53 acetylation by CBP/p300
    Woo Jae Kim
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA
    Mol Cell 45:587-97. 2012
    ..Together, these results suggest that WTX modulates p53 function, in part through regulation of its activator CBP/p300...
  4. pmc The predominant WT1 isoform (+KTS) encodes a DNA-binding protein targeting the planar cell polarity gene Scribble in renal podocytes
    Julie Wells
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts, USA
    Mol Cancer Res 8:975-85. 2010
    ..Together, our results support a role for the predominant WT1(+KTS) isoform in transcriptional regulation and suggest a link between the WT1-dependent tumor suppressor pathway and a key component of the planar cell polarity pathway...
  5. ncbi request reprint An X chromosome gene, WTX, is commonly inactivated in Wilms tumor
    Miguel N Rivera
    Massachusetts General Hospital Cancer Center, Harvard Medical Center, Boston, MA 02114, USA
    Science 315:642-5. 2007
    ..In contrast to biallelic inactivation of autosomal tumor-suppressor genes, WTX is inactivated by a monoallelic "single-hit" event targeting the single X chromosome in tumors from males and the active X chromosome in tumors from females...
  6. ncbi request reprint Wilms' tumor with an apparently balanced translocation t(X;18) resulting in deletion of the WTX gene
    Moonjoo Han
    Molecular Diagnostics Laboratory, Department of Pathology, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Genes Chromosomes Cancer 46:909-13. 2007
    ..This case demonstrates the importance of array CGH and FISH as adjuncts in tumor cytogenetics and in identifying pathogenic microdeletions in "balanced" translocations that are not truly balanced...