Miguel N Rivera

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Wilms' tumour: connecting tumorigenesis and organ development in the kidney
    Miguel N Rivera
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Nat Rev Cancer 5:699-712. 2005
  2. ncbi request reprint Vaccines for cervical cancer
    Christopher P Crum
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer J 9:368-76. 2003
  3. pmc The WTX tumor suppressor enhances p53 acetylation by CBP/p300
    Woo Jae Kim
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA
    Mol Cell 45:587-97. 2012
  4. pmc The predominant WT1 isoform (+KTS) encodes a DNA-binding protein targeting the planar cell polarity gene Scribble in renal podocytes
    Julie Wells
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts, USA
    Mol Cancer Res 8:975-85. 2010
  5. ncbi request reprint An X chromosome gene, WTX, is commonly inactivated in Wilms tumor
    Miguel N Rivera
    Massachusetts General Hospital Cancer Center, Harvard Medical Center, Boston, MA 02114, USA
    Science 315:642-5. 2007
  6. ncbi request reprint Wilms' tumor with an apparently balanced translocation t(X;18) resulting in deletion of the WTX gene
    Moonjoo Han
    Molecular Diagnostics Laboratory, Department of Pathology, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Genes Chromosomes Cancer 46:909-13. 2007

Research Grants

Collaborators

  • Christopher P Crum
  • Woo Jae Kim
  • Daniel A Haber
  • Julie Wells
  • Moonjoo Han
  • Erik J Coffman
  • Kristen Starbuck
  • Paola Dal Cin
  • A John Iafrate
  • Julie M Batten

Detail Information

Publications6

  1. ncbi request reprint Wilms' tumour: connecting tumorigenesis and organ development in the kidney
    Miguel N Rivera
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Nat Rev Cancer 5:699-712. 2005
    ..Our understanding of the roles of WT1 in tumour formation and organogenesis have advanced in parallel, providing a striking example of the intersection between tumour biology, cellular differentiation and normal organogenesis...
  2. ncbi request reprint Vaccines for cervical cancer
    Christopher P Crum
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer J 9:368-76. 2003
    ..However, success will require identifying and circumventing the mechanisms by which tumor cells evade the immune system...
  3. pmc The WTX tumor suppressor enhances p53 acetylation by CBP/p300
    Woo Jae Kim
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA
    Mol Cell 45:587-97. 2012
    ..Together, these results suggest that WTX modulates p53 function, in part through regulation of its activator CBP/p300...
  4. pmc The predominant WT1 isoform (+KTS) encodes a DNA-binding protein targeting the planar cell polarity gene Scribble in renal podocytes
    Julie Wells
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts, USA
    Mol Cancer Res 8:975-85. 2010
    ..Together, our results support a role for the predominant WT1(+KTS) isoform in transcriptional regulation and suggest a link between the WT1-dependent tumor suppressor pathway and a key component of the planar cell polarity pathway...
  5. ncbi request reprint An X chromosome gene, WTX, is commonly inactivated in Wilms tumor
    Miguel N Rivera
    Massachusetts General Hospital Cancer Center, Harvard Medical Center, Boston, MA 02114, USA
    Science 315:642-5. 2007
    ..In contrast to biallelic inactivation of autosomal tumor-suppressor genes, WTX is inactivated by a monoallelic "single-hit" event targeting the single X chromosome in tumors from males and the active X chromosome in tumors from females...
  6. ncbi request reprint Wilms' tumor with an apparently balanced translocation t(X;18) resulting in deletion of the WTX gene
    Moonjoo Han
    Molecular Diagnostics Laboratory, Department of Pathology, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Genes Chromosomes Cancer 46:909-13. 2007
    ..This case demonstrates the importance of array CGH and FISH as adjuncts in tumor cytogenetics and in identifying pathogenic microdeletions in "balanced" translocations that are not truly balanced...

Research Grants2

  1. Functional Characterization of WTX in Renal Development
    Miguel Rivera; Fiscal Year: 2007
    ..It is anticipated that, by furthering our knowledge of early kidney development, this project will have public health applications in pediatric and adult kidney disease, kidney tissue repair and kidney cancer. ..