Dorene M Rentz

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi IQ-based norms for highly intelligent adults
    Dorene M Rentz
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Clin Neuropsychol 20:637-48. 2006
  2. ncbi Intelligence quotient-adjusted memory impairment is associated with abnormal single photon emission computed tomography perfusion
    Dorene M Rentz
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Int Neuropsychol Soc 13:821-31. 2007
  3. pmc Face-name associative memory performance is related to amyloid burden in normal elderly
    Dorene M Rentz
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuropsychologia 49:2776-83. 2011
  4. ncbi Use of IQ-adjusted norms to predict progressive cognitive decline in highly intelligent older individuals
    Dorene M Rentz
    Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Neuropsychology 18:38-49. 2004
  5. pmc Cognition, reserve, and amyloid deposition in normal aging
    Dorene M Rentz
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, 33 Fruit Street, Boston, MA 02114, USA
    Ann Neurol 67:353-64. 2010
  6. ncbi Increased responsiveness to novelty is associated with successful cognitive aging
    Kirk R Daffner
    Division of Cognitive and Behavioral Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Cogn Neurosci 18:1759-73. 2006
  7. pmc Age-related changes in early novelty processing as measured by ERPs
    Jenna L Riis
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Biol Psychol 82:33-44. 2009
  8. pmc Subjective cognitive complaints and amyloid burden in cognitively normal older individuals
    Rebecca E Amariglio
    Department of Neurology, Division of Cognitive and Behavioral Neurology, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, United States
    Neuropsychologia 50:2880-6. 2012
  9. pmc Tracking cognitive change over 24 weeks with longitudinal functional magnetic resonance imaging in Alzheimer's disease
    Donald G McLaren
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    Neurodegener Dis 9:176-86. 2012
  10. pmc Amyloid-β associated cortical thinning in clinically normal elderly
    J Alex Becker
    Department of Radiology, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Ann Neurol 69:1032-42. 2011

Detail Information

Publications61

  1. ncbi IQ-based norms for highly intelligent adults
    Dorene M Rentz
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Clin Neuropsychol 20:637-48. 2006
    ....
  2. ncbi Intelligence quotient-adjusted memory impairment is associated with abnormal single photon emission computed tomography perfusion
    Dorene M Rentz
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Int Neuropsychol Soc 13:821-31. 2007
    ..IQ-adjusted memory impairment in individuals with high cognitive reserve is associated with baseline SPECT abnormality in a pattern consistent with prodromal AD and predicts subsequent cognitive and functional decline...
  3. pmc Face-name associative memory performance is related to amyloid burden in normal elderly
    Dorene M Rentz
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuropsychologia 49:2776-83. 2011
    ..Associative memory for faces and names, a common complaint among older adults, may be a sensitive marker of early Aβ-related impairment...
  4. ncbi Use of IQ-adjusted norms to predict progressive cognitive decline in highly intelligent older individuals
    Dorene M Rentz
    Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Neuropsychology 18:38-49. 2004
    ..Three participants with normal memory declined. Implications for using IQ-adjusted norms to predict preclinical AD are discussed...
  5. pmc Cognition, reserve, and amyloid deposition in normal aging
    Dorene M Rentz
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, 33 Fruit Street, Boston, MA 02114, USA
    Ann Neurol 67:353-64. 2010
    ..To determine whether amyloid deposition is associated with impaired neuropsychological (NP) performance and whether cognitive reserve (CR) modifies this association...
  6. ncbi Increased responsiveness to novelty is associated with successful cognitive aging
    Kirk R Daffner
    Division of Cognitive and Behavioral Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Cogn Neurosci 18:1759-73. 2006
    ....
  7. pmc Age-related changes in early novelty processing as measured by ERPs
    Jenna L Riis
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Biol Psychol 82:33-44. 2009
    ....
  8. pmc Subjective cognitive complaints and amyloid burden in cognitively normal older individuals
    Rebecca E Amariglio
    Department of Neurology, Division of Cognitive and Behavioral Neurology, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, United States
    Neuropsychologia 50:2880-6. 2012
    ..Our study suggests that SCC may be an early indicator of AD pathology detectable prior to significant objective impairment...
  9. pmc Tracking cognitive change over 24 weeks with longitudinal functional magnetic resonance imaging in Alzheimer's disease
    Donald G McLaren
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    Neurodegener Dis 9:176-86. 2012
    ....
  10. pmc Amyloid-β associated cortical thinning in clinically normal elderly
    J Alex Becker
    Department of Radiology, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Ann Neurol 69:1032-42. 2011
    ....
  11. pmc Cognitive status impacts age-related changes in attention to novel and target events in normal adults
    Kirk R Daffner
    Brigham Behavioral Neurology Group, Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuropsychology 21:291-300. 2007
    ..Moreover, the results support the notion of there being different patterns of normal cognitive aging and the need to identify the factors that influence them...
  12. pmc Instrumental activities of daily living impairment is associated with increased amyloid burden
    Gad A Marshall
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    Dement Geriatr Cogn Disord 31:443-50. 2011
    ..We sought to determine whether IADL impairment is associated with increased cortical Pittsburgh Compound B (PiB) retention...
  13. pmc Functional alterations in memory networks in early Alzheimer's disease
    Reisa A Sperling
    Department of Neurology, Center for Alzheimer s Research and Treatment, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    Neuromolecular Med 12:27-43. 2010
    ..Research is ongoing to determine if these early network alterations will serve as sensitive predictors of clinical decline, and eventually, as markers of pharmacological response to potential disease-modifying treatments for AD...
  14. pmc Amyloid and APOE ε4 interact to influence short-term decline in preclinical Alzheimer disease
    Elizabeth C Mormino
    From the Departments of Neurology E C M, A P S, D M R, K A J, R A S, Radiology T H, A P S, K A J, R A S, and Psychiatry A P S, A W, and the Division of Nuclear Medicine and Molecular Imaging, Department of Radiology K A J, Massachusetts General Hospital, Harvard Medical School the Department of Biostatistics R A B, Harvard School of Public Health, Boston the Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology T H, Massachusetts General Hospital, Charleston and the Center for Alzheimer Research and Treatment, Department of Neurology A W, w h, D M R, K A J, R A S, Brigham and Women s Hospital, Harvard Medical School, Boston, MA
    Neurology 82:1760-7. 2014
    ..To examine whether β-amyloid (Aβ) and APOE ε4 status independently contribute or interact to influence longitudinal cognitive decline in clinically normal older individuals (CN)...
  15. pmc Does modulation of selective attention to features reflect enhancement or suppression of neural activity?
    Kirk R Daffner
    Center for Brain Mind Medicine, Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    Biol Psychol 89:398-407. 2012
    ..However, there were markedly reduced responses under the ignore relative to the neutral condition, consistent with the view that early selection mechanisms reflect suppression of neural activity under the ignore condition...
  16. pmc Compensatory neural activity distinguishes different patterns of normal cognitive aging
    Jenna L Riis
    Brigham Behavioral Neurology Group, Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    Neuroimage 39:441-54. 2008
    ..These findings provide strong evidence for different patterns of age-related changes in the processing of salient environmental stimuli, with cognitive status serving as a key mediating variable...
  17. ncbi Age-related differences in attention to novelty among cognitively high performing adults
    Kirk R Daffner
    Brigham Behavioral Neurology Group, Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    Biol Psychol 72:67-77. 2006
    ..We hypothesise that cognitively high performing old individuals successfully manage the task by relying on additional neural resources and perhaps more effortful frontal activity than their younger counterparts...
  18. ncbi Age-related differences in novelty and target processing among cognitively high performing adults
    Kirk R Daffner
    Brigham Behavioral Neurology Group, Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neurobiol Aging 26:1283-95. 2005
    ....
  19. pmc Does compensatory neural activity survive old-old age?
    Kirk R Daffner
    Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuroimage 54:427-38. 2011
    ..This limits their ability to appropriate additional resources as compensatory activity for age-related impairments in earlier visual processing, and suggests that such a mechanism does not tend to "survive" old-old age...
  20. pmc The dissociation between early and late selection in older adults
    Brittany R Alperin
    Harvard Medical School and Brigham and Women s Hospital, Boston, MA
    J Cogn Neurosci 25:2189-206. 2013
    ..Despite relative preservation of the operations of early selection, processing delays may lead older participants to allocate excessive resources to task-irrelevant stimuli during late selection. ..
  21. pmc Neuropsychiatric symptoms and global functional impairment along the Alzheimer's continuum
    Lauren P Wadsworth
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Dement Geriatr Cogn Disord 34:96-111. 2012
    ..We sought to determine whether neuropsychiatric symptoms were related to global functional impairment at baseline and over a 3-year period in older normal control (NC), mild cognitive impairment (MCI) and mild AD dementia subjects...
  22. doi The Apathy Evaluation Scale: A Comparison of Subject, Informant, and Clinician Report in Cognitively Normal Elderly and Mild Cognitive Impairment
    Brendan J Guercio
    Harvard Medical School, Boston, MA, USA
    J Alzheimers Dis 47:421-32. 2015
    ..Detecting apathy accurately may facilitate earlier diagnosis of AD. The Apathy Evaluation Scale (AES) is a promising tool for measurement of apathy in prodromal and possibly preclinical AD...
  23. pmc Validation of the Face Name Associative Memory Exam in cognitively normal older individuals
    Rebecca E Amariglio
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Boston, MA, USA
    J Clin Exp Neuropsychol 34:580-7. 2012
    ..Correlations between the FNAME subtests and another episodic memory test were significant. The results indicated strong test-retest reliability in a subsample (n = 41). Normative data stratified by age were also generated...
  24. pmc Brain amyloid and cognition in Lewy body diseases
    STEPHEN N GOMPERTS
    Massachusetts General Hospital, 15 Parkman Street, Boston, MA 02114, USA
    Mov Disord 27:965-73. 2012
    ..Early amyloid deposits in DLB relative to PDD may account for their difference in the timing of dementia and parkinsonism...
  25. pmc Test-retest reliability of memory task functional magnetic resonance imaging in Alzheimer disease clinical trials
    Alireza Atri
    Memory Disorders Unit, Massachusetts General Hospital, 15 Parkman Street, Wang Ambulatory Care Center 715, Boston, MA 02114, USA
    Arch Neurol 68:599-606. 2011
    ..To examine the feasibility and test-retest reliability of encoding-task functional magnetic resonance imaging (fMRI) in mild Alzheimer disease (AD)...
  26. ncbi Imaging of amyloid burden and distribution in cerebral amyloid angiopathy
    Keith A Johnson
    Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    Ann Neurol 62:229-34. 2007
    ....
  27. pmc Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease
    David A Wolk
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:10256-61. 2010
    ....
  28. pmc A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly
    April J Ho
    Laboratory of Neuroimaging, Department of Neurology, University of California School of Medicine, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:8404-9. 2010
    ..These brain maps reveal that a commonly carried susceptibility allele for obesity is associated with structural brain atrophy, with implications for the health of the elderly...
  29. doi Depressive Symptoms and Biomarkers of Alzheimer's Disease in Cognitively Normal Older Adults
    Nancy J Donovan
    Center for Alzheimer Research and Treatment, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Alzheimers Dis 46:63-73. 2015
    ..Amyloid was not a significant predictor in any model. In conclusion, very low-level dysphoria, apathy and anhedonia may point to neurodegeneration in AD-related regions but this association appears to be independent of amyloid burden...
  30. doi Neuropsychiatric Symptoms and Functional Connectivity in Mild Cognitive Impairment
    Catherine E Munro
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    J Alzheimers Dis 46:727-35. 2015
    ..Prior studies have shown associations between affective NPS and neurodegeneration of medial frontal and inferior temporal regions in mild cognitive impairment (MCI) and AD dementia...
  31. ncbi Functional Activities Questionnaire Items that Best Discriminate and Predict Progression from Clinically Normal to Mild Cognitive Impairment
    Gad A Marshall
    Center for Alzheimer Research and Treatment, Brigham and Women s Hospital, 221 Longwood Avenue, BL 104H, Boston, MA 02115, USA
    Curr Alzheimer Res 12:493-502. 2015
    ..Some IADL scales are sensitive to early deficits in MCI, but none have been validated for detecting subtle functional changes in clinically normal (CN) elderly at risk for AD...
  32. pmc Apathy is associated with lower inferior temporal cortical thickness in mild cognitive impairment and normal elderly individuals
    Brendan J Guercio
    From the Harvard Medical School BG, NJD, Rea, DMR, KAJ, RAS, GAM Center for Alzheimer Research and Treatment BG, NJD, NL, Rea, DMR, KAJ, RAS, GAM Dept of Neurology NJD, AW, NL, REA DMR, KAJ, RAS, GAM and Dept of Psychiatry NJD, Rea, DMR Brigham and Women s Hospital, Boston, MA Dept of Neurology AW, As, NL, Rea, DMR, KAJ, RAS, GAM and Dept of Radiology KAJ, Massachusetts General Hospital, Boston, MA
    J Neuropsychiatry Clin Neurosci 27:e22-7. 2015
    ..Lower inferior temporal cortical thickness was predictive of greater apathy. Greater anterior cingulate cortical thickness was also predictive of greater apathy, suggesting an underlying reactive process...
  33. pmc Subjective cognitive concerns and neuropsychiatric predictors of progression to the early clinical stages of Alzheimer disease
    Nancy J Donovan
    Center for Alzheimer Research and Treatment and Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA Electronic address
    Am J Geriatr Psychiatry 22:1642-51. 2014
    ..To examine neuropsychiatric and neuropsychological predictors of progression from normal to early clinical stages of Alzheimer disease (AD)...
  34. pmc Amyloid-β deposition in mild cognitive impairment is associated with increased hippocampal activity, atrophy and clinical progression
    Willem Huijbers
    1 Centre for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA 2 Athinoula A Martinos Centre for Biomedical Imaging, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
    Brain 138:1023-35. 2015
    ..Increased hippocampal activity is discussed in relation to neuronal compensation and/or amyloid-β induced excitoxicity...
  35. pmc Synergistic effect of β-amyloid and neurodegeneration on cognitive decline in clinically normal individuals
    Elizabeth C Mormino
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston
    JAMA Neurol 71:1379-85. 2014
    ..Assessing the ability of Alzheimer disease neuroimaging markers to predict short-term cognitive decline among clinically normal (CN) individuals is critical for upcoming secondary prevention trials using cognitive outcomes...
  36. pmc Regional cortical thinning predicts worsening apathy and hallucinations across the Alzheimer disease spectrum
    Nancy J Donovan
    Center for Alzheimer Research and Treatment, Brigham and Women s Hospital, Harvard Medical School, Boston, MA Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA Electronic address
    Am J Geriatr Psychiatry 22:1168-79. 2014
    ....
  37. pmc Cognitive activity relates to cognitive performance but not to Alzheimer disease biomarkers
    Christopher M Gidicsin
    From the Division of Nuclear Medicine and Molecular Imaging C M G, J E M, L C P, M P, J A B, K A J and Departments of Neurology J J L, A P S, R E A, G A M, D M R, R A S, K A J, Psychiatry A P Y, A P S, and Radiology T H, K A J, Massachusetts General Hospital, Harvard Medical School, Boston Athinoula A Martinos Center for Biomedical Imaging A P Y, A P S, T H, R A S, Department of Radiology, Massachusetts General Hospital, Charlestown and Center for Alzheimer Research and Treatment M D, R E A, G A M, D M R, R A S, K A J, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA
    Neurology 85:48-55. 2015
    ..We aimed to determine whether there was a relationship between lifestyle factors and Alzheimer disease biomarkers...
  38. pmc Regional fluorodeoxyglucose metabolism and instrumental activities of daily living across the Alzheimer's disease spectrum
    Kamolika Roy
    Center for Alzheimer Research and Treatment, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    J Alzheimers Dis 42:291-300. 2014
    ..IADL impairment in AD dementia has been associated with inferior parietal, inferior temporal, and superior occipital hypometabolism using 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)...
  39. pmc Executive function and instrumental activities of daily living in mild cognitive impairment and Alzheimer's disease
    Gad A Marshall
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital Harvard Medical School, Boston, MA, USA
    Alzheimers Dement 7:300-8. 2011
    ....
  40. ncbi False recognition in Alzheimer disease: evidence from categorized pictures
    Andrew E Budson
    Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Cogn Behav Neurol 16:16-27. 2003
    ..To better understand memory distortions and false recognition in patients with Alzheimer disease (AD), using a paradigm of categorized color photographs...
  41. doi Free and cued memory in relation to biomarker-defined abnormalities in clinically normal older adults and those at risk for Alzheimer's disease
    Kathryn V Papp
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA Electronic address
    Neuropsychologia 73:169-75. 2015
    ..We sought to examine the relationship between free and cued recall paradigms, in addition to global composites of memory, executive functioning, and processing speed in relation to stages of preclinical AD...
  42. pmc Everyday cognition scale items that best discriminate between and predict progression from clinically normal to mild cognitive impairment
    Gad A Marshall
    Center for Alzheimer Research and Treatment, Brigham and Women s Hospital, 221 Longwood Avenue, BL 104H, Boston, MA 02115, USA
    Curr Alzheimer Res 11:853-61. 2014
    ..The objective of this study was to determine which of the IADL-related Everyday Cognition (ECog) scale items are most sensitive for detection of early functional changes...
  43. pmc Subjective cognitive concerns, amyloid-β, and neurodegeneration in clinically normal elderly
    Rebecca E Amariglio
    From the Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital R E A, A C P, G A M, P V, K A J, R A S, D M R, and the Departments of Neurology R E A, E C M, G A M, P V, K A J, R A S, D M R and Radiology K A J, Massachusetts General Hospital, Harvard Medical School, Boston, MA
    Neurology 85:56-62. 2015
    ..To determine whether neuroimaging biomarkers of amyloid-β (Aβ) and neurodegeneration (ND) are associated with greater self-reported subjective cognitive concerns (SCC) in clinically normal older individuals...
  44. pmc Regional cortical thinning and cerebrospinal biomarkers predict worsening daily functioning across the Alzheimer's disease spectrum
    Gad A Marshall
    Center for Alzheimer Research and Treatment, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA Massachusetts Alzheimer s Disease Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    J Alzheimers Dis 41:719-28. 2014
    ..Impairment in instrumental activities of daily living (IADL) heralds the transition from mild cognitive impairment (MCI) to dementia and is a major source of burden for both the patient and caregiver...
  45. pmc The influence of executive capacity on selective attention and subsequent processing
    Kirk R Daffner
    Center for Brain Mind Medicine, Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston MA, USA
    Front Hum Neurosci 6:167. 2012
    ..In summary, our findings suggest that current views regarding the relationship between top-down control mechanisms and SA may need refinement...
  46. pmc Reliability of functional magnetic resonance imaging associative encoding memory paradigms in non-demented elderly adults
    Deepti Putcha
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Hum Brain Mapp 32:2027-44. 2011
    ....
  47. pmc Vascular disease and risk factors are associated with cognitive decline in the alzheimer disease spectrum
    Natacha Lorius
    Department of Neurology, Center for Alzheimer Research and Treatment, Brigham and Women s Hospital Departments of Neurology Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
    Alzheimer Dis Assoc Disord 29:18-25. 2015
    ..These results suggest a significant association of increased vascular disease and risk factors with cognitive impairment at baseline and over time in the AD spectrum in a sample that was selected to have low vascular burden at baseline. ..
  48. pmc Subjective cognitive concerns, episodic memory, and the APOE ε4 allele
    Cecilia Samieri
    Channing Division of Network Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA INSERM, Centre INSERM U897 Epidemiologie Biostatistiques, Bordeaux, France Univ Bordeaux, Centre INSERM U897 Epidemiologie Biostatistiques, Bordeaux, France Electronic address
    Alzheimers Dement 10:752-759.e1. 2014
    ..Subjective cognitive concerns may represent a simple method to assess likelihood of memory decline among apolipoprotein E (APOE) ε4 carriers...
  49. pmc Conceptual and measurement challenges in research on cognitive reserve
    Richard N Jones
    Division of Gerontology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02131, USA
    J Int Neuropsychol Soc 17:593-601. 2011
    ..We review the theoretical and ontological status of latent variable modeling approaches to cognitive reserve, and suggest research strategies for advancing the field...
  50. pmc A life course model of cognitive activities, socioeconomic status, education, reading ability, and cognition
    Angela L Jefferson
    Alzheimer s Disease Center, School of Medicine, Boston University, Boston, Massachusetts, USA
    J Am Geriatr Soc 59:1403-11. 2011
    ..To cross-sectionally quantify the contribution of proxy measures of cognitive reserve reflective of the lifespan, such as education, socioeconomic status (SES), reading ability, and cognitive activities, in explaining late-life cognition...
  51. pmc Tracking early decline in cognitive function in older individuals at risk for Alzheimer disease dementia: the Alzheimer's Disease Cooperative Study Cognitive Function Instrument
    Rebecca E Amariglio
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts2Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts3Harvar
    JAMA Neurol 72:446-54. 2015
    ..The success of these trials depends on validated outcome measures that are sensitive to early clinical progression in individuals who are initially asymptomatic...
  52. pmc SIST-M-IR activities of daily living items that best discriminate clinically normal elderly from those with mild cognitive impairment
    Amy S Zoller
    Center for Alzheimer Research and Treatment, Brigham and Women s Hospital, 221 Longwood Avenue, BL 104H, Boston, MA 02115, USA
    Curr Alzheimer Res 11:785-91. 2014
    ..Of the 60 SIST-M-IR items, 41 address IADL; we aimed to determine which of these best discriminate individuals with MCI from clinically normal (CN) elderly...
  53. pmc Age-related decline in bottom-up processing and selective attention in the very old
    Tatyana Y Zhuravleva
    Division of Cognitive and Behavioral Neurology, Department of Neurology, Center for Brain Mind Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, U S A and Department of Psychology, Tufts University, Medford, Massachusetts, U S A
    J Clin Neurophysiol 31:261-71. 2014
    ..In the absence of a decline in top-down modulation indexed by the SP, the diminished SN may reflect age-related degradation of early bottom-up visual processing in old-old adults...
  54. pmc Amyloid deposition is associated with impaired default network function in older persons without dementia
    Reisa A Sperling
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuron 63:178-88. 2009
    ....
  55. pmc Development of a psychometrically equivalent short form of the Face-Name Associative Memory Exam for use along the early Alzheimer's disease trajectory
    Kathryn V Papp
    a Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Boston, MA, USA
    Clin Neuropsychol 28:771-85. 2014
    ..001). Mean performance on the FNAME 12A, stratified by education, was generated. The task could be completed by our MCI group yet remained challenging in the CN group, providing evidence for its utility along the AD trajectory. ..
  56. pmc Investigating the age-related "anterior shift" in the scalp distribution of the P3b component using principal component analysis
    Brittany R Alperin
    Center for Brain Mind Medicine, Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham, Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Psychophysiology 51:620-33. 2014
    ..The increase in the P3a in elderly adults may not represent a failure to habituate the novelty response, but may reflect greater reliance on executive control operations (P3a) to carry out the categorization/updating process (P3b). ..
  57. pmc Specific subjective memory complaints in older persons may indicate poor cognitive function
    Rebecca England Amariglio
    Department of Neurology, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Geriatr Soc 59:1612-7. 2011
    ..To examine the association between the type and number of subjective memory complaints (SMCs) and performance on objective cognitive tests...
  58. ncbi Use of a false recognition paradigm in an Alzheimer's disease clinical trial: a pilot study
    Andrew E Budson
    Harvard Medical School, Boston, Massachusetts, USA
    Am J Alzheimers Dis Other Demen 17:93-100. 2002
    ..Because medications to treat AD may preferentially improve gist memory or item-specific recollection, use of this type of paradigm may improve sensitivity for detection of drug effects more than standard memory tests...
  59. pmc The A4 study: stopping AD before symptoms begin?
    Reisa A Sperling
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Sci Transl Med 6:228fs13. 2014
    ..A new secondary prevention trial in older people with amyloid accumulation at high risk for Alzheimer's disease dementia should provide insights into whether anti-amyloid therapy can delay cognitive decline. ..
  60. pmc Voxelwise genome-wide association study (vGWAS)
    Jason L Stein
    Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles School of Medicine, Neuroscience Research Building 225E, 635 Charles Young Drive, Los Angeles, CA 90095 1769, USA
    Neuroimage 53:1160-74. 2010
    ..These genes have high relevance to brain structure. This is the first voxelwise genome wide association study to our knowledge, and offers a novel method to discover genetic influences on brain structure...
  61. pmc Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees
    William E Klunk
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 27:6174-84. 2007
    ..The early, focal striatal amyloid deposition observed in these PS1 mutation carriers is often is not associated with clinical symptoms...