Dorene M Rentz

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi IQ-based norms for highly intelligent adults
    Dorene M Rentz
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Clin Neuropsychol 20:637-48. 2006
  2. ncbi Intelligence quotient-adjusted memory impairment is associated with abnormal single photon emission computed tomography perfusion
    Dorene M Rentz
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Int Neuropsychol Soc 13:821-31. 2007
  3. ncbi Use of IQ-adjusted norms to predict progressive cognitive decline in highly intelligent older individuals
    Dorene M Rentz
    Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Neuropsychology 18:38-49. 2004
  4. pmc Face-name associative memory performance is related to amyloid burden in normal elderly
    Dorene M Rentz
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuropsychologia 49:2776-83. 2011
  5. pmc Cognition, reserve, and amyloid deposition in normal aging
    Dorene M Rentz
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, 33 Fruit Street, Boston, MA 02114, USA
    Ann Neurol 67:353-64. 2010
  6. ncbi Increased responsiveness to novelty is associated with successful cognitive aging
    Kirk R Daffner
    Division of Cognitive and Behavioral Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Cogn Neurosci 18:1759-73. 2006
  7. pmc Age-related changes in early novelty processing as measured by ERPs
    Jenna L Riis
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Biol Psychol 82:33-44. 2009
  8. pmc Subjective cognitive complaints and amyloid burden in cognitively normal older individuals
    Rebecca E Amariglio
    Department of Neurology, Division of Cognitive and Behavioral Neurology, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, United States
    Neuropsychologia 50:2880-6. 2012
  9. pmc Tracking cognitive change over 24 weeks with longitudinal functional magnetic resonance imaging in Alzheimer's disease
    Donald G McLaren
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    Neurodegener Dis 9:176-86. 2012
  10. pmc Cognitive status impacts age-related changes in attention to novel and target events in normal adults
    Kirk R Daffner
    Brigham Behavioral Neurology Group, Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuropsychology 21:291-300. 2007

Detail Information

Publications41

  1. ncbi IQ-based norms for highly intelligent adults
    Dorene M Rentz
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Clin Neuropsychol 20:637-48. 2006
    ....
  2. ncbi Intelligence quotient-adjusted memory impairment is associated with abnormal single photon emission computed tomography perfusion
    Dorene M Rentz
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Int Neuropsychol Soc 13:821-31. 2007
    ..IQ-adjusted memory impairment in individuals with high cognitive reserve is associated with baseline SPECT abnormality in a pattern consistent with prodromal AD and predicts subsequent cognitive and functional decline...
  3. ncbi Use of IQ-adjusted norms to predict progressive cognitive decline in highly intelligent older individuals
    Dorene M Rentz
    Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Neuropsychology 18:38-49. 2004
    ..Three participants with normal memory declined. Implications for using IQ-adjusted norms to predict preclinical AD are discussed...
  4. pmc Face-name associative memory performance is related to amyloid burden in normal elderly
    Dorene M Rentz
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuropsychologia 49:2776-83. 2011
    ..Associative memory for faces and names, a common complaint among older adults, may be a sensitive marker of early Aβ-related impairment...
  5. pmc Cognition, reserve, and amyloid deposition in normal aging
    Dorene M Rentz
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, 33 Fruit Street, Boston, MA 02114, USA
    Ann Neurol 67:353-64. 2010
    ..To determine whether amyloid deposition is associated with impaired neuropsychological (NP) performance and whether cognitive reserve (CR) modifies this association...
  6. ncbi Increased responsiveness to novelty is associated with successful cognitive aging
    Kirk R Daffner
    Division of Cognitive and Behavioral Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Cogn Neurosci 18:1759-73. 2006
    ....
  7. pmc Age-related changes in early novelty processing as measured by ERPs
    Jenna L Riis
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Biol Psychol 82:33-44. 2009
    ....
  8. pmc Subjective cognitive complaints and amyloid burden in cognitively normal older individuals
    Rebecca E Amariglio
    Department of Neurology, Division of Cognitive and Behavioral Neurology, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, United States
    Neuropsychologia 50:2880-6. 2012
    ..Our study suggests that SCC may be an early indicator of AD pathology detectable prior to significant objective impairment...
  9. pmc Tracking cognitive change over 24 weeks with longitudinal functional magnetic resonance imaging in Alzheimer's disease
    Donald G McLaren
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    Neurodegener Dis 9:176-86. 2012
    ....
  10. pmc Cognitive status impacts age-related changes in attention to novel and target events in normal adults
    Kirk R Daffner
    Brigham Behavioral Neurology Group, Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuropsychology 21:291-300. 2007
    ..Moreover, the results support the notion of there being different patterns of normal cognitive aging and the need to identify the factors that influence them...
  11. pmc Amyloid-β associated cortical thinning in clinically normal elderly
    J Alex Becker
    Department of Radiology, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Ann Neurol 69:1032-42. 2011
    ....
  12. pmc Instrumental activities of daily living impairment is associated with increased amyloid burden
    Gad A Marshall
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    Dement Geriatr Cogn Disord 31:443-50. 2011
    ..8; p = 0.0002) and in MCI subjects only (R(2) = 0.28; β = 6.1; p = 0.003), but not in NC subjects only. Conclusion: These results suggest that daily functional impairment is related to greater amyloid burden in MCI...
  13. pmc Functional alterations in memory networks in early Alzheimer's disease
    Reisa A Sperling
    Department of Neurology, Center for Alzheimer s Research and Treatment, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    Neuromolecular Med 12:27-43. 2010
    ..Research is ongoing to determine if these early network alterations will serve as sensitive predictors of clinical decline, and eventually, as markers of pharmacological response to potential disease-modifying treatments for AD...
  14. pmc Amyloid and APOE ε4 interact to influence short-term decline in preclinical Alzheimer disease
    Elizabeth C Mormino
    From the Departments of Neurology E C M, A P S, D M R, K A J, R A S, Radiology T H, A P S, K A J, R A S, and Psychiatry A P S, A W, and the Division of Nuclear Medicine and Molecular Imaging, Department of Radiology K A J, Massachusetts General Hospital, Harvard Medical School the Department of Biostatistics R A B, Harvard School of Public Health, Boston the Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology T H, Massachusetts General Hospital, Charleston and the Center for Alzheimer Research and Treatment, Department of Neurology A W, w h, D M R, K A J, R A S, Brigham and Women s Hospital, Harvard Medical School, Boston, MA
    Neurology 82:1760-7. 2014
    ..To examine whether β-amyloid (Aβ) and APOE ε4 status independently contribute or interact to influence longitudinal cognitive decline in clinically normal older individuals (CN)...
  15. pmc Does modulation of selective attention to features reflect enhancement or suppression of neural activity?
    Kirk R Daffner
    Center for Brain Mind Medicine, Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    Biol Psychol 89:398-407. 2012
    ..However, there were markedly reduced responses under the ignore relative to the neutral condition, consistent with the view that early selection mechanisms reflect suppression of neural activity under the ignore condition...
  16. ncbi Age-related differences in attention to novelty among cognitively high performing adults
    Kirk R Daffner
    Brigham Behavioral Neurology Group, Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    Biol Psychol 72:67-77. 2006
    ..We hypothesise that cognitively high performing old individuals successfully manage the task by relying on additional neural resources and perhaps more effortful frontal activity than their younger counterparts...
  17. pmc Does compensatory neural activity survive old-old age?
    Kirk R Daffner
    Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuroimage 54:427-38. 2011
    ..This limits their ability to appropriate additional resources as compensatory activity for age-related impairments in earlier visual processing, and suggests that such a mechanism does not tend to "survive" old-old age...
  18. pmc Compensatory neural activity distinguishes different patterns of normal cognitive aging
    Jenna L Riis
    Brigham Behavioral Neurology Group, Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    Neuroimage 39:441-54. 2008
    ..These findings provide strong evidence for different patterns of age-related changes in the processing of salient environmental stimuli, with cognitive status serving as a key mediating variable...
  19. ncbi Age-related differences in novelty and target processing among cognitively high performing adults
    Kirk R Daffner
    Brigham Behavioral Neurology Group, Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neurobiol Aging 26:1283-95. 2005
    ....
  20. ncbi The dissociation between early and late selection in older adults
    Brittany R Alperin
    Harvard Medical School and Brigham and Women s Hospital, Boston, MA
    J Cogn Neurosci 25:2189-206. 2013
    ..Despite relative preservation of the operations of early selection, processing delays may lead older participants to allocate excessive resources to task-irrelevant stimuli during late selection. ..
  21. pmc Neuropsychiatric symptoms and global functional impairment along the Alzheimer's continuum
    Lauren P Wadsworth
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Dement Geriatr Cogn Disord 34:96-111. 2012
    ..We sought to determine whether neuropsychiatric symptoms were related to global functional impairment at baseline and over a 3-year period in older normal control (NC), mild cognitive impairment (MCI) and mild AD dementia subjects...
  22. pmc Validation of the Face Name Associative Memory Exam in cognitively normal older individuals
    Rebecca E Amariglio
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Boston, MA, USA
    J Clin Exp Neuropsychol 34:580-7. 2012
    ..Correlations between the FNAME subtests and another episodic memory test were significant. The results indicated strong test-retest reliability in a subsample (n = 41). Normative data stratified by age were also generated...
  23. pmc Brain amyloid and cognition in Lewy body diseases
    STEPHEN N GOMPERTS
    Massachusetts General Hospital, 15 Parkman Street, Boston, MA 02114, USA
    Mov Disord 27:965-73. 2012
    ..Early amyloid deposits in DLB relative to PDD may account for their difference in the timing of dementia and parkinsonism...
  24. pmc Test-retest reliability of memory task functional magnetic resonance imaging in Alzheimer disease clinical trials
    Alireza Atri
    Memory Disorders Unit, Massachusetts General Hospital, 15 Parkman Street, Wang Ambulatory Care Center 715, Boston, MA 02114, USA
    Arch Neurol 68:599-606. 2011
    ..To examine the feasibility and test-retest reliability of encoding-task functional magnetic resonance imaging (fMRI) in mild Alzheimer disease (AD)...
  25. pmc Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease
    David A Wolk
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:10256-61. 2010
    ....
  26. pmc A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly
    April J Ho
    Laboratory of Neuroimaging, Department of Neurology, University of California School of Medicine, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:8404-9. 2010
    ..These brain maps reveal that a commonly carried susceptibility allele for obesity is associated with structural brain atrophy, with implications for the health of the elderly...
  27. ncbi Imaging of amyloid burden and distribution in cerebral amyloid angiopathy
    Keith A Johnson
    Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    Ann Neurol 62:229-34. 2007
    ....
  28. pmc Executive function and instrumental activities of daily living in mild cognitive impairment and Alzheimer's disease
    Gad A Marshall
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital Harvard Medical School, Boston, MA, USA
    Alzheimers Dement 7:300-8. 2011
    ....
  29. ncbi False recognition in Alzheimer disease: evidence from categorized pictures
    Andrew E Budson
    Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Cogn Behav Neurol 16:16-27. 2003
    ..To better understand memory distortions and false recognition in patients with Alzheimer disease (AD), using a paradigm of categorized color photographs...
  30. pmc The influence of executive capacity on selective attention and subsequent processing
    Kirk R Daffner
    Center for Brain Mind Medicine, Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston MA, USA
    Front Hum Neurosci 6:167. 2012
    ..In summary, our findings suggest that current views regarding the relationship between top-down control mechanisms and SA may need refinement...
  31. pmc Reliability of functional magnetic resonance imaging associative encoding memory paradigms in non-demented elderly adults
    Deepti Putcha
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Hum Brain Mapp 32:2027-44. 2011
    ....
  32. pmc Conceptual and measurement challenges in research on cognitive reserve
    Richard N Jones
    Division of Gerontology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02131, USA
    J Int Neuropsychol Soc 17:593-601. 2011
    ..We review the theoretical and ontological status of latent variable modeling approaches to cognitive reserve, and suggest research strategies for advancing the field...
  33. pmc A life course model of cognitive activities, socioeconomic status, education, reading ability, and cognition
    Angela L Jefferson
    Alzheimer s Disease Center, School of Medicine, Boston University, Boston, Massachusetts, USA
    J Am Geriatr Soc 59:1403-11. 2011
    ..To cross-sectionally quantify the contribution of proxy measures of cognitive reserve reflective of the lifespan, such as education, socioeconomic status (SES), reading ability, and cognitive activities, in explaining late-life cognition...
  34. pmc Age-related decline in bottom-up processing and selective attention in the very old
    Tatyana Y Zhuravleva
    Division of Cognitive and Behavioral Neurology, Department of Neurology, Center for Brain Mind Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, U S A and Department of Psychology, Tufts University, Medford, Massachusetts, U S A
    J Clin Neurophysiol 31:261-71. 2014
    ..In the absence of a decline in top-down modulation indexed by the SP, the diminished SN may reflect age-related degradation of early bottom-up visual processing in old-old adults...
  35. pmc Amyloid deposition is associated with impaired default network function in older persons without dementia
    Reisa A Sperling
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuron 63:178-88. 2009
    ....
  36. ncbi Investigating the age-related "anterior shift" in the scalp distribution of the P3b component using principal component analysis
    Brittany R Alperin
    Center for Brain Mind Medicine, Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham, Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Psychophysiology 51:620-33. 2014
    ..The increase in the P3a in elderly adults may not represent a failure to habituate the novelty response, but may reflect greater reliance on executive control operations (P3a) to carry out the categorization/updating process (P3b). ..
  37. pmc Specific subjective memory complaints in older persons may indicate poor cognitive function
    Rebecca England Amariglio
    Department of Neurology, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Geriatr Soc 59:1612-7. 2011
    ..To examine the association between the type and number of subjective memory complaints (SMCs) and performance on objective cognitive tests...
  38. ncbi Use of a false recognition paradigm in an Alzheimer's disease clinical trial: a pilot study
    Andrew E Budson
    Harvard Medical School, Boston, Massachusetts, USA
    Am J Alzheimers Dis Other Demen 17:93-100. 2002
    ..Because medications to treat AD may preferentially improve gist memory or item-specific recollection, use of this type of paradigm may improve sensitivity for detection of drug effects more than standard memory tests...
  39. pmc The A4 study: stopping AD before symptoms begin?
    Reisa A Sperling
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Sci Transl Med 6:228fs13. 2014
    ..A new secondary prevention trial in older people with amyloid accumulation at high risk for Alzheimer's disease dementia should provide insights into whether anti-amyloid therapy can delay cognitive decline. ..
  40. pmc Voxelwise genome-wide association study (vGWAS)
    Jason L Stein
    Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles School of Medicine, Neuroscience Research Building 225E, 635 Charles Young Drive, Los Angeles, CA 90095 1769, USA
    Neuroimage 53:1160-74. 2010
    ..These genes have high relevance to brain structure. This is the first voxelwise genome wide association study to our knowledge, and offers a novel method to discover genetic influences on brain structure...
  41. pmc Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees
    William E Klunk
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 27:6174-84. 2007
    ..The early, focal striatal amyloid deposition observed in these PS1 mutation carriers is often is not associated with clinical symptoms...