D E Reich

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. ncbi request reprint Detecting association in a case-control study while correcting for population stratification
    D E Reich
    Whitehead Institute MIT Center for Genome Research, Cambridge, Massachusetts 02142, USA
    Genet Epidemiol 20:4-16. 2001
  2. ncbi request reprint Linkage disequilibrium in the human genome
    D E Reich
    Whitehead Institute MIT Center for Genome Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 411:199-204. 2001
  3. ncbi request reprint On the allelic spectrum of human disease
    D E Reich
    The Whitehead Institute MIT Center for Genome Research, Nine Cambidge Center, Cambridge, MA 02142, USA
    Trends Genet 17:502-10. 2001
  4. ncbi request reprint Quality and completeness of SNP databases
    David E Reich
    Program in Medical and Population Genetics, Whitehead Institute MIT Center for Genome Research, One Kendall Square, Cambridge, Massachusetts 02139, USA
    Nat Genet 33:457-8. 2003
  5. ncbi request reprint Large-scale discovery and genotyping of single-nucleotide polymorphisms in the mouse
    K Lindblad-Toh
    Whitehead Institute MIT Center for Genome Research, Whitehead Institute for Biomedical Research, Cambridge, MA, USA
    Nat Genet 24:381-6. 2000
  6. ncbi request reprint Detecting recent positive selection in the human genome from haplotype structure
    Pardis C Sabeti
    Whitehead Institute MIT Center for Genome Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 419:832-7. 2002
  7. ncbi request reprint Evaluating potential for whole-genome studies in Kosrae, an isolated population in Micronesia
    Penelope E Bonnen
    Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nat Genet 38:214-7. 2006
  8. ncbi request reprint Human genome sequence variation and the influence of gene history, mutation and recombination
    David E Reich
    Whitehead Institute MIT Center for Genome Research, One Kendall Square, Cambridge, Massachusetts 02139, USA
    Nat Genet 32:135-42. 2002
  9. pmc Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans
    Jorge R Oksenberg
    Department of Neurology, University of California at San Francisco, San Francisco, CA 94143 0435, USA
    Am J Hum Genet 74:160-7. 2004
  10. pmc Genetic signatures of strong recent positive selection at the lactase gene
    Todd Bersaglieri
    Divisions of Genetics and Endocrinology, Harvard Medical School, Boston, MA 02115, USA
    Am J Hum Genet 74:1111-20. 2004

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Detecting association in a case-control study while correcting for population stratification
    D E Reich
    Whitehead Institute MIT Center for Genome Research, Cambridge, Massachusetts 02142, USA
    Genet Epidemiol 20:4-16. 2001
    ..The average of association statistics across the markers directly measures stratification. By dividing the candidate association statistic by this average, a P-value can be obtained that corrects for stratification...
  2. ncbi request reprint Linkage disequilibrium in the human genome
    D E Reich
    Whitehead Institute MIT Center for Genome Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 411:199-204. 2001
    ..By contrast, LD in a Nigerian population extends markedly less far. The results illuminate human history, suggesting that LD in northern Europeans is shaped by a marked demographic event about 27,000-53,000 years ago...
  3. ncbi request reprint On the allelic spectrum of human disease
    D E Reich
    The Whitehead Institute MIT Center for Genome Research, Nine Cambidge Center, Cambridge, MA 02142, USA
    Trends Genet 17:502-10. 2001
    ..It also has bearing on the Common Disease/Common Variants (CD/CV) hypothesis, predicting that at loci where the total frequency of disease alleles is not too small, disease loci will have relatively simple spectra...
  4. ncbi request reprint Quality and completeness of SNP databases
    David E Reich
    Program in Medical and Population Genetics, Whitehead Institute MIT Center for Genome Research, One Kendall Square, Cambridge, Massachusetts 02139, USA
    Nat Genet 33:457-8. 2003
    ..Approximately 45% of all human heterozygosity is attributable to SNPs already available from the two databases, and of SNPs with minor-allele frequencies >10%, more than half are represented...
  5. ncbi request reprint Large-scale discovery and genotyping of single-nucleotide polymorphisms in the mouse
    K Lindblad-Toh
    Whitehead Institute MIT Center for Genome Research, Whitehead Institute for Biomedical Research, Cambridge, MA, USA
    Nat Genet 24:381-6. 2000
    ..We have also developed a multiplex genotyping procedure by which a genome scan can be performed with only six genotyping reactions per animal...
  6. ncbi request reprint Detecting recent positive selection in the human genome from haplotype structure
    Pardis C Sabeti
    Whitehead Institute MIT Center for Genome Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 419:832-7. 2002
    ..More generally, the method could be used to scan the entire genome for evidence of recent positive selection...
  7. ncbi request reprint Evaluating potential for whole-genome studies in Kosrae, an isolated population in Micronesia
    Penelope E Bonnen
    Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nat Genet 38:214-7. 2006
    ..The long-range LD around common alleles and limited diversity result in improved efficiency in genetic studies in this population and augments the power to detect association of 'hidden SNPs'...
  8. ncbi request reprint Human genome sequence variation and the influence of gene history, mutation and recombination
    David E Reich
    Whitehead Institute MIT Center for Genome Research, One Kendall Square, Cambridge, Massachusetts 02139, USA
    Nat Genet 32:135-42. 2002
    ....
  9. pmc Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans
    Jorge R Oksenberg
    Department of Neurology, University of California at San Francisco, San Francisco, CA 94143 0435, USA
    Am J Hum Genet 74:160-7. 2004
    ..This finding is unlikely to be solely explained by admixture, since a substantial proportion of the susceptibility chromosomes from African American patients with MS displayed haplotypes consistent with an African origin...
  10. pmc Genetic signatures of strong recent positive selection at the lactase gene
    Todd Bersaglieri
    Divisions of Genetics and Endocrinology, Harvard Medical School, Boston, MA 02115, USA
    Am J Hum Genet 74:1111-20. 2004
    ....