Deborah A Quinn

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Involvement of Akt and endothelial nitric oxide synthase in ventilation-induced neutrophil infiltration: a prospective, controlled animal experiment
    Li Fu Li
    Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, and Chang Gung University, Kweishan, Taoyuan 333, Taiwan
    Crit Care 11:R89. 2007
  2. pmc High-molecular-weight hyaluronan--a possible new treatment for sepsis-induced lung injury: a preclinical study in mechanically ventilated rats
    Yung Yang Liu
    Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street Boston, MA 02114, USA
    Crit Care 12:R102. 2008
  3. pmc The role of phosphodiesterase 3 in endotoxin-induced acute kidney injury
    Won Il Choi
    Pulmonary Unit, Department of Internal Medicine, DongSan Hospital, Keimyung University School of Medicine, Daegu, Korea
    BMC Infect Dis 9:80. 2009
  4. ncbi request reprint Interactions of lung stretch, hyperoxia, and MIP-2 production in ventilator-induced lung injury
    Deborah A Quinn
    Pulmonary Critical Care Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Appl Physiol (1985) 93:517-25. 2002
  5. pmc Hyperoxia increases ventilator-induced lung injury via mitogen-activated protein kinases: a prospective, controlled animal experiment
    Li Fu Li
    Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, and Chang Gung University, Kweishan, Taoyuan 333, Taiwan
    Crit Care 11:R25. 2007
  6. doi request reprint Oxidant stress mediates inflammation and apoptosis in ventilator-induced lung injury
    Olga Syrkina
    Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02114, USA
    Respirology 13:333-40. 2008
  7. doi request reprint High MW hyaluronan inhibits smoke inhalation-induced lung injury and improves survival
    Pei Ming Huang
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Respirology 15:1131-9. 2010
  8. doi request reprint TLR4 through IFN-β promotes low molecular mass hyaluronan-induced neutrophil apoptosis
    Shaw Wei Leu
    Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    J Immunol 186:556-62. 2011
  9. pmc The role of hyaluronan synthase 3 in ventilator-induced lung injury
    Kuan Jen Bai
    Pulmonary and Critical Care Unit, Massachusetts General Hospital, 55 Fruit Street, Bulfinch 148, Boston, MA 02114, USA
    Am J Respir Crit Care Med 172:92-8. 2005
  10. ncbi request reprint Ventilation-induced neutrophil infiltration and apoptosis depend on apoptosis signal-regulated kinase 1 pathway
    Li Fu Li
    Graduate Institute of Clinical Medical Sciences and Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Crit Care Med 33:1913-21. 2005

Research Grants

Detail Information

Publications34

  1. pmc Involvement of Akt and endothelial nitric oxide synthase in ventilation-induced neutrophil infiltration: a prospective, controlled animal experiment
    Li Fu Li
    Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, and Chang Gung University, Kweishan, Taoyuan 333, Taiwan
    Crit Care 11:R89. 2007
    ....
  2. pmc High-molecular-weight hyaluronan--a possible new treatment for sepsis-induced lung injury: a preclinical study in mechanically ventilated rats
    Yung Yang Liu
    Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street Boston, MA 02114, USA
    Crit Care 12:R102. 2008
    ..High-molecular-weight hyaluronan (HMW HA), in contrast, has been found to be anti-inflammatory. We hypothesized that HMW HA would inhibit lung injury associated with sepsis and mechanical ventilation...
  3. pmc The role of phosphodiesterase 3 in endotoxin-induced acute kidney injury
    Won Il Choi
    Pulmonary Unit, Department of Internal Medicine, DongSan Hospital, Keimyung University School of Medicine, Daegu, Korea
    BMC Infect Dis 9:80. 2009
    ..We, therefore, hypothesized that endotoxin induced renal injury by activating phosphodiesterase 3 (PDE3) which metabolizes cAMP and that amrinone an inhibitor of PDE3 would prevent the renal injury...
  4. ncbi request reprint Interactions of lung stretch, hyperoxia, and MIP-2 production in ventilator-induced lung injury
    Deborah A Quinn
    Pulmonary Critical Care Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Appl Physiol (1985) 93:517-25. 2002
    ....
  5. pmc Hyperoxia increases ventilator-induced lung injury via mitogen-activated protein kinases: a prospective, controlled animal experiment
    Li Fu Li
    Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, and Chang Gung University, Kweishan, Taoyuan 333, Taiwan
    Crit Care 11:R25. 2007
    ....
  6. doi request reprint Oxidant stress mediates inflammation and apoptosis in ventilator-induced lung injury
    Olga Syrkina
    Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02114, USA
    Respirology 13:333-40. 2008
    ..This study aimed to determine the effect of N-acetylcysteine (NAC), a scavenger of oxygen radicals, on lung inflammation and apoptosis in an in vivo model of VILI...
  7. doi request reprint High MW hyaluronan inhibits smoke inhalation-induced lung injury and improves survival
    Pei Ming Huang
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Respirology 15:1131-9. 2010
    ..We hypothesized that treatment with HMW HA would block smoke inhalation lung injury by inhibiting smoke-induced lung inflammation and airway epithelial cell apoptosis...
  8. doi request reprint TLR4 through IFN-β promotes low molecular mass hyaluronan-induced neutrophil apoptosis
    Shaw Wei Leu
    Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    J Immunol 186:556-62. 2011
    ..Thus, TLR4 plays a novel homeostatic role in noninfectious lung inflammation by accelerating the elimination of inflammatory neutrophils...
  9. pmc The role of hyaluronan synthase 3 in ventilator-induced lung injury
    Kuan Jen Bai
    Pulmonary and Critical Care Unit, Massachusetts General Hospital, 55 Fruit Street, Bulfinch 148, Boston, MA 02114, USA
    Am J Respir Crit Care Med 172:92-8. 2005
    ..We conclude that high VT induced low-molecular-weight hyaluronan production is dependent on de novo synthesis through hyaluronan synthase 3, and plays a role in the inflammatory response of ventilator-induced lung injury...
  10. ncbi request reprint Ventilation-induced neutrophil infiltration and apoptosis depend on apoptosis signal-regulated kinase 1 pathway
    Li Fu Li
    Graduate Institute of Clinical Medical Sciences and Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Crit Care Med 33:1913-21. 2005
    ....
  11. ncbi request reprint Regulation of lung injury and repair by Toll-like receptors and hyaluronan
    Dianhua Jiang
    Department of Medicine, Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA
    Nat Med 11:1173-9. 2005
    ..Hyaluronan-TLR2 and hyaluronan-TLR4 interactions provide signals that initiate inflammatory responses, maintain epithelial cell integrity and promote recovery from acute lung injury...
  12. ncbi request reprint Intracellular glutathione in stretch-induced cytokine release from alveolar type-2 like cells
    Behrouz Jafari
    Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Respirology 9:43-53. 2004
    ..We hypothesized that stretch-induced cytokine production is dependent on oxidant release and is regulated by intracellular glutathione (GSH) inhibition of nuclear factor kappa B (NF-kappa B) and activator protein-1 (AP-1) binding...
  13. ncbi request reprint Ventilation-induced neutrophil infiltration depends on c-Jun N-terminal kinase
    Li Fu Li
    Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Respir Crit Care Med 169:518-24. 2004
    ..We conclude that lung cell stretch in vivo results in increased lung neutrophil sequestration and increased MIP-2 production, which was, at least in part, dependent upon the JNK pathway...
  14. doi request reprint Inhibition of HA synthase 3 mRNA expression, with a phosphodiesterase 3 inhibitor, blocks lung injury in a septic ventilated rat model
    Hicham Mrabat
    Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Lung 187:233-9. 2009
    ..The anti-inflammatory properties of MIL may be mediated by inhibition of HAS3 and/or MIP2 and could be beneficial in the treatment of sepsis...
  15. pmc Thrombospondin-1 null mice are resistant to hypoxia-induced pulmonary hypertension
    Cristhiaan D Ochoa
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    J Cardiothorac Surg 5:32. 2010
    ..In addition, TSP-1 produced by the pulmonary endothelium inhibits pulmonary artery smooth muscle cell growth. Based on these observations we sought to describe the pulmonary vascular changes in TSP-1(-/-) mice exposed to chronic hypoxia...
  16. ncbi request reprint Gene expression of cyclin-dependent kinase inhibitors and effect of heparin on their expression in mice with hypoxia-induced pulmonary hypertension
    Lunyin Yu
    Department of Medicine, Pulmonary and Critical Care Unit, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, USA
    Biochem Biophys Res Commun 345:1565-72. 2006
    ....
  17. doi request reprint TLR4 is a negative regulator in noninfectious lung inflammation
    Hang Zhao
    Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    J Immunol 184:5308-14. 2010
    ..These data provide a molecular level explanation for the function of TLR4 in LMW HA (200 kDa)-induced lung inflammation, as inhibition of the beta form of pro-IL-1 promotes an anti-inflammatory response...
  18. ncbi request reprint Low-molecular-weight heparin inhibits hypoxic pulmonary hypertension and vascular remodeling in guinea pigs
    Essam Al-Ansari
    Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Chest 132:1898-905. 2007
    ..We have shown previously that antiproliferative unfractionated heparins block hypoxia-induced pulmonary arterial hypertension (PAH) and vascular remodeling, and hypothesized that low-molecular-weight heparins (LMWHs) would too...
  19. pmc Deficiency of the NHE1 gene prevents hypoxia-induced pulmonary hypertension and vascular remodeling
    Lunyin Yu
    Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Bulfinch 148, Boston, MA 02114 2696, USA
    Am J Respir Crit Care Med 177:1276-84. 2008
    ..However, a causal role for the NHE1 gene in pulmonary hypertension has not been determined...
  20. pmc Serine/threonine kinase-protein kinase B and extracellular signal-regulated kinase regulate ventilator-induced pulmonary fibrosis after bleomycin-induced acute lung injury: a prospective, controlled animal experiment
    Li Fu Li
    Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, 5 Fu Hsing Street, Kweishan, Taoyuan 333, Taiwan
    Crit Care 12:R103. 2008
    ..We hypothesized that high-tidal-volume ventilation increased pulmonary fibrosis in acute lung injury via the serine/threonine kinase-protein kinase B (Akt) and mitogen-activated protein kinase pathways...
  21. pmc Unfractionated heparin and enoxaparin reduce high-stretch ventilation augmented lung injury: a prospective, controlled animal experiment
    Li Fu Li
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, 5 Fu Hsing Street, Kweishan, Taoyuan 333, Taiwan, Republic of China
    Crit Care 13:R108. 2009
    ....
  22. pmc Heparin inhibits pulmonary artery smooth muscle cell proliferation through guanine nucleotide exchange factor-H1/RhoA/Rho kinase/p27
    Lunyin Yu
    Pulmonary and Critical Care Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 2696, USA
    Am J Respir Cell Mol Biol 44:524-30. 2011
    ....
  23. pmc Cyclic stretch affects pulmonary endothelial cell control of pulmonary smooth muscle cell growth
    Cristhiaan D Ochoa
    Pulmonary and Critical Care Unit, Massachusetts General Hospital, Bullfinch 148, 55 Fruit Street, Boston, MA 02114, USA
    Am J Respir Cell Mol Biol 39:105-12. 2008
    ..The complete identification and understanding of the secreted proteome of stretched PAECs may lead to new insights into the pathophysiology of pulmonary vascular remodeling...
  24. pmc JNK activation is responsible for mucus overproduction in smoke inhalation injury
    Won Ii Choi
    Pulmonary Critical Care Unit, Department of Medicine, Massachusettes General Hospital and Harvard Medical School, Boston, MA, USA
    Respir Res 11:172. 2010
    ..We hypothesized that gel-forming mucins may contribute to the increased mucus production in a smoke inhalation injury. We investigated the role of c-Jun N-terminal kinase (JNK) in modulating smoke-induced mucus secretion...
  25. ncbi request reprint Heparin inhibits SMC growth in the presence of human and fetal bovine serum
    Naiyaratana Cindhuchao
    Pulmonary Critical Care Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Biochem Biophys Res Commun 302:84-8. 2003
    ..The antiproliferative activity of the above HP preparation in HS may lead to an effective treatment of pulmonary vascular and systemic remodeling...
  26. ncbi request reprint Inhibition of JNK activation prolongs survival after smoke inhalation from fires
    Olga L Syrkina
    Pulmonary and Critical Care Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Physiol Lung Cell Mol Physiol 292:L984-91. 2007
    ..05). These in vivo data show that the JNK pathway plays a critical role in smoke-induced lung injury and offer an attractive therapeutic approach for this injury...
  27. ncbi request reprint Low molecular weight hyaluronan from stretched lung enhances interleukin-8 expression
    Marcella M Mascarenhas
    Pulmonary and Critical Care Unit, Massachusetts General Hospital, 55 Fruit Street, Bulfinch 148, Boston, MA 02114, USA
    Am J Respir Cell Mol Biol 30:51-60. 2004
    ..These results indicated that de novo synthesis of LMW HA was induced in lung fibroblasts by stretch via tyrosine kinase signaling pathways, and may play a role in augmenting induction of proinflammatory cytokines in VILI...
  28. doi request reprint Low molecular weight hyaluronan, via AP-1 and NF-κB signalling, induces IL-8 in transformed bronchial epithelial cells
    Christiaan D Ochoa
    Pulmonary and Critical Care Unit, Dept of Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston, USA
    Swiss Med Wkly 141:w13255. 2011
    ..In the present study, it was investigated whether LMW-HA synthesised in the lung, in response to cyclic stretch, increased IL-8 production in the bronchial epithelium...
  29. ncbi request reprint Cyclin-dependent kinase inhibitor p27Kip1, but not p21WAF1/Cip1, is required for inhibition of hypoxia-induced pulmonary hypertension and remodeling by heparin in mice
    Lunyin Yu
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 2696, USA
    Circ Res 97:937-45. 2005
    ..Therefore, we conclude that the cyclin-dependent kinase inhibitor p27, but not p21, is required for the inhibition of hypoxic pulmonary vascular remodeling by heparin...
  30. ncbi request reprint Stretch-induced IL-8 depends on c-Jun NH2-terminal and nuclear factor-kappaB-inducing kinases
    Li Fu Li
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Physiol Lung Cell Mol Physiol 285:L464-75. 2003
    ..We conclude that stretch-induced transcriptional regulation of IL-8 mRNA and IL-8 production was via activation of AP-1 and NF-kappaB and was dependent on JNK and NIK activation, respectively...
  31. ncbi request reprint Systemic microvascular leak in an in vivo rat model of ventilator-induced lung injury
    Won Il Choi
    Department of Medicine, Pulmonary Critical Care Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Respir Crit Care Med 167:1627-32. 2003
    ..Endothelial NOS may mediate the systemic microvascular leak of the present model of VILI...
  32. ncbi request reprint Heparin oligosaccharide sequence and size essential for inhibition of pulmonary artery smooth muscle cell proliferation
    Hari G Garg
    Department of Medicine, Pulmonary Critical Care Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Carbohydr Res 337:2359-64. 2002
    ....
  33. ncbi request reprint Multidetector computed tomography for acute pulmonary embolism
    Paul D Stein
    Department of Research, St Joseph Mercy Oakland Hospital, Pontiac, Mich, USA
    N Engl J Med 354:2317-27. 2006
    ..The accuracy of multidetector computed tomographic angiography (CTA) for the diagnosis of acute pulmonary embolism has not been determined conclusively...
  34. pmc Atelectasis induced by thoracotomy causes lung injury during mechanical ventilation in endotoxemic rats
    Won Il Choi
    Department of Medicine, Keimyung University Dongsan Hospital, Daegu, Korea
    J Korean Med Sci 23:406-13. 2008
    ..In conclusion, the data suggest that atelectasis induced by thoracotomy causes lung injury during mechanical ventilation in endotoxemic rats through iNOS expression...

Research Grants1

  1. STRETCH INDUCED ACTIVATION OF MAP KINASES IN THE LUNG
    Deborah Quinn; Fiscal Year: 2003
    ....