Research Topics
Genomes and Genes
| Deborah A QuinnSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
Research Grants
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Publications
Involvement of Akt and endothelial nitric oxide synthase in ventilation-induced neutrophil infiltration: a prospective, controlled animal experimentLi Fu Li
Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, and Chang Gung University, Kweishan, Taoyuan 333, Taiwan
Crit Care 11:R89. 2007....- High-molecular-weight hyaluronan--a possible new treatment for sepsis-induced lung injury: a preclinical study in mechanically ventilated ratsYung Yang Liu
Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street Boston, MA 02114, USA
Crit Care 12:R102. 2008..High-molecular-weight hyaluronan (HMW HA), in contrast, has been found to be anti-inflammatory. We hypothesized that HMW HA would inhibit lung injury associated with sepsis and mechanical ventilation... - The role of phosphodiesterase 3 in endotoxin-induced acute kidney injuryWon Il Choi
Pulmonary Unit, Department of Internal Medicine, DongSan Hospital, Keimyung University School of Medicine, Daegu, Korea
BMC Infect Dis 9:80. 2009..We, therefore, hypothesized that endotoxin induced renal injury by activating phosphodiesterase 3 (PDE3) which metabolizes cAMP and that amrinone an inhibitor of PDE3 would prevent the renal injury... 
Interactions of lung stretch, hyperoxia, and MIP-2 production in ventilator-induced lung injuryDeborah A Quinn
Pulmonary Critical Care Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
J Appl Physiol 93:517-25. 2002....- Hyperoxia increases ventilator-induced lung injury via mitogen-activated protein kinases: a prospective, controlled animal experimentLi Fu Li
Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, and Chang Gung University, Kweishan, Taoyuan 333, Taiwan
Crit Care 11:R25. 2007.... 
Oxidant stress mediates inflammation and apoptosis in ventilator-induced lung injuryOlga Syrkina
Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02114, USA
Respirology 13:333-40. 2008..This study aimed to determine the effect of N-acetylcysteine (NAC), a scavenger of oxygen radicals, on lung inflammation and apoptosis in an in vivo model of VILI...- High MW hyaluronan inhibits smoke inhalation-induced lung injury and improves survivalPei Ming Huang
Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Respirology 15:1131-9. 2010..We hypothesized that treatment with HMW HA would block smoke inhalation lung injury by inhibiting smoke-induced lung inflammation and airway epithelial cell apoptosis... - The role of hyaluronan synthase 3 in ventilator-induced lung injuryKuan Jen Bai
Pulmonary and Critical Care Unit, Massachusetts General Hospital, 55 Fruit Street, Bulfinch 148, Boston, MA 02114, USA
Am J Respir Crit Care Med 172:92-8. 2005..We conclude that high VT induced low-molecular-weight hyaluronan production is dependent on de novo synthesis through hyaluronan synthase 3, and plays a role in the inflammatory response of ventilator-induced lung injury... - TLR4 through IFN-β promotes low molecular mass hyaluronan-induced neutrophil apoptosisShaw Wei Leu
Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
J Immunol 186:556-62. 2011..Thus, TLR4 plays a novel homeostatic role in noninfectious lung inflammation by accelerating the elimination of inflammatory neutrophils... - Inhibition of HA synthase 3 mRNA expression, with a phosphodiesterase 3 inhibitor, blocks lung injury in a septic ventilated rat modelHicham Mrabat
Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
Lung 187:233-9. 2009..The anti-inflammatory properties of MIL may be mediated by inhibition of HAS3 and/or MIP2 and could be beneficial in the treatment of sepsis... - Ventilation-induced neutrophil infiltration and apoptosis depend on apoptosis signal-regulated kinase 1 pathwayLi-Fu Li
Graduate Institute of Clinical Medical Sciences and Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan
Crit Care Med 33:1913-21. 2005..CONCLUSIONS: Our data showed that high tidal volume ventilation-induced MIP-2 production, neutrophil sequestration, and apoptotic cell death were dependent, in part, on activation of the ASK1/JNK/AP-1 pathway... - Intracellular glutathione in stretch-induced cytokine release from alveolar type-2 like cellsBehrouz Jafari
Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USA
Respirology 9:43-53. 2004..CONCLUSIONS: We conclude that oxidant release may play a role in lung cell stretch-induced cytokine release, and antioxidants, which increase intracellular GSH, may protect lung cells against stretch-induced injury... - Regulation of lung injury and repair by Toll-like receptors and hyaluronanDianhua Jiang
Department of Medicine, Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA
Nat Med 11:1173-9. 2005..Hyaluronan-TLR2 and hyaluronan-TLR4 interactions provide signals that initiate inflammatory responses, maintain epithelial cell integrity and promote recovery from acute lung injury... - Ventilation-induced neutrophil infiltration depends on c-Jun N-terminal kinaseLi-Fu Li
Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Respir Crit Care Med 169:518-24. 2004..We conclude that lung cell stretch in vivo results in increased lung neutrophil sequestration and increased MIP-2 production, which was, at least in part, dependent upon the JNK pathway... - Thrombospondin-1 null mice are resistant to hypoxia-induced pulmonary hypertensionCristhiaan D Ochoa
Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
J Cardiothorac Surg 5:32. 2010..In addition, TSP-1 produced by the pulmonary endothelium inhibits pulmonary artery smooth muscle cell growth. Based on these observations we sought to describe the pulmonary vascular changes in TSP-1(-/-) mice exposed to chronic hypoxia... - Gene expression of cyclin-dependent kinase inhibitors and effect of heparin on their expression in mice with hypoxia-induced pulmonary hypertensionLunyin Yu
Department of Medicine, Pulmonary and Critical Care Unit, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, USA
Biochem Biophys Res Commun 345:1565-72. 2006.... - TLR4 is a negative regulator in noninfectious lung inflammationHang Zhao
Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
J Immunol 184:5308-14. 2010..These data provide a molecular level explanation for the function of TLR4 in LMW HA (200 kDa)-induced lung inflammation, as inhibition of the beta form of pro-IL-1 promotes an anti-inflammatory response... - Low-molecular-weight heparin inhibits hypoxic pulmonary hypertension and vascular remodeling in guinea pigsEssam Al Ansari
Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Chest 132:1898-905. 2007..We have shown previously that antiproliferative unfractionated heparins block hypoxia-induced pulmonary arterial hypertension (PAH) and vascular remodeling, and hypothesized that low-molecular-weight heparins (LMWHs) would too... - Deficiency of the NHE1 gene prevents hypoxia-induced pulmonary hypertension and vascular remodelingLunyin Yu
Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Bulfinch 148, Boston, MA 02114 2696, USA
Am J Respir Crit Care Med 177:1276-84. 2008..However, a causal role for the NHE1 gene in pulmonary hypertension has not been determined... - Serine/threonine kinase-protein kinase B and extracellular signal-regulated kinase regulate ventilator-induced pulmonary fibrosis after bleomycin-induced acute lung injury: a prospective, controlled animal experimentLi Fu Li
Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, 5 Fu Hsing Street, Kweishan, Taoyuan 333, Taiwan
Crit Care 12:R103. 2008..We hypothesized that high-tidal-volume ventilation increased pulmonary fibrosis in acute lung injury via the serine/threonine kinase-protein kinase B (Akt) and mitogen-activated protein kinase pathways... - Unfractionated heparin and enoxaparin reduce high-stretch ventilation augmented lung injury: a prospective, controlled animal experimentLi Fu Li
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, 5 Fu Hsing Street, Kweishan, Taoyuan 333, Taiwan, Republic of China
Crit Care 13:R108. 2009.... - Heparin inhibits pulmonary artery smooth muscle cell proliferation through guanine nucleotide exchange factor-H1/RhoA/Rho kinase/p27Lunyin Yu
Pulmonary and Critical Care Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 2696, USA
Am J Respir Cell Mol Biol 44:524-30. 2011.... - Cyclic stretch affects pulmonary endothelial cell control of pulmonary smooth muscle cell growthCristhiaan D Ochoa
Pulmonary and Critical Care Unit, Massachusetts General Hospital, Bullfinch 148, 55 Fruit Street, Boston, MA 02114, USA
Am J Respir Cell Mol Biol 39:105-12. 2008..The complete identification and understanding of the secreted proteome of stretched PAECs may lead to new insights into the pathophysiology of pulmonary vascular remodeling... - JNK activation is responsible for mucus overproduction in smoke inhalation injuryWon Ii Choi
Pulmonary Critical Care Unit, Department of Medicine, Massachusettes General Hospital and Harvard Medical School, Boston, MA, USA
Respir Res 11:172. 2010..We hypothesized that gel-forming mucins may contribute to the increased mucus production in a smoke inhalation injury. We investigated the role of c-Jun N-terminal kinase (JNK) in modulating smoke-induced mucus secretion... - Heparin inhibits SMC growth in the presence of human and fetal bovine serumNaiyaratana Cindhuchao
Pulmonary/Critical Care Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Biochem Biophys Res Commun 302:84-8. 2003..The antiproliferative activity of the above HP preparation in HS may lead to an effective treatment of pulmonary vascular and systemic remodeling... - Inhibition of JNK activation prolongs survival after smoke inhalation from firesOlga L Syrkina
Pulmonary and Critical Care Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Am J Physiol Lung Cell Mol Physiol 292:L984-91. 2007..05). These in vivo data show that the JNK pathway plays a critical role in smoke-induced lung injury and offer an attractive therapeutic approach for this injury... - Low molecular weight hyaluronan from stretched lung enhances interleukin-8 expressionMarcella M Mascarenhas
Pulmonary and Critical Care Unit, Massachusetts General Hospital, 55 Fruit Street, Bulfinch 148, Boston, MA 02114, USA
Am J Respir Cell Mol Biol 30:51-60. 2004..These results indicated that de novo synthesis of LMW HA was induced in lung fibroblasts by stretch via tyrosine kinase signaling pathways, and may play a role in augmenting induction of proinflammatory cytokines in VILI... - Low molecular weight hyaluronan, via AP-1 and NF-κB signalling, induces IL-8 in transformed bronchial epithelial cellsChristiaan D Ochoa
Pulmonary and Critical Care Unit, Dept of Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston, USA
Swiss Med Wkly 141:w13255. 2011..In the present study, it was investigated whether LMW-HA synthesised in the lung, in response to cyclic stretch, increased IL-8 production in the bronchial epithelium... - Cyclin-dependent kinase inhibitor p27Kip1, but not p21WAF1/Cip1, is required for inhibition of hypoxia-induced pulmonary hypertension and remodeling by heparin in miceLunyin Yu
Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 2696, USA
Circ Res 97:937-45. 2005..Therefore, we conclude that the cyclin-dependent kinase inhibitor p27, but not p21, is required for the inhibition of hypoxic pulmonary vascular remodeling by heparin... - Systemic microvascular leak in an in vivo rat model of ventilator-induced lung injuryWon-Il Choi
Department of Medicine, Pulmonary/Critical Care Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Am J Respir Crit Care Med 167:1627-32. 2003..Endothelial NOS may mediate the systemic microvascular leak of the present model of VILI... - Stretch-induced IL-8 depends on c-Jun NH2-terminal and nuclear factor-kappaB-inducing kinasesLi-Fu Li
Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Am J Physiol Lung Cell Mol Physiol 285:L464-75. 2003..We conclude that stretch-induced transcriptional regulation of IL-8 mRNA and IL-8 production was via activation of AP-1 and NF-kappaB and was dependent on JNK and NIK activation, respectively... - Heparin oligosaccharide sequence and size essential for inhibition of pulmonary artery smooth muscle cell proliferationHari G Garg
Department of Medicine, Pulmonary Critical Care Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Carbohydr Res 337:2359-64. 2002.... - Multidetector computed tomography for acute pulmonary embolismPaul D Stein
Department of Research, St Joseph Mercy Oakland Hospital, Pontiac, Mich, USA
N Engl J Med 354:2317-27. 2006..The accuracy of multidetector computed tomographic angiography (CTA) for the diagnosis of acute pulmonary embolism has not been determined conclusively... - Atelectasis induced by thoracotomy causes lung injury during mechanical ventilation in endotoxemic ratsWon Il Choi
Department of Medicine, Keimyung University Dongsan Hospital, Daegu, Korea
J Korean Med Sci 23:406-13. 2008..In conclusion, the data suggest that atelectasis induced by thoracotomy causes lung injury during mechanical ventilation in endotoxemic rats through iNOS expression...
Research Grants
- STRETCH INDUCED ACTIVATION OF MAP KINASES IN THE LUNGDeborah Quinn; Fiscal Year: 2003....