Research Topics
Genomes and Genes | Louise E PurtonSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Publications
RARgamma is critical for maintaining a balance between hematopoietic stem cell self-renewal and differentiationLouise E Purton
Trescowthick Research Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
J Exp Med 203:1283-93. 2006..We conclude that the RARs have distinct roles in hematopoiesis and that RARgamma is a critical physiological and pharmacological regulator of the balance between HSC self-renewal and differentiation...
Limiting factors in murine hematopoietic stem cell assaysLouise E Purton
Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA 02114, USA
Cell Stem Cell 1:263-70. 2007..1990), the best single assay for quantitating HSC content...- A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiencyCarl R Walkley
Trescowthick Research Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria, 3002, Australia
Cell 129:1097-110. 2007..These data show that loss of RARgamma results in a nonhematopoietic cell-intrinsic MPS, revealing the capability of the microenvironment to be the sole cause of hematopoietic disorders... 
Osteopenia in Siah1a mutant miceIan J Frew
Trescowthick Research Laboratories, Peter MacCallum Cancer Institute, East Melbourne, Victoria 3002, Australia
J Biol Chem 279:29583-8. 2004..We propose that bone metabolism defects in Siah1a mutant mice are secondary to an alteration in an unidentified systemic, paracrine, or metabolic factor in these mice...- Negative cell-cycle regulators cooperatively control self-renewal and differentiation of haematopoietic stem cellsCarl R Walkley
Research Division, Peter MacCallum Cancer Centre, Victoria 3002, Australia
Nat Cell Biol 7:172-8. 2005..Together these data demonstrate that the MYC-antagonist MAD1 and cyclin-dependent kinase inhibitor p27(Kip1) cooperate to regulate the self-renewal and differentiation of HSCs in a context-dependent manner... - Gsα enhances commitment of mesenchymal progenitors to the osteoblast lineage but restrains osteoblast differentiation in miceJOY Y WU
Endocrine Unit, Massachusetts General Hospital, 50 Blossom Street, Boston, Massachusetts 02114, USA
J Clin Invest 121:3492-504. 2011.... - Granulocyte colony-stimulating factor and an RARalpha specific agonist, VTP195183, synergize to enhance the mobilization of hematopoietic progenitor cellsKirsten E Herbert
Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Transplantation 83:375-84. 2007.... - Identification of the molecular requirements for an RAR alpha-mediated cell cycle arrest during granulocytic differentiationCarl R Walkley
Division of Research, Peter MacCallum Cancer Centre, St Andrew s Place, East Melbourne, Victoria, 3002, Australia
Blood 103:1286-95. 2004..Moreover, these data demonstrate selectivity among the RARs for cell cycle arrest pathways and provide a direct mechanism to link differentiation induction and regulation of the Myc antagonist Mad1... - Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironmentCarl R Walkley
Department of Pediatric Oncology, Dana Farber Cancer Institute, Division of Hematology Oncology and Stem Cell Program, Children s Hospital Boston, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA
Cell 129:1081-95. 2007..Therefore, RB extrinsically regulates HSCs by maintaining the capacity of the BM to support normal hematopoiesis and HSCs... - The role of p202 in regulating hematopoietic cell proliferation and differentiationLouise E Ludlow
Gene Regulation Laboratory, Peter MacCallum Cancer Centre, East Melbourne VIC 3002, Australia
J Interferon Cytokine Res 28:5-11. 2008..Thus, p202 plays a role in regulating the proliferative capacity of hematopoietic cells... - Osteoblastic regulation of B lymphopoiesis is mediated by Gs{alpha}-dependent signaling pathwaysJOY Y WU
Endocrine Unit and Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 105:16976-81. 2008.... - Cell division and hematopoietic stem cells: not always exhaustingCarl R Walkley
Research Division, Peter MacCallum Cancer Centre, Victoria, Australia
Cell Cycle 4:893-6. 2005..One of the emerging themes of these studies is that of the importance of cell cycle regulators in the maintenance of HSCs... - Contrasting effects of P-selectin and E-selectin on the differentiation of murine hematopoietic progenitor cellsTetsuya Eto
Cell Adhesion and Trafficking Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Exp Hematol 33:232-42. 2005.... - The granulocyte-colony stimulating factor receptor (G-CSFR) interacts with retinoic acid receptors (RARs) in the regulation of myeloid differentiationLynette C Y Chee
Research Division, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
J Leukoc Biol 93:235-43. 2013..However, with the loss of G-CSFR, this expansion in granulopoiesis was attenuated, supporting the hypothesis that G-CSFR signaling interacts with RARs in the regulation of myeloid differentiation... - Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in miceSiddhartha Mukherjee
Center for Regenerative Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Invest 118:491-504. 2008..Thus, we show that a tissue-resident adult stem cell population in vivo can be pharmacologically modified to promote a regenerative function in adult animals... - MicroRNA miR-125a controls hematopoietic stem cell numberShangqin Guo
Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 107:14229-34. 2010..These data demonstrate cell-state-specific regulation by microRNA and identify a unique microRNA functioning to regulate the stem cell pool size... - Generation and analysis of Siah2 mutant miceIan J Frew
Trescowthick Research Laboratories, Peter MacCallum Cancer Institute, East Melbourne, Victoria 3002, Australia
Mol Cell Biol 23:9150-61. 2003..The observation that combined Siah2 and Siah1a mutation causes embryonic and neonatal lethality demonstrates that the highly homologous Siah proteins have partially overlapping functions in vivo... - Osteoclasts eat stem cells out of house and homeLouise E Purton
Nat Med 12:610-1. 2006 - An oxysterol-binding protein family identified in the mouseAngela M Anniss
Research Unit, Australian Red Cross Blood Service Victoria, South Melbourne, Australia
DNA Cell Biol 21:571-80. 2002..The identification of a family of ORP proteins in the mouse, the frequently preferred animal model for in vivo studies, should further our understanding of the function of these proteins and their interactions with each other...
Research Grants
- Regulation of HSC self-renewal by morphogensLOUISE PURTON; Fiscal Year: 2007..Previous attempts to increase the numbers of these cells both outside of and within the body have not been very successful. Our data suggest that a vitamin A compound may be very useful in improving both of these approaches. ..