Louise E Purton

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Roles of retinoids and retinoic Acid receptors in the regulation of hematopoietic stem cell self-renewal and differentiation
    Louise E Purton
    Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA 02114, USA
    PPAR Res 2007:87934. 2007
  2. doi request reprint Limiting factors in murine hematopoietic stem cell assays
    Louise E Purton
    Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA 02114, USA
    Cell Stem Cell 1:263-70. 2007
  3. pmc RARgamma is critical for maintaining a balance between hematopoietic stem cell self-renewal and differentiation
    Louise E Purton
    Trescowthick Research Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
    J Exp Med 203:1283-93. 2006
  4. pmc A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency
    Carl R Walkley
    Trescowthick Research Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria, 3002, Australia
    Cell 129:1097-110. 2007
  5. ncbi request reprint Negative cell-cycle regulators cooperatively control self-renewal and differentiation of haematopoietic stem cells
    Carl R Walkley
    Research Division, Peter MacCallum Cancer Centre, Victoria 3002, Australia
    Nat Cell Biol 7:172-8. 2005
  6. ncbi request reprint Osteopenia in Siah1a mutant mice
    Ian J Frew
    Trescowthick Research Laboratories, Peter MacCallum Cancer Institute, East Melbourne, Victoria 3002, Australia
    J Biol Chem 279:29583-8. 2004
  7. pmc Gsα enhances commitment of mesenchymal progenitors to the osteoblast lineage but restrains osteoblast differentiation in mice
    JOY Y WU
    Endocrine Unit, Massachusetts General Hospital, 50 Blossom Street, Boston, Massachusetts 02114, USA
    J Clin Invest 121:3492-504. 2011
  8. ncbi request reprint Granulocyte colony-stimulating factor and an RARalpha specific agonist, VTP195183, synergize to enhance the mobilization of hematopoietic progenitor cells
    Kirsten E Herbert
    Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
    Transplantation 83:375-84. 2007
  9. ncbi request reprint Identification of the molecular requirements for an RAR alpha-mediated cell cycle arrest during granulocytic differentiation
    Carl R Walkley
    Division of Research, Peter MacCallum Cancer Centre, St Andrew s Place, East Melbourne, Victoria, 3002, Australia
    Blood 103:1286-95. 2004
  10. pmc Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment
    Carl R Walkley
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Division of Hematology Oncology and Stem Cell Program, Children s Hospital Boston, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell 129:1081-95. 2007

Research Grants

  1. Regulation of HSC self-renewal by morphogens
    LOUISE PURTON; Fiscal Year: 2007

Collaborators

Detail Information

Publications20

  1. pmc Roles of retinoids and retinoic Acid receptors in the regulation of hematopoietic stem cell self-renewal and differentiation
    Louise E Purton
    Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA 02114, USA
    PPAR Res 2007:87934. 2007
    ..In recent years, however, a number of studies describing methods of increasing or decreasing the numbers of HSCs in a given population have emerged. Of major interest here are the emerging roles of retinoids in the regulation of HSCs...
  2. doi request reprint Limiting factors in murine hematopoietic stem cell assays
    Louise E Purton
    Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA 02114, USA
    Cell Stem Cell 1:263-70. 2007
    ..1990), the best single assay for quantitating HSC content...
  3. pmc RARgamma is critical for maintaining a balance between hematopoietic stem cell self-renewal and differentiation
    Louise E Purton
    Trescowthick Research Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
    J Exp Med 203:1283-93. 2006
    ..We conclude that the RARs have distinct roles in hematopoiesis and that RARgamma is a critical physiological and pharmacological regulator of the balance between HSC self-renewal and differentiation...
  4. pmc A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency
    Carl R Walkley
    Trescowthick Research Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria, 3002, Australia
    Cell 129:1097-110. 2007
    ..These data show that loss of RARgamma results in a nonhematopoietic cell-intrinsic MPS, revealing the capability of the microenvironment to be the sole cause of hematopoietic disorders...
  5. ncbi request reprint Negative cell-cycle regulators cooperatively control self-renewal and differentiation of haematopoietic stem cells
    Carl R Walkley
    Research Division, Peter MacCallum Cancer Centre, Victoria 3002, Australia
    Nat Cell Biol 7:172-8. 2005
    ..Together these data demonstrate that the MYC-antagonist MAD1 and cyclin-dependent kinase inhibitor p27(Kip1) cooperate to regulate the self-renewal and differentiation of HSCs in a context-dependent manner...
  6. ncbi request reprint Osteopenia in Siah1a mutant mice
    Ian J Frew
    Trescowthick Research Laboratories, Peter MacCallum Cancer Institute, East Melbourne, Victoria 3002, Australia
    J Biol Chem 279:29583-8. 2004
    ..We propose that bone metabolism defects in Siah1a mutant mice are secondary to an alteration in an unidentified systemic, paracrine, or metabolic factor in these mice...
  7. pmc Gsα enhances commitment of mesenchymal progenitors to the osteoblast lineage but restrains osteoblast differentiation in mice
    JOY Y WU
    Endocrine Unit, Massachusetts General Hospital, 50 Blossom Street, Boston, Massachusetts 02114, USA
    J Clin Invest 121:3492-504. 2011
    ....
  8. ncbi request reprint Granulocyte colony-stimulating factor and an RARalpha specific agonist, VTP195183, synergize to enhance the mobilization of hematopoietic progenitor cells
    Kirsten E Herbert
    Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
    Transplantation 83:375-84. 2007
    ....
  9. ncbi request reprint Identification of the molecular requirements for an RAR alpha-mediated cell cycle arrest during granulocytic differentiation
    Carl R Walkley
    Division of Research, Peter MacCallum Cancer Centre, St Andrew s Place, East Melbourne, Victoria, 3002, Australia
    Blood 103:1286-95. 2004
    ..Moreover, these data demonstrate selectivity among the RARs for cell cycle arrest pathways and provide a direct mechanism to link differentiation induction and regulation of the Myc antagonist Mad1...
  10. pmc Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment
    Carl R Walkley
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Division of Hematology Oncology and Stem Cell Program, Children s Hospital Boston, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell 129:1081-95. 2007
    ..Therefore, RB extrinsically regulates HSCs by maintaining the capacity of the BM to support normal hematopoiesis and HSCs...
  11. doi request reprint The role of p202 in regulating hematopoietic cell proliferation and differentiation
    Louise E Ludlow
    Gene Regulation Laboratory, Peter MacCallum Cancer Centre, East Melbourne VIC 3002, Australia
    J Interferon Cytokine Res 28:5-11. 2008
    ..Thus, p202 plays a role in regulating the proliferative capacity of hematopoietic cells...
  12. doi request reprint The granulocyte-colony stimulating factor receptor (G-CSFR) interacts with retinoic acid receptors (RARs) in the regulation of myeloid differentiation
    Lynette C Y Chee
    Research Division, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    J Leukoc Biol 93:235-43. 2013
    ..However, with the loss of G-CSFR, this expansion in granulopoiesis was attenuated, supporting the hypothesis that G-CSFR signaling interacts with RARs in the regulation of myeloid differentiation...
  13. ncbi request reprint Cell division and hematopoietic stem cells: not always exhausting
    Carl R Walkley
    Research Division, Peter MacCallum Cancer Centre, Victoria, Australia
    Cell Cycle 4:893-6. 2005
    ..One of the emerging themes of these studies is that of the importance of cell cycle regulators in the maintenance of HSCs...
  14. pmc Osteoblastic regulation of B lymphopoiesis is mediated by Gs{alpha}-dependent signaling pathways
    JOY Y WU
    Endocrine Unit and Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 105:16976-81. 2008
    ....
  15. ncbi request reprint Contrasting effects of P-selectin and E-selectin on the differentiation of murine hematopoietic progenitor cells
    Tetsuya Eto
    Cell Adhesion and Trafficking Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
    Exp Hematol 33:232-42. 2005
    ....
  16. pmc Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice
    Siddhartha Mukherjee
    Center for Regenerative Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 118:491-504. 2008
    ..Thus, we show that a tissue-resident adult stem cell population in vivo can be pharmacologically modified to promote a regenerative function in adult animals...
  17. pmc MicroRNA miR-125a controls hematopoietic stem cell number
    Shangqin Guo
    Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 107:14229-34. 2010
    ..These data demonstrate cell-state-specific regulation by microRNA and identify a unique microRNA functioning to regulate the stem cell pool size...
  18. pmc Generation and analysis of Siah2 mutant mice
    Ian J Frew
    Trescowthick Research Laboratories, Peter MacCallum Cancer Institute, East Melbourne, Victoria 3002, Australia
    Mol Cell Biol 23:9150-61. 2003
    ..The observation that combined Siah2 and Siah1a mutation causes embryonic and neonatal lethality demonstrates that the highly homologous Siah proteins have partially overlapping functions in vivo...
  19. ncbi request reprint Osteoclasts eat stem cells out of house and home
    Louise E Purton
    Nat Med 12:610-1. 2006
  20. ncbi request reprint An oxysterol-binding protein family identified in the mouse
    Angela M Anniss
    Research Unit, Australian Red Cross Blood Service Victoria, South Melbourne, Australia
    DNA Cell Biol 21:571-80. 2002
    ..The identification of a family of ORP proteins in the mouse, the frequently preferred animal model for in vivo studies, should further our understanding of the function of these proteins and their interactions with each other...

Research Grants1

  1. Regulation of HSC self-renewal by morphogens
    LOUISE PURTON; Fiscal Year: 2007
    ..Previous attempts to increase the numbers of these cells both outside of and within the body have not been very successful. Our data suggest that a vitamin A compound may be very useful in improving both of these approaches. ..