ARUNA DAS PRADHAN

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc High-molecular-weight and total adiponectin levels and incident symptomatic peripheral artery disease in women: a prospective investigation
    Deborah Y Ho
    Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
    Circulation 124:2303-11. 2011
  2. ncbi request reprint Cross-sectional correlates of fasting hyperinsulinaemia in post-menopausal women of different ethnic origin
    A D Pradhan
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Diabet Med 23:77-85. 2006
  3. doi request reprint Symptomatic peripheral arterial disease in women: nontraditional biomarkers of elevated risk
    Aruna D Pradhan
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Ave E, Boston, MA 02215 1204, USA
    Circulation 117:823-31. 2008
  4. ncbi request reprint Tissue plasminogen activator antigen and D-dimer as markers for atherothrombotic risk among healthy postmenopausal women
    Aruna D Pradhan
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Ave East, Boston, Mass 02215, USA
    Circulation 110:292-300. 2004
  5. ncbi request reprint Obesity, metabolic syndrome, and type 2 diabetes: inflammatory basis of glucose metabolic disorders
    Aruna Pradhan
    Harvard Medical School, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02215, USA
    Nutr Rev 65:S152-6. 2007
  6. pmc A randomized trial of low-dose aspirin in the prevention of clinical type 2 diabetes in women
    Aruna D Pradhan
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 32:3-8. 2009
  7. doi request reprint Effects of initiating insulin and metformin on glycemic control and inflammatory biomarkers among patients with type 2 diabetes: the LANCET randomized trial
    Aruna D Pradhan
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Ave E, Boston, MA 02215 1204, USA
    JAMA 302:1186-94. 2009
  8. pmc Hemoglobin A1c predicts diabetes but not cardiovascular disease in nondiabetic women
    Aruna D Pradhan
    Center for Cardiovascular Disease Prevention, Division of Cardiovascular Medicine, VA Boston Medical Center, Boston, Mass, USA
    Am J Med 120:720-7. 2007
  9. ncbi request reprint C-reactive protein is independently associated with fasting insulin in nondiabetic women
    Aruna D Pradhan
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, Mass 02215 1204, USA
    Arterioscler Thromb Vasc Biol 23:650-5. 2003
  10. ncbi request reprint Inflammatory biomarkers, hormone replacement therapy, and incident coronary heart disease: prospective analysis from the Women's Health Initiative observational study
    Aruna D Pradhan
    Center for Cardiovascular Disease Prevention, Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215 1204, USA
    JAMA 288:980-7. 2002

Detail Information

Publications25

  1. pmc High-molecular-weight and total adiponectin levels and incident symptomatic peripheral artery disease in women: a prospective investigation
    Deborah Y Ho
    Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
    Circulation 124:2303-11. 2011
    ..To our knowledge, no prior prospective studies have evaluated adiponectin, including high-molecular-weight (HMW) adiponectin, and incident peripheral artery disease (PAD)...
  2. ncbi request reprint Cross-sectional correlates of fasting hyperinsulinaemia in post-menopausal women of different ethnic origin
    A D Pradhan
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Diabet Med 23:77-85. 2006
    ..In a large ethnically diverse nationwide sample of post-menopausal women we explored the relationship between fasting insulin levels, ethnicity, and a wide range of anthropometric, socio-economic, and lifestyle factors...
  3. doi request reprint Symptomatic peripheral arterial disease in women: nontraditional biomarkers of elevated risk
    Aruna D Pradhan
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Ave E, Boston, MA 02215 1204, USA
    Circulation 117:823-31. 2008
    ..Few large-scale prospective studies have critically assessed plasma-based factors as predictors of peripheral arterial disease (PAD), and comparative data between individual biomarkers and lipid levels are sparse, especially among women...
  4. ncbi request reprint Tissue plasminogen activator antigen and D-dimer as markers for atherothrombotic risk among healthy postmenopausal women
    Aruna D Pradhan
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Ave East, Boston, Mass 02215, USA
    Circulation 110:292-300. 2004
    ..Few studies have evaluated this relationship in women. In addition, although menopausal hormone therapy (HT) may alter markers of fibrinolytic function, the relevance of this effect for coronary risk assessment has not been studied...
  5. ncbi request reprint Obesity, metabolic syndrome, and type 2 diabetes: inflammatory basis of glucose metabolic disorders
    Aruna Pradhan
    Harvard Medical School, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02215, USA
    Nutr Rev 65:S152-6. 2007
    ..These findings suggest that subclinical inflammation may be a contributing factor not only to the etiology of these metabolic disorders but also their cardiovascular complications...
  6. pmc A randomized trial of low-dose aspirin in the prevention of clinical type 2 diabetes in women
    Aruna D Pradhan
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 32:3-8. 2009
    ..We evaluated whether chronic low-dose aspirin prevents the development of clinical diabetes among initially healthy American women...
  7. doi request reprint Effects of initiating insulin and metformin on glycemic control and inflammatory biomarkers among patients with type 2 diabetes: the LANCET randomized trial
    Aruna D Pradhan
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Ave E, Boston, MA 02215 1204, USA
    JAMA 302:1186-94. 2009
    ..As diabetes is in part an inflammatory condition, the initiation of insulin and/or metformin may beneficially reduce levels of inflammatory biomarkers such as high-sensitivity C-reactive protein (hsCRP)...
  8. pmc Hemoglobin A1c predicts diabetes but not cardiovascular disease in nondiabetic women
    Aruna D Pradhan
    Center for Cardiovascular Disease Prevention, Division of Cardiovascular Medicine, VA Boston Medical Center, Boston, Mass, USA
    Am J Med 120:720-7. 2007
    ..Whether mild elevations of this biomarker provide prognostic information for development of clinically evident type 2 diabetes and cardiovascular disease among individuals at usual risk for these disorders is uncertain...
  9. ncbi request reprint C-reactive protein is independently associated with fasting insulin in nondiabetic women
    Aruna D Pradhan
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, Mass 02215 1204, USA
    Arterioscler Thromb Vasc Biol 23:650-5. 2003
    ..Insulin resistance is associated with chronic subclinical inflammation, and both conditions are linked with increased risk for type 2 diabetes mellitus and atherothrombotic cardiovascular disease...
  10. ncbi request reprint Inflammatory biomarkers, hormone replacement therapy, and incident coronary heart disease: prospective analysis from the Women's Health Initiative observational study
    Aruna D Pradhan
    Center for Cardiovascular Disease Prevention, Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215 1204, USA
    JAMA 288:980-7. 2002
    ..Several inflammatory biomarkers, including CRP, are associated with increased cardiovascular risk. However, whether the effect of HRT on CRP represents a clinical hazard is unknown...
  11. ncbi request reprint Soluble intercellular adhesion molecule-1, soluble vascular adhesion molecule-1, and the development of symptomatic peripheral arterial disease in men
    Aruna D Pradhan
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115 1204, USA
    Circulation 106:820-5. 2002
    ..It is not certain, however, whether similar relationships exist for the development of early systemic atherosclerosis...
  12. ncbi request reprint Platelet expression profiling and clinical validation of myeloid-related protein-14 as a novel determinant of cardiovascular events
    Aileen M Healy
    Millennium Pharmaceuticals, Inc, Cambridge, MA, USA
    Circulation 113:2278-84. 2006
    ..Because platelets lack nuclear DNA but retain megakaryocyte-derived mRNAs, the platelet transcriptome provides a novel window on gene expression preceding acute coronary events...
  13. pmc Myeloid-related protein 8/14 and the risk of cardiovascular death or myocardial infarction after an acute coronary syndrome in the Pravastatin or Atorvastatin Evaluation and Infection Therapy: Thrombolysis in Myocardial Infarction (PROVE IT-TIMI 22) trial
    David A Morrow
    Thrombolysis in Myocardial Infarction Study Group, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am Heart J 155:49-55. 2008
    ..Elevated concentrations of MRP-8/14 are associated with a higher risk for future cardiovascular events in apparently healthy individuals but have not been assessed with respect to prognosis in patients with acute coronary syndrome...
  14. ncbi request reprint Surgical management of infective endocarditis: early predictors of short-term morbidity and mortality
    Davinder S Jassal
    Cardiac Ultrasound Laboratory, Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Ann Thorac Surg 82:524-9. 2006
    ..Infective endocarditis is a diagnostic and therapeutic challenge that ultimately requires surgical intervention in 20% of all cases. Early determinants of morbidity and mortality in this high risk population are not well described...
  15. ncbi request reprint Plasma homocysteine concentration, statin therapy, and the risk of first acute coronary events
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02215, USA
    Circulation 105:1776-9. 2002
    ..Elevated homocysteine levels are associated with increased coronary risk, and it has been suggested that homocysteine screening may provide a method to identify high-risk patients for aggressive primary prevention...
  16. ncbi request reprint Insulin, proinsulin, proinsulin:insulin ratio, and the risk of developing type 2 diabetes mellitus in women
    Aruna D Pradhan
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Med 114:438-44. 2003
    ..To assess the associations among baseline levels of fasting insulin and proinsulin, proinsulin:insulin ratio, and the development of type 2 diabetes mellitus in apparently healthy middle-aged women...
  17. ncbi request reprint Hemoglobin A1c level and future cardiovascular events among women
    Gavin J Blake
    Cardiovascular Division, The Center for Cardiovascular Disease Prevention, and the Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Arch Intern Med 164:757-61. 2004
    ..We sought to test this hypothesis prospectively in a cohort of women without overt cardiovascular disease...
  18. ncbi request reprint Plasma lycopene, other carotenoids, and the risk of type 2 diabetes in women
    Lu Wang
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Am J Epidemiol 164:576-85. 2006
    ..91 (95% CI: 0.46, 1.81) for beta-cryptoxanthin, and 1.35 (95% CI: 0.68, 2.69) for lutein/zeaxanthin. There was no prospective association between baseline plasma carotenoids and the risk of type 2 diabetes in middle-aged and older women...
  19. ncbi request reprint Interrelationships between inflammation, C-reactive protein, and insulin resistance
    Chiadi E Ndumele
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Cardiometab Syndr 1:190-6. 2006
    ..Multiple clinical studies are now underway that are evaluating whether agents traditionally used to improve glycemic control may also significantly reduce hs-CRP...
  20. pmc Metabolic syndrome, inflammation, and risk of symptomatic peripheral artery disease in women: a prospective study
    David Conen
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Circulation 120:1041-7. 2009
    ..We therefore evaluated the relationship between MetS, inflammation, and incident PAD...
  21. ncbi request reprint Obesity, diabetes, and coronary risk in women
    Aruna D Pradhan
    Division of Preventive Medicine Division of Cardiology, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    J Cardiovasc Risk 9:323-30. 2002
    ..In order to further examine these complex associations, we review the available epidemiological data regarding the impact of obesity and diabetes on cardiovascular health in women...
  22. ncbi request reprint Tissue Doppler imaging predicts left ventricular dysfunction and mortality in a murine model of cardiac injury
    Tomas G Neilan
    Cardiac Ultrasound Laboratory, Cardiology Division of the Department of Medicine, Harvard Medical School, USA
    Eur Heart J 27:1868-75. 2006
    ..Tissue Doppler imaging (TDI) can detect subtle LV dysfunction. The aim of this study was to investigate whether TDI indices can predict LV systolic dysfunction and mortality following exposure to doxorubicin (DOX) in mice...
  23. ncbi request reprint Baseline associations between postmenopausal hormone therapy and inflammatory, haemostatic, and lipid biomarkers of coronary heart disease. The Women's Health Initiative Observational Study
    Robert D Langer
    Department of Family and Preventive Medicine, University of California, San Diego, 9500 Gilman Drive, MC 0978, La Jolla, CA 92093 0978, USA
    Thromb Haemost 93:1108-16. 2005
    ..Some associations differed between women with and without incident CHD, especially for EP, where inflammatory and thrombotic markers were higher in cases. These associations remain speculative pending confirmation in randomized trials...
  24. ncbi request reprint Accuracy of administrative coding for type 2 diabetes in children, adolescents, and young adults
    Eric L Ding
    Diabetes Care 30:e98; author reply e99. 2007
  25. doi request reprint Derivation of a size-independent variable for scaling of cardiac dimensions in a normal adult population
    Tomas G Neilan
    Cardiac Ultrasound Laboratory, Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02115 2696, USA
    J Am Soc Echocardiogr 21:779-85. 2008
    ..We therefore compared the isometric and allometric modeling approach to assess the optimal scaling method (using the left atrial dimension [LAD] as an example) in a large group of adults with normal echocardiograms...

Research Grants3

  1. Novel and Traditional Risk Factors for Symptomatic PAD in Women
    Aruna Pradhan; Fiscal Year: 2007
    ..End of Abstract) ..
  2. Mechanisms of Statin-Induced DM in JUPITER (Rosuvasatin for CVD Prevention)
    ARUNA DAS PRADHAN; Fiscal Year: 2010
    ....