MARK COLEMAN POZNANSKY

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Long-term survival of transplanted allogeneic cells engineered to express a T cell chemorepellent
    Natalia Papeta
    Infectious Diseases Medicine Division and Partner AIDS Research Center, Massachusetts General Hospital, Charlestown, MA, USA
    Transplantation 83:174-83. 2007
  2. pmc R5-SHIV induces multiple defects in T cell function during early infection of rhesus macaques including accumulation of T reg cells in lymph nodes
    Michael Santosuosso
    Infectious Diseases Medicine Division, Vaccine and Immunotherapy Center, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
    PLoS ONE 6:e18465. 2011
  3. pmc A novel mycobacterial Hsp70-containing fusion protein targeting mesothelin augments antitumor immunity and prolongs survival in murine models of ovarian cancer and mesothelioma
    Jianping Yuan
    Vaccine and Immunotherapy Center, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, 149 13th Street, Charlestown, Boston, MA 02129, USA
    J Hematol Oncol 7:15. 2014
  4. pmc Thymocyte emigration is mediated by active movement away from stroma-derived factors
    Mark C Poznansky
    AIDS Research Center and Massachusetts General Hospital Cancer Center, Building 149 13th Street, Room 4005A, Boston, MA 02129, USA
    J Clin Invest 109:1101-10. 2002
  5. ncbi request reprint Immune responses to HIV Gp120 that facilitate viral escape
    Liljana Stevceva
    Partners AIDS Research Center, Department of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, CNY Building 149, 13th Street, Charlestown, MA 02129, USA
    Curr HIV Res 5:47-54. 2007
  6. ncbi request reprint A CXCR4-dependent chemorepellent signal contributes to the emigration of mature single-positive CD4 cells from the fetal thymus
    Fabrizio Vianello
    Partners AIDS Research Center, Infectious Diseases Medicine, and Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Immunol 175:5115-25. 2005
  7. ncbi request reprint Murine B16 melanomas expressing high levels of the chemokine stromal-derived factor-1/CXCL12 induce tumor-specific T cell chemorepulsion and escape from immune control
    Fabrizio Vianello
    Partners AIDS Research Center, Infectious Diseases Division, and Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA
    J Immunol 176:2902-14. 2006
  8. ncbi request reprint The efficacy of T cell-mediated immune responses is reduced by the envelope protein of the chimeric HIV-1/SIV-KB9 virus in vivo
    Liljana Stevceva
    Partners AIDS Research Center and Infectious Diseases Medicine, Massachusetts General Hospital East, Charlestown, MA 02129, USA
    J Immunol 181:5510-21. 2008
  9. ncbi request reprint Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor
    Gregor B Adams
    Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 439:599-603. 2006
  10. pmc Dynamic alterations in chemokine gradients induce transendothelial shuttling of human T cells under physiologic shear conditions
    Jack Y Lee
    Harvard Skin Disease Research Center and Department of Dermatology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Leukoc Biol 86:1285-94. 2009

Collaborators

  • David Scadden
  • Liljana Stevceva
  • Ruth M Ruprecht
  • Andrew D Luster
  • Daniel Irimia
  • Nagadenahalli B Siddappa
  • FRANCOIS J VILLINGER
  • R Sackstein
  • Bruce Walker
  • MEGAN T SYKES
  • Nathalie Scholler
  • Fabrizio Vianello
  • Michael Santosuosso
  • Elda Righi
  • Agnes L Chenine
  • Gregor B Adams
  • Tao Chen
  • Natalia Papeta
  • Jianping Yuan
  • PIERRE R LEBLANC
  • Jack Y Lee
  • Anna Huttenlocher
  • Ying Ting Mok
  • Natasha White
  • William G Tharp
  • William K Hart
  • Paul Kraft
  • Karissa T Chabner
  • Diana M Brainard
  • Yuan Yang
  • Patrick Reeves
  • Glenn Dranoff
  • Timothy Brauns
  • Pierre LeBlanc
  • Huabiao Chen
  • Mai Nguyen
  • Ben Forbes
  • Roderick Bronson
  • Satoshi Kashiwagi
  • Gilberte Jean-Mary
  • Nadiah Hashim Arrifin
  • Xiaoyun Tong
  • Sandra Orsulic
  • Paramjit Uppal
  • Svetlana Korochkina
  • JEFFREY GELFAND
  • Jean Nezivar
  • Shiu Lok Hu
  • E David Hill
  • Musie Ghebremichael
  • Hari N Mylvaganam
  • Avi Hai Hovav
  • Brett Kodish
  • Elizabeth Strobert
  • Chris Souder
  • James G Else
  • Sandra J Lee
  • W Evan Secor
  • Gaia Sciaranghella
  • Rama R Amara
  • Victor G Kramer
  • Vijayakumar Velu
  • Francis J Novembre
  • Robert A Rasmussen
  • Daniel C Anderson
  • SHAWN P O'NEIL
  • Catherine D Buzney
  • Victoria Lindstrom
  • Ashish Malik
  • Jessamyn Bagley
  • Victor Yoon
  • Lyle Gererty
  • Guiling Zhao
  • John Iacomini
  • David Sachs
  • Sarah Rhee
  • Ralph Weissleder
  • Moritz F Kircher
  • Eric Swart
  • Ian R Alley
  • Zbigniew M Szczepiorkowski
  • Douglas P Olson
  • Claudine H Kos
  • Giorgio Palu
  • Edward M Brown
  • Martin R Pollak
  • Mehmet Toner
  • Ivona T Olszak
  • Xiang Hui Ren
  • Alicja K Trocha

Detail Information

Publications17

  1. ncbi request reprint Long-term survival of transplanted allogeneic cells engineered to express a T cell chemorepellent
    Natalia Papeta
    Infectious Diseases Medicine Division and Partner AIDS Research Center, Massachusetts General Hospital, Charlestown, MA, USA
    Transplantation 83:174-83. 2007
    ..We postulated that this mechanism could be exploited therapeutically and that allogeneic cells engineered to express a chemorepellent protein would not be rejected...
  2. pmc R5-SHIV induces multiple defects in T cell function during early infection of rhesus macaques including accumulation of T reg cells in lymph nodes
    Michael Santosuosso
    Infectious Diseases Medicine Division, Vaccine and Immunotherapy Center, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
    PLoS ONE 6:e18465. 2011
    ....
  3. pmc A novel mycobacterial Hsp70-containing fusion protein targeting mesothelin augments antitumor immunity and prolongs survival in murine models of ovarian cancer and mesothelioma
    Jianping Yuan
    Vaccine and Immunotherapy Center, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, 149 13th Street, Charlestown, Boston, MA 02129, USA
    J Hematol Oncol 7:15. 2014
    ....
  4. pmc Thymocyte emigration is mediated by active movement away from stroma-derived factors
    Mark C Poznansky
    AIDS Research Center and Massachusetts General Hospital Cancer Center, Building 149 13th Street, Room 4005A, Boston, MA 02129, USA
    J Clin Invest 109:1101-10. 2002
    ..Thymic emigration is mediated, at least in part, by specific fugetaxis-inducing factors to which only mature cells respond...
  5. ncbi request reprint Immune responses to HIV Gp120 that facilitate viral escape
    Liljana Stevceva
    Partners AIDS Research Center, Department of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, CNY Building 149, 13th Street, Charlestown, MA 02129, USA
    Curr HIV Res 5:47-54. 2007
    ..Therefore, apart from the essential role in viral attachment and infection of cells, gp120 possesses several properties that affect the behavior of immune cells and skew the immune response to the virus facilitating viral escape...
  6. ncbi request reprint A CXCR4-dependent chemorepellent signal contributes to the emigration of mature single-positive CD4 cells from the fetal thymus
    Fabrizio Vianello
    Partners AIDS Research Center, Infectious Diseases Medicine, and Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Immunol 175:5115-25. 2005
    ..These novel findings support the thesis that the CXCR4-mediated chemorepellent activity of intrathymic SDF-1 contributes to SP thymocyte egress from the fetal thymus...
  7. ncbi request reprint Murine B16 melanomas expressing high levels of the chemokine stromal-derived factor-1/CXCL12 induce tumor-specific T cell chemorepulsion and escape from immune control
    Fabrizio Vianello
    Partners AIDS Research Center, Infectious Diseases Division, and Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA
    J Immunol 176:2902-14. 2006
    ..The repulsion of tumor Ag-specific T cells away from melanomas expressing CXCL12 confirms the chemorepellent activity of high concentrations of CXCL12 and may represent a novel mechanism by which certain tumors evade the immune system...
  8. ncbi request reprint The efficacy of T cell-mediated immune responses is reduced by the envelope protein of the chimeric HIV-1/SIV-KB9 virus in vivo
    Liljana Stevceva
    Partners AIDS Research Center and Infectious Diseases Medicine, Massachusetts General Hospital East, Charlestown, MA 02129, USA
    J Immunol 181:5510-21. 2008
    ..These findings have significant implications for our understanding of the contribution of non-entry-related functions of HIV-1 gp120 to the pathogenesis of HIV/AIDS...
  9. ncbi request reprint Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor
    Gregor B Adams
    Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 439:599-603. 2006
    ..CaR has a function in retaining HSCs in close physical proximity to the endosteal surface and the regulatory niche components associated with it...
  10. pmc Dynamic alterations in chemokine gradients induce transendothelial shuttling of human T cells under physiologic shear conditions
    Jack Y Lee
    Harvard Skin Disease Research Center and Department of Dermatology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Leukoc Biol 86:1285-94. 2009
    ..These findings broaden our understanding of chemokine biology and support a novel paradigm by which temporospatial modulations in subendothelial chemokine display drive cell migration from interstitial compartments into the bloodstream...
  11. pmc Relative transmissibility of an R5 clade C simian-human immunodeficiency virus across different mucosae in macaques parallels the relative risks of sexual HIV-1 transmission in humans via different routes
    Agnes L Chenine
    Dana Farber Cancer Institute, Massachusetts General Hospital, Boston, Massachusetts 02115 6084, USA
    J Infect Dis 201:1155-63. 2010
    ..Worldwide, approximately 90% of all human immunodeficiency virus (HIV) transmissions occur mucosally; almost all involve R5 strains. Risks of sexual HIV acquisition are highest for rectal, then vaginal, and finally oral exposures...
  12. ncbi request reprint HIV-1 envelope protein gp120 is present at high concentrations in secondary lymphoid organs of individuals with chronic HIV-1 infection
    Michael Santosuosso
    Partners AIDS Research Center and Infectious Diseases Medicine, Massachusetts General Hospital East, Charlestown, MA 02129, USA
    J Infect Dis 200:1050-3. 2009
    ..These findings underpin the clinical relevance of nonentry functions of gp120 and the chronic nature of human immunodeficiency virus (HIV)-induced immune dysregulation...
  13. ncbi request reprint Heterologous cells cooperate to augment stem cell migration, homing, and engraftment
    Gregor B Adams
    Partners AIDS Research Center and MGH Cancer Center, Harvard Medical School, Massachusetts General Hospital, Boston 02129, USA
    Blood 101:45-51. 2003
    ..This modification of cell migration by neighboring cells provides broad possibilities for combinatorial effects between cells of different types to influence cell localization...
  14. pmc Migration of antigen-specific T cells away from CXCR4-binding human immunodeficiency virus type 1 gp120
    Diana M Brainard
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, 5th Floor, Charlestown, MA 02114, USA
    J Virol 78:5184-93. 2004
    ..These data suggest that the active movement of T cells away from CXCR4-binding HIV-1 gp120, which we previously termed fugetaxis, may provide a novel mechanism by which HIV-1 evades challenge by immune effector cells in vivo...
  15. pmc Reverse leukocyte migration can be attractive or repulsive
    Anna Huttenlocher
    Department of Medical Microbiology and Immunology and Pediatrics, University of Wisconsin Madison, 4205 Microbial Science Building, 1550 Linden Drive, Madison, WI 53706, USA
    Trends Cell Biol 18:298-306. 2008
    ....
  16. ncbi request reprint Generation of a tissue-engineered thymic organoid
    Fabrizio Vianello
    Department of Hematology, University Medical School of Padova, Italy
    Methods Mol Biol 380:163-70. 2007
    ....
  17. ncbi request reprint Fugetaxis: active movement of leukocytes away from a chemokinetic agent
    Fabrizio Vianello
    Partners AIDS Research Center, Massachusetts General Hospital East, Charlestown Navy Yard, 02129, USA
    J Mol Med (Berl) 83:752-63. 2005
    ..We believe that current data support the thesis that a greater understanding of leukocyte fugetaxis will lead to the development of novel therapeutic approaches for a wide range of human diseases...

Research Grants12

  1. Movement of Recipient T-Cells Away From an Allograft
    Mark Poznansky; Fiscal Year: 2003
    ....
  2. Active Movement of Immune Cells Away From HIV-1 gp120
    Mark Poznansky; Fiscal Year: 2001
    ....
  3. HIV-1 gp120 induced CTL chemorepulsion:dysregulation of migration & localization
    Mark Poznansky; Fiscal Year: 2009
    ..We hope, in this way, to delineate both a novel mechanism by which HIV-1 evades the immune system and a new immunotherapeutic target for HIV-1 infected individuals. ..
  4. HIV-1 gp120 induced CTL chemorepulsion:dysregulation of migration & localization
    Mark Poznansky; Fiscal Year: 2009
    ..We hope, in this way, to delineate both a novel mechanism by which HIV-1 evades the immune system and a new immunotherapeutic target for HIV-1 infected individuals. ..
  5. HIV-1 gp120 induced CTL chemorepulsion:dysregulation of migration & localization
    Mark Poznansky; Fiscal Year: 2007
    ..We hope, in this way, to delineate both a novel mechanism by which HIV-1 evades the immune system and a new immunotherapeutic target for HIV-1 infected individuals. ..
  6. HIV-1 gp120 induced CTL chemorepulsion:dysregulation of migration & localization
    Mark Poznansky; Fiscal Year: 2006
    ..We hope, in this way, to delineate both a novel mechanism by which HIV-1 evades the immune system and a new immunotherapeutic target for HIV-1 infected individuals. ..
  7. Active Movement of Immune Cells Away From HIV-1 gp120
    Mark Poznansky; Fiscal Year: 2005
    ....
  8. Active Movement of Immune Cells Away From HIV-1 gp120
    Mark Poznansky; Fiscal Year: 2004
    ....
  9. Active Movement of Immune Cells Away From HIV-1 gp120
    Mark Poznansky; Fiscal Year: 2003
    ....
  10. Active Movement of Immune Cells Away From HIV-1 gp120
    Mark Poznansky; Fiscal Year: 2002
    ....
  11. HIV-1 gp120 induced CTL chemorepulsion:dysregulation of migration & localization
    MARK COLEMAN POZNANSKY; Fiscal Year: 2010
    ..We hope, in this way, to delineate both a novel mechanism by which HIV-1 evades the immune system and a new immunotherapeutic target for HIV-1 infected individuals. ..