Michael A Posternak

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi Therapeutic effect of follow-up assessments on antidepressant and placebo response rates in antidepressant efficacy trials: meta-analysis
    Michael A Posternak
    Depression Clinical and Research Program, Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, 50 Staniford Street, Suite 4 01, Boston, MA 02114, USA
    Br J Psychiatry 190:287-92. 2007
  2. ncbi A pilot effectiveness study: placebo-controlled trial of adjunctive L-triiodothyronine (T3) used to accelerate and potentiate the antidepressant response
    Michael Posternak
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Neuropsychopharmacol 11:15-25. 2008
  3. ncbi A description of next-step switching versus augmentation practices for outpatients with treatment-resistant major depressive disorder enrolled in an academic specialty clinic
    George I Papakostas
    Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Ann Clin Psychiatry 17:161-5. 2005
  4. doi Simultaneous initiation (coinitiation) of pharmacotherapy with triiodothyronine and a selective serotonin reuptake inhibitor for major depressive disorder: a quantitative synthesis of double-blind studies
    George I Papakostas
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Int Clin Psychopharmacol 24:19-25. 2009
  5. ncbi Prevalence and features of intermittent explosive disorder in a clinical setting
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, The Pritzker School of Medicine, The University of Chicago, Chicago, IL 60637, USA
    J Clin Psychiatry 66:1221-7. 2005
  6. ncbi Empirical testing of two models for staging antidepressant treatment resistance
    Timothy Petersen
    Depression Clinical and Research Program, Massachusetts General Hospital, 15 Parkman Street, WACC 812, Boston, MA 02114, USA
    J Clin Psychopharmacol 25:336-41. 2005
  7. ncbi Unipolar mania over the course of a 20-year follow-up study
    David A Solomon
    NIMH Collaborative Program on the Psychobiology of Depression Clinical Studies, at Mood Disorders Program, Department of Psychiatry, Rhode Island Hospital, 593 Eddy Street, Providence RI 02903 4970, USA
    Am J Psychiatry 160:2049-51. 2003
  8. ncbi Heterogeneity among depressed outpatients considered to be in remission
    Mark Zimmerman
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Rhode Island Hospital, Providence, RI 02905, USA
    Compr Psychiatry 48:113-7. 2007
  9. ncbi Tachyphylaxis in unipolar major depressive disorder
    David A Solomon
    Department of Psychiatry and Human Behavior, Brown University, 593 Eddy Street, Providence, RI 02903, USA
    J Clin Psychiatry 66:283-90. 2005
  10. ncbi Standardized clinical outcome rating scale for depression for use in clinical practice
    Mark Zimmerman
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Rhode Island Hospital, Providence, Rhode Island 02905, USA
    Depress Anxiety 22:36-40. 2005

Detail Information

Publications46

  1. ncbi Therapeutic effect of follow-up assessments on antidepressant and placebo response rates in antidepressant efficacy trials: meta-analysis
    Michael A Posternak
    Depression Clinical and Research Program, Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, 50 Staniford Street, Suite 4 01, Boston, MA 02114, USA
    Br J Psychiatry 190:287-92. 2007
    ..It remains unclear how much various factors contribute to the placebo response...
  2. ncbi A pilot effectiveness study: placebo-controlled trial of adjunctive L-triiodothyronine (T3) used to accelerate and potentiate the antidepressant response
    Michael Posternak
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Neuropsychopharmacol 11:15-25. 2008
    ..The effectiveness model may be an untapped mechanism for evaluating the value of psychopharmacological agents...
  3. ncbi A description of next-step switching versus augmentation practices for outpatients with treatment-resistant major depressive disorder enrolled in an academic specialty clinic
    George I Papakostas
    Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Ann Clin Psychiatry 17:161-5. 2005
    ....
  4. doi Simultaneous initiation (coinitiation) of pharmacotherapy with triiodothyronine and a selective serotonin reuptake inhibitor for major depressive disorder: a quantitative synthesis of double-blind studies
    George I Papakostas
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Int Clin Psychopharmacol 24:19-25. 2009
    ..Clearly, further work is needed to help determine whether there are specific MDD populations that can, indeed, benefit from T3-SSRI coinitiation therapy...
  5. ncbi Prevalence and features of intermittent explosive disorder in a clinical setting
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, The Pritzker School of Medicine, The University of Chicago, Chicago, IL 60637, USA
    J Clin Psychiatry 66:1221-7. 2005
    ....
  6. ncbi Empirical testing of two models for staging antidepressant treatment resistance
    Timothy Petersen
    Depression Clinical and Research Program, Massachusetts General Hospital, 15 Parkman Street, WACC 812, Boston, MA 02114, USA
    J Clin Psychopharmacol 25:336-41. 2005
    ..This study was undertaken to empirically test 2 recent models for staging treatment resistance...
  7. ncbi Unipolar mania over the course of a 20-year follow-up study
    David A Solomon
    NIMH Collaborative Program on the Psychobiology of Depression Clinical Studies, at Mood Disorders Program, Department of Psychiatry, Rhode Island Hospital, 593 Eddy Street, Providence RI 02903 4970, USA
    Am J Psychiatry 160:2049-51. 2003
    ..Using data from a longitudinal study of the mood disorders, the investigators address the phenomenon of unipolar mania...
  8. ncbi Heterogeneity among depressed outpatients considered to be in remission
    Mark Zimmerman
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Rhode Island Hospital, Providence, RI 02905, USA
    Compr Psychiatry 48:113-7. 2007
    ..These results suggest that there is as much heterogeneity among patients who are typically considered to be in remission as there is among responders. This supports recommendations to lower the cutoff on the HAM-D to define remission...
  9. ncbi Tachyphylaxis in unipolar major depressive disorder
    David A Solomon
    Department of Psychiatry and Human Behavior, Brown University, 593 Eddy Street, Providence, RI 02903, USA
    J Clin Psychiatry 66:283-90. 2005
    ..This study describes recurrence of major depression despite maintenance pharmacotherapy, termed tachyphylaxis...
  10. ncbi Standardized clinical outcome rating scale for depression for use in clinical practice
    Mark Zimmerman
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Rhode Island Hospital, Providence, Rhode Island 02905, USA
    Depress Anxiety 22:36-40. 2005
    ..This measure could make it more feasible to conduct effectiveness studies in clinical practice...
  11. ncbi Why isn't bupropion the most frequently prescribed antidepressant?
    Mark Zimmerman
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Rhode Island Hospital, Providence, RI, USA
    J Clin Psychiatry 66:603-10. 2005
    ....
  12. ncbi Dual reuptake inhibitors incur lower rates of tachyphylaxis than selective serotonin reuptake inhibitors: a retrospective study
    Michael A Posternak
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Rhode Island Hospital, Providence, 02905, USA
    J Clin Psychiatry 66:705-7. 2005
    ..Rates of tachyphylaxis were compared in venlafaxine and tricyclic antidepressants (TCAs), which act as dual reuptake inhibitors, versus SSRIs...
  13. ncbi Discordance between self-reported symptom severity and psychosocial functioning ratings in depressed outpatients: implications for how remission from depression should be defined
    Mark Zimmerman
    Department of Psychiatry and Human Behavior, Brown Medical School, Rhode Island Hospital, Providence, RI, USA
    Psychiatry Res 141:185-91. 2006
    ..This suggests that current symptom-based definitions of remission might be too narrow...
  14. ncbi Differences between minimally depressed patients who do and do not consider themselves to be in remission
    Mark Zimmerman
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Rhode Island Hospital, Providence, RI 02905, USA
    J Clin Psychiatry 66:1134-8. 2005
    ....
  15. doi A clinically useful depression outcome scale
    Mark Zimmerman
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Providence, RI 02905, USA
    Compr Psychiatry 49:131-40. 2008
    ..Thus, the results of this large validation study of the CUDOS shows that it is a reliable and valid measure of depression that is feasible to incorporate into routine clinical practice...
  16. ncbi How should remission from depression be defined? The depressed patient's perspective
    Mark Zimmerman
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Providence, RI, USA
    Am J Psychiatry 163:148-50. 2006
    ..The authors' goal was to determine what depressed patients consider important in defining remission from depression...
  17. ncbi Impact of study design on the results of continuation studies of antidepressants
    Mark Zimmerman
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Rhode Island Hospital, Providence, RI, USA
    J Clin Psychopharmacol 27:177-81. 2007
    ....
  18. ncbi Partial validation of the atypical features subtype of major depressive disorder
    Michael A Posternak
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Rhode Island Hospital, 235 Plain St, Suite 501, Providence, RI 02905, USA
    Arch Gen Psychiatry 59:70-6. 2002
    ..Our study sought to reevaluate the validity of atypical depression by examining the demographic and clinical features of a large cohort of depressed patients who met DSM-IV criteria for atypical features...
  19. ncbi Validity of a self-report depression symptom scale for identifying remission in depressed outpatients
    Mark Zimmerman
    Department of Psychiatry and Human Behavior, Brown Medical School, Rhode Island Hospital, Providence, RI 02905, USA
    Compr Psychiatry 47:185-8. 2006
    ..These findings support the validity of a self-report depression questionnaire as an index of remission status among treatment responders...
  20. ncbi The naturalistic course of unipolar major depression in the absence of somatic therapy
    Michael A Posternak
    Brown University School of Medicine, Department of Psychiatry and Human Behavior, Providence, Rhode Island, USA
    J Nerv Ment Dis 194:324-9. 2006
    ..Because treatment-seeking behavior is known to be associated with a worse prognosis, 23 weeks probably represents a lower-limit approximation of the median duration of an untreated depressive episode...
  21. ncbi Developing brief scales for use in clinical practice: the reliability and validity of single-item self-report measures of depression symptom severity, psychosocial impairment due to depression, and quality of life
    Mark Zimmerman
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Rhode Island Hospital, Providence, USA
    J Clin Psychiatry 67:1536-41. 2006
    ....
  22. ncbi Generalizability of antidepressant efficacy trials: differences between depressed psychiatric outpatients who would or would not qualify for an efficacy trial
    Mark Zimmerman
    Department of Psychiatry and Human Behavior, Brown Medical School, Rhode Island Hospital, Providence, RI 02905, USA
    Am J Psychiatry 162:1370-2. 2005
    ....
  23. ncbi Is the cutoff to define remission on the Hamilton Rating Scale for Depression too high?
    Mark Zimmerman
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Rhode Island Hospital, Providence, Rhode Island
    J Nerv Ment Dis 193:170-5. 2005
    ..Our results thus support the use of a lower cutoff on the HRSD than has been traditionally used to define remission...
  24. ncbi Is there a delay in the antidepressant effect? A meta-analysis
    Michael A Posternak
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Rhode Island Hospital, Providence, RI 02905, USA
    J Clin Psychiatry 66:148-58. 2005
    ....
  25. ncbi An open-label study of citalopram in the treatment of pathological gambling
    Mark Zimmerman
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Providence, RI, USA
    J Clin Psychiatry 63:44-8. 2002
    ..This study evaluated the effectiveness of citalopram in the treatment of pathological gambling...
  26. ncbi Are subjects in pharmacological treatment trials of depression representative of patients in routine clinical practice?
    Mark Zimmerman
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Rhode Island Hospital, Providence, USA
    Am J Psychiatry 159:469-73. 2002
    ..This study estimated the proportion of depressed patients treated in routine clinical practice who would meet standard inclusion/exclusion criteria for an efficacy trial...
  27. ncbi Anger and aggression in psychiatric outpatients
    Michael A Posternak
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Rhode Island Hospital, Providence, RI, USA
    J Clin Psychiatry 63:665-72. 2002
    ..We also sought to determine which Axis I and Axis II disorders were associated with increased rates of subjective anger and aggressive behavior...
  28. ncbi Symptom severity and exclusion from antidepressant efficacy trials
    Mark Zimmerman
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Rhode Island Hospital, Providence, USA
    J Clin Psychopharmacol 22:610-4. 2002
    ..AETs tend to include the subset of depressed individuals with moderate to severe MDD and exclude a significant proportion of depressed patients who have mild MDD. The implications of these findings are discussed...
  29. ncbi How many subjects with major depressive disorder meet eligibility requirements of an antidepressant efficacy trial?
    Gabor I Keitner
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Rhode Island Hospital, 593 Eddy St, Providence, RI 02903, USA
    J Clin Psychiatry 64:1091-3. 2003
    ..To evaluate the generalizability of the results of antidepressant efficacy trials by determining how many subjects with DSM-IV major depressive disorder who apply for entry into such trials are ultimately enrolled...
  30. ncbi Exclusion criteria used in antidepressant efficacy trials: consistency across studies and representativeness of samples included
    Mark Zimmerman
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Rhode Island Hospital, Providence, USA
    J Nerv Ment Dis 192:87-94. 2004
    ....
  31. ncbi Assessing past treatment history: test-retest reliability of the Treatment Response to Antidepressant Questionnaire
    Michael A Posternak
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Rhode Island Hospital, Providence, USA
    J Nerv Ment Dis 192:95-102. 2004
    ..The TRAQ can be administered by non-MDs as a reliable measure for collecting standardized information regarding antidepressant treatment history via patient interview...
  32. ncbi Defining remission on the Montgomery-Asberg depression rating scale
    Mark Zimmerman
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Bayside Medical Center, 235 Plain Street, Providence, R I 02905, USA
    J Clin Psychiatry 65:163-8. 2004
    ..The goal of the present study was to establish an empirically based cutoff on the MADRS for defining remission...
  33. ncbi Using questionnaires to screen for psychiatric disorders: a comment on a study of screening for bipolar disorder in the community
    Mark Zimmerman
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Rhode Island Hospital, Providence, RI, USA
    J Clin Psychiatry 65:605-10; discussion 721. 2004
  34. ncbi Elevated rates of psychosis among treatment-seeking Hispanic patients with major depression
    Michael A Posternak
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Rhode Island Hospital, Providence, Rhode Island, USA
    J Nerv Ment Dis 193:66-9. 2005
    ..It remains unclear whether these reports represent true psychosis or culturally influenced idioms of distress...
  35. ncbi Generalizability of antidepressant efficacy trials
    Mark Zimmerman
    Brown University School of Medicine, Rhode Island Hospital, USA
    Essent Psychopharmacol 6:45-58. 2004
  36. ncbi Using a self-report depression scale to identify remission in depressed outpatients
    Mark Zimmerman
    Bayside Medical Center, 235 Plain St, Providence, RI 02905, USA
    Am J Psychiatry 161:1911-3. 2004
    ..This study derived a cutoff on a self-report depression questionnaire corresponding to the most widely used definition of remission (a score < or =7 on the 17-item Hamilton Depression Rating Scale)...
  37. ncbi A reevaluation of the exclusion criteria used in antidepressant efficacy trials
    Michael A Posternak
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Rhode Island Hospital, Providence 02905, USA
    Am J Psychiatry 159:191-200. 2002
    ..The authors review the current state of knowledge about treatment response rates in individuals who are typically excluded from antidepressant efficacy trials...
  38. ncbi Derivation of a definition of remission on the Montgomery-Asberg depression rating scale corresponding to the definition of remission on the Hamilton rating scale for depression
    Mark Zimmerman
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Rhode Island Hospital, 235 Plain Street, Suite 501, Providence, RI 02905, USA
    J Psychiatr Res 38:577-82. 2004
    ..To facilitate comparisons of studies using the HRSD and MADRS our results suggest that a cutoff of 10 on the MADRS is equivalent to the HRSD cutoff of 7...
  39. ncbi Implications of using different cut-offs on symptom severity scales to define remission from depression
    Mark Zimmerman
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Rhode Island Hospital, Providence, Rhode Island, USA
    Int Clin Psychopharmacol 19:215-20. 2004
    ..The cut-offs used to define remission from depression considerably influence the percentage of patients considered to be in remission. Lower cut-off scores than those most commonly used to define remission appear to be more valid...
  40. ncbi How accurate are patients in reporting their antidepressant treatment history?
    Michael A Posternak
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Rhode Island Hospital, Providence, RI, USA
    J Affect Disord 75:115-24. 2003
    ..It is currently unknown how accurate patients are in describing and characterizing their antidepressant treatment history...
  41. ncbi The prevalence of atypical features across mood, anxiety, and personality disorders
    Michael A Posternak
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Rhode Island Hospital, Providence, RI 02905, USA
    Compr Psychiatry 43:253-62. 2002
    ..It is unclear whether personality pathology is independently associated with the atypical features subtype...
  42. ncbi Is it time to replace the Hamilton Depression Rating Scale as the primary outcome measure in treatment studies of depression?
    Mark Zimmerman
    J Clin Psychopharmacol 25:105-10. 2005
  43. ncbi The effectiveness of switching antidepressants during remission: a case series of depressed patients who experienced intolerable side effects
    Michael A Posternak
    Bayside Medical Center, 235 Plain St, Suite 501, Providence, RI 02905, USA
    J Affect Disord 69:237-40. 2002
    ..The present study sought to determine the viability of such a strategy...
  44. ncbi Remission in depressed outpatients: more than just symptom resolution?
    Mark Zimmerman
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Rhode Island Hospital, Bayside Medical Center, Providence, RI 02905, USA
    J Psychiatr Res 42:797-801. 2008
    ....
  45. pmc Assessment of insight into delusional beliefs in schizophrenia using the Brown Assessment of Beliefs Scale
    Gary B Kaplan
    Schizophr Res 82:279-81. 2006
  46. ncbi Lack of association between seasonality and psychopathology in psychiatric outpatients
    Michael A Posternak
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Bayside Medical Center, Providence, RI 02905, USA
    Psychiatry Res 112:187-94. 2002
    ..We conclude from these results that the association between seasonality and psychopathology may not be discernible at the level of presentations to an outpatient psychiatric practice...