K D Poss

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. pmc Heme oxygenase 1 is required for mammalian iron reutilization
    K D Poss
    Howard Hughes Medical Institute, Center for Learning and Memory, Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 94:10919-24. 1997
  2. pmc Reduced stress defense in heme oxygenase 1-deficient cells
    K D Poss
    Howard Hughes Medical Institute, Center for Learning and Memory, Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 94:10925-30. 1997
  3. ncbi request reprint Hippocampal long-term potentiation is normal in heme oxygenase-2 mutant mice
    K D Poss
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139, USA
    Neuron 15:867-73. 1995
  4. ncbi request reprint Roles for Fgf signaling during zebrafish fin regeneration
    K D Poss
    Howard Hughes Medical Institute, Eccles Institute of Human Genetics, University of Utah Health Sciences Center, 15N 2030E, Salt Lake City, Utah, 84112, USA
    Dev Biol 222:347-58. 2000
  5. pmc Targeted gene deletion of heme oxygenase 2 reveals neural role for carbon monoxide
    R Zakhary
    Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 94:14848-53. 1997
  6. ncbi request reprint Ejaculatory abnormalities in mice with targeted disruption of the gene for heme oxygenase-2
    A L Burnett
    Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Med 4:84-7. 1998
  7. pmc Oxygen toxicity and iron accumulation in the lungs of mice lacking heme oxygenase-2
    P A Dennery
    Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305, USA
    J Clin Invest 101:1001-11. 1998
  8. ncbi request reprint Haem oxygenase-1 prevents cell death by regulating cellular iron
    C D Ferris
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Cell Biol 1:152-7. 1999
  9. pmc The indispensability of heme oxygenase-1 in protecting against acute heme protein-induced toxicity in vivo
    K A Nath
    Nephrology Research Unit, Mayo Clinic Foundation, Rochester, Minnesota 55905, USA
    Am J Pathol 156:1527-35. 2000

Collaborators

Detail Information

Publications9

  1. pmc Heme oxygenase 1 is required for mammalian iron reutilization
    K D Poss
    Howard Hughes Medical Institute, Center for Learning and Memory, Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 94:10919-24. 1997
    ..Our results indicate that Hmox1 has an important recycling role by facilitating the release of iron from hepatic and renal cells, and describe a mouse model of human iron metabolic disorders...
  2. pmc Reduced stress defense in heme oxygenase 1-deficient cells
    K D Poss
    Howard Hughes Medical Institute, Center for Learning and Memory, Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 94:10925-30. 1997
    ..Our in vitro and in vivo results provide genetic evidence that up-regulation of Hmox1 serves as an adaptive mechanism to protect cells from oxidative damage during stress...
  3. ncbi request reprint Hippocampal long-term potentiation is normal in heme oxygenase-2 mutant mice
    K D Poss
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139, USA
    Neuron 15:867-73. 1995
    ..Our data indicate that carbon monoxide produced endogenously by HO is unlikely to be a neuromodulator required for LTP in the hippocampus...
  4. ncbi request reprint Roles for Fgf signaling during zebrafish fin regeneration
    K D Poss
    Howard Hughes Medical Institute, Eccles Institute of Human Genetics, University of Utah Health Sciences Center, 15N 2030E, Salt Lake City, Utah, 84112, USA
    Dev Biol 222:347-58. 2000
    ..Our findings indicate that zebrafish fin blastema formation and regenerative outgrowth require Fgf signaling...
  5. pmc Targeted gene deletion of heme oxygenase 2 reveals neural role for carbon monoxide
    R Zakhary
    Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 94:14848-53. 1997
    ..In nNOSDelta/Delta animals, NOS inhibitors selectively lost their efficacy, and HO inhibitors were inactive in HO-2(Delta)/Delta animals...
  6. ncbi request reprint Ejaculatory abnormalities in mice with targeted disruption of the gene for heme oxygenase-2
    A L Burnett
    Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Med 4:84-7. 1998
    ..Reflex activity of the bulbospongiosus muscle, which mediates ejaculation and ejaculatory behavior, is markedly diminished in mice with targeted deletion of the gene for HO2 (HO2-)...
  7. pmc Oxygen toxicity and iron accumulation in the lungs of mice lacking heme oxygenase-2
    P A Dennery
    Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305, USA
    J Clin Invest 101:1001-11. 1998
    ..These results suggest that HO-2 functions to augment the turnover of lung iron during oxidative stress, and that this function does not appear to be compensated for by induction of HO-1 in the knockouts...
  8. ncbi request reprint Haem oxygenase-1 prevents cell death by regulating cellular iron
    C D Ferris
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Cell Biol 1:152-7. 1999
    ..Thus, cytoprotection by HO1 is attributable to its augmentation of iron efflux, reflecting a role for HO1 in modulating intracellular iron levels and regulating cell viability...
  9. pmc The indispensability of heme oxygenase-1 in protecting against acute heme protein-induced toxicity in vivo
    K A Nath
    Nephrology Research Unit, Mayo Clinic Foundation, Rochester, Minnesota 55905, USA
    Am J Pathol 156:1527-35. 2000
    ..We conclude that the induction of HO-1 is an indispensable response in protecting against acute heme protein toxicity in vivo...