Gabriel Popescu

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. ncbi request reprint Diffraction phase microscopy for quantifying cell structure and dynamics
    Gabriel Popescu
    George R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Lett 31:775-7. 2006
  2. ncbi request reprint Fourier phase microscopy for investigation of biological structures and dynamics
    Gabriel Popescu
    George R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Lett 29:2503-5. 2004
  3. ncbi request reprint Quantitative phase imaging of live cells using fast Fourier phase microscopy
    Niyom Lue
    Spectroscopy Laboratory, Massachusetts Institute of Technology, MA 02139, USA
    Appl Opt 46:1836-42. 2007
  4. pmc Synthetic aperture tomographic phase microscopy for 3D imaging of live cells in translational motion
    Niyom Lue
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Express 16:16240-6. 2008
  5. pmc Measurement of red blood cell mechanics during morphological changes
    Yongkeun Park
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 107:6731-6. 2010
  6. pmc Live cell refractometry using Hilbert phase microscopy and confocal reflectance microscopy
    Niyom Lue
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Phys Chem A 113:13327-30. 2009
  7. pmc Static and dynamic light scattering of healthy and malaria-parasite invaded red blood cells
    Yongkeun Park
    Massachusetts Institute of Technology, G R Harrison Spectroscopy Laboratory, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    J Biomed Opt 15:020506. 2010
  8. pmc Optical imaging of cell mass and growth dynamics
    Gabriel Popescu
    George R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA
    Am J Physiol Cell Physiol 295:C538-44. 2008
  9. pmc Measurement of the nonlinear elasticity of red blood cell membranes
    Yongkeun Park
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 83:051925. 2011
  10. ncbi request reprint Quantitative phase imaging using actively stabilized phase-shifting low-coherence interferometry
    Hidenao Iwai
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Lett 29:2399-401. 2004

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Diffraction phase microscopy for quantifying cell structure and dynamics
    Gabriel Popescu
    George R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Lett 31:775-7. 2006
    ..The potential of the technique for quantifying nanoscale motions in live cells is demonstrated by experiments on red blood cells...
  2. ncbi request reprint Fourier phase microscopy for investigation of biological structures and dynamics
    Gabriel Popescu
    George R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Lett 29:2503-5. 2004
    ..The results obtained on epithelial and red blood cells demonstrate the potential of this instrument for quantitative investigation of the structure and dynamics associated with biological systems without sample preparation...
  3. ncbi request reprint Quantitative phase imaging of live cells using fast Fourier phase microscopy
    Niyom Lue
    Spectroscopy Laboratory, Massachusetts Institute of Technology, MA 02139, USA
    Appl Opt 46:1836-42. 2007
    ....
  4. pmc Synthetic aperture tomographic phase microscopy for 3D imaging of live cells in translational motion
    Niyom Lue
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Express 16:16240-6. 2008
    ....
  5. pmc Measurement of red blood cell mechanics during morphological changes
    Yongkeun Park
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 107:6731-6. 2010
    ..This mechanical transition can alter cell circulation and impede oxygen delivery...
  6. pmc Live cell refractometry using Hilbert phase microscopy and confocal reflectance microscopy
    Niyom Lue
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Phys Chem A 113:13327-30. 2009
    ..The accuracy of the axially averaged index measurement is 0.002. This approach can provide novel biological assays of label-free living cells in situ...
  7. pmc Static and dynamic light scattering of healthy and malaria-parasite invaded red blood cells
    Yongkeun Park
    Massachusetts Institute of Technology, G R Harrison Spectroscopy Laboratory, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    J Biomed Opt 15:020506. 2010
    ..Progressive changes to the biophysical properties of the Pf-RBC membrane are captured from dynamic light scattering...
  8. pmc Optical imaging of cell mass and growth dynamics
    Gabriel Popescu
    George R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA
    Am J Physiol Cell Physiol 295:C538-44. 2008
    ..Overall, this study shows that interferometeric quantitative phase microscopy represents a noninvasive optical assay for monitoring cell growth, characterizing cellular motility, and investigating the subcellular motions of living cells...
  9. pmc Measurement of the nonlinear elasticity of red blood cell membranes
    Yongkeun Park
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 83:051925. 2011
    ..As the cell swells, the elastic contribution from the now tensed lipid membrane becomes dominant...
  10. ncbi request reprint Quantitative phase imaging using actively stabilized phase-shifting low-coherence interferometry
    Hidenao Iwai
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Lett 29:2399-401. 2004
    ..Depth gating via low-coherence light allows phase measurement from weakly reflecting biological samples. We demonstrate phase images from a test structure and living cells...
  11. ncbi request reprint Harmonic phase-dispersion microscope with a Mach-Zehnder interferometer
    Andrew Ahn
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Appl Opt 44:1188-90. 2005
    ..We demonstrate quantitative phase-dispersion images of test structures and biological samples...
  12. pmc Tissue refractometry using Hilbert phase microscopy
    Niyom Lue
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Lett 32:3522-4. 2007
    ..We present results obtained for liver tissue affected by a lysosomal storage disease and show that our technique can quantify structural changes during this disease development...
  13. pmc Imaging red blood cell dynamics by quantitative phase microscopy
    Gabriel Popescu
    George R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Blood Cells Mol Dis 41:10-6. 2008
    ..By providing non-invasive methods for imaging mechanics of live cells, these novel techniques provide an opportunity for high-throughput analysis and study of RBC mechanical properties in health and disease...
  14. pmc Light scattering of human red blood cells during metabolic remodeling of the membrane
    Yongkeun Park
    Massachusetts Institute of Technology, G R Harrison Spectroscopy Laboratory, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    J Biomed Opt 16:011013. 2011
    ..RBC cytosolic ATPs are both chemically and metabolically depleted, and the corresponding scattering signals are compared with the light scattering signal of normal RBCs having physiologic levels of ATP...
  15. pmc Metabolic remodeling of the human red blood cell membrane
    Yongkeun Park
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 107:1289-94. 2010
    ....
  16. ncbi request reprint Live cell refractometry using microfluidic devices
    Niyom Lue
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Opt Lett 31:2759-61. 2006
    ..To decouple the contributions to the phase signal from the cell refractive index and thickness, we confined the cells in microchannels. The results are confirmed by comparison with measurements of spherical cells in suspension...
  17. pmc Confocal diffraction phase microscopy of live cells
    Niyom Lue
    G H Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Opt Lett 33:2074-6. 2008
    ....
  18. ncbi request reprint Fresnel particle tracing in three dimensions using diffraction phase microscopy
    Yongkeun Park
    GR Harrison Spectroscopy Laboratory, Massachusettes Institute of Technology, Cambridge, Massachusettes 02139, USA
    Opt Lett 32:811-3. 2007
    ..The particles are localized in space within an error cube of 20 nm x 20 nm x 20 nm for a 33 Hz acquisition rate and 20s recording time...
  19. pmc Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum
    Yongkeun Park
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 105:13730-5. 2008
    ..These findings offer potential, and sufficiently general, avenues for identifying, through cell membrane dynamics, pathological states that cause or accompany human diseases...
  20. ncbi request reprint Optical measurement of cell membrane tension
    Gabriel Popescu
    George R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Phys Rev Lett 97:218101. 2006
    ..This is consistent with the cytoskeleton confinement model, in which the cytoskeleton inhibits membrane fluctuations [Gov et al., Phys. Rev. Lett. 90, 228101, (2003)...
  21. ncbi request reprint Tissue self-affinity and polarized light scattering in the born approximation: a new model for precancer detection
    Martin Hunter
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Phys Rev Lett 97:138102. 2006
    ..Power law exponents used to fit dysplastic tissue site spectra are significantly smaller than those from normal sites, indicating that changes in tissue self-affinity can serve as a potential biomarker for precancer...
  22. ncbi request reprint Observation of dynamic subdomains in red blood cells
    Gabriel Popescu
    J Biomed Opt 11:040503. 2006
    ..75 nm over 45 min. The results reveal the existence of dynamic, independent subdomains across the cells that fluctuate at various dominant frequencies...
  23. ncbi request reprint Erythrocyte structure and dynamics quantified by Hilbert phase microscopy
    Gabriel Popescu
    J Biomed Opt 10:060503. 2005
    ..The subnanometer path-length sensitivity at the millisecond time scales is exemplified by measuring the hemoglobin flow out of the cell during hemolysis...
  24. ncbi request reprint Hilbert phase microscopy for investigating fast dynamics in transparent systems
    Takahiro Ikeda
    Hamamatsu Photonics K K, 5000 Hirakuchi, Hamakita, Shizuoka 434 8601, Japan
    Opt Lett 30:1165-7. 2005
    ....
  25. ncbi request reprint Jones phase microscopy of transparent and anisotropic samples
    Zhuo Wang
    Quantitative Light Imaging Laboratory, Department of Electrical and Computer Engineering, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Opt Lett 33:1270-2. 2008
    ..The principle of the technique is demonstrated with measurements of a liquid crystal spatial light modulator and the potential for live cell imaging with experiments on live neurons in culture...