M H Pollack

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Aripiprazole as augmentation treatment of refractory generalized anxiety disorder and panic disorder
    Elizabeth A Hoge
    Department of Psychiatry, Harvard Medical School, Boston, MA 02114, USA
    CNS Spectr 13:522-7. 2008
  2. ncbi request reprint A novel cognitive-behavioral approach for treatment-resistant drug dependence
    Mark H Pollack
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Subst Abuse Treat 23:335-42. 2002
  3. ncbi request reprint Comorbidity, neurobiology, and pharmacotherapy of social anxiety disorder
    M H Pollack
    Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston 02114, USA
    J Clin Psychiatry 62:24-9. 2001
  4. ncbi request reprint Novel treatment approaches for refractory anxiety disorders
    Mark H Pollack
    Harvard Medical School and Center for Anxiety and Traumatic Stress Related Disorders, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Depress Anxiety 25:467-76. 2008
  5. ncbi request reprint Optimizing pharmacotherapy of generalized anxiety disorder to achieve remission
    M H Pollack
    Anxiety Disorders Program, Massachusetts General Hospital, Boston 02114, USA
    J Clin Psychiatry 62:20-5. 2001
  6. ncbi request reprint A double-blind study of the efficacy of venlafaxine extended-release, paroxetine, and placebo in the treatment of panic disorder
    Mark H Pollack
    Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Depress Anxiety 24:1-14. 2007
  7. ncbi request reprint Persistent posttraumatic stress disorder following September 11 in patients with bipolar disorder
    Mark H Pollack
    Department of Psychiatry, Massachusetts General Hospital, Boston, Mass, USA
    J Clin Psychiatry 67:394-9. 2006
  8. ncbi request reprint The selective GABA reuptake inhibitor tiagabine for the treatment of generalized anxiety disorder: results of a placebo-controlled study
    Mark H Pollack
    Anxiety Disorders Program, Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA
    J Clin Psychiatry 66:1401-8. 2005
  9. ncbi request reprint Comorbid anxiety and depression
    Mark H Pollack
    Center for Anxiety and Traumatic Stress Related Disorders, Massachusetts General Hospital, Harvard Medical School, Boston, Mass 02114, USA
    J Clin Psychiatry 66:22-9. 2005
  10. ncbi request reprint Olanzapine augmentation of fluoxetine for refractory generalized anxiety disorder: a placebo controlled study
    Mark H Pollack
    Center for Anxiety and Traumatic Stress Related Disorders, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Biol Psychiatry 59:211-5. 2006

Detail Information

Publications127 found, 100 shown here

  1. ncbi request reprint Aripiprazole as augmentation treatment of refractory generalized anxiety disorder and panic disorder
    Elizabeth A Hoge
    Department of Psychiatry, Harvard Medical School, Boston, MA 02114, USA
    CNS Spectr 13:522-7. 2008
    ..Individuals with anxiety disorders often remain symptomatic despite treatment with a first-line pharmacologic agent. More research examining pharmacotherapy augmentation strategies to improve outcomes is needed...
  2. ncbi request reprint A novel cognitive-behavioral approach for treatment-resistant drug dependence
    Mark H Pollack
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Subst Abuse Treat 23:335-42. 2002
    ..Reasons for differential performance by women and men and future directions for this new treatment are discussed...
  3. ncbi request reprint Comorbidity, neurobiology, and pharmacotherapy of social anxiety disorder
    M H Pollack
    Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston 02114, USA
    J Clin Psychiatry 62:24-9. 2001
    ..Efforts to increase the recognition of social anxiety disorder as a common, distressing, and disabling condition are critical. This article discusses the comorbidity, neurobiology, and pharmacotherapy of social anxiety disorder...
  4. ncbi request reprint Novel treatment approaches for refractory anxiety disorders
    Mark H Pollack
    Harvard Medical School and Center for Anxiety and Traumatic Stress Related Disorders, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Depress Anxiety 25:467-76. 2008
    ..Progress in the development of new treatments has great promise, but will only succeed through a concerted research effort that systematically evaluates potential areas of importance and properly uses scarce resources...
  5. ncbi request reprint Optimizing pharmacotherapy of generalized anxiety disorder to achieve remission
    M H Pollack
    Anxiety Disorders Program, Massachusetts General Hospital, Boston 02114, USA
    J Clin Psychiatry 62:20-5. 2001
    ..This article discusses the optimization of pharmacotherapy with the goal of promoting remission in patients with GAD...
  6. ncbi request reprint A double-blind study of the efficacy of venlafaxine extended-release, paroxetine, and placebo in the treatment of panic disorder
    Mark H Pollack
    Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Depress Anxiety 24:1-14. 2007
    ..Adverse events were mild or moderate and similar between active treatment groups. Venlafaxine ER and paroxetine were effective and well tolerated in the treatment of panic disorder...
  7. ncbi request reprint Persistent posttraumatic stress disorder following September 11 in patients with bipolar disorder
    Mark H Pollack
    Department of Psychiatry, Massachusetts General Hospital, Boston, Mass, USA
    J Clin Psychiatry 67:394-9. 2006
    ....
  8. ncbi request reprint The selective GABA reuptake inhibitor tiagabine for the treatment of generalized anxiety disorder: results of a placebo-controlled study
    Mark H Pollack
    Anxiety Disorders Program, Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA
    J Clin Psychiatry 66:1401-8. 2005
    ..To evaluate the efficacy and tolerability of tiagabine, a selective gamma-aminobutyric acid (GABA) reuptake inhibitor, in adults with generalized anxiety disorder (GAD)...
  9. ncbi request reprint Comorbid anxiety and depression
    Mark H Pollack
    Center for Anxiety and Traumatic Stress Related Disorders, Massachusetts General Hospital, Harvard Medical School, Boston, Mass 02114, USA
    J Clin Psychiatry 66:22-9. 2005
    ..Cognitive-behavioral therapy is also an effective therapeutic alternative for affected patients...
  10. ncbi request reprint Olanzapine augmentation of fluoxetine for refractory generalized anxiety disorder: a placebo controlled study
    Mark H Pollack
    Center for Anxiety and Traumatic Stress Related Disorders, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Biol Psychiatry 59:211-5. 2006
    ..We present one of the first randomized controlled trials for refractory GAD, comprising double blind augmentation with olanzapine or placebo for patients remaining symptomatic on fluoxetine...
  11. ncbi request reprint Early improvement predicts endpoint remission status in sertraline and placebo treatments of panic disorder
    Mark H Pollack
    Anxiety Disorders Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, WAC 812, 15 Parkman Street, Boston, MA 02114, USA
    J Psychiatr Res 36:229-36. 2002
    ....
  12. ncbi request reprint The pharmacotherapy of panic disorder
    Mark H Pollack
    Center for Anxiety and Traumatic Stress Related Disorders, Massachusetts General Hospital, Harvard Medical School, Boston, Mass, USA
    J Clin Psychiatry 66:23-7. 2005
    ....
  13. ncbi request reprint Unmet needs in the treatment of anxiety disorders
    Mark H Pollack
    Center for Anxiety and Traumatic Stress Related Disorders, Massachusetts General Hospital, Boston, MA, 02114
    Psychopharmacol Bull 38:31-7. 2004
    ..However, a definitive place for these newer therapeutic strategies in the anxiety disorder treatment armamentarium awaits evidence from large, controlled studies. Psychopharmacology Bulletin. 2004;38(Suppl 1): 31-37...
  14. ncbi request reprint Predictors of outcome following venlafaxine extended-release treatment of DSM-IV generalized anxiety disorder: a pooled analysis of short- and long-term studies
    Mark H Pollack
    Department of Psychiatry, Anxiety Disorders Program, Massachusetts General Hospital, WAC 812, 15 Parkman Street, Boston, MA 02215, USA
    J Clin Psychopharmacol 23:250-9. 2003
    ..The strongest trends emerged for history of substance abuse or dependence and symptoms of restlessness, sleep disturbance, and difficulty concentrating...
  15. ncbi request reprint WCA recommendations for the long-term treatment of panic disorder
    Mark H Pollack
    Division of Psychiatry, Huddinge University Hospital, Stockholm, Sweden
    CNS Spectr 8:17-30. 2003
    ..Long-term efficacy and ease of use are important considerations in treatment selection, as maintenance treatment is recommended for at least 12-24 months, and in some cases, indefinitely...
  16. ncbi request reprint Combined paroxetine and clonazepam treatment strategies compared to paroxetine monotherapy for panic disorder
    Mark H Pollack
    Department of Psychiatry, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    J Psychopharmacol 17:276-82. 2003
    ..Initiating combined treatment followed by benzodiazepine taper after a few weeks may provide early benefit while avoiding the potential adverse consequences of long-term combination therapy...
  17. ncbi request reprint Paroxetine in the treatment of generalized anxiety disorder: results of a placebo-controlled, flexible-dosage trial
    M H Pollack
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    J Clin Psychiatry 62:350-7. 2001
    ..The objective of this randomized, double-blind, placebo-controlled study was to investigate the efficacy and safety of paroxetine in outpatients with generalized anxiety disorder (GAD)...
  18. doi request reprint Eszopiclone for the treatment of posttraumatic stress disorder and associated insomnia: a randomized, double-blind, placebo-controlled trial
    Mark H Pollack
    Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital, One Bowdoin Square, Sixth Floor, Boston, MA 02114, USA
    J Clin Psychiatry 72:892-7. 2011
    ..We present the first prospective, randomized, double-blind, placebo-controlled trial of a non-benzodiazepine hypnotic agent for the treatment of PTSD and associated insomnia...
  19. ncbi request reprint Refractory generalized anxiety disorder
    Mark H Pollack
    Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychiatry 70:32-8. 2009
    ..Innovative treatments, including anticonvulsants, atypical antipsychotics, and others, as well as treatment targeting concomitant insomnia, may help improve outcomes for affected individuals...
  20. doi request reprint Tiagabine in adult patients with generalized anxiety disorder: results from 3 randomized, double-blind, placebo-controlled, parallel-group studies
    Mark H Pollack
    Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA
    J Clin Psychopharmacol 28:308-16. 2008
    ..018; study 3, P = 0.036). The most common adverse events were dizziness, headache, nausea, fatigue, and somnolence. In conclusion, the results of these studies do not support the efficacy of tiagabine in adult patients with GAD...
  21. ncbi request reprint Sertraline in the treatment of panic disorder: a flexible-dose multicenter trial
    M H Pollack
    Anxiety Disorders Program, Department of Psychiatry, Massachusetts General Hospital, Boston 02114 3117, USA
    Arch Gen Psychiatry 55:1010-6. 1998
    ..We examined the efficacy and safety of the serotonin selective reuptake inhibitor sertraline hydrochloride in patients with panic disorder...
  22. doi request reprint Eszopiclone coadministered with escitalopram in patients with insomnia and comorbid generalized anxiety disorder
    Mark Pollack
    Massachusetts General Hospital, Simches Research Bldg, 185 Cambridge St, Ste 2200, 2nd Floor, Boston, MA 02114, USA
    Arch Gen Psychiatry 65:551-62. 2008
    ..Insomnia and generalized anxiety disorder (GAD) are prevalent disorders that may coexist...
  23. doi request reprint Early improvement during duloxetine treatment of generalized anxiety disorder predicts response and remission at endpoint
    Mark H Pollack
    Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital, Harvard Medical School, Simches Research Building, 185 Cambridge Street, Suite 2200, 2nd Floor, Boston, MA 02114, United States
    J Psychiatr Res 42:1176-84. 2008
    ..These data suggest a connection between early improvement and endpoint response and remission status that can be used to guide clinical decision-making...
  24. ncbi request reprint Social anxiety disorder: designing a pharmacologic treatment strategy
    M H Pollack
    Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston 02114, USA
    J Clin Psychiatry 60:20-6. 1999
    ....
  25. ncbi request reprint Treatment of panic disorder: focus on paroxetine
    Mark H Pollack
    Center for Anxiety and Traumatic Stress Related Disorders, Massachusetts General Hospital, Boston, MA 02114, USA
    Psychopharmacol Bull 37:53-63. 2003
    ..Continued treatment with paroxetine results in sustained rates of remission compared with placebo. The combination of paroxetine and cognitive behavioral therapy appears to offer benefits of efficacy and sustained therapeutic response...
  26. ncbi request reprint Panic: course, complications and treatment of panic disorder
    M H Pollack
    Clinical Psychopharmacology Behavior Therapy Unit, Massachusetts General Hospital, Boston 02114, USA
    J Psychopharmacol 14:S25-30. 2000
    ..We provide an overview of the prevalence, presentation and associated complications of panic disorder, review the therapeutic options and discuss the management of refractory patients...
  27. ncbi request reprint A randomized controlled trial of venlafaxine ER and paroxetine in the treatment of outpatients with panic disorder
    Mark Pollack
    Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114 2790, USA
    Psychopharmacology (Berl) 194:233-42. 2007
    ..Few randomized, placebo-controlled trials have evaluated the comparative efficacy and tolerability of more than one pharmacological agent for panic disorder...
  28. doi request reprint Examining quality of life in patients with generalized anxiety disorder: clinical relevance and response to duloxetine treatment
    Mark H Pollack
    Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    J Psychiatr Res 42:1042-9. 2008
    ..Using comparison norms, the current work describes the clinical relevance of these functional improvements in terms of return to normative functioning and symptom remission...
  29. ncbi request reprint Sertraline treatment of panic disorder: response in patients at risk for poor outcome
    M H Pollack
    Department of Psychiatry, Massachusetts General Hospital, Boston 02114 7541, USA
    J Clin Psychiatry 61:922-7. 2000
    ..No published research has systematically examined the differential antipanic efficacy of selective serotonin reuptake inhibitors in patients at high risk for poor outcome...
  30. doi request reprint High-field MRS study of GABA, glutamate and glutamine in social anxiety disorder: response to treatment with levetiracetam
    Mark H Pollack
    Psychiatry Department, Massachusetts General Hospital, Boston, MA 02114, United States
    Prog Neuropsychopharmacol Biol Psychiatry 32:739-43. 2008
    ..Abnormalities in brain gamma-aminobutyric acid (GABA) and glutamate may be relevant to the underlying pathophysiology of anxiety disorders including social anxiety disorder (SAD)...
  31. ncbi request reprint Panic disorder and response to sertraline: the effect of previous treatment with benzodiazepines
    M H Rapaport
    Department of Psychiatry, University of California at San Diego, La Jolla, USA
    J Clin Psychopharmacol 21:104-7. 2001
    ..Sertraline is both well-tolerated and has significant efficacy in patients with panic disorder, including the subset of patients with panic disorder who have previously been treated with BZs...
  32. ncbi request reprint Neck-focused panic attacks among Cambodian refugees; a logistic and linear regression analysis
    Devon E Hinton
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, WACC 812, Boston, MA 02114, USA
    J Anxiety Disord 20:119-38. 2006
    ..In the care of traumatized Cambodian refugees, NP severity, as well as NP-associated flashbacks and catastrophic cognitions, should be specifically assessed and treated...
  33. ncbi request reprint The anxiety sensitivity index: item analysis and suggestions for refinement
    M A Blais
    Inpatient Psychiatry Service, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    J Pers Assess 77:272-94. 2001
    ..The 11-item ASI appears to tap 2 primary aspects of anxiety sensitivity: fears of somatic sensations of anxiety and fears of loss of mental control. Suggestions for further development of the ASI are offered...
  34. ncbi request reprint Assessment of posttraumatic stress disorder in Cambodian refugees using the Clinician-Administered PTSD Scale: psychometric properties and symptom severity
    Devon E Hinton
    Department of Psychiatry, Massachusetts General Hospital, 15 Parkman Street, WACC 812, Boston, MA 02114, USA
    J Trauma Stress 19:405-9. 2006
    ..Those patients who met criteria for current PTSD had significantly higher CAPS total scores (M = 65.3, SD = 18.1) than those who did not meet the criteria (M = 13.9, SD = 16.7)...
  35. ncbi request reprint Group cognitive-behavior therapy for patients failing to respond to pharmacotherapy for panic disorder: a clinical case series
    M W Otto
    Massachusetts General Hospital, Boston, USA
    Behav Res Ther 37:763-70. 1999
    ....
  36. ncbi request reprint Efficacy of low and higher dose extended-release venlafaxine in generalized social anxiety disorder: a 6-month randomized controlled trial
    Murray B Stein
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0985, USA
    Psychopharmacology (Berl) 177:280-8. 2005
    ..There is a need for new pharmacological treatments for generalized social anxiety disorder (GSAD), which is a common, often disabling condition...
  37. pmc The panic attack-posttraumatic stress disorder model: applicability to orthostatic panic among Cambodian refugees
    Devon E Hinton
    Southeast Asian Clinic, Arbour Counseling Services, Lowell, MA 02114, USA
    Cogn Behav Ther 37:101-16. 2008
    ....
  38. ncbi request reprint Prevalence of body dysmorphic disorder in patients with anxiety disorders
    S Wilhelm
    OCD Clinic and Research Unit, Massachusetts General Hospital, Charlestown 02129, USA
    J Anxiety Disord 11:499-502. 1997
    ..In all cases, onset of social phobia preceded onset of BDD. Our findings draw attention to the prevalence of BDD in patients with social phobia. The potential etiologic significance of our findings is discussed...
  39. ncbi request reprint Fluvoxamine treatment of social phobia (social anxiety disorder): a double-blind, placebo-controlled study
    M B Stein
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0985, USA
    Am J Psychiatry 156:756-60. 1999
    ..The purpose of this study was to determine the efficacy of fluvoxamine for the treatment of social phobia (social anxiety disorder)...
  40. ncbi request reprint Rate of improvement during cognitive-behavioral group treatment for panic disorder
    S J Penava
    Department of Psychiatry, Massachusetts General Hospital, Boston 02114, USA
    Behav Res Ther 36:665-73. 1998
    ..Information on rats of symptom improvement is valuable for providing patients with accurate expectations about potential treatment benefits and for helping to maintain motivation during initial treatment sessions...
  41. ncbi request reprint Does recovery from substance use disorder matter in patients with bipolar disorder?
    Roger D Weiss
    Department of Psychiatry, Harvard Medical School, Boston, USA
    J Clin Psychiatry 66:730-5; quiz 808-9. 2005
    ..To examine the potential impact of recovery from substance use disorder (SUD) on the course of bipolar disorder among patients diagnosed with both bipolar and substance use disorders according to DSM-IV criteria...
  42. ncbi request reprint History of childhood abuse in panic disorder, social phobia, and generalized anxiety disorder
    Steven A Safren
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, MGH Psychiatry, WACC 815, 15 Parkman Street, Boston, Massachusetts 02114, USA
    J Nerv Ment Dis 190:453-6. 2002
    ..These findings are discussed in terms of biological and behavioral factors that may influence the development of anxiety disorders after the experience of a traumatic event...
  43. ncbi request reprint A comparison of the efficacy of clonazepam and cognitive-behavioral group therapy for the treatment of social phobia
    M W Otto
    Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    J Anxiety Disord 14:345-58. 2000
    ....
  44. doi request reprint Broad spectrum of cytokine abnormalities in panic disorder and posttraumatic stress disorder
    E A Hoge
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Depress Anxiety 26:447-55. 2009
    ..Much less is known about cytokines in anxiety disorders such as posttraumatic stress disorder (PTSD) and panic disorder (PD). We hypothesized that PD and PTSD would be associated with a generalized proinflammatory cytokine signature...
  45. ncbi request reprint Childhood history of anxiety disorders among adults with social phobia: rates, correlates, and comparisons with patients with panic disorder
    M W Otto
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Depress Anxiety 14:209-13. 2001
    ....
  46. ncbi request reprint Anxiety is associated with impulsivity in bipolar disorder
    Charles T Taylor
    Department of Psychiatry, Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Anxiety Disord 22:868-76. 2008
    ..These data demonstrate that anxiety is positively associated with impulsivity in patients with BD. Further studies are needed to elucidate the implications of and reasons for this association...
  47. ncbi request reprint Benzodiazepines in clinical practice: consideration of their long-term use and alternative agents
    Julie C Stevens
    Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 66:21-7. 2005
    ..We also consider currently available alternatives to benzodiazepines and novel mechanisms of action that may prove fruitful in the development of future generations of anxiolytics...
  48. ncbi request reprint Pregabalin for treatment of generalized anxiety disorder: a 4-week, multicenter, double-blind, placebo-controlled trial of pregabalin and alprazolam
    Karl Rickels
    Department of Psychiatry, University of Pennsylvania, Philadelphia 19104 3309, USA
    Arch Gen Psychiatry 62:1022-30. 2005
    ..Pregabalin inhibits release of excess excitatory neurotransmitters, presumably by binding to the alpha2-delta subunit protein of widely distributed voltage-dependent calcium channels in the brain and spinal cord...
  49. doi request reprint Khyâl attacks: a key idiom of distress among traumatized cambodia refugees
    Devon E Hinton
    Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, 15 Parkman Street, WACC 812, Boston, MA 02114, USA
    Cult Med Psychiatry 34:244-78. 2010
    ....
  50. ncbi request reprint Ataque de nervios: relationship to anxiety sensitivity and dissociation predisposition
    Devon E Hinton
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Depress Anxiety 25:489-95. 2008
    ..46) and the DES (beta=.29). The theoretical and clinical implications of the strong relationship of the ASI to ataque severity are discussed...
  51. doi request reprint The role of anxiety sensitivity in sleep disturbance in panic disorder
    E A Hoge
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114 2790, USA
    J Anxiety Disord 25:536-8. 2011
    ..Our data suggest that sleep disturbance, and in particular sleep latency, in PD may be partly due to high levels of AS, which can be targeted with cognitive-behavioral therapeutic strategies...
  52. ncbi request reprint Prospective 12-month course of bipolar disorder in out-patients with and without comorbid anxiety disorders
    M W Otto
    Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Br J Psychiatry 189:20-5. 2006
    ..The impact of anxiety disorders has not been well delineated in prospective studies of bipolar disorder...
  53. ncbi request reprint Do antidepressants selectively suppress spontaneous (unexpected) panic attacks? A replication
    E H Uhlenhuth
    Department of Psychiatry, University of New Mexico School of Medicine, Albuquerque 87131, USA
    J Clin Psychopharmacol 20:622-7. 2000
    ..Implications of these results for concepts of pathogenesis, clinical practice, and therapeutic research regarding panic disorder are discussed...
  54. ncbi request reprint How do clinicians respond to patients who miss appointments?
    J W Smoller
    Department of Psychiatry, Massachusetts General Hospital, Boston 02114, USA
    J Clin Psychiatry 59:330-8; quiz 339-40. 1998
    ..quot; In an effort to determine how clinicians customarily handle missed appointments, we surveyed mental health clinicians and internists at 2 academic hospitals: a private psychiatric hospital and an urban general hospital...
  55. ncbi request reprint An open-label study of levetiracetam for the treatment of social anxiety disorder
    Naomi M Simon
    Center for Anxiety and Traumatic Stress Related Disorders, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychiatry 65:1219-22. 2004
    ..Levetiracetam thus warrants systematic evaluation as a treatment option for anxiety disorders...
  56. ncbi request reprint Orthostatic panic attacks among Vietnamese refugees
    Devon E Hinton
    Harvard Medical School, Massachusetts General Hospital, Department of Psychiatry, Boston 02114, USA
    Transcult Psychiatry 44:515-44. 2007
    ..To illustrate the mechanisms producing OP, we adduce the multiplex model of panic generation. Culturally appropriate care of Vietnamese refugees should include assessment and treatment of OP...
  57. ncbi request reprint Aripiprazole as an augmentor of selective serotonin reuptake inhibitors in depression and anxiety disorder patients
    John J Worthington
    Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital, Boston, Massachusetts, USA
    Int Clin Psychopharmacol 20:9-11. 2005
    ..Because this is a retrospective case review, further prospective studies are required to confirm these findings...
  58. ncbi request reprint Posttraumatic stress disorder symptoms following media exposure to tragic events: impact of 9/11 on children at risk for anxiety disorders
    Michael W Otto
    Massachusetts General Hospital and Harvard Medical School, MA, United States
    J Anxiety Disord 21:888-902. 2007
    ..Given the links between PTSD symptoms and viewing habits, parental monitoring of media exposure may be important for younger children...
  59. pmc Anger, PTSD, and the nuclear family: a study of Cambodian refugees
    Devon E Hinton
    Massachusetts General Hospital, Harvard Medical School, Department of Psychiatry, Boston, USA
    Soc Sci Med 69:1387-94. 2009
    ....
  60. ncbi request reprint Citalopram for social phobia: a clinical case series
    N M Simon
    Anxiety Disorders Program, Massachusetts General Hospital, Boston 02114, USA
    Prog Neuropsychopharmacol Biol Psychiatry 25:1469-74. 2001
    ..This series of patients improved significantly on all measures. Results suggest that citalopram may be a safe and effective treatment for social anxiety disorder...
  61. ncbi request reprint Nefazodone for social phobia: a clinical case series
    J J Worthington
    Anxiety Disorders Program, Massachusetts General Hospital, Boston, USA
    Depress Anxiety 8:131-3. 1998
    ..Results from this case series suggest that nefazodone may be an effective treatment for social phobia and that formal randomized trials are warranted...
  62. ncbi request reprint Empirically supported treatments for panic disorder: costs, benefits, and stepped care
    M W Otto
    Massachusetts General Hospital, Boston 02114, USA
    J Consult Clin Psychol 68:556-63. 2000
    ..Analysis of the "services" data indicated that CBT was at least equal to pharmacotherapy in terms of pretreatment severity and acute treatment outcome and that CBT is an especially cost-effective treatment option...
  63. ncbi request reprint Gastrointestinal-focused panic attacks among Cambodian refugees: associated psychopathology, flashbacks, and catastrophic cognitions
    Devon E Hinton
    Massachusetts General Hospital, Harvard Medical School, Department of Psychiatry, 15 Parkman Street, WACC 812 Boston, USA
    J Anxiety Disord 21:42-58. 2007
    ..A mediational analysis indicated that SCL's effect on GIP severity was mediated by GIP-associated flashbacks and catastrophic cognitions...
  64. ncbi request reprint Establishment of remission criteria for anxiety disorders
    Alicia C Doyle
    Center for Anxiety and Traumatic Stress Related Disorders, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA
    J Clin Psychiatry 64:40-5. 2003
    ....
  65. doi request reprint Efficacy of CBT for benzodiazepine discontinuation in patients with panic disorder: Further evaluation
    Michael W Otto
    Department of Psychology, Boston University, 648 Beacon Street, 5th Floor, Boston, MA 02215, USA
    Behav Res Ther 48:720-7. 2010
    ..These findings suggest that CBT provides specific efficacy for the successful discontinuation from BZs, even when controlling for therapist contact and relaxation training...
  66. ncbi request reprint WCA recommendations for the long-term treatment of generalized anxiety disorder
    Christer Allgulander
    Department of Psychiatry, Harvard University School of Medicine, Boston, Massachusetts, USA
    CNS Spectr 8:53-61. 2003
    ..Treatment gains after a 12-week course of CBT may be maintained for up to 1 year. Currently, no guidelines exist for the long-term treatment of GAD...
  67. doi request reprint Brain GABA levels in patients with bipolar disorder
    Rebecca E Kaufman
    Massachusetts General Hospital Department of Psychiatry, Boston, MA 02114, United States
    Prog Neuropsychopharmacol Biol Psychiatry 33:427-34. 2009
    ..GENERAL METHODS: We used magnetic resonance spectroscopy (MRS) to examine whole brain and regional GABA, glutamate and glutamine in 13 patients with bipolar disorder compared to a matched group of 11 healthy controls...
  68. doi request reprint Mechanisms of efficacy of CBT for Cambodian refugees with PTSD: improvement in emotion regulation and orthostatic blood pressure response
    Devon E Hinton
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, WACC 812, Boston, MA, USA
    CNS Neurosci Ther 15:255-63. 2009
    ..It also suggests that vagal tone is involved in emotion regulation, and that both vagal tone and emotion regulation improve across treatment...
  69. ncbi request reprint Olfactory-triggered panic attacks among Cambodian refugees attending a psychiatric clinic
    Devon E Hinton
    Department of Psychiatry, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Gen Hosp Psychiatry 26:390-7. 2004
    ....
  70. ncbi request reprint Targeted genome screen of panic disorder and anxiety disorder proneness using homology to murine QTL regions
    J W Smoller
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA
    Am J Med Genet 105:195-206. 2001
    ..05, P = 0.035). While these linkage results are merely suggestive, this study illustrates the potential advantages of using mouse gene-mapping results and exploring alternative phenotype definitions in linkage studies of anxiety disorder...
  71. ncbi request reprint Additional findings on the association between anxiety sensitivity and hypochondriacal concerns: examination of patients with major depression
    M W Otto
    Cognitive Behavior Therapy Program, Massachusetts General Hospital, Boston 02114, USA
    J Anxiety Disord 12:225-32. 1998
    ..Findings are discussed in relation to the role of catastrophic interpretations of somatic symptoms in depression, panic disorder, and hypochondriasis...
  72. ncbi request reprint Sleep paralysis among Cambodian refugees: association with PTSD diagnosis and severity
    Devon E Hinton
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Depress Anxiety 22:47-51. 2005
    ..SP seems to be a core aspect of the Cambodian refugee's response to trauma. When treating Cambodian refugees, and traumatized refugees in general, clinicians should assess for its presence...
  73. ncbi request reprint Prevalence and correlates of panic attacks in postmenopausal women: results from an ancillary study to the Women's Health Initiative
    Jordan W Smoller
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Arch Intern Med 163:2041-50. 2003
    ..Panic attacks are known to be more common in women than in men, but the prevalence and correlates of panic in the postmenopausal period have not been well defined...
  74. ncbi request reprint Long-term management of panic disorder
    Alicia Doyle
    Center for Anxiety and Traumatic Stress Related Disorders, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Mass, USA
    J Clin Psychiatry 65:24-8. 2004
    ..Further research is necessary to determine the long-term effectiveness of these multifaceted treatment strategies among patients suffering from refractory panic disorder...
  75. ncbi request reprint Augmentation of exposure therapy with D-cycloserine for social anxiety disorder
    Stefan G Hofmann
    Department of Psychology and Center for Anxiety and Related Disorders, Boston University, Boston, MA 02215, USA
    Arch Gen Psychiatry 63:298-304. 2006
    ....
  76. ncbi request reprint Orthostatically induced panic attacks among Vietnamese refugees: associated psychopathology, flashbacks, and catastrophic cognitions
    Devon E Hinton
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Depress Anxiety 23:113-5. 2006
  77. ncbi request reprint Cerebral phosphorus metabolite and transverse relaxation time abnormalities in heroin-dependent subjects at onset of methadone maintenance treatment
    Marisa M Silveri
    Brain Imaging Center, McLean Hospital, Department of Psychiatry, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Psychiatry Res 131:217-26. 2004
    ..Taken together, these cross-sectional data suggest that the first month of MM treatment may be associated with altered cerebral bioenergetics and phospholipid metabolite levels...
  78. ncbi request reprint Ropinirole for antidepressant-induced sexual dysfunction
    J J Worthington
    Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Int Clin Psychopharmacol 17:307-10. 2002
    ..The addition of ropinirole may represent a potentially useful treatment strategy for antidepressant-induced sexual dysfunction...
  79. ncbi request reprint An effect-size analysis of the relative efficacy and tolerability of serotonin selective reuptake inhibitors for panic disorder
    M W Otto
    Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 158:1989-92. 2001
    ..In this study the authors used an effect-size analysis to provide an initial comparison...
  80. doi request reprint Nightmares among Cambodian refugees: the breaching of concentric ontological security
    D E Hinton
    Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cult Med Psychiatry 33:219-65. 2009
    ..quot; Cases are presented to illustrate these findings. The Discussion considers some treatment implications of the study...
  81. ncbi request reprint Panic attacks and risk of incident cardiovascular events among postmenopausal women in the Women's Health Initiative Observational Study
    Jordan W Smoller
    Department of Psychiatry, Massachusetts General Hospital, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA
    Arch Gen Psychiatry 64:1153-60. 2007
    ..Previous studies have documented an association of depression and phobic anxiety with cardiovascular morbidity and mortality, but little is known about the cardiovascular sequelae of panic anxiety...
  82. ncbi request reprint Paroxetine CR augmentation for posttraumatic stress disorder refractory to prolonged exposure therapy
    Naomi M Simon
    Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 69:400-5. 2008
    ..This study prospectively examines the relative efficacy of augmentation of continued prolonged exposure therapy (PE) with paroxetine CR versus placebo for individuals remaining symptomatic despite a course of PE...
  83. pmc Next-step strategies for panic disorder refractory to initial pharmacotherapy: a 3-phase randomized clinical trial
    Naomi M Simon
    Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital, Simches Research Building, 2nd Floor, 185 Cambridge St, Boston, MA 02114, USA
    J Clin Psychiatry 70:1563-70. 2009
    ..More data are needed to guide next-step interventions for panic disorder refractory to initial intervention...
  84. ncbi request reprint An open-label trial of risperidone augmentation for refractory anxiety disorders
    Naomi M Simon
    Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital, Boston, Mass, USA
    J Clin Psychiatry 67:381-5. 2006
    ..There is a paucity of data to support "next-step" treatments for the many patients with anxiety disorders who remain symptomatic after initial pharmacotherapy...
  85. ncbi request reprint A functional MRI study of amygdala responses to angry schematic faces in social anxiety disorder
    Karleyton C Evans
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    Depress Anxiety 25:496-505. 2008
    ..However, extending earlier findings in healthy subjects, schematic faces appear more effective for probing amygdala responses to arousal-based (Angry versus Neutral) as opposed to valence-based (Angry versus Happy) contrasts...
  86. ncbi request reprint Resilience: research evidence and conceptual considerations for posttraumatic stress disorder
    Elizabeth A Hoge
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Depress Anxiety 24:139-52. 2007
    ....
  87. ncbi request reprint Understanding the link between anxiety symptoms and suicidal ideation and behaviors in outpatients with bipolar disorder
    Naomi M Simon
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston MA 02114, United States
    J Affect Disord 97:91-9. 2007
    ..Prior studies suggest an association between anxiety comorbidity and suicidal ideation and behaviors in bipolar disorder. However, the nature of this association remains unclear...
  88. ncbi request reprint White matter hyperintensities in subjects with cocaine and opiate dependence and healthy comparison subjects
    In Kyoon Lyoo
    McLean Hospital Brain Imaging Center and Department of Psychiatry, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Psychiatry Res 131:135-45. 2004
    ..Also, there was a trend for lower WMH severity in substance-dependent women relative to the healthy comparison group, possibly due to estrogen's protective effect against cerebrovascular accidents...
  89. ncbi request reprint Valproic acid for the treatment of social anxiety disorder
    Gustavo Kinrys
    Massachusetts General Hospital, Boston 02114, USA
    Int Clin Psychopharmacol 18:169-72. 2003
    ..The results from this open-label trial suggest the potential efficacy of valproic acid for the treatment of social anxiety disorder. Placebo-controlled trials are indicated to confirm these findings...
  90. ncbi request reprint Predicting panic disorder among patients with chest pain: an analysis of the literature
    Jeff C Huffman
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Psychosomatics 44:222-36. 2003
    ..female sex, 4). younger age, and 5). a high level of self-reported anxiety. Further studies of these and other variables associated with panic disorder should aid in the detection of this disabling but treatable cause of chest pain...
  91. ncbi request reprint Anxiety sensitivity in traumatized Cambodian refugees: a discriminant function and factor analytic investigation
    Devon E Hinton
    Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Behav Res Ther 43:1631-43. 2005
    ..The item clustering within the factor solution of both the ASI and Augmented ASI illustrates the role of cultural syndromes in generating fear of mental and bodily events...
  92. ncbi request reprint Quality of life in social anxiety disorder compared with panic disorder and the general population
    Naomi M Simon
    Anxiety Disorders Program, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Psychiatr Serv 53:714-8. 2002
    ..Quality of life in a treatment-seeking cohort of patients with social anxiety disorder was compared with that of patients with panic disorder who were matched for age, comorbid illnesses, and gender and with population-based norms...
  93. ncbi request reprint Fluoxetine for vestibular dysfunction and anxiety: a prospective pilot study
    Naomi M Simon
    Center for Anxiety and Traumatic Stress Related Disorders, Massachusetts General Hospital, WACC 815, Boston, MA 02114, USA
    Psychosomatics 46:334-9. 2005
    ..The data add to the literature suggesting a role for selective serotonin reuptake inhibitors in the treatment of dizziness and anxiety...
  94. ncbi request reprint Patterns of comorbidity in panic disorder and major depression: findings from a nonreferred sample
    Joseph Biederman
    Pediatric Psychopharmacology Unit of the Child Psychiatry Service, Massachusetts General Hospital, Boston 02114, USA
    Depress Anxiety 21:55-60. 2005
    ....
  95. ncbi request reprint Changes in anxiety sensitivity with pharmacotherapy for panic disorder
    Naomi M Simon
    Anxiety Disorders Program, Massachusetts General Hospital and Harvard Medical School, WACC 812, 15 Parkman Street, Boston, MA 02114, USA
    J Psychiatr Res 38:491-5. 2004
    ..Implications of these findings are discussed relative to optimizing pharmacologic treatment of panic disorder...
  96. doi request reprint A PET study of tiagabine treatment implicates ventral medial prefrontal cortex in generalized social anxiety disorder
    Karleyton C Evans
    Department of Psychiatry, Psychiatric Neuroscience Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Neuropsychopharmacology 34:390-8. 2009
    ..Given the pharmacological profile of tiagabine, these findings suggest that its therapeutic effects in gSAD may be mediated by GABAergic modulation within the vmPFC...
  97. doi request reprint Oxytocin levels in social anxiety disorder
    Elizabeth A Hoge
    Department of Economics, Claremont University, Claremont, CA, USA
    CNS Neurosci Ther 14:165-70. 2008
    ..These findings may suggest a possible role for oxytocin as a facilitator of social behavior, an effect which may not be fully utilized in individuals with severe social anxiety...
  98. ncbi request reprint Pharmacotherapy for bipolar disorder and comorbid conditions: baseline data from STEP-BD
    Naomi M Simon
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychopharmacol 24:512-20. 2004
    ..Our findings highlight the need for greater clinical guidance and treatment options for patients with bipolar disorder and comorbidity...
  99. doi request reprint Open-label support for duloxetine for the treatment of panic disorder
    Naomi M Simon
    Department of Psychiatry, Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA
    CNS Neurosci Ther 15:19-23. 2009
    ....
  100. ncbi request reprint Hypothyroidism and hyperthyroidism in anxiety disorders revisited: new data and literature review
    Naomi M Simon
    Anxiety Disorders Program, Massachusetts General Hospital and Harvard Medical School, 15 Parkman Street, WAC 815, Boston, MA 02114, USA
    J Affect Disord 69:209-17. 2002
    ..The need for thyroid screening of patients presenting with panic disorder (PD), social phobia (SP) or generalized anxiety disorder (GAD) remains uncertain...
  101. doi request reprint A comparison of emotional approach coping (EAC) between individuals with anxiety disorders and nonanxious controls
    Luana Marques
    Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    CNS Neurosci Ther 15:100-6. 2009
    ..Overall, gender did not moderate the anxiety-EAC effect, but the results suggested that women utilize EAC to a greater degree than men. Clinical techniques designed to improve emotional coping may be beneficial to individuals with ADs...

Research Grants21

  1. 3/3-Exposure D-Cycloserine Enhancement and Genetic Modulators in Panic Disorder
    Mark Pollack; Fiscal Year: 2009
    ....
  2. Improving Outcomes in Pharmacotherapy of Social Phobia
    Mark Pollack; Fiscal Year: 2009
    ..It thus directly addresses a critical public health issue that adversely affects a substantial proportion of the population. ..
  3. 3/3-Exposure D-Cycloserine Enhancement and Genetic Modulators in Panic Disorder
    Mark H Pollack; Fiscal Year: 2010
    ....
  4. D-Cycloserine Enhancement of Exposure in Social Phobia
    Mark H Pollack; Fiscal Year: 2010
    ..This study addresses an important public health issue by assessing an intervention that may lead to a more efficient and effective application of empirically based psychosocial interventions for the treatment of SAD. ..
  5. Improving Outcomes in Pharmacotherapy of Social Phobia
    Mark Pollack; Fiscal Year: 2007
    ..It thus directly addresses a critical public health issue that adversely affects a substantial proportion of the population. ..
  6. MR SPECTROSCOPIC IMAGING DURING METHADONE MAINTENANCE
    Mark Pollack; Fiscal Year: 2002
    ....
  7. Impact of Trauma of Terroist Attack on Bipolar Patients
    Mark Pollack; Fiscal Year: 2003
    ..abstract_text> ..
  8. D-Cycloserine Enhancement of Exposure in Social Phobia
    Mark H Pollack; Fiscal Year: 2010
    ..This study addresses an important public health issue by assessing an intervention that may lead to a more efficient and effective application of empirically based psychosocial interventions for the treatment of SAD. ..