Luminita Pojoga


Affiliation: Massachusetts General Hospital
Country: USA


  1. Mayurasakorn K, Hasanah N, Homma T, Homma M, Rangel I, Garza A, et al. Caloric restriction improves glucose homeostasis, yet increases cardiometabolic risk in caveolin-1-deficient mice. Metabolism. 2018;83:92-101 pubmed publisher
    ..CR improved the metabolic phenotype in CAV-1 KO mice by increasing insulin sensitivity; nevertheless, this intervention also increased CV risk by inappropriate adaptive responses in the RAAS and BP. ..
  2. Baudrand R, Goodarzi M, Vaidya A, Underwood P, Williams J, Jeunemaitre X, et al. A prevalent caveolin-1 gene variant is associated with the metabolic syndrome in Caucasians and Hispanics. Metabolism. 2015;64:1674-81 pubmed publisher
    ..Additional studies are needed to confirm the clinical implications of our results. ..
  3. Baudrand R, Gupta N, Garza A, Vaidya A, Leopold J, Hopkins P, et al. Caveolin 1 Modulates Aldosterone-Mediated Pathways of Glucose and Lipid Homeostasis. J Am Heart Assoc. 2016;5: pubmed publisher
    ..In contrast, hyperinsulinemia and hypertriglyceridemia are likely mediated by MR-independent mechanisms. Future human studies will elucidate the clinical relevance of MR blockade in patients with genotype-mediated cav-1 deficiency. ..