Affiliation: Massachusetts General Hospital
Mayurasakorn K, Hasanah N, Homma T, Homma M, Rangel I, Garza A, et al
. Caloric restriction improves glucose homeostasis, yet increases cardiometabolic risk in caveolin-1-deficient mice. Metabolism. 2018;83:92-101 pubmed publisher
..CR improved the metabolic phenotype in CAV-1 KO mice by increasing insulin sensitivity; nevertheless, this intervention also increased CV risk by inappropriate adaptive responses in the RAAS and BP. ..
Baudrand R, Goodarzi M, Vaidya A, Underwood P, Williams J, Jeunemaitre X, et al
. A prevalent caveolin-1 gene variant is associated with the metabolic syndrome in Caucasians and Hispanics. Metabolism. 2015;64:1674-81 pubmed publisher
..Additional studies are needed to confirm the clinical implications of our results. ..
Baudrand R, Gupta N, Garza A, Vaidya A, Leopold J, Hopkins P, et al
. Caveolin 1 Modulates Aldosterone-Mediated Pathways of Glucose and Lipid Homeostasis. J Am Heart Assoc. 2016;5: pubmed publisher
..In contrast, hyperinsulinemia and hypertriglyceridemia are likely mediated by MR-independent mechanisms. Future human studies will elucidate the clinical relevance of MR blockade in patients with genotype-mediated cav-1 deficiency. ..