Robert Plenge

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci
    Alexandra Zhernakova
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS Genet 7:e1002004. 2011
  2. pmc Fine mapping the TAGAP risk locus in rheumatoid arthritis
    R Chen
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
    Genes Immun 12:314-8. 2011
  3. pmc Human genetics in rheumatoid arthritis guides a high-throughput drug screen of the CD40 signaling pathway
    Gang Li
    Division of Rheumatology, Immunology, and Allergy and Division of Genetics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    PLoS Genet 9:e1003487. 2013
  4. pmc Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis
    Jing Cui
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 9:e1003394. 2013
  5. doi request reprint Validating therapeutic targets through human genetics
    Robert M Plenge
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Nat Rev Drug Discov 12:581-94. 2013
  6. pmc Data for Genetic Analysis Workshop 16 Problem 1, association analysis of rheumatoid arthritis data
    Christopher I Amos
    Departments of Epidemiology and Biomathematics, University of Texas, MD Anderson Cancer Center, 1155 Pressler Street, Houston, Texas 77030, USA
    BMC Proc 3:S2. 2009
  7. pmc Data for Genetic Analysis Workshop (GAW) 15 Problem 2, genetic causes of rheumatoid arthritis and associated traits
    Christopher I Amos
    Departments of Epidemiology and Biomathematics, University of Texas, Anderson Cancer Center, 1155 Pressler Street, Unit 1340, Houston, Texas 77030, USA
    BMC Proc 1:S3. 2007
  8. ncbi request reprint Rheumatoid arthritis genetics: 2009 update
    Robert M Plenge
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Suite 168, Boston, MA 02115, USA
    Curr Rheumatol Rep 11:351-6. 2009
  9. pmc Two independent alleles at 6q23 associated with risk of rheumatoid arthritis
    Robert M Plenge
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Genet 39:1477-82. 2007
  10. doi request reprint Recent progress in rheumatoid arthritis genetics: one step towards improved patient care
    Robert M Plenge
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s, Hospital, Harvard Medical School, Boston, USA
    Curr Opin Rheumatol 21:262-71. 2009

Detail Information

Publications51

  1. pmc Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci
    Alexandra Zhernakova
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS Genet 7:e1002004. 2011
    ....
  2. pmc Fine mapping the TAGAP risk locus in rheumatoid arthritis
    R Chen
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
    Genes Immun 12:314-8. 2011
    ..Our study also underscores the utility of comprehensive imputation in large GWAS data sets to fine map disease risk alleles...
  3. pmc Human genetics in rheumatoid arthritis guides a high-throughput drug screen of the CD40 signaling pathway
    Gang Li
    Division of Rheumatology, Immunology, and Allergy and Division of Genetics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    PLoS Genet 9:e1003487. 2013
    ..Our study demonstrates proof-of-concept that human genetics can be used to guide the development of phenotype-based, high-throughput small-molecule screens to identify potential novel therapies in complex traits such as RA...
  4. pmc Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis
    Jing Cui
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 9:e1003394. 2013
    ..These findings support a model in which CD84 genotypes and/or expression may serve as a useful biomarker for response to etanercept treatment in RA patients of European ancestry...
  5. doi request reprint Validating therapeutic targets through human genetics
    Robert M Plenge
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Nat Rev Drug Discov 12:581-94. 2013
    ....
  6. pmc Data for Genetic Analysis Workshop 16 Problem 1, association analysis of rheumatoid arthritis data
    Christopher I Amos
    Departments of Epidemiology and Biomathematics, University of Texas, MD Anderson Cancer Center, 1155 Pressler Street, Houston, Texas 77030, USA
    BMC Proc 3:S2. 2009
    ..Several questions could be addressed using the data, including analysis of genetic associations using single SNPs or haplotypes, as well as gene-gene and genetic analysis of SNPs for qualitative and quantitative factors...
  7. pmc Data for Genetic Analysis Workshop (GAW) 15 Problem 2, genetic causes of rheumatoid arthritis and associated traits
    Christopher I Amos
    Departments of Epidemiology and Biomathematics, University of Texas, Anderson Cancer Center, 1155 Pressler Street, Unit 1340, Houston, Texas 77030, USA
    BMC Proc 1:S3. 2007
    ....
  8. ncbi request reprint Rheumatoid arthritis genetics: 2009 update
    Robert M Plenge
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Suite 168, Boston, MA 02115, USA
    Curr Rheumatol Rep 11:351-6. 2009
    ..This review discusses recent RA genetic discoveries in terms of their potential to improve patient care...
  9. pmc Two independent alleles at 6q23 associated with risk of rheumatoid arthritis
    Robert M Plenge
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Genet 39:1477-82. 2007
    ..We show that these two SNP associations are statistically independent, are each reproducible in the comparison of our data and WTCCC data, and define risk and protective haplotypes for rheumatoid arthritis at 6q23...
  10. doi request reprint Recent progress in rheumatoid arthritis genetics: one step towards improved patient care
    Robert M Plenge
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s, Hospital, Harvard Medical School, Boston, USA
    Curr Opin Rheumatol 21:262-71. 2009
    ..Recent human genetic discoveries have increased our understanding of rheumatoid arthritis (RA) susceptibility. These discoveries are reviewed and placed in the context of potential important clinical applications...
  11. pmc Rare protection against type 1 diabetes
    Robert M Plenge
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
    Genome Biol 10:219. 2009
    ..A large population study using ultra-high-throughput DNA sequencing to re-sequence a genetic locus associated with type 1 diabetes reveals rare protective alleles...
  12. pmc Leveraging human genetics to develop future therapeutic strategies in rheumatoid arthritis
    Robert M Plenge
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Suite 168, Boston, MA 02115, USA
    Rheum Dis Clin North Am 36:259-70. 2010
    ....
  13. pmc GWASs and the age of human as the model organism for autoimmune genetic research
    Robert Plenge
    Brigham and Women s Hospital, Division of Rheumatology, Immunology and Allergy, Boston, MA 02115, USA
    Genome Biol 11:212. 2010
    ..Genetic studies have identified more than 150 autoimmune loci, and next-generation sequencing will identify more. Is it time to make human the model organism for autoimmune research?..
  14. pmc Common variants at CD40 and other loci confer risk of rheumatoid arthritis
    Soumya Raychaudhuri
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Genet 40:1216-23. 2008
    ..1 x 10(-7) overall), CDK6 (rs42041, P = 0.010 replication, P = 4.0 x 10(-6) overall), PRKCQ (rs4750316, P = 0.0078 replication, P = 4.4 x 10(-6) overall), and KIF5A-PIP4K2C (rs1678542, P = 0.0026 replication, P = 8.8 x 10(-8) overall)...
  15. pmc TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study
    Robert M Plenge
    Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, MA, USA
    N Engl J Med 357:1199-209. 2007
    ..We carried out a genomewide association analysis to identify additional genetic loci associated with an increased risk of rheumatoid arthritis...
  16. pmc Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4
    Robert M Plenge
    Broad Institute of MIT and Harvard, Cambridge, MA, USA
    Am J Hum Genet 77:1044-60. 2005
    ....
  17. ncbi request reprint Principal components analysis corrects for stratification in genome-wide association studies
    Alkes L Price
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 38:904-9. 2006
    ..Our simple, efficient approach can easily be applied to disease studies with hundreds of thousands of markers...
  18. pmc Integrating autoimmune risk loci with gene-expression data identifies specific pathogenic immune cell subsets
    Xinli Hu
    Division of Genetics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Hum Genet 89:496-506. 2011
    ..Our approach has application in other phenotypes, outside of autoimmunity, where many loci have been discovered and high-quality cell-type-specific gene expression is available...
  19. pmc Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk
    Soumya Raychaudhuri
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Nat Genet 41:1313-8. 2009
    ..0008 replication, P = 4 x 10(-6) overall) and FCGR2A (rs12746613, P = 0.0022 replication, P = 2 x 10(-5) overall). Many of these loci are also associated to other immunologic diseases...
  20. pmc Genome-wide association study of determinants of anti-cyclic citrullinated peptide antibody titer in adults with rheumatoid arthritis
    Jing Cui
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Med 15:136-43. 2009
    ..We identified a SNP in moderate linkage disequilibrium (LD) with HLA-DR3, which may influence anti-CCP titer independently of the HLA-SE...
  21. pmc The PRL -1149 G/T polymorphism and rheumatoid arthritis susceptibility
    Yvonne C Lee
    Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Arthritis Rheum 60:1250-4. 2009
    ..The aim of this study was to determine the role of the PRL -1149 G/T polymorphism (rs1341239) in rheumatoid arthritis (RA) susceptibility...
  22. pmc Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis
    Chunyu Liu
    Biogen Idec Inc, Cambridge, Massachusetts, USA
    Mol Med 14:575-81. 2008
    ..Replications of these results in independent and larger data sets clearly are required. We provide a reference list of candidate SNPs (P < 0.01) that can be investigated in future pharmacogenomic studies...
  23. doi request reprint Using genetic and clinical data to understand response to disease-modifying anti-rheumatic drug therapy: data from the Brigham and Women's Hospital Rheumatoid Arthritis Sequential Study
    Christine K Iannaccone
    Department of Medicine, Brigham and Women s Hospital, PBB B3, 75 Francis Street, Boston, MA 02115, USA
    Rheumatology (Oxford) 50:40-6. 2011
    ....
  24. pmc Specific association of type 1 diabetes mellitus with anti-cyclic citrullinated peptide-positive rheumatoid arthritis
    Katherine P Liao
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, MA 02114, USA
    Arthritis Rheum 60:653-60. 2009
    ..In this study, the strength and nature of this association were investigated at the population level in a Swedish case-control cohort...
  25. pmc Cumulative association of 22 genetic variants with seropositive rheumatoid arthritis risk
    Elizabeth W Karlson
    75 Francis Street, Boston, MA 02115, USA
    Ann Rheum Dis 69:1077-85. 2010
    ..This study examined whether a cumulative score based on 22 validated genetic risk alleles for seropositive RA would identify high-risk, asymptomatic individuals who might benefit from preventive interventions...
  26. pmc Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking
    Karen H Costenbader
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arthritis Res Ther 10:R52. 2008
    ..We investigated whether polymorphisms in these genes were associated with RA in Caucasian women included in two large prospective cohorts, adjusting for confounding factors and testing for interactions with smoking...
  27. pmc A broad analysis of IL1 polymorphism and rheumatoid arthritis
    Alyssa K Johnsen
    Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Rheum 58:1947-57. 2008
    ..The aim of this study was to perform a broad and well-powered search for association between allelic polymorphism in IL1A and IL1B and the susceptibility to or severity of RA...
  28. pmc Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus
    Robert R Graham
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Nat Genet 40:1059-61. 2008
    ..These results establish that variants near TNFAIP3 contribute to differential risk of SLE and RA...
  29. ncbi request reprint Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
    Eli A Stahl
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Nat Genet 42:508-14. 2010
    ..An additional 11 SNPs replicated at P < 0.05, many of which are validated autoimmune risk alleles, suggesting that most represent genuine rheumatoid arthritis risk alleles...
  30. pmc Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy
    Jing Cui
    Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Arthritis Rheum 62:1849-61. 2010
    ..The aim of the present study was to test established RA genetic risk factors to determine whether the same alleles also influence the response to anti-TNF therapy...
  31. ncbi request reprint Allele-specific methylation occurs at genetic variants associated with complex disease
    John N Hutchinson
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, United States of America Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 9:e98464. 2014
    ....
  32. doi request reprint Genetic variants that predict response to anti-tumor necrosis factor therapy in rheumatoid arthritis: current challenges and future directions
    Robert M Plenge
    Division of Rheumatology, Immunology and Allergy, Harvard Medical School, Brigham and Women s Hospital, Boston, MA, USA
    Curr Opin Rheumatol 20:145-52. 2008
    ..Here we review genetic association studies conducted to search for DNA biomarkers of response to anti-TNF therapy...
  33. ncbi request reprint A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus
    Robert R Graham
    Program in Medical and Population Genetics, Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Genet 38:550-5. 2006
    ..Thus, a common IRF5 haplotype driving elevated expression of multiple unique isoforms of IRF5 is an important genetic risk factor for SLE, establishing a causal role for type I IFN pathway genes in human autoimmunity...
  34. ncbi request reprint Identifying susceptibility genes for immunological disorders: patterns, power, and proof
    Robert Plenge
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA, USA
    Immunol Rev 210:40-51. 2006
    ..Recent developments in the fields of human genetics and genomics are overcoming limitations within the field, and we anticipate many exciting discoveries in the near future...
  35. pmc Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions
    Soumya Raychaudhuri
    Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
    PLoS Genet 5:e1000534. 2009
    ..An online version of this method is available for public use (http://www.broad.mit.edu/mpg/grail/)...
  36. pmc The major genetic determinants of HIV-1 control affect HLA class I peptide presentation
    Florencia Pereyra
    Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology MIT and Harvard, Boston, MA, USA
    Science 330:1551-7. 2010
    ..These results implicate the nature of the HLA-viral peptide interaction as the major factor modulating durable control of HIV infection...
  37. pmc Electronic medical records for discovery research in rheumatoid arthritis
    Katherine P Liao
    Brigham and Women s Hospital, Boston, Massachusetts, USA
    Arthritis Care Res (Hoboken) 62:1120-7. 2010
    ..We assessed whether a classification algorithm incorporating narrative EMR data (typed physician notes) more accurately classifies subjects with rheumatoid arthritis (RA) compared with an algorithm using codified EMR data alone...
  38. pmc De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of Fallot
    Steven C Greenway
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
    Nat Genet 41:931-5. 2009
    ..Our findings predict that at least 10% (4.5-15.5%, 95% confidence interval) of sporadic nonsyndromic TOF cases result from de novo CNVs and suggest that mutations within these loci might be etiologic in other cases of TOF...
  39. pmc Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus
    Robert R Graham
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 104:6758-63. 2007
    ....
  40. pmc Xenotropic murine leukemia virus-related virus prevalence in patients with chronic fatigue syndrome or chronic immunomodulatory conditions
    Timothy J Henrich
    Division of Infectious Diseases, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Infect Dis 202:1478-81. 2010
    ..XMRV DNA was not detected in any participant samples. We found no association between XMRV and patients with chronic fatigue syndrome or chronic immunomodulatory conditions...
  41. pmc Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis
    Henrik Kallberg
    Institute for Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Am J Hum Genet 80:867-75. 2007
    ..The data extend the basis for a pathogenetic hypothesis for RA involving genetic and environmental factors. The study also raises and illustrates principal questions concerning ways to define interactions in complex diseases...
  42. ncbi request reprint Evaluating potential for whole-genome studies in Kosrae, an isolated population in Micronesia
    Penelope E Bonnen
    Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nat Genet 38:214-7. 2006
    ..The long-range LD around common alleles and limited diversity result in improved efficiency in genetic studies in this population and augments the power to detect association of 'hidden SNPs'...
  43. pmc Specificity of the STAT4 genetic association for severe disease manifestations of systemic lupus erythematosus
    Kimberly E Taylor
    Rosalind Russell Medical Research Center for Arthritis, University of California San Francisco, California, USA
    PLoS Genet 4:e1000084. 2008
    ..We conclude that this common polymorphism of STAT4 contributes to the phenotypic heterogeneity of SLE, predisposing specifically to more severe disease...
  44. pmc STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus
    Elaine F Remmers
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, USA
    N Engl J Med 357:977-86. 2007
    ..Rheumatoid arthritis is a chronic inflammatory disease with a substantial genetic component. Susceptibility to disease has been linked with a region on chromosome 2q...
  45. pmc Analysis and application of European genetic substructure using 300 K SNP information
    Chao Tian
    Rowe Program in Human Genetics, University of California Davis, Davis, California, United States of America
    PLoS Genet 4:e4. 2008
    ..The results provide further insight into European population genetic substructure and show that this information can be used for improving error rates in association testing of candidate genes and in replication studies of WGA scans...
  46. pmc Several regions in the major histocompatibility complex confer risk for anti-CCP-antibody positive rheumatoid arthritis, independent of the DRB1 locus
    Hye Soon Lee
    The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, New York 11030, United States of America
    Mol Med 14:293-300. 2008
    ..These data emphasize that further analysis of the MHC is likely to reveal genetic risk factors for rheumatoid arthritis that are independent of the DRB1 shared epitope alleles...
  47. pmc Defining the role of the MHC in autoimmunity: a review and pooled analysis
    Michelle M A Fernando
    Section of Molecular Genetics and Rheumatology, Faculty of Medicine, Imperial College London, London, United Kingdom
    PLoS Genet 4:e1000024. 2008
    ..Furthermore, we find a number of interesting commonalities and differences across diseases that implicate both general and disease-specific pathogenetic mechanisms in autoimmunity...
  48. ncbi request reprint Autosomal dominant mutations affecting X inactivation choice in the mouse
    Ivona Percec
    Howard Hughes Medical Institute and Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 296:1136-9. 2002
    ..We have used chemical mutagenesis in the mouse to identify specific factors involved in X inactivation and report two genetically distinct autosomal mutations with dominant effects on X chromosome choice early in embryogenesis...
  49. pmc A novel polymorphism of the human CD40 receptor with enhanced function
    Anna L Peters
    Medical Scientist Training Program, University of Iowa, Iowa City, IA 52242, USA
    Blood 112:1863-71. 2008
    ..We have thus identified a novel genetic variant of hCD40 with a gain-of-function immune phenotype...
  50. pmc An N-ethyl-N-nitrosourea mutagenesis screen for epigenetic mutations in the mouse
    Ivona Percec
    Howard Hughes Medical Institute, and Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Genetics 164:1481-94. 2003
    ....
  51. pmc Skewed X-chromosome inactivation is a common feature of X-linked mental retardation disorders
    Robert M Plenge
    Department of Genetics, Case Western Reserve University School of Medicine, and Center for Human Genetics and Research Institute, University Hospitals of Cleveland, OH 44106, USA
    Am J Hum Genet 71:168-73. 2002
    ....

Research Grants7

  1. Mapping HIV/AIDS genes with haplotype-based strategies
    Robert Plenge; Fiscal Year: 2007
    ..These studies hope to identify novel genes that influence susceptibility to HIV/AIDS, thereby providing insight into HIV/AIDS pathogenesis and, ultimately, improving patient care. ..
  2. Meta-analysis of GWAS data to identify novel rheumatoid arthritis risk loci
    Robert M Plenge; Fiscal Year: 2010
    ..In addition, genetics should provide insight into important steps of the disease pathway, allowing for the development of new therapies that target these pathways in at-risk individuals. ..
  3. Dissection of two rheumatoid arthritis risk loci from genome-wide studies
    Robert Plenge; Fiscal Year: 2009
    ..In addition, genetics should provide insight into important steps of the disease pathway, allowing for the development of new therapies that target these pathways in at-risk individuals. ..
  4. Meta-analysis of GWAS data to identify novel rheumatoid arthritis risk loci
    Robert Plenge; Fiscal Year: 2009
    ..In addition, genetics should provide insight into important steps of the disease pathway, allowing for the development of new therapies that target these pathways in at-risk individuals. ..
  5. Dissection of two rheumatoid arthritis risk loci from genome-wide studies
    Robert M Plenge; Fiscal Year: 2010
    ..In addition, genetics should provide insight into important steps of the disease pathway, allowing for the development of new therapies that target these pathways in at-risk individuals. ..
  6. Deep Re-Sequencing of Rheumatoid Arthritis Risk Loci
    Robert M Plenge; Fiscal Year: 2010
    ..In addition, genetics should provide insight into important steps of the disease pathway, allowing for the development of new therapies that target these pathways in at-risk individuals. ..