Research Topics
| William F PirlSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
Research Grants
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Detail Information
Publications
Depression and survival in metastatic non-small-cell lung cancer: effects of early palliative careWilliam F Pirl
Massachusetts General Hospital Cancer Center, Center for Psychiatric Oncology and Behavioral Sciences, Yawkey 9A, 55 Fruit St, Boston, MA 02114, USA
J Clin Oncol 30:1310-5. 2012..In a secondary analysis, we explored the hypothesis that the survival benefit resulted from improving depression...
Psychological complications of prostate cancerWilliam F Pirl
Massachusetts General Hospital, Boston 02114, USA
Oncology (Williston Park) 16:1448-53; discussion 1453-4, 1457-8, 1467. 2002..This article reviews the prevalence of psychiatric symptomatology among prostate cancer patients, the psychological challenges of coping with the disease, and general guidelines for treatment...
Depression after diagnosis of advanced non-small cell lung cancer and survival: a pilot studyWilliam F Pirl
Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA
Psychosomatics 49:218-24. 2008..Major depressive disorder is estimated to occur in 10%-25% of people with cancer, and it has been inconsistently linked to increased mortality...
Screening for psychosocial distress: a national survey of oncologistsWilliam F Pirl
Department of Psychiatry, Massachusetts General Hospital Cancer Center, Boston, Massachusetts 02114, USA
J Support Oncol 5:499-504. 2007..Future efforts should focus on the dissemination and validation of the NCCN guidelines...
Prospective study of depression and fatigue in men with advanced prostate cancer receiving hormone therapyWilliam F Pirl
Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA
Psychooncology 17:148-53. 2008..We prospectively examined the development of depressive symptoms and fatigue among men with locally advanced prostate cancer receiving hormone therapy...
Tumor epidermal growth factor receptor genotype and depression in stage IV non-small cell lung cancerWilliam F Pirl
M P H, Massachusetts General Hospital Cancer Center, Yawkey 9A, 55 Fruit Street, Boston, Massachusetts 02114 USA
Oncologist 16:1299-306. 2011..We examined differences in depression severity and rates of positive screens for major depressive disorder among newly diagnosed patients with stage IV NSCLC and known epidermal growth factor receptor (EGFR) genotype...
Major depressive disorder in long-term cancer survivors: analysis of the National Comorbidity Survey ReplicationWilliam F Pirl
Department of Biostatistics, Massachusetts General Hospital, Yawkey 9A, 55 Fruit St, Boston, MA 02114, USA
J Clin Oncol 27:4130-4. 2009....
Screening for infectious diseases among patients in a state psychiatric hospitalWilliam F Pirl
Department of Psychiatry, Massachusetts General Hospital, Wang Ambulatory Care Center 812, 15 Parkman Street, and Department of Psychology, Boston University, Massachusetts 02114, USA
Psychiatr Serv 56:1614-6. 2005..These results confirm the importance of screening for infectious diseases among individuals with severe and persistent mental illness...
Effect of early palliative care on chemotherapy use and end-of-life care in patients with metastatic non-small-cell lung cancerJoseph A Greer
Massachusetts General Hospital Cancer Center, Yawkey Building, Suite 9A, 55 Fruit St, Boston, MA 02114, USA
J Clin Oncol 30:394-400. 2012..We sought to investigate whether early palliative care also affects the frequency and timing of chemotherapy use and hospice care for these patients...
Early palliative care for patients with metastatic non-small-cell lung cancerJennifer S Temel
Massachusetts General Hospital, Boston, MA 02114, USA
N Engl J Med 363:733-42. 2010..We examined the effect of introducing palliative care early after diagnosis on patient-reported outcomes and end-of-life care among ambulatory patients with newly diagnosed disease...
Parsing depression from fatigue in patients with cancer using the fatigue symptom inventoryLara Traeger
The Center for Psychiatric Oncology and Behavioral Sciences, Massachusetts General Hospital, Boston, Massachusetts, USA
J Pain Symptom Manage 42:52-9. 2011..A central aim in the management of cancer-related fatigue (CRF) is to identify treatable causes, such as depression. However, CRF and depression symptoms overlap and frequently co-occur, complicating diagnostic assessment...
Aggressiveness of care in a prospective cohort of patients with advanced NSCLCJennifer S Temel
Department of Hematology Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Cancer 113:826-33. 2008..Optimal end of life care of patients with terminal cancer is poorly understood. In this study, the aggressiveness of care is described in a cohort of patients with newly diagnosed advanced nonsmall-cell lung cancer (NSCLC)...
Longitudinal perceptions of prognosis and goals of therapy in patients with metastatic non-small-cell lung cancer: results of a randomized study of early palliative careJennifer S Temel
Massachusetts GeneralHospital Cancer Center, 55 Fruit Street, Massachusetts General Hospital, Boston, MA 02114, USA
J Clin Oncol 29:2319-26. 2011..The aims of this study were to explore perceptions of prognosis and goals of therapy in patients with metastatic non-small-cell lung cancer (NSCLC) and to examine the effect of early palliative care on these views over time...
Anxiety disorders in long-term survivors of adult cancersJoseph A Greer
Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA
Psychosomatics 52:417-23. 2011..Using data from the National Comorbidity Survey Replication (NCS-R), we compared rates of anxiety disorders between long-term cancer survivors and individuals without a history of cancer...
A structured exercise program for patients with advanced non-small cell lung cancerJennifer S Temel
Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Thorac Oncol 4:595-601. 2009..In this study, we examined the feasibility of a hospital-based exercise program for patients with advanced non-small cell lung cancer...
Phase II study: integrated palliative care in newly diagnosed advanced non-small-cell lung cancer patientsJennifer S Temel
Massachusetts General Hospital, Boston, MA 02114, USA
J Clin Oncol 25:2377-82. 2007..To assess the feasibility of early palliative care in the ambulatory setting in patients with newly diagnosed advanced non-small-cell lung cancer (NSCLC)...
Electronic prompt to improve outpatient code status documentation for patients with advanced lung cancerJennifer S Temel
Massachusetts General Hospital Cancer Center, 55 Fruit St, Yawkey 7E, Boston, MA 02114
J Clin Oncol 31:710-5. 2013..6 months [95% CI, 7.6 to 9.5]) compared with controls (10.5 months [95% CI, 9.8 to 11.3]; P = .004). CONCLUSION e-mail prompts may improve the rate and timing of code status documentation in the EHR and warrant further investigation...
A pilot randomized controlled trial of brief cognitive-behavioral therapy for anxiety in patients with terminal cancerJoseph A Greer
Center for Psychiatric Oncology and Behavioral Sciences, Massachusetts General Hospital Cancer Center, Yawkey Building, Suite 10B, 55 Fruit Street, Boston, Massachusetts 02114, USA
Oncologist 17:1337-45. 2012..04) and a large effect size for the intervention (Cohen's d = 0.80). Conclusion. Providing brief CBT tailored to the concerns of patients with terminal cancer was not only feasible but also led to significant improvements in anxiety...
Comparison of self-reported cognitive difficulties in a national sample of long-term cancer survivors and cancer-naive controlsIlana M Braun
Dana Farber Cancer Institute, Boston, MA 02215 5450, USA
Psychosomatics 53:68-74. 2012..This analysis of a population-based sample of United States residents compares self-reported cognitive difficulties in LTCS and cancer naïve controls (CNC), controlling for psychiatric disorders...
Using the differential from complete blood counts as a biomarker of fatigue in advanced non-small-cell lung cancer: an exploratory analysisJohanna S Paddison
Division of Psychiatry and Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Palliat Support Care 7:213-7. 2009..Our exploratory investigation considered whether variations in routinely available hematological parameters relate to the severity of fatigue reports...
Comprehensive symptom management in patients with advanced-stage non-small-cell lung cancerJennifer S Temel
Department of Medicine, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
Clin Lung Cancer 7:241-9. 2006..Therefore, comprehensive care of patients with advanced-stage NSCLC must include therapies targeted at these difficult and distressing symptoms...
Evidence-based treatment of anxiety in patients with cancerLara Traeger
Massachusetts General Hospital Cancer Center, Boston, MA, USA
J Clin Oncol 30:1197-205. 2012..Treatment planning should incorporate contributing factors to anxiety and patient preferences for psychiatric care...
Screening for major depression in post-myocardial infarction patients: operating characteristics of the Beck Depression Inventory-IIJeff C Huffman
Harvard Medical School, Boston, Massachusetts, USA
Int J Psychiatry Med 40:187-97. 2010..To assess the operating characteristics of the Beck-Depression Inventory-II (BDI-II) and the BDI-II cognitive subscale (BDI-II-cog) in screening for major depression (MDD) in post-myocardial infarction (MI) patients...
Clinical correlates of suicidal thoughts in patients with advanced cancerRyan J Spencer
Department of Obstetrics, Gynecology and Reproductive Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Geriatr Psychiatry 20:327-36. 2012..Clinical correlates of suicidal ideation in advanced cancer patients were examined to identify those at risk and to inform the development of interventions to reduce suicidal ideation in this vulnerable group...
Depression in men receiving androgen deprivation therapy for prostate cancer: a pilot studyWilliam F Pirl
Psychiatry Department, The Massachusetts General Hospital, Boston, MA 02114, USA
Psychooncology 11:518-23. 2002..Reports of depressive symptoms arising during ADT are emerging. This study examines the prevalence rates and risk factors associated with major depression in this population...
Evidenced-based report on the occurrence of fatigue in long-term cancer survivorsIlana M Braun
Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
J Natl Compr Canc Netw 6:347-54. 2008..Prospective longitudinal studies are needed to determine causal relationships between excessive fatigue and surviving cancer...
Code status documentation in the outpatient electronic medical records of patients with metastatic cancerJennifer S Temel
Massachusetts General Hospital Cancer Center, 55 Fruit Street, Yawkey 7B, Boston, MA 02114, USA
J Gen Intern Med 25:150-3. 2010..However, little is known about clinical practices in outpatient oncology settings related to discussing end-of-life care and documenting code status preferences in ambulatory medical records...
Low-dose clozapine and diabetic ketoacidosisJennifer M Lafayette
Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
Psychosomatics 44:249-52. 2003
Behavioral and psychological predictors of chemotherapy adherence in patients with advanced non-small cell lung cancerJoseph A Greer
Massachusetts General Hospital and Harvard Medical School, MA, USA
J Psychosom Res 65:549-52. 2008..The goal of this study was to explore the frequency and clinical predictors of infusion dose delays and reductions in this patient population...
Mutuality and specificity of mental disorders in advanced cancer patients and caregiversKara Zivin Bambauer
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, 133 Brookline Ave, 6th Floor, Boston, MA 02215, USA
Soc Psychiatry Psychiatr Epidemiol 41:819-24. 2006..We sought to determine mutuality and specificity in rates of mental disorders between advanced cancer patients and their caregivers...
Feasibility and validity of a one-item fatigue screen in a thoracic oncology clinicJennifer S Temel
Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Thorac Oncol 1:454-9. 2006..Despite its high prevalence, it is often unrecognized and undetected. This study assessed the feasibility and validity of a one-item fatigue scale (OIFS) in an outpatient oncology clinic...
Early palliative care and metastatic non-small cell lung cancer: Potential mechanisms of prolonged survivalKelly E Irwin
1Massachusetts General Hospital Cancer Center, Boston, MA, USA
Chron Respir Dis 10:35-47. 2013..This review summarizes the literature on potential survival benefits of palliative care and presents a model of how early integrated palliative care could potentially influence survival in patients with advanced cancer...
A comparison of clinician and patient concerns about antipsychotic side effects: a pilot studyJeff C Huffman
Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
J Nerv Ment Dis 192:328-30. 2004..Larger studies are needed to further investigate these findings...
Clozapine-induced eosinophilic colitisRakesh Karmacharya
Am J Psychiatry 162:1386-7. 2005
Research Grants
- Survey of oncology providers on psychosocial distressWilliam Pirl; Fiscal Year: 2005..abstract_text> ..
- Symptom Management Trial in Cancer SurvivorsWilliam Pirl; Fiscal Year: 2007..Secondary goals include evaluating tolerability and investigating moderators of treatment response. ..
