William F Pirl

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. doi request reprint Depression, survival, and epidermal growth factor receptor genotypes in patients with metastatic non-small cell lung cancer
    William F Pirl
    Center for Psychiatric Oncology and Behavioral Sciences, Massachusetts General Hospital Cancer Center, Boston, MA, USA
    Palliat Support Care 11:223-9. 2013
  2. pmc Depression and survival in metastatic non-small-cell lung cancer: effects of early palliative care
    William F Pirl
    Massachusetts General Hospital Cancer Center, Center for Psychiatric Oncology and Behavioral Sciences, Yawkey 9A, 55 Fruit St, Boston, MA 02114, USA
    J Clin Oncol 30:1310-5. 2012
  3. ncbi request reprint Psychological complications of prostate cancer
    William F Pirl
    Massachusetts General Hospital, Boston 02114, USA
    Oncology (Williston Park) 16:1448-53; discussion 1453-4, 1457-8, 1467. 2002
  4. ncbi request reprint Screening for psychosocial distress: a national survey of oncologists
    William F Pirl
    Department of Psychiatry, Massachusetts General Hospital Cancer Center, Boston, Massachusetts 02114, USA
    J Support Oncol 5:499-504. 2007
  5. ncbi request reprint Screening for infectious diseases among patients in a state psychiatric hospital
    William F Pirl
    Department of Psychiatry, Massachusetts General Hospital, Wang Ambulatory Care Center 812, 15 Parkman Street, and Department of Psychology, Boston University, Massachusetts 02114, USA
    Psychiatr Serv 56:1614-6. 2005
  6. pmc Tumor epidermal growth factor receptor genotype and depression in stage IV non-small cell lung cancer
    William F Pirl
    M P H, Massachusetts General Hospital Cancer Center, Yawkey 9A, 55 Fruit Street, Boston, Massachusetts 02114 USA
    Oncologist 16:1299-306. 2011
  7. doi request reprint Depression after diagnosis of advanced non-small cell lung cancer and survival: a pilot study
    William F Pirl
    Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA
    Psychosomatics 49:218-24. 2008
  8. pmc Major depressive disorder in long-term cancer survivors: analysis of the National Comorbidity Survey Replication
    William F Pirl
    Department of Biostatistics, Massachusetts General Hospital, Yawkey 9A, 55 Fruit St, Boston, MA 02114, USA
    J Clin Oncol 27:4130-4. 2009
  9. pmc Prospective study of depression and fatigue in men with advanced prostate cancer receiving hormone therapy
    William F Pirl
    Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA
    Psychooncology 17:148-53. 2008
  10. doi request reprint Effect of early palliative care on chemotherapy use and end-of-life care in patients with metastatic non-small-cell lung cancer
    Joseph A Greer
    Massachusetts General Hospital Cancer Center, Yawkey Building, Suite 9A, 55 Fruit St, Boston, MA 02114, USA
    J Clin Oncol 30:394-400. 2012

Research Grants

Detail Information

Publications43

  1. doi request reprint Depression, survival, and epidermal growth factor receptor genotypes in patients with metastatic non-small cell lung cancer
    William F Pirl
    Center for Psychiatric Oncology and Behavioral Sciences, Massachusetts General Hospital Cancer Center, Boston, MA, USA
    Palliat Support Care 11:223-9. 2013
    ..We investigated this possible relationship in a cohort of patients with metastatic NSCLC, in which we had previously demonstrated an association between depression and worse survival...
  2. pmc Depression and survival in metastatic non-small-cell lung cancer: effects of early palliative care
    William F Pirl
    Massachusetts General Hospital Cancer Center, Center for Psychiatric Oncology and Behavioral Sciences, Yawkey 9A, 55 Fruit St, Boston, MA 02114, USA
    J Clin Oncol 30:1310-5. 2012
    ..In a secondary analysis, we explored the hypothesis that the survival benefit resulted from improving depression...
  3. ncbi request reprint Psychological complications of prostate cancer
    William F Pirl
    Massachusetts General Hospital, Boston 02114, USA
    Oncology (Williston Park) 16:1448-53; discussion 1453-4, 1457-8, 1467. 2002
    ..This article reviews the prevalence of psychiatric symptomatology among prostate cancer patients, the psychological challenges of coping with the disease, and general guidelines for treatment...
  4. ncbi request reprint Screening for psychosocial distress: a national survey of oncologists
    William F Pirl
    Department of Psychiatry, Massachusetts General Hospital Cancer Center, Boston, Massachusetts 02114, USA
    J Support Oncol 5:499-504. 2007
    ..Future efforts should focus on the dissemination and validation of the NCCN guidelines...
  5. ncbi request reprint Screening for infectious diseases among patients in a state psychiatric hospital
    William F Pirl
    Department of Psychiatry, Massachusetts General Hospital, Wang Ambulatory Care Center 812, 15 Parkman Street, and Department of Psychology, Boston University, Massachusetts 02114, USA
    Psychiatr Serv 56:1614-6. 2005
    ..These results confirm the importance of screening for infectious diseases among individuals with severe and persistent mental illness...
  6. pmc Tumor epidermal growth factor receptor genotype and depression in stage IV non-small cell lung cancer
    William F Pirl
    M P H, Massachusetts General Hospital Cancer Center, Yawkey 9A, 55 Fruit Street, Boston, Massachusetts 02114 USA
    Oncologist 16:1299-306. 2011
    ..We examined differences in depression severity and rates of positive screens for major depressive disorder among newly diagnosed patients with stage IV NSCLC and known epidermal growth factor receptor (EGFR) genotype...
  7. doi request reprint Depression after diagnosis of advanced non-small cell lung cancer and survival: a pilot study
    William F Pirl
    Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA
    Psychosomatics 49:218-24. 2008
    ..Major depressive disorder is estimated to occur in 10%-25% of people with cancer, and it has been inconsistently linked to increased mortality...
  8. pmc Major depressive disorder in long-term cancer survivors: analysis of the National Comorbidity Survey Replication
    William F Pirl
    Department of Biostatistics, Massachusetts General Hospital, Yawkey 9A, 55 Fruit St, Boston, MA 02114, USA
    J Clin Oncol 27:4130-4. 2009
    ....
  9. pmc Prospective study of depression and fatigue in men with advanced prostate cancer receiving hormone therapy
    William F Pirl
    Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA
    Psychooncology 17:148-53. 2008
    ..We prospectively examined the development of depressive symptoms and fatigue among men with locally advanced prostate cancer receiving hormone therapy...
  10. doi request reprint Effect of early palliative care on chemotherapy use and end-of-life care in patients with metastatic non-small-cell lung cancer
    Joseph A Greer
    Massachusetts General Hospital Cancer Center, Yawkey Building, Suite 9A, 55 Fruit St, Boston, MA 02114, USA
    J Clin Oncol 30:394-400. 2012
    ..We sought to investigate whether early palliative care also affects the frequency and timing of chemotherapy use and hospice care for these patients...
  11. doi request reprint Early palliative care for patients with metastatic non-small-cell lung cancer
    Jennifer S Temel
    Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 363:733-42. 2010
    ..We examined the effect of introducing palliative care early after diagnosis on patient-reported outcomes and end-of-life care among ambulatory patients with newly diagnosed disease...
  12. doi request reprint The cultivation of prognostic awareness through the provision of early palliative care in the ambulatory setting: a communication guide
    Vicki A Jackson
    Division of Palliative Care, Massachusetts General Hospital, Boston, Massachusetts 02114, USA partners org
    J Palliat Med 16:894-900. 2013
    ..This approach can be used by both novice and more experienced palliative care clinicians...
  13. ncbi request reprint Associations among prognostic understanding, quality of life, and mood in patients with advanced cancer
    Areej El-Jawahri
    Division of Hematology Oncology, Massachusetts General Hospital, Boston, Massachusetts
    Cancer 120:278-85. 2014
    ..The objectives of this study were to assess perceptions of prognosis and preferences for prognostic information among patients with advanced cancer and to explore the associations of prognostic understanding with QoL and mood...
  14. pmc A pilot randomized controlled trial of brief cognitive-behavioral therapy for anxiety in patients with terminal cancer
    Joseph A Greer
    Center for Psychiatric Oncology and Behavioral Sciences, Massachusetts General Hospital Cancer Center, Yawkey Building, Suite 10B, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Oncologist 17:1337-45. 2012
    ..In this pilot randomized controlled trial (clinicaltrials.gov identifier NCT00706290), we examined the feasibility and potential efficacy of brief CBT to reduce anxiety in patients with terminal cancer...
  15. doi request reprint Parsing depression from fatigue in patients with cancer using the fatigue symptom inventory
    Lara Traeger
    The Center for Psychiatric Oncology and Behavioral Sciences, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Pain Symptom Manage 42:52-9. 2011
    ..A central aim in the management of cancer-related fatigue (CRF) is to identify treatable causes, such as depression. However, CRF and depression symptoms overlap and frequently co-occur, complicating diagnostic assessment...
  16. doi request reprint Aggressiveness of care in a prospective cohort of patients with advanced NSCLC
    Jennifer S Temel
    Department of Hematology Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Cancer 113:826-33. 2008
    ..Optimal end of life care of patients with terminal cancer is poorly understood. In this study, the aggressiveness of care is described in a cohort of patients with newly diagnosed advanced nonsmall-cell lung cancer (NSCLC)...
  17. doi request reprint Longitudinal perceptions of prognosis and goals of therapy in patients with metastatic non-small-cell lung cancer: results of a randomized study of early palliative care
    Jennifer S Temel
    Massachusetts GeneralHospital Cancer Center, 55 Fruit Street, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Oncol 29:2319-26. 2011
    ..The aims of this study were to explore perceptions of prognosis and goals of therapy in patients with metastatic non-small-cell lung cancer (NSCLC) and to examine the effect of early palliative care on these views over time...
  18. pmc Anxiety disorders in long-term survivors of adult cancers
    Joseph A Greer
    Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA
    Psychosomatics 52:417-23. 2011
    ..Using data from the National Comorbidity Survey Replication (NCS-R), we compared rates of anxiety disorders between long-term cancer survivors and individuals without a history of cancer...
  19. doi request reprint Early palliative care in advanced lung cancer: a qualitative study
    Jaclyn Yoong
    Massachusetts General Hospital, Boston, MA 02114, USA
    JAMA Intern Med 173:283-90. 2013
    ..During critical clinical time points, PC and oncologic care visits have distinct features that suggest a key role for PC involvement and enable oncologists to focus on cancer treatment and managing medical complications...
  20. doi request reprint Electronic prompt to improve outpatient code status documentation for patients with advanced lung cancer
    Jennifer S Temel
    Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA
    J Clin Oncol 31:710-5. 2013
    ....
  21. doi request reprint Early palliative care and metastatic non-small cell lung cancer: potential mechanisms of prolonged survival
    Kelly E Irwin
    Massachusetts General Hospital Cancer Center, Boston, MA, USA
    Chron Respir Dis 10:35-47. 2013
    ..This review summarizes the literature on potential survival benefits of palliative care and presents a model of how early integrated palliative care could potentially influence survival in patients with advanced cancer...
  22. ncbi request reprint Phase II study: integrated palliative care in newly diagnosed advanced non-small-cell lung cancer patients
    Jennifer S Temel
    Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Oncol 25:2377-82. 2007
    ..To assess the feasibility of early palliative care in the ambulatory setting in patients with newly diagnosed advanced non-small-cell lung cancer (NSCLC)...
  23. pmc A structured exercise program for patients with advanced non-small cell lung cancer
    Jennifer S Temel
    Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Thorac Oncol 4:595-601. 2009
    ..In this study, we examined the feasibility of a hospital-based exercise program for patients with advanced non-small cell lung cancer...
  24. doi request reprint Evidence-based treatment of anxiety in patients with cancer
    Lara Traeger
    Massachusetts General Hospital Cancer Center, Boston, MA, USA
    J Clin Oncol 30:1197-205. 2012
    ..The evidence-based literature supports the use of psychosocial and psychopharmacologic treatments to prevent or alleviate anxiety symptoms...
  25. ncbi request reprint Behavioral and psychological predictors of chemotherapy adherence in patients with advanced non-small cell lung cancer
    Joseph A Greer
    Massachusetts General Hospital and Harvard Medical School, MA, USA
    J Psychosom Res 65:549-52. 2008
    ..The goal of this study was to explore the frequency and clinical predictors of infusion dose delays and reductions in this patient population...
  26. doi request reprint Comparison of self-reported cognitive difficulties in a national sample of long-term cancer survivors and cancer-naive controls
    Ilana M Braun
    Dana Farber Cancer Institute, Boston, MA 02215 5450, USA
    Psychosomatics 53:68-74. 2012
    ..This analysis of a population-based sample of United States residents compares self-reported cognitive difficulties in LTCS and cancer naïve controls (CNC), controlling for psychiatric disorders...
  27. doi request reprint Depression and undertreatment of depression: potential risks and outcomes in black patients with lung cancer
    Lara Traeger
    Center for Psychiatric Oncology and Behavioral Sciences, Massachusetts General Hospital, Boston, MA, USA
    J Psychosoc Oncol 31:123-35. 2013
    ..Racial barriers to depression identification and treatment in the general population may compound these risks. Prospective data are needed to examine whether depression plays a role in racial disparities in lung cancer outcomes...
  28. ncbi request reprint Comprehensive symptom management in patients with advanced-stage non-small-cell lung cancer
    Jennifer S Temel
    Department of Medicine, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin Lung Cancer 7:241-9. 2006
    ..Therefore, comprehensive care of patients with advanced-stage NSCLC must include therapies targeted at these difficult and distressing symptoms...
  29. doi request reprint Using the differential from complete blood counts as a biomarker of fatigue in advanced non-small-cell lung cancer: an exploratory analysis
    Johanna S Paddison
    Division of Psychiatry and Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Palliat Support Care 7:213-7. 2009
    ..Our exploratory investigation considered whether variations in routinely available hematological parameters relate to the severity of fatigue reports...
  30. ncbi request reprint Screening for major depression in post-myocardial infarction patients: operating characteristics of the Beck Depression Inventory-II
    Jeff C Huffman
    Harvard Medical School, Boston, Massachusetts, USA
    Int J Psychiatry Med 40:187-97. 2010
    ..To assess the operating characteristics of the Beck-Depression Inventory-II (BDI-II) and the BDI-II cognitive subscale (BDI-II-cog) in screening for major depression (MDD) in post-myocardial infarction (MI) patients...
  31. pmc Code status documentation in the outpatient electronic medical records of patients with metastatic cancer
    Jennifer S Temel
    Massachusetts General Hospital Cancer Center, 55 Fruit Street, Yawkey 7B, Boston, MA 02114, USA
    J Gen Intern Med 25:150-3. 2010
    ..However, little is known about clinical practices in outpatient oncology settings related to discussing end-of-life care and documenting code status preferences in ambulatory medical records...
  32. pmc Clinical correlates of suicidal thoughts in patients with advanced cancer
    Ryan J Spencer
    Department of Obstetrics, Gynecology and Reproductive Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Geriatr Psychiatry 20:327-36. 2012
    ..Clinical correlates of suicidal ideation in advanced cancer patients were examined to identify those at risk and to inform the development of interventions to reduce suicidal ideation in this vulnerable group...
  33. ncbi request reprint Evidenced-based report on the occurrence of fatigue in long-term cancer survivors
    Ilana M Braun
    Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Natl Compr Canc Netw 6:347-54. 2008
    ..Prospective longitudinal studies are needed to determine causal relationships between excessive fatigue and surviving cancer...
  34. ncbi request reprint Depression in men receiving androgen deprivation therapy for prostate cancer: a pilot study
    William F Pirl
    Psychiatry Department, The Massachusetts General Hospital, Boston, MA 02114, USA
    Psychooncology 11:518-23. 2002
    ..Reports of depressive symptoms arising during ADT are emerging. This study examines the prevalence rates and risk factors associated with major depression in this population...
  35. doi request reprint Development and evaluation of targeted psychological skills training for oncology nurses in managing stressful patient and family encounters
    Lara Traeger
    Massachusetts General Hospital Cancer Center, Boston, USA
    Oncol Nurs Forum 40:E327-36. 2013
    ..To reduce workplace stress by developing a brief psychological skills training for nurses and to evaluate program feasibility, acceptability, and preliminary efficacy in decreasing burnout and stress...
  36. doi request reprint Documentation of oral versus intravenous chemotherapy plans in patients with metastatic non-small-cell lung cancer
    Joseph A Greer
    Massachusetts General Hospital Cancer Center, Boston, MA
    J Oncol Pract 10:e103-6. 2014
    ....
  37. ncbi request reprint Low-dose clozapine and diabetic ketoacidosis
    Jennifer M Lafayette
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Psychosomatics 44:249-52. 2003
  38. ncbi request reprint Role of biopsychosocial screening in cancer care
    Matthew Loscalzo
    From the Supportive Care Programs, City of Hope, Duarte, CA Department of Medical Oncology and Therapeutics Research, City of Hope, Duarte, CA and Center for Psychiatric Oncology and Behavioral Sciences at the Massachusetts General Hospital Cancer Center, Boston, MA
    Cancer J 19:414-20. 2013
    ..Biopsychosocial screening programs have the potential to be the connective tissue of these patient- and family-centered systems. ..
  39. doi request reprint Cancer care for individuals with schizophrenia
    Kelly E Irwin
    Massachusetts General Hospital Cancer Center, Center for Psychiatric Oncology and Behavioral Sciences, Boston, Massachusetts Massachusetts General Hospital Schizophrenia Program, Massachusetts General Hospital, Boston, Massachusetts
    Cancer 120:323-34. 2014
    ..Despite significant challenges, with collaboration between oncology and mental health teams, individuals with schizophrenia can receive high-quality cancer care...
  40. ncbi request reprint Feasibility and validity of a one-item fatigue screen in a thoracic oncology clinic
    Jennifer S Temel
    Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Thorac Oncol 1:454-9. 2006
    ..Despite its high prevalence, it is often unrecognized and undetected. This study assessed the feasibility and validity of a one-item fatigue scale (OIFS) in an outpatient oncology clinic...
  41. pmc Mutuality and specificity of mental disorders in advanced cancer patients and caregivers
    Kara Zivin Bambauer
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, 133 Brookline Ave, 6th Floor, Boston, MA 02215, USA
    Soc Psychiatry Psychiatr Epidemiol 41:819-24. 2006
    ..We sought to determine mutuality and specificity in rates of mental disorders between advanced cancer patients and their caregivers...
  42. ncbi request reprint A comparison of clinician and patient concerns about antipsychotic side effects: a pilot study
    Jeff C Huffman
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    J Nerv Ment Dis 192:328-30. 2004
    ..Larger studies are needed to further investigate these findings...
  43. ncbi request reprint Clozapine-induced eosinophilic colitis
    Rakesh Karmacharya
    Am J Psychiatry 162:1386-7. 2005

Research Grants3

  1. Survey of oncology providers on psychosocial distress
    William Pirl; Fiscal Year: 2005
    ..abstract_text> ..
  2. Symptom Management Trial in Cancer Survivors
    William Pirl; Fiscal Year: 2007
    ..Secondary goals include evaluating tolerability and investigating moderators of treatment response. ..