R H Perlis

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Long-term implications of early onset in bipolar disorder: data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD)
    Roy H Perlis
    Partners Bipolar Treatment Center at Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 55:875-81. 2004
  2. ncbi request reprint Depressive illness burden associated with complex polypharmacy in patients with bipolar disorder: findings from the STEP-BD
    Joseph F Goldberg
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    J Clin Psychiatry 70:155-62. 2009
  3. pmc QT interval and antidepressant use: a cross sectional study of electronic health records
    Victor M Castro
    Partners Research Computing, Partners HealthCare System, One Constitution Center, Boston, MA 02129, USA
    BMJ 346:f288. 2013
  4. pmc Incident user cohort study of risk for gastrointestinal bleed and stroke in individuals with major depressive disorder treated with antidepressants
    Victor M Castro
    Partners Research Computing, Partners HealthCare System, Boston, MA
    BMJ Open 2:e000544. 2012
  5. pmc A clinical risk stratification tool for predicting treatment resistance in major depressive disorder
    Roy H Perlis
    Center for Experimental Drugs and Diagnostics, Department of Psychiatry and Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Biol Psychiatry 74:7-14. 2013
  6. pmc Do suicidal thoughts or behaviors recur during a second antidepressant treatment trial?
    Roy H Perlis
    Center for Experimental Drugs and Diagnostics, Massachusetts General Hospital, 185 Cambridge St, 6th Floor, Boston, MA 02114, USA
    J Clin Psychiatry 73:1439-42. 2012
  7. pmc Using electronic medical records to enable large-scale studies in psychiatry: treatment resistant depression as a model
    R H Perlis
    Depression Clinic and Research Program, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
    Psychol Med 42:41-50. 2012
  8. doi request reprint Variation in catechol-O-methyltransferase is associated with duloxetine response in a clinical trial for major depressive disorder
    Roy H Perlis
    Department of Psychiatry and Center for Human Genetics Research, Massachusetts General Hospital, Boston, Massachusetts 02144, USA
    Biol Psychiatry 65:785-91. 2009
  9. doi request reprint Pharmacogenetic analysis of genes implicated in rodent models of antidepressant response: association of TREK1 and treatment resistance in the STAR(*)D study
    Roy H Perlis
    Depression Clinical and Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Neuropsychopharmacology 33:2810-9. 2008
  10. ncbi request reprint Treatment of bipolar disorder: the evolving role of atypical antipsychotics
    Roy H Perlis
    Harvard Medical School, 15 Parkman St, AC 812, Boston, MA 02114 3117, USA
    Am J Manag Care 13:S178-88. 2007

Collaborators

Detail Information

Publications97

  1. ncbi request reprint Long-term implications of early onset in bipolar disorder: data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD)
    Roy H Perlis
    Partners Bipolar Treatment Center at Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 55:875-81. 2004
    ..Early onset of mood symptoms in bipolar disorder has been associated with poor outcome in many studies; however, the factors that might contribute to poor outcome have not been adequately investigated...
  2. ncbi request reprint Depressive illness burden associated with complex polypharmacy in patients with bipolar disorder: findings from the STEP-BD
    Joseph F Goldberg
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    J Clin Psychiatry 70:155-62. 2009
    ..Many patients with bipolar disorder receive multi-drug treatment regimens, but the distinguishing profiles of patients who receive complex pharmacologies have not been established...
  3. pmc QT interval and antidepressant use: a cross sectional study of electronic health records
    Victor M Castro
    Partners Research Computing, Partners HealthCare System, One Constitution Center, Boston, MA 02129, USA
    BMJ 346:f288. 2013
    ..To quantify the impact of citalopram and other selective serotonin reuptake inhibitors on corrected QT interval (QTc), a marker of risk for ventricular arrhythmia, in a large and diverse clinical population...
  4. pmc Incident user cohort study of risk for gastrointestinal bleed and stroke in individuals with major depressive disorder treated with antidepressants
    Victor M Castro
    Partners Research Computing, Partners HealthCare System, Boston, MA
    BMJ Open 2:e000544. 2012
    ..To examine the association between exposure to newer antidepressants and risk of gastrointestinal (GI) and other bleeding complications among individuals with major depressive disorder (MDD)...
  5. pmc A clinical risk stratification tool for predicting treatment resistance in major depressive disorder
    Roy H Perlis
    Center for Experimental Drugs and Diagnostics, Department of Psychiatry and Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Biol Psychiatry 74:7-14. 2013
    ..At present, validated tools to facilitate this risk stratification are rarely used in psychiatric practice...
  6. pmc Do suicidal thoughts or behaviors recur during a second antidepressant treatment trial?
    Roy H Perlis
    Center for Experimental Drugs and Diagnostics, Massachusetts General Hospital, 185 Cambridge St, 6th Floor, Boston, MA 02114, USA
    J Clin Psychiatry 73:1439-42. 2012
    ..The present study explores whether this subset of patients is also more likely to experience recurrence or worsening of these symptoms during a second treatment trial with a different antidepressant...
  7. pmc Using electronic medical records to enable large-scale studies in psychiatry: treatment resistant depression as a model
    R H Perlis
    Depression Clinic and Research Program, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
    Psychol Med 42:41-50. 2012
    ..Electronic medical records (EMR) provide a unique opportunity for efficient, large-scale clinical investigation in psychiatry. However, such studies will require development of tools to define treatment outcome...
  8. doi request reprint Variation in catechol-O-methyltransferase is associated with duloxetine response in a clinical trial for major depressive disorder
    Roy H Perlis
    Department of Psychiatry and Center for Human Genetics Research, Massachusetts General Hospital, Boston, Massachusetts 02144, USA
    Biol Psychiatry 65:785-91. 2009
    ..The study objective was to evaluate variations in genes implicated in antidepressant mechanism of action for association with response to duloxetine treatment in major depressive disorder (MDD)...
  9. doi request reprint Pharmacogenetic analysis of genes implicated in rodent models of antidepressant response: association of TREK1 and treatment resistance in the STAR(*)D study
    Roy H Perlis
    Depression Clinical and Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Neuropsychopharmacology 33:2810-9. 2008
    ..More broadly, they indicate the utility of animal models in identifying genes for pharmacogenetic studies of antidepressant response...
  10. ncbi request reprint Treatment of bipolar disorder: the evolving role of atypical antipsychotics
    Roy H Perlis
    Harvard Medical School, 15 Parkman St, AC 812, Boston, MA 02114 3117, USA
    Am J Manag Care 13:S178-88. 2007
    ....
  11. pmc Stability of symptoms across major depressive episodes in bipolar disorder
    Roy H Perlis
    Bipolar Clinic and Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Bipolar Disord 11:867-75. 2009
    ..These studies make the implicit assumption of stability of symptoms across episodes in mood disorders, which has rarely been investigated...
  12. ncbi request reprint Association between treatment-emergent suicidal ideation with citalopram and polymorphisms near cyclic adenosine monophosphate response element binding protein in the STAR*D study
    Roy H Perlis
    Massachusetts General Hospital, Boston, MA 02114, USA
    Arch Gen Psychiatry 64:689-97. 2007
    ....
  13. ncbi request reprint Pharmacogenetic studies of antidepressant response: how far from the clinic?
    Roy H Perlis
    Pharmacogenetics Research Unit, Depression and Bipolar Clinical and Research Programs, Center for Human Genetics Research, Massachusetts General Hospital, 15 Parkman St, WACC 812, Boston, MA 02114, USA
    Psychiatr Clin North Am 30:125-38. 2007
    ....
  14. ncbi request reprint Use of treatment guidelines in clinical decision making in bipolar disorder: a pilot survey of clinicians
    Roy H Perlis
    Depression and Bipolar Clinical and Research Programs, Massachusetts General Hospital, Boston, MA 02114, USA
    Curr Med Res Opin 23:467-75. 2007
    ..The objective of this study was to assess the extent to which such guidelines are used in the treatment of bipolar disorder...
  15. ncbi request reprint Clinical and genetic dissection of anger expression and CREB1 polymorphisms in major depressive disorder
    Roy H Perlis
    Depression Clinical and Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 62:536-40. 2007
    ..Therefore, we examined the association between CREB1 polymorphisms and anger expression in MDD...
  16. ncbi request reprint Olanzapine versus risperidone in the treatment of manic or mixed States in bipolar I disorder: a randomized, double-blind trial
    Roy H Perlis
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychiatry 67:1747-53. 2006
    ..To compare olanzapine and risperidone in the treatment of nonpsychotic acute manic or mixed episodes...
  17. ncbi request reprint Treatment-associated suicidal ideation and adverse effects in an open, multicenter trial of fluoxetine for major depressive episodes
    Roy H Perlis
    Depression Clinical and Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Psychother Psychosom 76:40-6. 2007
    ..The time course and clinical correlates of this phenomenon have not been characterized in detail...
  18. pmc Irritability is associated with anxiety and greater severity, but not bipolar spectrum features, in major depressive disorder
    R H Perlis
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Acta Psychiatr Scand 119:282-9. 2009
    ..We examined clinical correlates of irritability in a confirmatory cohort of Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study participants with major depressive disorder (MDD)...
  19. ncbi request reprint Clinical decision making in the treatment of mania
    Roy H Perlis
    Department of Psychiatry, Harvard Medical School, and Bipolar Clinical and Research Program, Massachusetts General Hospital, Boston, MA, USA
    J Clin Psychiatry 69:16-21. 2008
    ..Considering data from recent clinical studies that have compared the efficacy, safety, and tolerability of medications for bipolar mania both between and within classes may facilitate such treatment decisions...
  20. doi request reprint Genetic and clinical predictors of sexual dysfunction in citalopram-treated depressed patients
    Roy H Perlis
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
    Neuropsychopharmacology 34:1819-28. 2009
    ..These hypothesis-generating analyses suggest the potential for glutamatergic treatment targets for sexual dysfunction during major depressive episodes...
  21. pmc Association between bipolar spectrum features and treatment outcomes in outpatients with major depressive disorder
    Roy H Perlis
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Arch Gen Psychiatry 68:351-60. 2011
    ..It has been suggested that patients with major depressive disorder (MDD) who display pretreatment features suggestive of bipolar disorder or bipolar spectrum features might have poorer treatment outcomes...
  22. pmc Genome-wide association study of suicide attempts in mood disorder patients
    Roy H Perlis
    Department of Psychiatry, Massachusetts General Hospital, Boston, 02114, USA
    Am J Psychiatry 167:1499-507. 2010
    ..The authors therefore examined the association between common genomewide variation and lifetime suicide attempts...
  23. pmc Transition to mania during treatment of bipolar depression
    Roy H Perlis
    Department of Psychiatry, Bipolar Clinic and Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Neuropsychopharmacology 35:2545-52. 2010
    ..These results indicate that certain clinical features may be associated with greater risk of transition from depression to manic or mixed states, but the majority of them are not specific to antidepressant-treated patients...
  24. pmc Prevalence of incompletely penetrant Huntington's disease alleles among individuals with major depressive disorder
    Roy H Perlis
    Center for Human Genetic Research and the Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 167:574-9. 2010
    ..However, the prevalence of HTT CAG repeat expansions among individuals diagnosed with major depressive disorder has not been established...
  25. doi request reprint Clinical features associated with poor pharmacologic adherence in bipolar disorder: results from the STEP-BD study
    Roy H Perlis
    Bipolar Clinic and Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychiatry 71:296-303. 2010
    ..Poor medication adherence is common among bipolar patients...
  26. doi request reprint Benzodiazepine use and risk of recurrence in bipolar disorder: a STEP-BD report
    Roy H Perlis
    Bipolar Clinic and Research Programs, 50 Staniford St, 5th Floor, Boston, MA 02114, USA
    J Clin Psychiatry 71:194-200. 2010
    ..Benzodiazepines are widely prescribed to patients with bipolar disorder, but their impact on relapse and recurrence has not been examined...
  27. ncbi request reprint Genetic association study of treatment response with olanzapine/fluoxetine combination or lamotrigine in bipolar I depression
    Roy H Perlis
    Bipolar Clinic and Research Program, 50 Staniford St, 5th Floor, Boston, MA 02114, USA
    J Clin Psychiatry 71:599-605. 2010
    ..To evaluate common genetic variations for association with symptomatic improvement in bipolar I depression following treatment with olanzapine/fluoxetine combination (OFC) or lamotrigine...
  28. pmc Retrospective age at onset of bipolar disorder and outcome during two-year follow-up: results from the STEP-BD study
    Roy H Perlis
    Bipolar Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, ACC 812 15 Parkman Street, Boston, MA 02114, USA
    Bipolar Disord 11:391-400. 2009
    ..Symptoms of bipolar disorder are increasingly recognized among children and adolescents, but little is known about the course of bipolar disorder among adults who experience childhood onset of symptoms...
  29. pmc When is pharmacogenetic testing for antidepressant response ready for the clinic? A cost-effectiveness analysis based on data from the STAR*D study
    Roy H Perlis
    Center for Human Genetics Research, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Neuropsychopharmacology 34:2227-36. 2009
    ..These circumstances, particularly availability of alternative treatment strategies and test effect sizes, can be estimated and should be considered before these tests are broadly applied in clinical settings...
  30. pmc A genomewide association study of response to lithium for prevention of recurrence in bipolar disorder
    Roy H Perlis
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
    Am J Psychiatry 166:718-25. 2009
    ....
  31. ncbi request reprint Atypical antipsychotics in the treatment of mania: a meta-analysis of randomized, placebo-controlled trials
    Roy H Perlis
    Bipolar Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychiatry 67:509-16. 2006
    ..However, there are no published comparisons of individual atypical antipsychotics for mania...
  32. ncbi request reprint Predictors of recurrence in bipolar disorder: primary outcomes from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
    Roy H Perlis
    Bipolar Clinical and Research Program, Massachusetts General Hospital, ACC 812, 15 Parkman Street, Boston, MA 02114, USA
    Am J Psychiatry 163:217-24. 2006
    ..The authors looked for the features associated with risk of recurrence...
  33. ncbi request reprint Industry sponsorship and financial conflict of interest in the reporting of clinical trials in psychiatry
    Roy H Perlis
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Psychiatry 162:1957-60. 2005
    ..The extent and implications of industry sponsorship and financial conflict of interest in psychiatric clinical trials have not been investigated, to the authors' knowledge...
  34. ncbi request reprint Revisiting depressive-prone bipolar disorder: polarity of initial mood episode and disease course among bipolar I systematic treatment enhancement program for bipolar disorder participants
    Roy H Perlis
    Bipolar Clinical and Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Biol Psychiatry 58:549-53. 2005
    ..We examined the hypothesis that a first depressive rather than manic episode in bipolar disorder might herald a subsequent course notable for greater burden of depressive symptoms...
  35. ncbi request reprint Clinical and sociodemographic predictors of response to augmentation, or dose increase among depressed outpatients resistant to fluoxetine 20 mg/day
    R H Perlis
    Depression Clinical and Research Program, Massachusetts General Hospital, WACC 812, 15 Parkman Street, Boston, MA 02114, USA
    Acta Psychiatr Scand 108:432-8. 2003
    ..Factors moderating response to these next-step interventions are not well-studied...
  36. ncbi request reprint Prevalence and clinical correlates of irritability in major depressive disorder: a preliminary report from the Sequenced Treatment Alternatives to Relieve Depression study
    Roy H Perlis
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychiatry 66:159-66; quiz 147, 273-4. 2005
    ..Irritability with or without depression has been associated with risk for suicide, violence, and cardiovascular disease...
  37. ncbi request reprint Pharmacogenetic testing in the clinical management of schizophrenia: a decision-analytic model
    Roy H Perlis
    Pharmacogenomics Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychopharmacol 25:427-34. 2005
    ..More consistent reporting of test parameters such as sensitivity and specificity would greatly facilitate assessment of future pharmacogenetic studies...
  38. ncbi request reprint The prevalence and clinical correlates of anger attacks during depressive episodes in bipolar disorder
    Roy H Perlis
    Massachusetts General Hospital Department of Psychiatry, Boston, MA, USA
    J Affect Disord 79:291-5. 2004
    ..This study compared the prevalence and clinical significance of anger attacks in unipolar versus bipolar depression...
  39. ncbi request reprint Effect of medical comorbidity on response to fluoxetine augmentation or dose increase in outpatients with treatment-resistant depression
    Roy H Perlis
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston 02114, USA
    Psychosomatics 45:224-9. 2004
    ..Medical comorbidity thus does not appear to be associated with significantly poorer outcome among patients whose major depressive disorder failed initially to respond to an initial trial of 20 mg/day of fluoxetine...
  40. ncbi request reprint The Texas implementation of medication algorithms update for treatment of bipolar I disorder
    Roy H Perlis
    Bipolar Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    J Clin Psychiatry 66:818-20. 2005
  41. ncbi request reprint The role of pharmacologic treatment guidelines for bipolar disorder
    Roy H Perlis
    Bipolar Clinic and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 66:37-47. 2005
    ....
  42. ncbi request reprint Misdiagnosis of bipolar disorder
    Roy H Perlis
    Harvard Medical School, Boston, MA 02114, USA
    Am J Manag Care 11:S271-4. 2005
    ..Careful screening for current and past symptoms of mania or hypomania, as well as close clinical follow-up, can help to reduce misdiagnosis...
  43. ncbi request reprint Effects of adding cognitive therapy to fluoxetine dose increase on risk of relapse and residual depressive symptoms in continuation treatment of major depressive disorder
    Roy H Perlis
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, 02114, USA
    J Clin Psychopharmacol 22:474-80. 2002
    ....
  44. ncbi request reprint Strategies for treatment of SSRI-associated sexual dysfunction: a survey of an academic psychopharmacology practice
    Roy H Perlis
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston 02114, USA
    Harv Rev Psychiatry 10:109-14. 2002
  45. ncbi request reprint Biological predictors of treatment response in affective illness
    Roy H Perlis
    Department of Psychiatry, Depression Clinical and Research Program, Massachusetts General Hospital, 15 Parkman Street, WACC 812, Boston, MA 02114, USA
    Psychiatr Clin North Am 26:323-44, vii. 2003
    ....
  46. ncbi request reprint Effect of abrupt change from standard to low serum levels of lithium: a reanalysis of double-blind lithium maintenance data
    Roy H Perlis
    Department of Psychiatry, Massachusetts General Hospital, 50 Staniford Street, Boston, MA 02114, USA
    Am J Psychiatry 159:1155-9. 2002
    ..To assess the effect of abrupt change in lithium dose, the authors reanalyzed data from a previously reported, randomized, double-blind trial of standard- versus low-dose lithium for maintenance therapy in bipolar disorder...
  47. ncbi request reprint Clinical features of bipolar depression versus major depressive disorder in large multicenter trials
    Roy H Perlis
    Massachusetts General Hospital, ACC 812, 15 Parkman Street, Boston, MA 02114, USA
    Am J Psychiatry 163:225-31. 2006
    ..Clinical features that could distinguish bipolar from unipolar depression would facilitate more appropriate treatment selection...
  48. doi request reprint Pretreatment frontal EEG and changes in suicidal ideation during SSRI treatment in major depressive disorder
    D V Iosifescu
    Depression Clinical and Research Program, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Acta Psychiatr Scand 117:271-6. 2008
    ..We investigated frontal quantitative EEG (QEEG) as predictor of changes in suicidal ideation (SI) during SSRI treatment in major depressive disorder (MDD)...
  49. doi request reprint Personality and bipolar disorder: dissecting state and trait associations between mood and personality
    J H Barnett
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, and Psychiatric Genetics Program in Mood and Anxiety Disorders, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
    Psychol Med 41:1593-604. 2011
    ..This study aimed to determine whether there is a characteristic personality profile in BD, and whether associations between BD and personality are best explained by state or trait effects...
  50. ncbi request reprint Association between the 5HT1B receptor gene (HTR1B) and the inattentive subtype of ADHD
    Jordan W Smoller
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Biol Psychiatry 59:460-7. 2006
    ..Association with a single nucleotide polymorphism (SNP; G861C) has been observed, but more extensive linkage disequilibrium analyses have not been reported...
  51. pmc Whole-genome association study of bipolar disorder
    P Sklar
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Mol Psychiatry 13:558-69. 2008
    ..Given the heritability of BP disorder, the lack of agreement between studies emphasizes that susceptibility alleles are likely to be modest in effect size and require even larger samples for detection...
  52. ncbi request reprint Failure to replicate genetic associations with antidepressant treatment response in duloxetine-treated patients
    Roy H Perlis
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 67:1110-3. 2010
    ..We sought to replicate these associations in a study of a serotonin-norepinephrine reuptake inhibitor...
  53. pmc Psychiatric co-morbidity is associated with increased risk of surgery in Crohn's disease
    A N Ananthakrishnan
    Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA
    Aliment Pharmacol Ther 37:445-54. 2013
    ..Prior studies examining this may be confounded by the co-existence of functional bowel symptoms. Limited data exist examining an association between depression or anxiety and disease-specific endpoints such as bowel surgery...
  54. ncbi request reprint BDNF, relative preference, and reward circuitry responses to emotional communication
    G P Gasic
    Motivation and Emotion Neuroscience Collaboration MENC, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Med Genet B Neuropsychiatr Genet 150:762-81. 2009
    ..This study demonstrates that functional allelic variation in BDNF modulates human brain circuits processing reward/aversion information and relative preference transactions...
  55. ncbi request reprint Clinical insights into pharmacogenetics and schizophrenia, part 2
    John M Kane
    Department of Psychiatry, Zucker Hillside Hospital, Glen Oaks, NY, USA
    J Clin Psychiatry 69:1006-13. 2008
  56. pmc Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression
    Jie Huang
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, and Psychiatric Genetics Program in Mood and Anxiety Disorders, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 167:1254-63. 2010
    ..The purpose of this study was to apply genomewide association study (GWAS) analysis to address the specificity of genetic effects on these disorders...
  57. pmc Association of a polymorphism near CREB1 with differential aversion processing in the insula of healthy participants
    Roy H Perlis
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Arch Gen Psychiatry 65:882-92. 2008
    ....
  58. ncbi request reprint Weight gain during treatment of bipolar I patients with olanzapine
    John Hennen
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    J Clin Psychiatry 65:1679-87. 2004
    ..Body weight increase during long-term treatment with olanzapine in schizophrenia patients is well documented, but weight gain and its association with other medical measures are less well evaluated in bipolar disorder patients...
  59. ncbi request reprint Serotonin transporter polymorphisms and adverse effects with fluoxetine treatment
    Roy H Perlis
    Department of Psychiatry, Massachusetts General Hospital, Boston 02114, USA
    Biol Psychiatry 54:879-83. 2003
    ..This study investigated a possible association with treatment-emergent insomnia or agitation...
  60. doi request reprint Pharmacogenetic investigation of response to duloxetine treatment in generalized anxiety disorder
    R H Perlis
    Psychiatric Pharmacogenomics Laboratory, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Pharmacogenomics J 13:280-5. 2013
    ..Only rs4792888 in CRHR1 showed modest evidence of association with duloxetine response in MDD (P=0.029 in GAD, P=0.054 in MDD). In conclusion, CRHR1 variation merits investigation in pathophysiology of anxiety and its treatment response...
  61. pmc Translating biomarkers to clinical practice
    R H Perlis
    Laboratory of Psychiatric Pharmacogenomics, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Mol Psychiatry 16:1076-87. 2011
    ..Finally, it addresses ways in which a biomarker-based test might be validated for clinical application in terms of efficacy and cost-effectiveness...
  62. ncbi request reprint Investigation of variation in SNAP-25 and ADHD and relationship to co-morbid major depressive disorder
    J W Kim
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Med Genet B Neuropsychiatr Genet 144:781-90. 2007
    ..We further suggest that co-morbidity with MDD may enhance detection of the association between SNAP-25 and ADHD...
  63. ncbi request reprint Comorbid medical illness and relapse of major depressive disorder in the continuation phase of treatment
    Dan V Iosifescu
    Depression Clinical and Research Program, Psychiatry Department, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Psychosomatics 45:419-25. 2004
    ..Greater medical comorbidity was also associated with higher increases in self-reported symptoms of depression, anxiety, and anger during the follow-up...
  64. ncbi request reprint Presence of irritability during depressive episodes in bipolar disorder
    Thilo Deckersbach
    Department of Psychiatry, Psychiatric Neuroscience Program and Bipolar Research Program, Harvard Medical School 149 2611, Massachusetts General Hospital Bldg 149, 13th Street, Charlestown, MA 02129, USA
    CNS Spectr 9:227-31. 2004
    ....
  65. pmc Impact of substance use disorders on recovery from episodes of depression in bipolar disorder patients: prospective data from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
    Michael J Ostacher
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Am J Psychiatry 167:289-97. 2010
    ..The authors hypothesized that comorbid drug and alcohol use disorders would be associated with longer time to recovery in patients with bipolar disorder...
  66. pmc Low-dose transdermal testosterone augmentation therapy improves depression severity in women
    Karen K Miller
    Neurendocrine Research Program in Women s Health, Neuendocrine Unit, Massachusetts General Hospital, Boston, MA, USA
    CNS Spectr 14:688-94. 2009
    ..However, the effects of low-dose testosterone as augmentation therapy in women with treatment-resistant depression have not been studied...
  67. ncbi request reprint The development of new antidepressants: focus on duloxetine and escitalopram
    Jeff C Huffman
    Massachusetts General Hospital, 15 Parkman St, Wang 812, Boston, MA 02114, USA
    Harv Rev Psychiatry 11:30-6. 2003
  68. pmc Cigarette smoking is associated with suicidality in bipolar disorder
    Michael J Ostacher
    Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Bipolar Disord 11:766-71. 2009
    ..Cigarette smoking in individuals with bipolar disorder has been associated with suicidal behavior, although the precise relationship between the two remains unclear...
  69. ncbi request reprint Antidepressant dose reduction and the risk of relapse in major depressive disorder
    George I Papakostas
    Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, Mass 02114, USA
    Psychother Psychosom 76:266-70. 2007
    ....
  70. ncbi request reprint An open study of triiodothyronine augmentation of selective serotonin reuptake inhibitors in treatment-resistant major depressive disorder
    Dan V Iosifescu
    Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    J Clin Psychiatry 66:1038-42. 2005
    ..In an open trial, we investigated the efficacy of triiodothyronine (T(3)) adjuvant to selective serotonin reuptake inhibitors (SSRIs) in subjects with major depressive disorder (MDD) resistant to SSRI treatment...
  71. doi request reprint A brief review of antidepressant efficacy, effectiveness, indications, and usage for major depressive disorder
    Andrew A Nierenberg
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    J Occup Environ Med 50:428-36. 2008
    ..Antidepressants treat major depressive disorder (MDD) with the burden of associated side effects and difficulties with compliance. The purpose of this article is to review the efficacy and effectiveness of antidepressants for MDD...
  72. ncbi request reprint Brain white-matter hyperintensities and treatment outcome in major depressive disorder
    Dan V Iosifescu
    Massachusetts General Hospital, 50 Staniford Street, Suite 401, Boston, Massachusetts 02114, USA
    Br J Psychiatry 188:180-5. 2006
    ..An increased incidence of brain white-matter hyperintensities has been described in major depressive disorder, butthe impact of such hyperintensities on treatment outcome is still controversial...
  73. pmc Personality disorders and perceived stress in major depressive disorder
    Michele Candrian
    Depression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, Boston, MA 02114, USA
    Psychiatry Res 160:184-91. 2008
    ....
  74. ncbi request reprint Early symptomatic worsening during treatment with fluoxetine in major depressive disorder: prevalence and implications
    Cristina Cusin
    Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychiatry 68:52-7. 2007
    ..While patterns of response have been examined as possible predictors of outcome, the clinical correlates and implications of early worsening per se have not been investigated...
  75. ncbi request reprint The relationship between smoking and suicidal behavior, comorbidity, and course of illness in bipolar disorder
    Michael J Ostacher
    Massachusetts General Hospital, Bipolar Clinic and Research Program, Boston, MA 02114, USA
    J Clin Psychiatry 67:1907-11. 2006
    ..The purpose of this retrospective study was to examine the relationship between smoking, severity of bipolar disorder, suicidal behavior, and psychiatric and substance use disorder comorbidity...
  76. ncbi request reprint The integration of measurement and management for the treatment of bipolar disorder: a STEP-BD model of collaborative care in psychiatry
    Andrew A Nierenberg
    Bipolar Clinic and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 67:3-7. 2006
    ..This method was shown to be successful in the National Institute of Mental Health (NIMH) Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)...
  77. doi request reprint Family-based association study of lithium-related and other candidate genes in bipolar disorder
    Roy H Perlis
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, 185 Cambridge St, Boston, MA 02114, USA
    Arch Gen Psychiatry 65:53-61. 2008
    ..Recent developments suggest that a broader pool of genes may be associated with this disorder...
  78. doi request reprint Aims and results of the NIMH systematic treatment enhancement program for bipolar disorder (STEP-BD)
    C L Bowden
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    CNS Neurosci Ther 18:243-9. 2012
    ..STEP-BD has established procedures that are relevant to future collaborative research programs aimed at the systematic study of the complex, intrinsically important elements of bipolar disorders...
  79. ncbi request reprint Ropinirole for antidepressant-induced sexual dysfunction
    J J Worthington
    Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Int Clin Psychopharmacol 17:307-10. 2002
    ..The addition of ropinirole may represent a potentially useful treatment strategy for antidepressant-induced sexual dysfunction...
  80. pmc Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder
    Manuel A R Ferreira
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Genet 40:1056-8. 2008
    ..0 x 10(-8), rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder...
  81. doi request reprint Antidepressant use and risk of incident cardiovascular morbidity and mortality among postmenopausal women in the Women's Health Initiative study
    Jordan W Smoller
    Department of Psychiatry, Massachusetts General Hospital, Boston, 02114, USA
    Arch Intern Med 169:2128-39. 2009
    ..Antidepressants are commonly prescribed medications, but their effect on cardiovascular morbidity and mortality remains unclear...
  82. ncbi request reprint Proposed DSM-5 mixed features are associated with greater likelihood of remission in out-patients with major depressive disorder
    R H Perlis
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Psychol Med 44:1361-7. 2014
    ..Draft DSM-5 criteria for a mixed major depressive episode have been proposed, but their predictive validity has not yet been established. We hypothesized that such symptoms would be associated with poorer antidepressant treatment outcomes...
  83. pmc Multi-locus genome-wide association analysis supports the role of glutamatergic synaptic transmission in the etiology of major depressive disorder
    P H Lee
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA
    Transl Psychiatry 2:e184. 2012
    ..This result is consistent with previous studies that support a role of the glutamatergic system in synaptic plasticity and MDD and support the potential utility of targeting glutamatergic neurotransmission in the treatment of MDD...
  84. ncbi request reprint Prospective predictors of suicide and suicide attempts in 1,556 patients with bipolar disorders followed for up to 2 years
    Lauren B Marangell
    Mood Disorders Center, Menninger Department of Psychiatry, Baylor College of Medicine and the Department of Veterans Affairs, VISN 16 MIRECC, Houston, TX 77030, USA
    Bipolar Disord 8:566-75. 2006
    ....
  85. ncbi request reprint A 24-week open-label extension study of olanzapine-fluoxetine combination and olanzapine monotherapy in the treatment of bipolar depression
    Sara A Corya
    Lilly Research Laboratories, Indianapolis, Ind, USA
    J Clin Psychiatry 67:798-806. 2006
    ..The present analyses examined the efficacy and safety of longer term treatment with olanzapine-fluoxetine combination or olanzapine monotherapy in a 6-month open-label extension study...
  86. ncbi request reprint Pharmacogenetics, race, and psychiatry: prospects and challenges
    David S Jones
    Program in Science, Technology, and Society, Massachusetts Institute of Technology, Department of Social Medicine, Harvard Medical School, Cambridge, MA, USA
    Harv Rev Psychiatry 14:92-108. 2006
    ..This approach remains extremely controversial because of the complexity of the genetic structure of the human population, the complexity of gene-environment interactions, and the complexity of the meanings of race in the United States...
  87. ncbi request reprint A meta-analysis of early sustained response rates between antidepressants and placebo for the treatment of major depressive disorder
    George I Papakostas
    Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychopharmacol 26:56-60. 2006
    ....
  88. ncbi request reprint Adjunctive antidepressant use and symptomatic recovery among bipolar depressed patients with concomitant manic symptoms: findings from the STEP-BD
    Joseph F Goldberg
    Affective Disorders Program, Silver Hill Hospital, New Canaan, Connecticut, USA
    Am J Psychiatry 164:1348-55. 2007
    ..However, few studies have examined the outcomes of patients with co-occurring manic and depressive symptoms who are treated with antidepressants plus mood stabilizing drugs...
  89. ncbi request reprint A roadmap to key pharmacologic principles in using antipsychotics in the treatment of bipolar disorder
    Roy H Perlis
    J Clin Psychiatry 69:1176-83. 2008
  90. ncbi request reprint Extent and impact of industry sponsorship conflicts of interest in dermatology research
    Clifford S Perlis
    Department of Dermatology, Rhode Island Hospital and Brown Medical School, Providence, Rhode Island, USA
    J Am Acad Dermatol 52:967-71. 2005
    ..Despite this evolving discussion in the general medical literature, little is known about the extent or role of financial conflicts of interest in dermatology research...
  91. pmc Cytochrome P450 genotyping and antidepressants
    Roy H Perlis
    BMJ 334:759. 2007
  92. ncbi request reprint Clinical relevance of depressive symptom improvement in bipolar I depressed patients
    Doug Williamson
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46221, USA
    J Affect Disord 92:261-6. 2006
    ..Gaps remain between rating scale changes obtained in a clinical trial and what those results mean in clinical practice...
  93. ncbi request reprint A survey of antidepressant prescribing practices in major depression with comorbid attention-deficit hyperactivity disorder
    George I Papakostas
    J Clin Psychopharmacol 26:216-8. 2006
  94. pmc Cortical thickness abnormalities in cocaine addiction--a reflection of both drug use and a pre-existing disposition to drug abuse?
    Nikos Makris
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Neuron 60:174-88. 2008
    ..These observations suggest that brain structure abnormalities in addicts are related in part to drug use and in part to predisposition toward addiction...
  95. ncbi request reprint Treatment of bipolar depression
    Robert M Post
    Bipolar Collaborative Network, Chevy Chase, Maryland, USA
    CNS Spectr 8:1-10; quiz 11. 2003
    ..Other adjuncts for treatment-refractory patients include monoamine oxidase inhibitors and electroconvulsive therapy...
  96. pmc Euthymic patients with bipolar disorder show decreased reward learning in a probabilistic reward task
    Diego A Pizzagalli
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    Biol Psychiatry 64:162-8. 2008
    ..Our goal was to test the hypothesis that BPD is characterized by impairments in adjusting behavior as a function of prior reinforcement history, particularly in the presence of residual anhedonic symptoms...
  97. ncbi request reprint Incidence of and risk factors for medical malpractice lawsuits among Mohs surgeons
    Clifford S Perlis
    Department of Dermatology, Rhode Island Hospital and Brown Medical School, 593 Eddy Street, Providence, RI 02903, USA
    Dermatol Surg 32:79-83. 2006
    ..Despite rising medical malpractice costs, little is known about the factors associated with claims filed against Mohs surgeons...

Research Grants3

  1. Pramipexole in Treatment-Resistant Depression
    Roy Perlis; Fiscal Year: 2007
    ..The proposed investigation and training program will provide critical skills, experience and data to aid the candidate in writing an R01 and becoming an independent investigator. ..
  2. Building a Risk Stratification Model for Treatment Resistance in Major Depressive
    Roy Perlis; Fiscal Year: 2009
    ..Then, it will examine a second group of patients to see how well this technique might work if it is applied in a large health system. ..
  3. Building a Risk Stratification Model for Treatment Resistance in Major Depressive
    Roy H Perlis; Fiscal Year: 2010
    ..Then, it will examine a second group of patients to see how well this technique might work if it is applied in a large health system. ..