Research Topics
| Amanda R PatrickSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Detail Information
Publications
The implications of propensity score variable selection strategies in pharmacoepidemiology: an empirical illustrationAmanda R Patrick
Division of Pharmacoepidemiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Pharmacoepidemiol Drug Saf 20:551-9. 2011....
Strategies for the management of suspected heparin-induced thrombocytopenia: a cost-effectiveness analysisAmanda R Patrick
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham, Massachusetts 02120, USA
Pharmacoeconomics 25:949-61. 2007..Drugs used to treat HIT are costly and may carry an increased risk of bleeding...- The economics of improving medication adherence in osteoporosis: validation and application of a simulation modelAmanda R Patrick
Brigham and Women s Hospital Division of Pharmacoepidemiology, 1620 Tremont Street, Suite 3030, Boston, Massachusetts 02120
J Clin Endocrinol Metab 96:2762-70. 2011..Adherence to osteoporosis treatment is low. Although new therapies and behavioral interventions may improve medication adherence, questions are likely to arise regarding their cost-effectiveness... 
The association between statin use and outcomes potentially attributable to an unhealthy lifestyle in older adultsAmanda R Patrick
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Value Health 14:513-20. 2011....- Cost-effectiveness of genotype-guided warfarin dosing for patients with atrial fibrillationAmanda R Patrick
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
Circ Cardiovasc Qual Outcomes 2:429-36. 2009..However, the effectiveness of genotyping in improving anticoagulation control and reducing major bleeding has not yet been compellingly demonstrated. Genotyping currently costs $400 to $550... - The complex relation between bisphosphonate adherence and fracture reductionAmanda R Patrick
Divisions of Pharmacoepidemiology and Pharmacoeconomics Department of Medicine, Brigham and Women s Hospital, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
J Clin Endocrinol Metab 95:3251-9. 2010.... - Identification of hospitalizations for intentional self-harm when E-codes are incompletely recordedAmanda R Patrick
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
Pharmacoepidemiol Drug Saf 19:1263-75. 2010..However, rates of E-code completeness in US government and commercial claims databases are low due to issues with hospital billing software... - Variation in the risk of suicide attempts and completed suicides by antidepressant agent in adults: a propensity score-adjusted analysis of 9 years' dataSebastian Schneeweiss
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
Arch Gen Psychiatry 67:497-506. 2010..This prompted a meta-analysis of trials in adults that found no overall increase in risk, but individual agents could not be studied... - Prevalence of atrial fibrillation and warfarin use in older patients receiving hemodialysisWolfgang C Winkelmayer
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Nephrol 25:341-53. 2012..Little is known about the use of warfarin in hemodialysis (HD) patients with atrial fibrillation (AF). We studied temporal trends of AF among older HD patients, and of warfarin use among those with AF... - Increasing levels of restriction in pharmacoepidemiologic database studies of elderly and comparison with randomized trial resultsSebastian Schneeweiss
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Med Care 45:S131-42. 2007..The goal of restricting study populations is to make patients more homogeneous regarding potential confounding factors and treatment effects and thereby achieve less biased effect estimates... - Physician follow-up and provider continuity are associated with long-term medication adherence: a study of the dynamics of statin useM Alan Brookhart
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
Arch Intern Med 167:847-52. 2007.... - Adherence to beta-blocker therapy under drug cost-sharing in patients with and without acute myocardial infarctionSebastian Schneeweiss
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont St Ste 3030, Boston, MA 02120, USA
Am J Manag Care 13:445-52. 2007.... - Adherence to lipid-lowering therapy and the use of preventive health services: an investigation of the healthy user effectM Alan Brookhart
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, MA 02120, USA
Am J Epidemiol 166:348-54. 2007..Further work is needed to identify study design and analysis methods that can be used to minimize the healthy user bias in studies of preventive therapies... - Comparative efficacy and safety of new oral anticoagulants in patients with atrial fibrillationSebastian Schneeweiss
Department of Medicine, Harvard Medical School, Boston, MA, USA
Circ Cardiovasc Qual Outcomes 5:480-6. 2012..We sought to compare the efficacy and safety of the 3 new agents based on data from their published warfarin-controlled randomized trials, using the method of adjusted indirect comparisons... - Identification of individuals with CKD from Medicare claims data: a validation studyWolfgang C Winkelmayer
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
Am J Kidney Dis 46:225-32. 2005..The validity of this approach to identify patients with CKD has not been sufficiently studied... - Cost-effectiveness of providing full drug coverage to increase medication adherence in post-myocardial infarction Medicare beneficiariesNiteesh K Choudhry
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
Circulation 117:1261-8. 2008.... - Gaps in treatment among users of osteoporosis medications: the dynamics of noncomplianceM Alan Brookhart
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, Mass 02120, USA
Am J Med 120:251-6. 2007..We sought to estimate the percentage of patients who restart osteoporosis therapy after a prolonged lapse in medication use and to identify the factors associated with a return to compliance... - Elevated risk of preeclampsia in pregnant women with depression: depression or antidepressants?Kristin Palmsten
Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
Am J Epidemiol 175:988-97. 2012..24) for TCA monotherapy. Study results suggest that women who use antidepressants during pregnancy, especially SNRIs and TCAs, have an elevated risk of preeclampsia. These associations may reflect drug effects or more severe depression... - Does knowledge of medication prices predict physicians' support for cost effective prescribing policiesJennifer M Polinski
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Boston, MA, USA
Can J Clin Pharmacol 15:e286-94. 2008..Years after implementation, these policies remain controversial among physicians... - Early steps in the development of a claims-based targeted healthcare safety monitoring system and application to three empirical examplesPeter M Wahl
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Womens Hospital, Harvard Medical School, Boston, MA 02120, USA
Drug Saf 35:407-16. 2012..Prospective monitoring systems must incorporate signalling algorithms and techniques to mitigate confounding in order to minimize false positive and false negative signals due to chance and bias... - Adherence to statin therapy under drug cost sharing in patients with and without acute myocardial infarction: a population-based natural experimentSebastian Schneeweiss
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont St, Suite 3030, Boston, MA 02120, USA
Circulation 115:2128-35. 2007.... - Anticonvulsant medications and the risk of suicide, attempted suicide, or violent deathElisabetta Patorno
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, 1620 Tremont St, Ste 3030, Boston, MA 02120, USA
JAMA 303:1401-9. 2010..The decision was based on a meta-analysis not sufficiently large to investigate individual drugs... - Osteoporosis telephonic intervention to improve medication regimen adherence: a large, pragmatic, randomized controlled trialDaniel H Solomon
Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
Arch Intern Med 172:477-83. 2012..We examined the effectiveness of a telephone-based counseling program rooted in motivational interviewing to improve adherence to a medication regimen for osteoporosis... - Trends in the use and outcomes of implantable cardioverter-defibrillators in patients undergoing dialysis in the United StatesDavid M Charytan
Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
Am J Kidney Dis 58:409-17. 2011..Sudden cardiac death constitutes the leading cause of death in patients receiving dialysis. Little is known about the trends in implantable cardioverter-defibrillator (ICD) use and the outcomes of such device placement... - Suboptimal antidepressant use in the elderlyPhilip S Wang
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
J Clin Psychopharmacol 25:118-26. 2005..Suboptimal antidepressant use remains common in the elderly, especially the use of inadequately intensive regimens. Interventions are needed to improve the quality and outcomes of antidepressant use in this vulnerable population... - Comparative safety of antidepressant agents for children and adolescents regarding suicidal actsSebastian Schneeweiss
Harvard Medical School, Brigham and Women s Hospital, Department of Medicine, Division of Pharmacoepidemiology and Pharmacoeconomics, Boston, MA 02120, USA
Pediatrics 125:876-88. 2010..The objective of this study was to assess the risk of suicide attempts and suicides after initiation of antidepressant medication use by children and adolescents, for individual agents... - Comparative cost-effectiveness of interventions to improve medication adherence after myocardial infarctionKouta Ito
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
Health Serv Res 47:2097-117. 2012..To evaluate the comparative cost-effectiveness of interventions to improve adherence to evidence-based medications among postmyocardial infarction (MI) patients... - Health advisories and patterns of patient monitoring among new users of antidepressant medicationsJoshua J Gagne
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Suite 3030, 1620 Tremont St, Boston, MA 02120, USA
J Clin Psychopharmacol 29:590-4. 2009..We sought to identify patterns of patient monitoring after antidepressant initiation in British Columbia before and after issuance of health advisories... - The cost-effectiveness of C-reactive protein testing and rosuvastatin treatment for patients with normal cholesterol levelsNiteesh K Choudhry
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
J Am Coll Cardiol 57:784-91. 2011..We sought to evaluate the cost-effectiveness of applying the JUPITER (Justification for the Use of statins in Prevention: an Intervention Trial Evaluating Rosuvastatin) trial results into clinical practice... - Healthy user and related biases in observational studies of preventive interventions: a primer for physiciansWilliam H Shrank
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
J Gen Intern Med 26:546-50. 2011..More careful consideration of these sources of bias and study designs by providers can enhance evidence-based decision-making... - The effect of Medicare Part D coverage on drug use and cost sharing among seniors without prior drug benefitsSebastian Schneeweiss
Division of Pharmacoepidemiology and Pharmacoeconomics at Brigham and Women s Hospital in Boston, Massachusetts, USA
Health Aff (Millwood) 28:w305-16. 2009..Patients reaching the Part D coverage gap (12 percent) experienced a decrease in essential medication use ranging from 5.7 percentage points per month for warfarin to 6.3 percentage points for statins... - The effect of transitioning to medicare part d drug coverage in seniors dually eligible for medicare and medicaidWilliam H Shrank
Department of Medicine, Division of Pharmacoepidemiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
J Am Geriatr Soc 56:2304-10. 2008..To evaluate medication use, out-of-pocket spending, and medication switching during the transition period for patients dually eligible for Medicaid and Medicare (dual eligibles)... - Psychotropic medication use for behavioral symptoms of dementiaPhilip S Wang
Department of Psychiatry, Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
Curr Neurol Neurosci Rep 6:490-5. 2006..Also, although various psychotropic medications used for behavioral disturbances in dementia patients may be somewhat effective, they have been increasingly associated with important safety risks... - Osteoporosis management in patients with rheumatoid arthritis: Evidence for improvementDaniel H Solomon
Division of Pharmacoepidemiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
Arthritis Rheum 55:873-7. 2006..The goal was to examine the frequency of osteoporosis management in patients with RA treated at a large academic rheumatology practice... - Cost of managing complications resulting from type 2 diabetes mellitus in CanadaJudith A O'Brien
Caro Research Institute, Concord, MA, USA
BMC Health Serv Res 3:7. 2003..Data were obtained from many Canadian sources, including the Ontario Case Cost Project, physician and laboratory fee schedules, formularies, reports, and literature. All costs are expressed in 2000 Canadian dollars... - Cost of managing an episode of relapse in multiple sclerosis in the United StatesJudith A O'Brien
Caro Research Institute, Concord, MA 01742, USA
BMC Health Serv Res 3:17. 2003..The purpose of this study was to determine the direct medical US cost of managing multiple sclerosis relapses... - The impact of cost sharing on antidepressant use among older adults in British ColumbiaPhilip S Wang
National Institute of Mental Health, Bethesda, MD 20892 9629, USA
Psychiatr Serv 59:377-83. 2008....