Amanda R Patrick

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi Trends in insulin initiation and treatment intensification among patients with type 2 diabetes
    Amanda R Patrick
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, 1620 Tremont Street, Suite 3030, Boston, MA, 02120, USA
    J Gen Intern Med 29:320-7. 2014
  2. ncbi Strategies for the management of suspected heparin-induced thrombocytopenia: a cost-effectiveness analysis
    Amanda R Patrick
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham, Massachusetts 02120, USA
    Pharmacoeconomics 25:949-61. 2007
  3. pmc Identification of hospitalizations for intentional self-harm when E-codes are incompletely recorded
    Amanda R Patrick
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Pharmacoepidemiol Drug Saf 19:1263-75. 2010
  4. pmc The complex relation between bisphosphonate adherence and fracture reduction
    Amanda R Patrick
    Divisions of Pharmacoepidemiology and Pharmacoeconomics Department of Medicine, Brigham and Women s Hospital, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
    J Clin Endocrinol Metab 95:3251-9. 2010
  5. pmc The implications of propensity score variable selection strategies in pharmacoepidemiology: an empirical illustration
    Amanda R Patrick
    Division of Pharmacoepidemiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Pharmacoepidemiol Drug Saf 20:551-9. 2011
  6. doi The association between statin use and outcomes potentially attributable to an unhealthy lifestyle in older adults
    Amanda R Patrick
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Value Health 14:513-20. 2011
  7. pmc The economics of improving medication adherence in osteoporosis: validation and application of a simulation model
    Amanda R Patrick
    Brigham and Women s Hospital Division of Pharmacoepidemiology, 1620 Tremont Street, Suite 3030, Boston, Massachusetts 02120
    J Clin Endocrinol Metab 96:2762-70. 2011
  8. doi Cost-effectiveness of genotype-guided warfarin dosing for patients with atrial fibrillation
    Amanda R Patrick
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    Circ Cardiovasc Qual Outcomes 2:429-36. 2009
  9. pmc Variation in the risk of suicide attempts and completed suicides by antidepressant agent in adults: a propensity score-adjusted analysis of 9 years' data
    Sebastian Schneeweiss
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
    Arch Gen Psychiatry 67:497-506. 2010
  10. pmc Prevalence of atrial fibrillation and warfarin use in older patients receiving hemodialysis
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Nephrol 25:341-53. 2012

Detail Information

Publications43

  1. ncbi Trends in insulin initiation and treatment intensification among patients with type 2 diabetes
    Amanda R Patrick
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, 1620 Tremont Street, Suite 3030, Boston, MA, 02120, USA
    J Gen Intern Med 29:320-7. 2014
    ....
  2. ncbi Strategies for the management of suspected heparin-induced thrombocytopenia: a cost-effectiveness analysis
    Amanda R Patrick
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham, Massachusetts 02120, USA
    Pharmacoeconomics 25:949-61. 2007
    ..Drugs used to treat HIT are costly and may carry an increased risk of bleeding...
  3. pmc Identification of hospitalizations for intentional self-harm when E-codes are incompletely recorded
    Amanda R Patrick
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Pharmacoepidemiol Drug Saf 19:1263-75. 2010
    ..However, rates of E-code completeness in US government and commercial claims databases are low due to issues with hospital billing software...
  4. pmc The complex relation between bisphosphonate adherence and fracture reduction
    Amanda R Patrick
    Divisions of Pharmacoepidemiology and Pharmacoeconomics Department of Medicine, Brigham and Women s Hospital, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
    J Clin Endocrinol Metab 95:3251-9. 2010
    ....
  5. pmc The implications of propensity score variable selection strategies in pharmacoepidemiology: an empirical illustration
    Amanda R Patrick
    Division of Pharmacoepidemiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Pharmacoepidemiol Drug Saf 20:551-9. 2011
    ....
  6. doi The association between statin use and outcomes potentially attributable to an unhealthy lifestyle in older adults
    Amanda R Patrick
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Value Health 14:513-20. 2011
    ..To explore the "healthy user" and "healthy adherer" effects-hypothetical sources of bias thought to arise when patients who initiate and adhere to preventive therapies are more likely to engage in healthy behaviors than are other subjects...
  7. pmc The economics of improving medication adherence in osteoporosis: validation and application of a simulation model
    Amanda R Patrick
    Brigham and Women s Hospital Division of Pharmacoepidemiology, 1620 Tremont Street, Suite 3030, Boston, Massachusetts 02120
    J Clin Endocrinol Metab 96:2762-70. 2011
    ..Adherence to osteoporosis treatment is low. Although new therapies and behavioral interventions may improve medication adherence, questions are likely to arise regarding their cost-effectiveness...
  8. doi Cost-effectiveness of genotype-guided warfarin dosing for patients with atrial fibrillation
    Amanda R Patrick
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    Circ Cardiovasc Qual Outcomes 2:429-36. 2009
    ..However, the effectiveness of genotyping in improving anticoagulation control and reducing major bleeding has not yet been compellingly demonstrated. Genotyping currently costs $400 to $550...
  9. pmc Variation in the risk of suicide attempts and completed suicides by antidepressant agent in adults: a propensity score-adjusted analysis of 9 years' data
    Sebastian Schneeweiss
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
    Arch Gen Psychiatry 67:497-506. 2010
    ..This prompted a meta-analysis of trials in adults that found no overall increase in risk, but individual agents could not be studied...
  10. pmc Prevalence of atrial fibrillation and warfarin use in older patients receiving hemodialysis
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Nephrol 25:341-53. 2012
    ..Little is known about the use of warfarin in hemodialysis (HD) patients with atrial fibrillation (AF). We studied temporal trends of AF among older HD patients, and of warfarin use among those with AF...
  11. pmc Increasing levels of restriction in pharmacoepidemiologic database studies of elderly and comparison with randomized trial results
    Sebastian Schneeweiss
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Med Care 45:S131-42. 2007
    ..The goal of restricting study populations is to make patients more homogeneous regarding potential confounding factors and treatment effects and thereby achieve less biased effect estimates...
  12. pmc Adherence to beta-blocker therapy under drug cost-sharing in patients with and without acute myocardial infarction
    Sebastian Schneeweiss
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont St Ste 3030, Boston, MA 02120, USA
    Am J Manag Care 13:445-52. 2007
    ....
  13. ncbi Physician follow-up and provider continuity are associated with long-term medication adherence: a study of the dynamics of statin use
    M Alan Brookhart
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Arch Intern Med 167:847-52. 2007
    ....
  14. ncbi Gaps in treatment among users of osteoporosis medications: the dynamics of noncompliance
    M Alan Brookhart
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, Mass 02120, USA
    Am J Med 120:251-6. 2007
    ..We sought to estimate the percentage of patients who restart osteoporosis therapy after a prolonged lapse in medication use and to identify the factors associated with a return to compliance...
  15. ncbi Adherence to lipid-lowering therapy and the use of preventive health services: an investigation of the healthy user effect
    M Alan Brookhart
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, MA 02120, USA
    Am J Epidemiol 166:348-54. 2007
    ..Further work is needed to identify study design and analysis methods that can be used to minimize the healthy user bias in studies of preventive therapies...
  16. pmc Comparative efficacy and safety of new oral anticoagulants in patients with atrial fibrillation
    Sebastian Schneeweiss
    Department of Medicine, Harvard Medical School, Boston, MA, USA
    Circ Cardiovasc Qual Outcomes 5:480-6. 2012
    ..We sought to compare the efficacy and safety of the 3 new agents based on data from their published warfarin-controlled randomized trials, using the method of adjusted indirect comparisons...
  17. pmc Cost-effectiveness of providing full drug coverage to increase medication adherence in post-myocardial infarction Medicare beneficiaries
    Niteesh K Choudhry
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    Circulation 117:1261-8. 2008
    ....
  18. ncbi Identification of individuals with CKD from Medicare claims data: a validation study
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Am J Kidney Dis 46:225-32. 2005
    ..The validity of this approach to identify patients with CKD has not been sufficiently studied...
  19. doi Anticonvulsant medications and the risk of suicide, attempted suicide, or violent death
    Elisabetta Patorno
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, 1620 Tremont St, Ste 3030, Boston, MA 02120, USA
    JAMA 303:1401-9. 2010
    ..The decision was based on a meta-analysis not sufficiently large to investigate individual drugs...
  20. pmc Elevated risk of preeclampsia in pregnant women with depression: depression or antidepressants?
    Kristin Palmsten
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Am J Epidemiol 175:988-97. 2012
    ..24) for TCA monotherapy. Study results suggest that women who use antidepressants during pregnancy, especially SNRIs and TCAs, have an elevated risk of preeclampsia. These associations may reflect drug effects or more severe depression...
  21. pmc Does knowledge of medication prices predict physicians' support for cost effective prescribing policies
    Jennifer M Polinski
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Boston, MA, USA
    Can J Clin Pharmacol 15:e286-94. 2008
    ..Years after implementation, these policies remain controversial among physicians...
  22. doi Near-real-time monitoring of new drugs: an application comparing prasugrel versus clopidogrel
    Joshua J Gagne
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA, 02120, USA
    Drug Saf 37:151-61. 2014
    ..Methods for near-real-time monitoring of new drugs in electronic healthcare data are needed...
  23. doi Early steps in the development of a claims-based targeted healthcare safety monitoring system and application to three empirical examples
    Peter M Wahl
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Womens Hospital, Harvard Medical School, Boston, MA 02120, USA
    Drug Saf 35:407-16. 2012
    ..Prospective monitoring systems must incorporate signalling algorithms and techniques to mitigate confounding in order to minimize false positive and false negative signals due to chance and bias...
  24. ncbi Adherence to statin therapy under drug cost sharing in patients with and without acute myocardial infarction: a population-based natural experiment
    Sebastian Schneeweiss
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont St, Suite 3030, Boston, MA 02120, USA
    Circulation 115:2128-35. 2007
    ....
  25. pmc Estimation using all available covariate information versus a fixed look-back window for dichotomous covariates
    Steven M Brunelli
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    Pharmacoepidemiol Drug Saf 22:542-50. 2013
    ..When available historical data differs among subjects, investigators must choose between using all available historical data versus data from a fixed window to assess C. Our purpose was to compare estimation under these two approaches...
  26. doi Osteoporosis telephonic intervention to improve medication regimen adherence: a large, pragmatic, randomized controlled trial
    Daniel H Solomon
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Arch Intern Med 172:477-83. 2012
    ..We examined the effectiveness of a telephone-based counseling program rooted in motivational interviewing to improve adherence to a medication regimen for osteoporosis...
  27. doi Trends in the use and outcomes of implantable cardioverter-defibrillators in patients undergoing dialysis in the United States
    David M Charytan
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Am J Kidney Dis 58:409-17. 2011
    ..Sudden cardiac death constitutes the leading cause of death in patients receiving dialysis. Little is known about the trends in implantable cardioverter-defibrillator (ICD) use and the outcomes of such device placement...
  28. pmc Comparative safety of antidepressant agents for children and adolescents regarding suicidal acts
    Sebastian Schneeweiss
    Harvard Medical School, Brigham and Women s Hospital, Department of Medicine, Division of Pharmacoepidemiology and Pharmacoeconomics, Boston, MA 02120, USA
    Pediatrics 125:876-88. 2010
    ..The objective of this study was to assess the risk of suicide attempts and suicides after initiation of antidepressant medication use by children and adolescents, for individual agents...
  29. ncbi Suboptimal antidepressant use in the elderly
    Philip S Wang
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    J Clin Psychopharmacol 25:118-26. 2005
    ..Suboptimal antidepressant use remains common in the elderly, especially the use of inadequately intensive regimens. Interventions are needed to improve the quality and outcomes of antidepressant use in this vulnerable population...
  30. ncbi Sequential value-of-information assessment for prospective drug safety monitoring using claims databases: the comparative safety of prasugrel v. clopidogrel
    Amanda R Patrick
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts ARP, JMF, RJG, SS
    Med Decis Making 33:949-60. 2013
    ....
  31. doi Cost-effectiveness of oral anticoagulants for treatment of atrial fibrillation
    William J Canestaro
    Department of Medicine, Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, Boston, MA
    Circ Cardiovasc Qual Outcomes 6:724-31. 2013
    ..New anticoagulants may improve health outcomes in patients with atrial fibrillation, but it is unclear whether their use is cost-effective...
  32. pmc Comparative cost-effectiveness of interventions to improve medication adherence after myocardial infarction
    Kouta Ito
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Health Serv Res 47:2097-117. 2012
    ..To evaluate the comparative cost-effectiveness of interventions to improve adherence to evidence-based medications among postmyocardial infarction (MI) patients...
  33. pmc Health advisories and patterns of patient monitoring among new users of antidepressant medications
    Joshua J Gagne
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Suite 3030, 1620 Tremont St, Boston, MA 02120, USA
    J Clin Psychopharmacol 29:590-4. 2009
    ..We sought to identify patterns of patient monitoring after antidepressant initiation in British Columbia before and after issuance of health advisories...
  34. pmc Healthy user and related biases in observational studies of preventive interventions: a primer for physicians
    William H Shrank
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    J Gen Intern Med 26:546-50. 2011
    ..More careful consideration of these sources of bias and study designs by providers can enhance evidence-based decision-making...
  35. doi The cost-effectiveness of C-reactive protein testing and rosuvastatin treatment for patients with normal cholesterol levels
    Niteesh K Choudhry
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
    J Am Coll Cardiol 57:784-91. 2011
    ..We sought to evaluate the cost-effectiveness of applying the JUPITER (Justification for the Use of statins in Prevention: an Intervention Trial Evaluating Rosuvastatin) trial results into clinical practice...
  36. pmc The effect of Medicare Part D coverage on drug use and cost sharing among seniors without prior drug benefits
    Sebastian Schneeweiss
    Division of Pharmacoepidemiology and Pharmacoeconomics at Brigham and Women s Hospital in Boston, Massachusetts, USA
    Health Aff (Millwood) 28:w305-16. 2009
    ..Patients reaching the Part D coverage gap (12 percent) experienced a decrease in essential medication use ranging from 5.7 percentage points per month for warfarin to 6.3 percentage points for statins...
  37. pmc The effect of transitioning to medicare part d drug coverage in seniors dually eligible for medicare and medicaid
    William H Shrank
    Department of Medicine, Division of Pharmacoepidemiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
    J Am Geriatr Soc 56:2304-10. 2008
    ..To evaluate medication use, out-of-pocket spending, and medication switching during the transition period for patients dually eligible for Medicaid and Medicare (dual eligibles)...
  38. ncbi Osteoporosis management in patients with rheumatoid arthritis: Evidence for improvement
    Daniel H Solomon
    Division of Pharmacoepidemiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
    Arthritis Rheum 55:873-7. 2006
    ..The goal was to examine the frequency of osteoporosis management in patients with RA treated at a large academic rheumatology practice...
  39. ncbi Psychotropic medication use for behavioral symptoms of dementia
    Philip S Wang
    Department of Psychiatry, Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
    Curr Neurol Neurosci Rep 6:490-5. 2006
    ..Also, although various psychotropic medications used for behavioral disturbances in dementia patients may be somewhat effective, they have been increasingly associated with important safety risks...
  40. ncbi The Potential Economic Benefits of Improved Postfracture Care: A Cost-Effectiveness Analysis of a Fracture Liaison Service in the US Health-Care System
    Daniel H Solomon
    Division of Rheumatology, Brigham and Women s Hospital, Boston, MA, USA Division of Pharmacoepidemiology, Brigham and Women s Hospital, Boston, MA, USA
    J Bone Miner Res 29:1667-74. 2014
    ..An FLS targeting patients post-hip fracture should result in cost savings and reduced fractures under most scenarios. © 2014 American Society for Bone and Mineral Research. ..
  41. pmc Cost of managing complications resulting from type 2 diabetes mellitus in Canada
    Judith A O'Brien
    Caro Research Institute, Concord, MA, USA
    BMC Health Serv Res 3:7. 2003
    ..Data were obtained from many Canadian sources, including the Ontario Case Cost Project, physician and laboratory fee schedules, formularies, reports, and literature. All costs are expressed in 2000 Canadian dollars...
  42. pmc Cost of managing an episode of relapse in multiple sclerosis in the United States
    Judith A O'Brien
    Caro Research Institute, Concord, MA 01742, USA
    BMC Health Serv Res 3:17. 2003
    ..The purpose of this study was to determine the direct medical US cost of managing multiple sclerosis relapses...
  43. pmc The impact of cost sharing on antidepressant use among older adults in British Columbia
    Philip S Wang
    National Institute of Mental Health, Bethesda, MD 20892 9629, USA
    Psychiatr Serv 59:377-83. 2008
    ....