MARY PARDUE

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. ncbi request reprint Retrotransposons provide an evolutionarily robust non-telomerase mechanism to maintain telomeres
    MARY LOU PARDUE
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Annu Rev Genet 37:485-511. 2003
  2. pmc Gag proteins of the two Drosophila telomeric retrotransposons are targeted to chromosome ends
    Svetlana Rashkova
    Department of Biology, 68 670, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Cell Biol 159:397-402. 2002
  3. pmc Retrotransposons that maintain chromosome ends
    MARY LOU PARDUE
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 108:20317-24. 2011
  4. pmc RNA interference has a role in regulating Drosophila telomeres
    Elena Casacuberta
    ICREA, IBMB CSIC, Parc Cientific de Barcelona, Josep Samitier 1 5, Barcelona 08028, Spain
    Genome Biol 7:220. 2006
  5. ncbi request reprint Drosophila telomeres: A variation on the telomerase theme
    MARY LOU PARDUE
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Fly (Austin) 2:101-10. 2008
  6. ncbi request reprint Following the chromosome path to the garden of the genome
    MARY LOU PARDUE
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Annu Rev Cell Dev Biol 23:1-22. 2007
  7. pmc Two retrotransposons maintain telomeres in Drosophila
    M L Pardue
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Chromosome Res 13:443-53. 2005
  8. ncbi request reprint Drosophila telomeres: new views on chromosome evolution
    M L Pardue
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Trends Genet 12:48-52. 1996
  9. ncbi request reprint Drosophila telomeres: two transposable elements with important roles in chromosomes
    M L Pardue
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Genetica 107:189-96. 1999
  10. ncbi request reprint Drosophila telomere transposons: genetically active elements in heterochromatin
    M L Pardue
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Genetica 109:45-52. 2000

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Retrotransposons provide an evolutionarily robust non-telomerase mechanism to maintain telomeres
    MARY LOU PARDUE
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Annu Rev Genet 37:485-511. 2003
    ..These telomeres are now known to predate the separation of extant Drosophila species, allowing ample time for elements and hosts to coevolve interesting mechanisms...
  2. pmc Gag proteins of the two Drosophila telomeric retrotransposons are targeted to chromosome ends
    Svetlana Rashkova
    Department of Biology, 68 670, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Cell Biol 159:397-402. 2002
    ..They also imply a symbiotic relationship between the two elements, with HeT-A Gag directing the telomere-specific targeting of the elements, whereas TART provides reverse transcriptase for transposition...
  3. pmc Retrotransposons that maintain chromosome ends
    MARY LOU PARDUE
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 108:20317-24. 2011
    ..Here, we discuss ways in which these three telomere-specific retrotransposons have been modified for their roles in Drosophila chromosomes...
  4. pmc RNA interference has a role in regulating Drosophila telomeres
    Elena Casacuberta
    ICREA, IBMB CSIC, Parc Cientific de Barcelona, Josep Samitier 1 5, Barcelona 08028, Spain
    Genome Biol 7:220. 2006
    ....
  5. ncbi request reprint Drosophila telomeres: A variation on the telomerase theme
    MARY LOU PARDUE
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Fly (Austin) 2:101-10. 2008
    ....
  6. ncbi request reprint Following the chromosome path to the garden of the genome
    MARY LOU PARDUE
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Annu Rev Cell Dev Biol 23:1-22. 2007
    ....
  7. pmc Two retrotransposons maintain telomeres in Drosophila
    M L Pardue
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Chromosome Res 13:443-53. 2005
    ..Gags of other non-LTR elements remain predominantly in the cytoplasm. These studies provide intriguing evolutionary links between telomeres and retrotransposable elements...
  8. ncbi request reprint Drosophila telomeres: new views on chromosome evolution
    M L Pardue
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Trends Genet 12:48-52. 1996
    ..Studies of these telomere-specific retrotransposable elements raise questions about conventional wisdom concerning not only telomeres, but also transposable elements and heterochromatin...
  9. ncbi request reprint Drosophila telomeres: two transposable elements with important roles in chromosomes
    M L Pardue
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Genetica 107:189-96. 1999
    ..The finding also raises the possibility that other transposable elements with bona fide roles in the cell will be detected, not only in Drosophila, but also in other organisms...
  10. ncbi request reprint Drosophila telomere transposons: genetically active elements in heterochromatin
    M L Pardue
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Genetica 109:45-52. 2000
    ..Such heterochromatic sequences could be important for the cell, perhaps as docking stations for essential proteins...
  11. pmc HeT-A elements in Drosophila virilis: retrotransposon telomeres are conserved across the Drosophila genus
    Elena Casacuberta
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 100:14091-6. 2003
    ..melanogaster. In addition, we have identified a chimeric element, Uvir, carrying a pol coding sequence only distantly related to sequences thus far found in any telomere arrays...
  12. pmc Coevolution of the telomeric retrotransposons across Drosophila species
    Elena Casacuberta
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Genetics 161:1113-24. 2002
    ..As in D. melanogaster, other retrotransposons are excluded from the D. yakuba terminal arrays studied to date...
  13. pmc Transposon telomeres are widely distributed in the Drosophila genus: TART elements in the virilis group
    Elena Casacuberta
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 100:3363-8. 2003
    ..Comparison of the D. virilis and D. melanogaster telomeres suggests that the retrotransposon mechanism of telomere maintenance may have arisen before the separation of the genus Drosophila...
  14. pmc The promoter of the heterochromatic Drosophila telomeric retrotransposon, HeT-A, is active when moved into euchromatic locations
    Janet A George
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genetics 163:625-35. 2003
    ....
  15. pmc Genomic organization of the Drosophila telomere retrotransposable elements
    Janet A George
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genome Res 16:1231-40. 2006
    ....
  16. pmc Comparison of dot chromosome sequences from D. melanogaster and D. virilis reveals an enrichment of DNA transposon sequences in heterochromatic domains
    Elizabeth E Slawson
    Biology Department, Washington University, St Louis, MO 63130, USA
    Genome Biol 7:R15. 2006
    ..In contrast, the absence of HP1 and H3K9me from the dot chromosome in D. virilis suggests that this region is euchromatic. D. virilis diverged from D. melanogaster 40 to 60 million years ago...
  17. pmc Intracellular targeting of telomeric retrotransposon Gag proteins of distantly related Drosophila species
    Elena Casacuberta
    Institute of Molecular Biology of Barcelona, Consejo Superior de Investigaciones Científicas and Institute for Research on Biomedicine of Barcelona IRB, 08028 Barcelona, Spain
    Proc Natl Acad Sci U S A 104:8391-6. 2007
    ..Our findings suggest that, despite dramatic rates of protein evolution, protein and cellular determinants that correctly localize these Gag proteins have been conserved throughout the 60 MY separating these species...

Research Grants17

  1. AN EVOLUTIONARY LINK BETWEEN TELOMERES AND TRANSPOSONS
    MARY LOU PARDUE; Fiscal Year: 2006
    ..abstract_text> ..
  2. AN EVOLUTIONARY LINK BETWEEN TELOMERES AND TRANSPOSONS
    MARY PARDUE; Fiscal Year: 2005
    ..abstract_text> ..
  3. AN EVOLUTIONARY LINK BETWEEN TELOMERES AND TRANSPOSONS
    MARY PARDUE; Fiscal Year: 2004
    ..abstract_text> ..
  4. AN EVOLUTIONARY LINK BETWEEN TELOMERES AND TRANSPOSONS
    MARY PARDUE; Fiscal Year: 2003
    ..abstract_text> ..
  5. DROSOPHILA TELOMERES--GENE, TRANSCRIPTS, AND CHROMATIN
    MARY PARDUE; Fiscal Year: 2002
    ..The phylogenetic study of the transposon mechanism for telomere maintenance will be extended to include insects outside the genus Drosophila to broaden the view of its essential features of this mechanism. ..
  6. DROSOPHILA TELOMERES--GENE, TRANSCRIPTS, AND CHROMATIN
    MARY PARDUE; Fiscal Year: 2001
    ..The phylogenetic study of the transposon mechanism for telomere maintenance will be extended to include insects outside the genus Drosophila to broaden the view of its essential features of this mechanism. ..
  7. PROTEINS OF TELOMERE RETROTRANSPOSABLE ELEMENTS
    MARY PARDUE; Fiscal Year: 2001
    ....
  8. DROSOPHILA TELOMERES--GENE, TRANSCRIPTS, AND CHROMATIN
    MARY PARDUE; Fiscal Year: 2000
    ..The phylogenetic study of the transposon mechanism for telomere maintenance will be extended to include insects outside the genus Drosophila to broaden the view of its essential features of this mechanism. ..
  9. PROTEINS OF TELOMERE RETROTRANSPOSABLE ELEMENTS
    MARY PARDUE; Fiscal Year: 2000
    ....
  10. DROSOPHILA TELOMERES--GENE, TRANSCRIPTS, AND CHROMATIN
    MARY PARDUE; Fiscal Year: 1999
    ..The phylogenetic study of the transposon mechanism for telomere maintenance will be extended to include insects outside the genus Drosophila to broaden the view of its essential features of this mechanism. ..
  11. PROTEINS OF TELOMERE RETROTRANSPOSABLE ELEMENTS
    MARY PARDUE; Fiscal Year: 1999
    ....