Harald Paganetti

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Nuclear interactions in proton therapy: dose and relative biological effect distributions originating from primary and secondary particles
    H Paganetti
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Phys Med Biol 47:747-64. 2002
  2. ncbi request reprint Relative biological effectiveness (RBE) values for proton beam therapy
    Harald Paganetti
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 53:407-21. 2002
  3. ncbi request reprint Significance and implementation of RBE variations in proton beam therapy
    H Paganetti
    Massachusetts General Hospital, Department of Radiation Oncology and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Technol Cancer Res Treat 2:413-26. 2003
  4. ncbi request reprint Interpretation of proton relative biological effectiveness using lesion induction, lesion repair, and cellular dose distribution
    H Paganetti
    Northeast Proton Therapy Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Med Phys 32:2548-56. 2005
  5. ncbi request reprint Secondary carcinogenesis in patients treated with radiation: a review of data on radiation-induced cancers in human, non-human primate, canine and rodent subjects
    Herman Suit
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Radiat Res 167:12-42. 2007
  6. doi request reprint Biological considerations when comparing proton therapy with photon therapy
    Harald Paganetti
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Semin Radiat Oncol 23:77-87. 2013
  7. pmc Assessment of the risk for developing a second malignancy from scattered and secondary radiation in radiation therapy
    Harald Paganetti
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Health Phys 103:652-61. 2012
  8. doi request reprint Assessment of radiation-induced second cancer risks in proton therapy and IMRT for organs inside the primary radiation field
    Harald Paganetti
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Phys Med Biol 57:6047-61. 2012
  9. pmc Range uncertainties in proton therapy and the role of Monte Carlo simulations
    Harald Paganetti
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Phys Med Biol 57:R99-117. 2012
  10. ncbi request reprint 4D Monte Carlo simulation of proton beam scanning: modelling of variations in time and space to study the interplay between scanning pattern and time-dependent patient geometry
    H Paganetti
    Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Phys Med Biol 50:983-90. 2005

Research Grants

  1. PBeam: Fast and Easy Monte Carlo System for Proton Therapy
    Harald Paganetti; Fiscal Year: 2010
  2. Four-Dimensional Monte Carlo Dose Calculation
    Harald Paganetti; Fiscal Year: 2007
  3. Four-Dimensional Monte Carlo Dose Calculation
    Harald Paganetti; Fiscal Year: 2005
  4. Four-Dimensional Monte Carlo Dose Calculation
    Harald Paganetti; Fiscal Year: 2006
  5. PBeam: Fast and Easy Monte Carlo System for Proton Therapy
    Harald Paganetti; Fiscal Year: 2009

Detail Information

Publications74

  1. ncbi request reprint Nuclear interactions in proton therapy: dose and relative biological effect distributions originating from primary and secondary particles
    H Paganetti
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Phys Med Biol 47:747-64. 2002
    ..The biological dose was found to be below 0.5% of the prescribed target dose (for a 3 x 3 x 3 cm3 SOBP) but depends on the size of the SOBP. This dose should not be significant with respect to late effects, e.g. cancer induction...
  2. ncbi request reprint Relative biological effectiveness (RBE) values for proton beam therapy
    Harald Paganetti
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 53:407-21. 2002
    ..0-1.1...
  3. ncbi request reprint Significance and implementation of RBE variations in proton beam therapy
    H Paganetti
    Massachusetts General Hospital, Department of Radiation Oncology and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Technol Cancer Res Treat 2:413-26. 2003
    ..In order to do detailed model calculations more experimental data, in particular for in vivo endpoints, are needed..
  4. ncbi request reprint Interpretation of proton relative biological effectiveness using lesion induction, lesion repair, and cellular dose distribution
    H Paganetti
    Northeast Proton Therapy Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Med Phys 32:2548-56. 2005
    ..The formalism provides a framework for a mechanistic interpretation of RBE values...
  5. ncbi request reprint Secondary carcinogenesis in patients treated with radiation: a review of data on radiation-induced cancers in human, non-human primate, canine and rodent subjects
    Herman Suit
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Radiat Res 167:12-42. 2007
    ..1 Gy, i.e. dose to tissues distant from the target. The proportionate gain should be greatest for dose decrement to less than 2 Gy...
  6. doi request reprint Biological considerations when comparing proton therapy with photon therapy
    Harald Paganetti
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Semin Radiat Oncol 23:77-87. 2013
    ..This article discusses the controversies associated with these 3 issues when comparing proton and photon therapy...
  7. pmc Assessment of the risk for developing a second malignancy from scattered and secondary radiation in radiation therapy
    Harald Paganetti
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Health Phys 103:652-61. 2012
    ..1 Gy). The dosimetry as well as the risk model formalisms are outlined. Furthermore, example calculations and results are presented for intensity-modulated photon therapy versus proton therapy...
  8. doi request reprint Assessment of radiation-induced second cancer risks in proton therapy and IMRT for organs inside the primary radiation field
    Harald Paganetti
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Phys Med Biol 57:6047-61. 2012
    ..The risk depends on treatment planning parameters, i.e. an analysis based on our formalism could be applied within treatment planning programs to guide treatment plans for pediatric patients...
  9. pmc Range uncertainties in proton therapy and the role of Monte Carlo simulations
    Harald Paganetti
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Phys Med Biol 57:R99-117. 2012
    ..In these cases Monte Carlo techniques might reduce the range uncertainty by several mm...
  10. ncbi request reprint 4D Monte Carlo simulation of proton beam scanning: modelling of variations in time and space to study the interplay between scanning pattern and time-dependent patient geometry
    H Paganetti
    Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Phys Med Biol 50:983-90. 2005
    ..Time-dependent beam delivery to a changing patient geometry is simulated in a single 4D dose calculation. Interplay effects between respiratory motion and beam scanning speed are demonstrated...
  11. ncbi request reprint Changes in tumor cell response due to prolonged dose delivery times in fractionated radiation therapy
    Harald Paganetti
    Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 63:892-900. 2005
    ..The goal of this study was to investigate the significance of this effect in fractionated radiation therapy...
  12. doi request reprint Spread-out antiproton beams deliver poor physical dose distributions for radiation therapy
    Harald Paganetti
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Radiother Oncol 95:79-86. 2010
    ..Previous studies have focused on small-diameter near-monoenergetic antiproton beams. The goal of this work was to study more clinically relevant beams...
  13. doi request reprint Dose to water versus dose to medium in proton beam therapy
    Harald Paganetti
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Phys Med Biol 54:4399-421. 2009
    ..It is insufficient, however, when analyzing the beam range. For proton beams stopping in bony anatomy, the predicted beam range can differ by 2-3 mm when comparing dose to tissue and dose to water...
  14. ncbi request reprint Monte Carlo simulations with time-dependent geometries to investigate effects of organ motion with high temporal resolution
    Harald Paganetti
    Department of Radiation Oncology, Massachusetts General Hospital, Northeast Proton Therapy Center, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 60:942-50. 2004
    ..The purpose of this project was the implementation of continuous (four-dimensional [4D]) Monte Carlo simulation to study the irradiation of tumors under respiratory motion...
  15. ncbi request reprint Four-dimensional Monte Carlo simulation of time-dependent geometries
    H Paganetti
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Phys Med Biol 49:N75-81. 2004
    ..We present a technique to simulate time-dependent geometries within a single four-dimensional Monte Carlo simulation using the GEANT4 Monte Carlo package. Results for proton therapy applications are shown...
  16. ncbi request reprint Biophysical modelling of proton radiation effects based on amorphous track models
    H Paganetti
    Massachusetts General Hospital, Department of Radiation Oncology and Harvard Medical School, Boston, MA, USA
    Int J Radiat Biol 77:911-28. 2001
    ..Both have been reported to give good agreement with observed radiobiological data. We were interested in a general comparison and in the predictive power of these models for protons...
  17. ncbi request reprint Foreword: Hadron therapy--from yesterday's physics laboratory to today's modern clinical routine
    Harald Paganetti
    Massachusetts General Hospital, Department of Radiation Oncology and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Technol Cancer Res Treat 2:353-4. 2003
  18. ncbi request reprint Test of GEANT3 and GEANT4 nuclear models for 160 MeV protons stopping in CH2
    H Paganetti
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114 2696, USA
    Med Phys 30:1926-31. 2003
    ..The GEANT3/Fluka and GEANT4/precompound simulations agree moderately well with the observed range distribution. The data are given in a convenient form for testing other Monte Carlo programs...
  19. doi request reprint Breathing interplay effects during proton beam scanning: simulation and statistical analysis
    Joao Seco
    Department of Radiation Oncology, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA
    Phys Med Biol 54:N283-94. 2009
    ..5 x 8.5 x 10 cm(3). For smaller tumor volumes more repaintings will be required, while for larger volumes five repaintings should be sufficient to achieve the required dose accuracy...
  20. pmc Patient study of in vivo verification of beam delivery and range, using positron emission tomography and computed tomography imaging after proton therapy
    Katia Parodi
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 68:920-34. 2007
    ..To investigate the feasibility and value of positron emission tomography and computed tomography (PET/CT) for treatment verification after proton radiotherapy...
  21. doi request reprint Clinical implementation of full Monte Carlo dose calculation in proton beam therapy
    Harald Paganetti
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Phys Med Biol 53:4825-53. 2008
    ..The presented solutions can be easily adopted for other planning systems or other Monte Carlo codes...
  22. doi request reprint Linear energy transfer-guided optimization in intensity modulated proton therapy: feasibility study and clinical potential
    Drosoula Giantsoudi
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Int J Radiat Oncol Biol Phys 87:216-22. 2013
    ..To investigate the feasibility and potential clinical benefit of linear energy transfer (LET) guided plan optimization in intensity modulated proton therapy (IMPT)...
  23. ncbi request reprint Simulation of organ-specific patient effective dose due to secondary neutrons in proton radiation treatment
    Hongyu Jiang
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Phys Med Biol 50:4337-53. 2005
    ..162 Sv and 0.0266 Sv, respectively, to which the major contributor is due to neutrons from the proton treatment nozzle. There is a substantial difference among organs depending on the treatment site...
  24. doi request reprint Should positive phase III clinical trial data be required before proton beam therapy is more widely adopted? No
    Herman Suit
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Radiother Oncol 86:148-53. 2008
    ..Evaluate the rationale for the proposals that prior to a wider use of proton radiation therapy there must be supporting data from phase III clinical trials. That is, would less dose to normal tissues be an advantage to the patient?..
  25. doi request reprint Proton vs carbon ion beams in the definitive radiation treatment of cancer patients
    Herman Suit
    Department of Radiation Oncology, Boston, MA, USA
    Radiother Oncol 95:3-22. 2010
    ..The principal differences are LET, low for (1)H and high for (12)C, and a narrower penumbra of (12)C beams. Were (12)C to yield a higher TCP for a defined NTCP than (1)H therapy, would LET, fractionation or penumbra width be the basis?..
  26. doi request reprint Extension of the NCAT phantom for the investigation of intra-fraction respiratory motion in IMRT using 4D Monte Carlo
    Ross McGurk
    Department of Radiation Oncology, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Phys Med Biol 55:1475-90. 2010
    ..Our results indicate that the NCAT phantom, combined with 4D-MC simulations, is a useful tool in radiation therapy investigations and may allow the study of relative effects in many clinically relevant situations...
  27. pmc Motion interplay as a function of patient parameters and spot size in spot scanning proton therapy for lung cancer
    Clemens Grassberger
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Int J Radiat Oncol Biol Phys 86:380-6. 2013
    ..To quantify the impact of respiratory motion on the treatment of lung tumors with spot scanning proton therapy...
  28. doi request reprint Range uncertainty in proton therapy due to variable biological effectiveness
    Alejandro Carabe
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Phys Med Biol 57:1159-72. 2012
    ..The results of our study allow a quantitative consideration of RBE-caused range uncertainties as a function of treatment site and dose in treatment planning...
  29. pmc Effects of Hounsfield number conversion on CT based proton Monte Carlo dose calculations
    Hongyu Jiang
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Med Phys 34:1439-49. 2007
    ..In addition, the significance of the elemental composition effect (dose to water vs. dose to tissue) is tissue-type dependent and is also affected by nuclear reactions...
  30. doi request reprint Sensitivity of different dose scoring methods on organ-specific neutron dose calculations in proton therapy
    Christina Zacharatou Jarlskog
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Phys Med Biol 53:4523-32. 2008
    ..We found that the scoring procedure can lead to differences in the organ equivalent dose of about 25%. As to the ICRP definition of neutron quality factors, the most recent recommendation results in about 10% higher organ doses...
  31. doi request reprint Accuracy of proton beam range verification using post-treatment positron emission tomography/computed tomography as function of treatment site
    Antje Christin Knopf
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 79:297-304. 2011
    ..A well-balanced population of patients was investigated to assess the effect of the tumor location on the accuracy of the technique...
  32. pmc PET/CT imaging for treatment verification after proton therapy: a study with plastic phantoms and metallic implants
    Katia Parodi
    Department of Radiation Oncology, Massachusetts General Hospital, 30 Fruit Street, Boston, Massachusetts 02114, USA
    Med Phys 34:419-35. 2007
    ..In addition to PET alone, PET/CT imaging provides accurate information on the position of the imaged object and may assess possible anatomical changes during fractionated radiotherapy in clinical applications...
  33. pmc Comparison of out-of-field photon doses in 6 MV IMRT and neutron doses in proton therapy for adult and pediatric patients
    Basit S Athar
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Phys Med Biol 55:2879-91. 2010
    ..At larger distances to the field (beyond approximately 25 cm), protons offer an advantage, resulting in doses that are roughly a factor of 2-3 lower...
  34. pmc Variations in linear energy transfer within clinical proton therapy fields and the potential for biological treatment planning
    Clemens Grassberger
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 80:1559-66. 2011
    ..These distributions can be used to identify areas of elevated or diminished biological effect. The location of such areas might be influenced in intensity-modulated proton therapy (IMPT) optimization...
  35. doi request reprint Patterns of failure after proton therapy in medulloblastoma; linear energy transfer distributions and relative biological effectiveness associations for relapses
    Roshan V Sethi
    Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts
    Int J Radiat Oncol Biol Phys 88:655-63. 2014
    ..Here we report the patterns of failure after the use of protons, compare it to that in the available photon literature, and determine the LET and RBE values in areas of recurrence...
  36. ncbi request reprint Proton beams to replace photon beams in radical dose treatments
    Herman Suit
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Acta Oncol 42:800-8. 2003
    ..5 provided there were to be no charge for the original facility and that there were sufficient patients for operating on an extended schedule (6-7 days of 14-16 h) with > or = two gantries and one fixed horizontal beam...
  37. pmc Maximizing the biological effect of proton dose delivered with scanned beams via inhomogeneous daily dose distributions
    Chuan Zeng
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Med Phys 40:051708. 2013
    ..The authors describe a method to construct inhomogeneous fractional dose (IFD) distributions, and evaluate the potential gain in the therapeutic effect from their delivery in proton therapy delivered by pencil beam scanning...
  38. pmc Assessment of organ-specific neutron equivalent doses in proton therapy using computational whole-body age-dependent voxel phantoms
    Christina Zacharatou Jarlskog
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Phys Med Biol 53:693-717. 2008
    ..The neutron dose from a course of proton therapy treatment (assuming 70 Gy in 30 fractions) could potentially (depending on patient's age, organ, treatment site and area of CT scan) be equivalent to up to approximately 30 CT scans...
  39. pmc Monitoring proton radiation therapy with in-room PET imaging
    Xuping Zhu
    Department of Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Phys Med Biol 56:4041-57. 2011
    ..In-room PET is a promising low cost, high sensitivity modality for the in vivo verification of proton therapy. Better accuracy in Monte Carlo predictions, especially for biological decay modeling, is necessary...
  40. pmc Dosimetric impact of motion in free-breathing and gated lung radiotherapy: a 4D Monte Carlo study of intrafraction and interfraction effects
    Joao Seco
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Med Phys 35:356-66. 2008
    ..These differences are a consequence of the larger contribution of the inhale phase in the 3DCT data than in the 4DCT...
  41. doi request reprint Clinical consequences of relative biological effectiveness variations in proton radiotherapy of the prostate, brain and liver
    Alejandro Carabe
    Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA19104, USA
    Phys Med Biol 58:2103-17. 2013
    ..Most importantly, this study shows that the consideration of RBE variations could influence the comparison of proton and photon treatments in clinical trials, in particular in the case of the prostate...
  42. pmc Clinical application of in-room positron emission tomography for in vivo treatment monitoring in proton radiation therapy
    Chul Hee Min
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Int J Radiat Oncol Biol Phys 86:183-9. 2013
    ..The purpose of this study is to evaluate the potential of using in-room positron emission tomography (PET) for treatment verification in proton therapy and for deriving suitable PET scan times...
  43. doi request reprint Comparison of whole-body phantom designs to estimate organ equivalent neutron doses for secondary cancer risk assessment in proton therapy
    Maryam Moteabbed
    Massachusetts General Hospital, Boston, MA 02114, USA
    Phys Med Biol 57:499-515. 2012
    ....
  44. doi request reprint Neutron equivalent doses and associated lifetime cancer incidence risks for head & neck and spinal proton therapy
    Basit S Athar
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Phys Med Biol 54:4907-26. 2009
    ..For an 11-year-old male patient treated with a spinal field, bronchi and rectum show the highest risks of 0.32% and 0.43%, respectively. Risks for male and female patients increase as their age at treatment time decreases...
  45. doi request reprint Uncertainties in planned dose due to the limited voxel size of the planning CT when treating lung tumors with proton therapy
    Samuel España
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Phys Med Biol 56:3843-56. 2011
    ..In conclusion, when assigning margins for treatment planning for lung cancer, proton range uncertainties due to the heterogeneous lung geometry and CT image resolution need to be considered...
  46. ncbi request reprint Adaptation of GEANT4 to Monte Carlo dose calculations based on CT data
    H Jiang
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Med Phys 31:2811-8. 2004
    ..Recalculation of a proton therapy treatment plan generated by a commercial treatment planning program for a paranasal sinus case is presented as an example...
  47. ncbi request reprint Monte Carlo calculations in support of the commissioning of the Northeast Proton Therapy Center
    J Flanz
    Massachusetts General Hospital, Department of Radiation Oncology, Harvard Medical School, Northeast Proton Therapy Center, Boston 02114, USA
    Australas Phys Eng Sci Med 26:156-61. 2003
    ..In radiobiology studies we found that the RBE at beam entrance increases due to the build-up of the secondary particle fluence...
  48. ncbi request reprint Lifetime increased cancer risk in mice following exposure to clinical proton beam-generated neutrons
    Leo E Gerweck
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts Electronic address
    Int J Radiat Oncol Biol Phys 89:161-6. 2014
    ..To evaluate the life span and risk of cancer following whole-body exposure of mice to neutrons generated by a passively scattered clinical spread-out Bragg peak (SOBP) proton beam...
  49. doi request reprint The impact of uncertainties in the CT conversion algorithm when predicting proton beam ranges in patients from dose and PET-activity distributions
    Samuel España
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Phys Med Biol 55:7557-71. 2010
    ..Calculated PET images used for range verification are more sensitive to conversion uncertainties causing an intrinsic limitation due to CT conversion alone of at least 1 mm...
  50. doi request reprint Adjuvant radiation therapy for early stage seminoma: proton versus photon planning comparison and modeling of second cancer risk
    Jason A Efstathiou
    Massachusetts General Hospital, Department of Radiation Oncology, Boston, MA 02114, USA
    Radiother Oncol 103:12-7. 2012
    ..Given concerns of excess malignancies following adjuvant radiation for seminoma, we evaluated photon and proton beam therapy (PBT) treatment plans to assess dose distributions to organs at risk and model rates of second cancers...
  51. pmc Assessment of out-of-field absorbed dose and equivalent dose in proton fields
    Ben Clasie
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Med Phys 37:311-21. 2010
    ....
  52. ncbi request reprint Field size dependence of the output factor in passively scattered proton therapy: influence of range, modulation, air gap, and machine settings
    J Daartz
    Department of Radiation Oncology, Francis H Burr Proton Therapy Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Med Phys 36:3205-10. 2009
    ..The output was shown to be field size dependent even for large fields, indicating an effect beyond charged particle disequilibrium caused by lateral scatter...
  53. pmc Dosimetric accuracy of planning and delivering small proton therapy fields
    Bryan Bednarz
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Phys Med Biol 55:7425-38. 2010
    ..For the four cases studied in this paper, these limitations appear to impact individual field calculations, but do not have a significant impact on the prescribed dose over multiple fields...
  54. pmc Monte Carlo calculations for absolute dosimetry to determine machine outputs for proton therapy fields
    Harald Paganetti
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Phys Med Biol 51:2801-12. 2006
    ..Compared to experimental methods the Monte Carlo method has the advantage of being able to verify the dose in the patient geometry...
  55. ncbi request reprint Radiobiological significance of beamline dependent proton energy distributions in a spread-out Bragg peak
    H Paganetti
    Department of Radiation Oncology, Massachusetts General Hospital, Boston 02114, USA
    Med Phys 27:1119-26. 2000
    ..However, these differences are remarkable only at the very distal edge of the SOBP, for low doses, and/or for large differences in beam setup...
  56. ncbi request reprint Accurate Monte Carlo simulations for nozzle design, commissioning and quality assurance for a proton radiation therapy facility
    H Paganetti
    Northeast Proton Therapy Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Med Phys 31:2107-18. 2004
    ..This allows the definition of tolerances for quality assurance and the design of quality assurance procedures...
  57. doi request reprint Systematic analysis of biological and physical limitations of proton beam range verification with offline PET/CT scans
    A Knopf
    Department of Radiation Oncology, MGH and Harvard Medical School, Boston, MA 02114, USA
    Phys Med Biol 54:4477-95. 2009
    ..By implementing technological and methodological improvements like the use of in-room PET scanners, PET measurements could soon be used to provide proton range verification in clinical routine...
  58. ncbi request reprint Quantification of proton dose calculation accuracy in the lung
    Clemens Grassberger
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts Center for Proton Radiotherapy, Paul Scherrer Institute, Villigen, Switzerland Electronic address
    Int J Radiat Oncol Biol Phys 89:424-30. 2014
    ..To quantify the accuracy of a clinical proton treatment planning system (TPS) as well as Monte Carlo (MC)-based dose calculation through measurements and to assess the clinical impact in a cohort of patients with tumors located in the lung...
  59. pmc Monte Carlo study of the potential reduction in out-of-field dose using a patient-specific aperture in pencil beam scanning proton therapy
    Stephen J Dowdell
    Centre for Medical Radiation Physics, University of Wollongong, Wollongong, NSW 2522, Australia
    Phys Med Biol 57:2829-42. 2012
    ..In conclusion, using a patient-specific aperture has the potential to further improve the normal tissue sparing capabilities of PBS...
  60. doi request reprint Proton radiation in the management of localized cancer
    Harald Paganetti
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Expert Rev Med Devices 7:275-85. 2010
    ..This article summarizes the rationale for (proton) radiation therapy and addresses the promises and challenges of proton-beam therapy in the management of localized cancer...
  61. ncbi request reprint The biologic relevance of daily dose variations in adaptive treatment planning
    Thomas Bortfeld
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 65:899-906. 2006
    ..To explore the biologic relevance of deviations from the intended uniform fractionation scheme...
  62. doi request reprint Fractionation effects in particle radiotherapy: implications for hypo-fractionation regimes
    A Carabe-Fernandez
    Department of Radiation Oncology, Harvard Medical School, Francis H Burr Proton Therapy Center, Massachusetts General Hospital, Boston, MA 02114, USA
    Phys Med Biol 55:5685-700. 2010
    ..The results provide evidence of the impact that variations in the β parameter may have when calculating clinically relevant RBE values, especially when using high doses per fraction (i.e. hypofractionation) of high-LET radiations...
  63. doi request reprint Monte Carlo patient study on the comparison of prompt gamma and PET imaging for range verification in proton therapy
    M Moteabbed
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Phys Med Biol 56:1063-82. 2011
    ....
  64. ncbi request reprint The prediction of output factors for spread-out proton Bragg peak fields in clinical practice
    Hanne M Kooy
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Phys Med Biol 50:5847-56. 2005
    ..We describe the calibration and protocol for SOBP fields, the effects of apertures and range-compensators and the use of output factors in the treatment planning process...
  65. pmc Effects of organ motion on IMRT treatments with segments of few monitor units
    J Seco
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Med Phys 34:923-34. 2007
    ..In addition, dose averaging may not work well for hypo-fractionation, where fewer fractions are used. For hypo-fractionation, PDF modeling of the tumor motion in IMRT optimization may not be adequate...
  66. ncbi request reprint The risk of radiation-induced second cancers in the high to medium dose region: a comparison between passive and scanned proton therapy, IMRT and VMAT for pediatric patients with brain tumors
    Maryam Moteabbed
    Massachusetts General Hospital, Boston, MA 02114, USA Harvard Medical School, Boston, MA 02115, USA
    Phys Med Biol 59:2883-99. 2014
    ..When planning treatments and deciding on the treatment modality, the probability of second cancer incidence should be carefully examined and weighed against the possibility of developing acute side effects for each patient individually. ..
  67. pmc Four-dimensional Monte Carlo simulations demonstrating how the extent of intensity-modulation impacts motion effects in proton therapy lung treatments
    Stephen Dowdell
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114
    Med Phys 40:121713. 2013
    ..To compare motion effects in intensity modulated proton therapy (IMPT) lung treatments with different levels of intensity modulation...
  68. pmc Comparison of second cancer risk due to out-of-field doses from 6-MV IMRT and proton therapy based on 6 pediatric patient treatment plans
    Basit S Athar
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, MA, USA
    Radiother Oncol 98:87-92. 2011
    ..This study compared 6-MV IMRT and proton therapy in terms of organ specific second cancer lifetime attributable risks (LARs) caused by scattered and secondary out-of-field radiation...
  69. ncbi request reprint The general relation between tissue response to x-radiation (alpha/beta-values) and the relative biological effectiveness (RBE) of protons: prediction by the Katz track-structure model
    H Paganetti
    Department of Radiation Oncology, Massachusetts General Hospital, Boston 02114, USA
    Int J Radiat Biol 76:985-98. 2000
    ..In an effort to explore the basis for this observation, calculations were performed to investigate the response of different biological targets through a range of proton energies and doses...
  70. pmc Clinical CT-based calculations of dose and positron emitter distributions in proton therapy using the FLUKA Monte Carlo code
    K Parodi
    Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Phys Med Biol 52:3369-87. 2007
    ..g., PET imaging during or after irradiation) on the intensity and spatial distribution of the irradiation-induced beta+-activity signal for the cases of head and neck and para-spinal tumour sites...
  71. doi request reprint Quantitative assessment of the physical potential of proton beam range verification with PET/CT
    A Knopf
    Department of Radiation Oncology, MGH and Harvard Medical School, Boston, MA 02114 USA
    Phys Med Biol 53:4137-51. 2008
    ..This study indicates the physical potential of the PET/CT verification method to detect the full-range characteristic of the delivered dose in the patient...
  72. ncbi request reprint Neutron dose in proton radiation therapy: in regard to Eric J. Hall (Int J Radiat Oncol Biol Phys 2006;65:1-7)
    Harald Paganetti
    Int J Radiat Oncol Biol Phys 66:1594-5; author reply 1595. 2006
  73. ncbi request reprint A review of dosimetry studies on external-beam radiation treatment with respect to second cancer induction
    X George Xu
    Nuclear Engineering and Engineering Physics, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
    Phys Med Biol 53:R193-241. 2008
    ..Selected clinical data on second cancer induction among radiotherapy patients are also covered. Problems in past studies and controversial issues are discussed. The needs for future studies are presented at the end...
  74. doi request reprint Risk of developing second cancer from neutron dose in proton therapy as function of field characteristics, organ, and patient age
    Christina Zacharatou Jarlskog
    Department of Radiation Oncology, Copenhagen University Hospital, Copenhagen, Denmark
    Int J Radiat Oncol Biol Phys 72:228-35. 2008
    ..The focus was on the cancer risk caused by neutrons outside the treatment volume and the dependency on the patient's age...

Research Grants6

  1. PBeam: Fast and Easy Monte Carlo System for Proton Therapy
    Harald Paganetti; Fiscal Year: 2010
    ....
  2. Four-Dimensional Monte Carlo Dose Calculation
    Harald Paganetti; Fiscal Year: 2007
    ..abstract_text> ..
  3. Four-Dimensional Monte Carlo Dose Calculation
    Harald Paganetti; Fiscal Year: 2005
    ..abstract_text> ..
  4. Four-Dimensional Monte Carlo Dose Calculation
    Harald Paganetti; Fiscal Year: 2006
    ..abstract_text> ..
  5. PBeam: Fast and Easy Monte Carlo System for Proton Therapy
    Harald Paganetti; Fiscal Year: 2009
    ....