Robert L Owens

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Influencing the decline of lung function in COPD: use of pharmacotherapy
    Ekaterina S Gladysheva
    Harvard Combined Pulmonary and Critical Care Fellowship, Harvard Medical School, Boston, MA, USA
    Int J Chron Obstruct Pulmon Dis 5:153-64. 2010
  2. pmc Sitting and supine esophageal pressures in overweight and obese subjects
    Robert L Owens
    Sleep Disorders Research Program, Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Obesity (Silver Spring) 20:2354-60. 2012
  3. doi request reprint Supplemental oxygen needs during sleep. Who benefits?
    Robert L Owens
    Division of Pulmonary and Critical Care Medicine, and the Division of Sleep Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Respir Care 58:32-47. 2013
  4. pmc Upper airway collapsibility and patterns of flow limitation at constant end-expiratory lung volume
    Robert L Owens
    Sleep Disorders Research Program, Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Appl Physiol (1985) 113:691-9. 2012
  5. pmc Sleep-disordered breathing and COPD: the overlap syndrome
    Robert L Owens
    Sleep Disorders Research Program, Brigham and Women s Hospital, Boston, MA 02115, USA
    Respir Care 55:1333-44; discussion 1344-6. 2010
  6. pmc The influence of end-expiratory lung volume on measurements of pharyngeal collapsibility
    Robert L Owens
    Sleep Disorders Research Program, Div of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Appl Physiol (1985) 108:445-51. 2010
  7. pmc Is the way to man's heart (and lung) through the abdomen?
    Robert L Owens
    Sleep Disorders Research Program, Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Crit Care 13:199. 2009
  8. pmc Upper airway function in the pathogenesis of obstructive sleep apnea: a review of the current literature
    Robert L Owens
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Pulm Med 14:519-24. 2008
  9. pmc A method for measuring and modeling the physiological traits causing obstructive sleep apnea
    Andrew Wellman
    221 Longwood Ave, 036 BLI, Boston, MA 02115, USA
    J Appl Physiol (1985) 110:1627-37. 2011
  10. pmc Acetazolamide improves loop gain but not the other physiological traits causing obstructive sleep apnoea
    Bradley A Edwards
    Sleep Disorders Research Program, Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    J Physiol 590:1199-211. 2012

Detail Information

Publications19

  1. pmc Influencing the decline of lung function in COPD: use of pharmacotherapy
    Ekaterina S Gladysheva
    Harvard Combined Pulmonary and Critical Care Fellowship, Harvard Medical School, Boston, MA, USA
    Int J Chron Obstruct Pulmon Dis 5:153-64. 2010
    ..A variety of newer classes of medications may help target other pathophysiologically important pathways, and could be used in the future to prevent lung function decline in COPD...
  2. pmc Sitting and supine esophageal pressures in overweight and obese subjects
    Robert L Owens
    Sleep Disorders Research Program, Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Obesity (Silver Spring) 20:2354-60. 2012
    ..These data indicate that mediastinal weight and postural effects on P(Es) are within a clinically acceptable range, and suggest that esophageal manometry can be used to inform clinical decision making across wide range of body types...
  3. doi request reprint Supplemental oxygen needs during sleep. Who benefits?
    Robert L Owens
    Division of Pulmonary and Critical Care Medicine, and the Division of Sleep Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Respir Care 58:32-47. 2013
    ..Because of its prevalence, obstructive sleep apnea may commonly overlap with lung disease in many patients and have important consequences. Patients with overlap syndromes may be good candidates for noninvasive ventilation during sleep...
  4. pmc Upper airway collapsibility and patterns of flow limitation at constant end-expiratory lung volume
    Robert L Owens
    Sleep Disorders Research Program, Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Appl Physiol (1985) 113:691-9. 2012
    ..These results also highlight the importance of inspiratory collapse in OSA pathogenesis. The cause of negative effort dependence within and across breaths is not known and requires further study...
  5. pmc Sleep-disordered breathing and COPD: the overlap syndrome
    Robert L Owens
    Sleep Disorders Research Program, Brigham and Women s Hospital, Boston, MA 02115, USA
    Respir Care 55:1333-44; discussion 1344-6. 2010
    ..Treatment currently consists of continuous positive airway pressure, and oxygen as needed. Noninvasive ventilation may be helpful in overlap syndrome patients, but this has not yet been well studied...
  6. pmc The influence of end-expiratory lung volume on measurements of pharyngeal collapsibility
    Robert L Owens
    Sleep Disorders Research Program, Div of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Appl Physiol (1985) 108:445-51. 2010
    ..Changes in lung volume alter Pcrit substantially. This work supports a role for lung volume in the pathogenesis of OSA, and lung volume changes should be a consideration during assessment of pharyngeal mechanics...
  7. pmc Is the way to man's heart (and lung) through the abdomen?
    Robert L Owens
    Sleep Disorders Research Program, Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Crit Care 13:199. 2009
    ..However, their work raises several questions for clinicians and researchers regarding the pathophysiology and management of IAP...
  8. pmc Upper airway function in the pathogenesis of obstructive sleep apnea: a review of the current literature
    Robert L Owens
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Pulm Med 14:519-24. 2008
    ..However, recent work has focused on the function, rather than structure alone, of the upper airway...
  9. pmc A method for measuring and modeling the physiological traits causing obstructive sleep apnea
    Andrew Wellman
    221 Longwood Ave, 036 BLI, Boston, MA 02115, USA
    J Appl Physiol (1985) 110:1627-37. 2011
    ..This technique could conceivably be used clinically to define a patient's physiology and guide therapy based on the traits...
  10. pmc Acetazolamide improves loop gain but not the other physiological traits causing obstructive sleep apnoea
    Bradley A Edwards
    Sleep Disorders Research Program, Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    J Physiol 590:1199-211. 2012
    ..Identification of patients who may benefit from reductions in LG alone or in combination with other therapies to alter the remaining traits may facilitate pharmacological resolution of OSA in the future...
  11. pmc A simplified method for determining phenotypic traits in patients with obstructive sleep apnea
    Andrew Wellman
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Appl Physiol (1985) 114:911-22. 2013
    ..This technique is a relatively simple way of defining mechanisms underlying OSA and could potentially be used in a clinical setting to individualize therapy...
  12. pmc The classical Starling resistor model often does not predict inspiratory airflow patterns in the human upper airway
    Robert L Owens
    Sleep Disorders Research Program, Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts
    J Appl Physiol (1985) 116:1105-12. 2014
    ..In contrast to the classical Starling resistor model, the upper airway exhibits marked NED in some subjects. ..
  13. ncbi request reprint Effect of the chest wall on pressure-volume curve analysis of acute respiratory distress syndrome lungs
    Robert L Owens
    Departments of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Crit Care Med 36:2980-5. 2008
    ..We sought to quantify the effect of the chest wall by considering the chest wall and lung in series...
  14. ncbi request reprint Obstructive Sleep Apnea in Older Adults is a Distinctly Different Physiological Phenotype
    Bradley A Edwards
    Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA
    Sleep 37:1227-36. 2014
    ..However, previous studies examining individual physiological traits known to contribute to OSA pathogenesis have been assessed in isolation, primarily in healthy individuals...
  15. pmc Obstructive airway disease and obstructive sleep apnea: effect of pulmonary function
    Bhavneesh Sharma
    Division of Sleep Medicine, Harvard Medical School Brigham and Women s Hospital, Boston, MA 02115, USA
    Lung 189:37-41. 2011
    ..However, the high prevalence of OSA in OAD patients appears to be due to obesity, and reduced pulmonary function is not an independent risk factor for OSA...
  16. pmc Evaluation of right ventricular remodeling using cardiac magnetic resonance imaging in co-existent chronic obstructive pulmonary disease and obstructive sleep apnea
    Bhavneesh Sharma
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    COPD 10:4-10. 2013
    ..65, p = 0.03). Our pilot results suggest that untreated overlap syndrome may cause more extensive RV remodeling than COPD alone...
  17. pmc Eszopiclone increases the respiratory arousal threshold and lowers the apnoea/hypopnoea index in obstructive sleep apnoea patients with a low arousal threshold
    Danny J Eckert
    Sleep Disorders Program, Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Clin Sci (Lond) 120:505-14. 2011
    ..However, additional treatment strategies are probably required to achieve elimination of apnoea...
  18. pmc What is central sleep apnea?
    Atul Malhotra
    Division of Sleep, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Respir Care 55:1168-78. 2010
    ..A paucity of research exists in this area, emphasizing the opportunities for young investigators who are interested in this field...
  19. ncbi request reprint Do newer monitors of exhaled gases, mechanics, and esophageal pressure add value?
    Robert L Owens
    Department of Medicine, Pulmonary and Critical Care Unit, Cox 2, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Clin Chest Med 29:297-312, vi-vii. 2008
    ..The authors explore the concepts, benefits, difficulties, and relevant clinical trials of each...