M W Otto

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Psychoeducational and cognitive-behavioral strategies in the management of bipolar disorder
    Michael W Otto
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Affect Disord 73:171-81. 2003
  2. ncbi request reprint Benzodiazepine discontinuation difficulties in panic disorder: conceptual model and outcome for cognitive-behavior therapy
    M W Otto
    Harvard Medical School and Massachusetts General Hospital, 15 Parkman St, Boston, MA 02114, USA
    Curr Pharm Des 8:75-80. 2002
  3. ncbi request reprint Prevalence of body dysmorphic disorder in a community sample of women
    M W Otto
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 158:2061-3. 2001
  4. ncbi request reprint Internal cue exposure and the treatment of substance use disorders: lessons from the treatment of panic disorder
    Michael W Otto
    Massachusetts General Hospital and Harvard Medical School, WACC 812, 15 Parkman St, Boston, MA 02114, USA
    J Anxiety Disord 18:69-87. 2004
  5. ncbi request reprint Empirically supported treatments for panic disorder: costs, benefits, and stepped care
    M W Otto
    Massachusetts General Hospital, Boston 02114, USA
    J Consult Clin Psychol 68:556-63. 2000
  6. ncbi request reprint An effect-size analysis of the relative efficacy and tolerability of serotonin selective reuptake inhibitors for panic disorder
    M W Otto
    Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 158:1989-92. 2001
  7. ncbi request reprint Cognitive-behavioral therapy for the treatment of anxiety disorders
    Michael W Otto
    Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    J Clin Psychiatry 65:34-41. 2004
  8. ncbi request reprint Treatment of pharmacotherapy-refractory posttraumatic stress disorder among Cambodian refugees: a pilot study of combination treatment with cognitive-behavior therapy vs sertraline alone
    Michael W Otto
    Massachusetts General Hospital and Harvard Medical School, WACC 812, 15 Parkman St, Boston, MA 02114, USA
    Behav Res Ther 41:1271-6. 2003
  9. ncbi request reprint Prevalence and predictors of depressive symptoms in older premenopausal women: the Harvard Study of Moods and Cycles
    B L Harlow
    Harvard Medical School, Obstetrics and Gynecology Epidemiology Center, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Arch Gen Psychiatry 56:418-24. 1999
  10. ncbi request reprint Prevalence of body dysmorphic disorder in patients with anxiety disorders
    S Wilhelm
    OCD Clinic and Research Unit, Massachusetts General Hospital, Charlestown 02129, USA
    J Anxiety Disord 11:499-502. 1997

Collaborators

Detail Information

Publications84

  1. ncbi request reprint Psychoeducational and cognitive-behavioral strategies in the management of bipolar disorder
    Michael W Otto
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Affect Disord 73:171-81. 2003
    ....
  2. ncbi request reprint Benzodiazepine discontinuation difficulties in panic disorder: conceptual model and outcome for cognitive-behavior therapy
    M W Otto
    Harvard Medical School and Massachusetts General Hospital, 15 Parkman St, Boston, MA 02114, USA
    Curr Pharm Des 8:75-80. 2002
    ..Outcome studies are reviewed, and are placed in the context of other evidence for the efficacy of CBT in patients with this disorder...
  3. ncbi request reprint Prevalence of body dysmorphic disorder in a community sample of women
    M W Otto
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 158:2061-3. 2001
    ..In a large population-based study, the authors examined the prevalence and correlates of body dysmorphic disorder, a debilitating and chronic condition characterized by an imagined defect in appearance...
  4. ncbi request reprint Internal cue exposure and the treatment of substance use disorders: lessons from the treatment of panic disorder
    Michael W Otto
    Massachusetts General Hospital and Harvard Medical School, WACC 812, 15 Parkman St, Boston, MA 02114, USA
    J Anxiety Disord 18:69-87. 2004
    ....
  5. ncbi request reprint Empirically supported treatments for panic disorder: costs, benefits, and stepped care
    M W Otto
    Massachusetts General Hospital, Boston 02114, USA
    J Consult Clin Psychol 68:556-63. 2000
    ..Analysis of the "services" data indicated that CBT was at least equal to pharmacotherapy in terms of pretreatment severity and acute treatment outcome and that CBT is an especially cost-effective treatment option...
  6. ncbi request reprint An effect-size analysis of the relative efficacy and tolerability of serotonin selective reuptake inhibitors for panic disorder
    M W Otto
    Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 158:1989-92. 2001
    ..In this study the authors used an effect-size analysis to provide an initial comparison...
  7. ncbi request reprint Cognitive-behavioral therapy for the treatment of anxiety disorders
    Michael W Otto
    Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    J Clin Psychiatry 65:34-41. 2004
    ..Relative to combination therapy, we review some of the conditions that may influence the longevity of treatment gains from CBT...
  8. ncbi request reprint Treatment of pharmacotherapy-refractory posttraumatic stress disorder among Cambodian refugees: a pilot study of combination treatment with cognitive-behavior therapy vs sertraline alone
    Michael W Otto
    Massachusetts General Hospital and Harvard Medical School, WACC 812, 15 Parkman St, Boston, MA 02114, USA
    Behav Res Ther 41:1271-6. 2003
    ....
  9. ncbi request reprint Prevalence and predictors of depressive symptoms in older premenopausal women: the Harvard Study of Moods and Cycles
    B L Harlow
    Harvard Medical School, Obstetrics and Gynecology Epidemiology Center, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Arch Gen Psychiatry 56:418-24. 1999
    ..The Harvard Study of Moods and Cycles is a community-based cohort study designed to evaluate the relationship between major depression and changes in menstrual and ovarian function...
  10. ncbi request reprint Prevalence of body dysmorphic disorder in patients with anxiety disorders
    S Wilhelm
    OCD Clinic and Research Unit, Massachusetts General Hospital, Charlestown 02129, USA
    J Anxiety Disord 11:499-502. 1997
    ..In all cases, onset of social phobia preceded onset of BDD. Our findings draw attention to the prevalence of BDD in patients with social phobia. The potential etiologic significance of our findings is discussed...
  11. ncbi request reprint Sertraline in the treatment of panic disorder: a flexible-dose multicenter trial
    M H Pollack
    Anxiety Disorders Program, Department of Psychiatry, Massachusetts General Hospital, Boston 02114 3117, USA
    Arch Gen Psychiatry 55:1010-6. 1998
    ..We examined the efficacy and safety of the serotonin selective reuptake inhibitor sertraline hydrochloride in patients with panic disorder...
  12. ncbi request reprint Rate of improvement during cognitive-behavioral group treatment for panic disorder
    S J Penava
    Department of Psychiatry, Massachusetts General Hospital, Boston 02114, USA
    Behav Res Ther 36:665-73. 1998
    ..Information on rats of symptom improvement is valuable for providing patients with accurate expectations about potential treatment benefits and for helping to maintain motivation during initial treatment sessions...
  13. ncbi request reprint Childhood history of anxiety disorders among adults with social phobia: rates, correlates, and comparisons with patients with panic disorder
    M W Otto
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Depress Anxiety 14:209-13. 2001
    ....
  14. ncbi request reprint Cognitive behavior group therapy for body dysmorphic disorder: a case series
    S Wilhelm
    Massachusetts General Hospital, Charlestown, USA
    Behav Res Ther 37:71-5. 1999
    ..This finding adds to a nascent literature documenting the potential efficacy of short-term cognitive-behavior therapy for patients suffering from BDD...
  15. ncbi request reprint Group cognitive-behavior therapy for patients failing to respond to pharmacotherapy for panic disorder: a clinical case series
    M W Otto
    Massachusetts General Hospital, Boston, USA
    Behav Res Ther 37:763-70. 1999
    ....
  16. ncbi request reprint A comparison of the efficacy of clonazepam and cognitive-behavioral group therapy for the treatment of social phobia
    M W Otto
    Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    J Anxiety Disord 14:345-58. 2000
    ....
  17. ncbi request reprint The anxiety sensitivity index: item analysis and suggestions for refinement
    M A Blais
    Inpatient Psychiatry Service, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    J Pers Assess 77:272-94. 2001
    ..The 11-item ASI appears to tap 2 primary aspects of anxiety sensitivity: fears of somatic sensations of anxiety and fears of loss of mental control. Suggestions for further development of the ASI are offered...
  18. ncbi request reprint How do clinicians respond to patients who miss appointments?
    J W Smoller
    Department of Psychiatry, Massachusetts General Hospital, Boston 02114, USA
    J Clin Psychiatry 59:330-8; quiz 339-40. 1998
    ..In an effort to determine how clinicians customarily handle missed appointments, we surveyed mental health clinicians and internists at 2 academic hospitals: a private psychiatric hospital and an urban general hospital...
  19. ncbi request reprint Nefazodone for social phobia: a clinical case series
    J J Worthington
    Anxiety Disorders Program, Massachusetts General Hospital, Boston, USA
    Depress Anxiety 8:131-3. 1998
    ..Results from this case series suggest that nefazodone may be an effective treatment for social phobia and that formal randomized trials are warranted...
  20. ncbi request reprint Additional findings on the association between anxiety sensitivity and hypochondriacal concerns: examination of patients with major depression
    M W Otto
    Cognitive Behavior Therapy Program, Massachusetts General Hospital, Boston 02114, USA
    J Anxiety Disord 12:225-32. 1998
    ..Findings are discussed in relation to the role of catastrophic interpretations of somatic symptoms in depression, panic disorder, and hypochondriasis...
  21. ncbi request reprint Two strategies to increase adherence to HIV antiretroviral medication: life-steps and medication monitoring
    S A Safren
    Massachusetts General Hospital and Harvard Medical School, Boston MA 02114, USA
    Behav Res Ther 39:1151-62. 2001
    ..Both interventions yielded improvement in adherence from baseline, and the Life-Steps intervention showed faster improvements in adherence for persons with extant adherence problems...
  22. ncbi request reprint Characteristics of women with premenstrual dysphoric disorder (PMDD) who did or did not report history of depression: a preliminary report from the Harvard Study of Moods and Cycles
    C N Soares
    Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, Boston, MA 02114, USA
    J Womens Health Gend Based Med 10:873-8. 2001
    ....
  23. ncbi request reprint Cognitive-behavioral therapy for depression. Applications and outcome
    T Deckersbach
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Psychiatr Clin North Am 23:795-809, VII. 2000
    ..This article discusses cognitive-behavioral therapy for depression, including evidence for its efficacy and how to choose between this therapy and antidepressants. The use of this therapy to prevent relapse also is presented...
  24. ncbi request reprint Anger-associated panic attacks in Cambodian refugees with PTSD; a multiple baseline examination of clinical data
    D Hinton
    Massachusetts General Hospital and Harvard Medical School, Revere, MA, USA
    Behav Res Ther 41:647-54. 2003
    ..Mechanisms for this high rate of fear of death during anger arousal are discussed with a focus on culture-specific catastrophic cognitions...
  25. ncbi request reprint Is age at symptom onset associated with severity of memory impairment in adults with obsessive-compulsive disorder?
    A Henin
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129 2060, USA
    Am J Psychiatry 158:137-9. 2001
    ..Age at onset is a potentially important marker for neurobiological features of obsessive-compulsive disorder (OCD). This study examined the relationship between age at symptom onset and memory impairment in adults with OCD...
  26. ncbi request reprint Prospective 12-month course of bipolar disorder in out-patients with and without comorbid anxiety disorders
    M W Otto
    Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Br J Psychiatry 189:20-5. 2006
    ..The impact of anxiety disorders has not been well delineated in prospective studies of bipolar disorder...
  27. ncbi request reprint Psychosocial approaches to suicide prevention: applications to patients with bipolar disorder
    S M Gray
    Partners Bipolar Treatment Center, Massachusetts General Hospital, Boston 02114, USA
    J Clin Psychiatry 62:56-64. 2001
    ..On the basis of their review of the literature, the authors make recommendations for suicide prevention for patients with bipolar disorder...
  28. ncbi request reprint Do baseline client characteristics predict the therapeutic alliance in the treatment of schizophrenia?
    Shannon M Couture
    University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27599 3270, USA
    J Nerv Ment Dis 194:10-4. 2006
    ..Low correlations between clients' and therapists' ratings of the alliance should be examined in future research...
  29. ncbi request reprint Augmentation of exposure therapy with D-cycloserine for social anxiety disorder
    Stefan G Hofmann
    Department of Psychology and Center for Anxiety and Related Disorders, Boston University, Boston, MA 02215, USA
    Arch Gen Psychiatry 63:298-304. 2006
    ....
  30. ncbi request reprint Risk for new onset of depression during the menopausal transition: the Harvard study of moods and cycles
    Lee S Cohen
    Perinatal and Reproductive Psychiatry Clinical Research Program and Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, 02114, USA
    Arch Gen Psychiatry 63:385-90. 2006
    ..However, it is unclear whether this period is one of increased risk for major depressive disorder, particularly for women who have not had a previous episode of depression...
  31. ncbi request reprint Quality of life and treatment outcome in panic disorder: cognitive behavior group therapy effects in patients refractory to medication treatment
    Elizeth Heldt
    Program of Anxiety Disorders, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil
    Psychother Psychosom 75:183-6. 2006
    ..The aim of this study is to assess the impact of brief cognitive behavior group therapy (CBGT) for panic disorder on QoL and to identify the clinical features associated with these changes...
  32. ncbi request reprint Validity of the distinction between primary and secondary substance use disorder in patients with bipolar disorder: data from the first 1000 STEP-BD participants
    Mark D Fossey
    Department of Psychiatry, University of Oklahoma College of Medicine Tulsa, Tulsa, Oklahoma 74135, USA
    Am J Addict 15:138-43. 2006
    ..The primary/secondary distinction for SUD is not valid when variations in the age of onset of the non-SUD are linked to course characteristics...
  33. ncbi request reprint A Double-blind, randomized trial of St John's wort, fluoxetine, and placebo in major depressive disorder
    Maurizio Fava
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychopharmacol 25:441-7. 2005
    ..This study looks to compare the antidepressant efficacy and safety of a standardized extract of St John's wort with both placebo and fluoxetine...
  34. ncbi request reprint Rates of isolated sleep paralysis in outpatients with anxiety disorders
    Michael W Otto
    Center for Anxiety and Related Disorders, Boston University, 648 Beacon St, Floor 6, Boston, MA 02114, USA
    J Anxiety Disord 20:687-93. 2006
    ..Results are discussed relative to other variables predicting variability in the occurrence of ISP...
  35. ncbi request reprint One-year follow-up of pharmacotherapy-resistant patients with panic disorder treated with cognitive-behavior therapy: Outcome and predictors of remission
    Elizeth Heldt
    Anxiety Disorders Program, Hospital de Clinicas de Porto Alegre, RS and Post Graduate Program in Medical Sciences Psychiatry, Universidade Federal do Rio Grande do Sul, Brazil
    Behav Res Ther 44:657-65. 2006
    ..Negative predictors of remission status included comorbid dysthymia, social phobia, and generalized anxiety disorder. These results provide additional evidence for the efficacy of CBT for medication non-responders with PD...
  36. ncbi request reprint Does recovery from substance use disorder matter in patients with bipolar disorder?
    Roger D Weiss
    Department of Psychiatry, Harvard Medical School, Boston, USA
    J Clin Psychiatry 66:730-5; quiz 808-9. 2005
    ..To examine the potential impact of recovery from substance use disorder (SUD) on the course of bipolar disorder among patients diagnosed with both bipolar and substance use disorders according to DSM-IV criteria...
  37. ncbi request reprint Clinical and diagnostic implications of lifetime attention-deficit/hyperactivity disorder comorbidity in adults with bipolar disorder: data from the first 1000 STEP-BD participants
    Andrew A Nierenberg
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Depression and Clinical Research Program ACC 812, Boston, Massachusetts 02114, USA
    Biol Psychiatry 57:1467-73. 2005
    ....
  38. pmc Influence of psychiatric comorbidity on recovery and recurrence in generalized anxiety disorder, social phobia, and panic disorder: a 12-year prospective study
    Steven E Bruce
    Department of Psychiatry and Human Behavior, Brown University, RI 02906, USA
    Am J Psychiatry 162:1179-87. 2005
    ....
  39. ncbi request reprint Cognitive-behavioral therapy for ADHD in medication-treated adults with continued symptoms
    Steven A Safren
    Massachusetts General Hospital, MGH Psychiatry, Harvard Medical School, WACC 815, 15 Parkman Street, Boston, MA 02114, USA
    Behav Res Ther 43:831-42. 2005
    ..02). These data support the hypothesis that CBT for adults with ADHD with residual symptoms is a feasible, acceptable, and potentially efficacious next-step treatment approach, worthy of further testing...
  40. ncbi request reprint Panic disorder and bipolar disorder: anxiety sensitivity as a potential mediator of panic during manic states
    Naomi M Simon
    Massachusetts General Hospital, WACC 815, 15 Parkman Street, Boston, Massachusetts 02114, United States
    J Affect Disord 87:101-5. 2005
    ..Anxiety sensitivity (AS), a risk factor for PD appears greater in bipolar disorder compared to unipolar depression, although the association of specific mood states with AS remains unknown...
  41. ncbi request reprint Predictors of recurrence in bipolar disorder: primary outcomes from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
    Roy H Perlis
    Bipolar Clinical and Research Program, Massachusetts General Hospital, ACC 812, 15 Parkman Street, Boston, MA 02114, USA
    Am J Psychiatry 163:217-24. 2006
    ..The authors looked for the features associated with risk of recurrence...
  42. ncbi request reprint Persistent posttraumatic stress disorder following September 11 in patients with bipolar disorder
    Mark H Pollack
    Department of Psychiatry, Massachusetts General Hospital, Boston, Mass, USA
    J Clin Psychiatry 67:394-9. 2006
    ....
  43. ncbi request reprint Cost-efficacy of individual and combined treatments for panic disorder
    R Kathryn McHugh
    Department of Psychology, Center for Anxiety and Related Disorders, Boston University, Boston, MA 02215, USA
    J Clin Psychiatry 68:1038-44. 2007
    ..As psychosocial, pharmacologic, and combined treatments have all demonstrated efficacy in the treatment of panic disorder, cost-efficacy analysis provides an additional source of information to guide clinical decision making...
  44. ncbi request reprint Defense mechanisms after brief cognitive-behavior group therapy for panic disorder: one-year follow-up
    Elizeth Heldt
    Anxiety Disorders Program, Hospital de Clinicas de Porto Alegre, Rio Grande do Sul, Brazil
    J Nerv Ment Dis 195:540-3. 2007
    ..359; p = 0.047). These findings are consistent with the hypothesis that defense styles are malleable in short-term treatment and are, at least partially, symptom-state dependent...
  45. ncbi request reprint Novel treatment approaches for refractory anxiety disorders
    Mark H Pollack
    Harvard Medical School and Center for Anxiety and Traumatic Stress Related Disorders, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Depress Anxiety 25:467-76. 2008
    ..Progress in the development of new treatments has great promise, but will only succeed through a concerted research effort that systematically evaluates potential areas of importance and properly uses scarce resources...
  46. pmc Psychosocial treatments for bipolar depression: a 1-year randomized trial from the Systematic Treatment Enhancement Program
    David J Miklowitz
    Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
    Arch Gen Psychiatry 64:419-26. 2007
    ..Psychosocial interventions have been shown to enhance pharmacotherapy outcomes in bipolar disorder...
  47. ncbi request reprint Effectiveness of adjunctive antidepressant treatment for bipolar depression
    Gary S Sachs
    Bipolar Clinic and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    N Engl J Med 356:1711-22. 2007
    ..Our study was designed to determine whether adjunctive antidepressant therapy reduces symptoms of bipolar depression without increasing the risk of mania...
  48. ncbi request reprint Posttraumatic stress disorder symptoms following media exposure to tragic events: impact of 9/11 on children at risk for anxiety disorders
    Michael W Otto
    Massachusetts General Hospital and Harvard Medical School, MA, United States
    J Anxiety Disord 21:888-902. 2007
    ..Given the links between PTSD symptoms and viewing habits, parental monitoring of media exposure may be important for younger children...
  49. ncbi request reprint Clinical perspectives on the combination of D-cycloserine and cognitive-behavioral therapy for the treatment of anxiety disorders
    Michael W Otto
    Center for Anxiety and Related Disorders, Department of Psychology, Boston University, Boston, MA 02215, USA
    CNS Spectr 12:51-6, 59-61. 2007
    ..This strategy is contrasted with the chronic-dosing applications of DCS for schizophrenia and Alzheimer's disease, and future directions for isolated-dosing strategies are discussed...
  50. ncbi request reprint The relationship of anxiety disorders, anxiety sensitivity and pulmonary dysfunction with dyspnea-related distress and avoidance
    Naomi M Simon
    Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Nerv Ment Dis 194:951-7. 2006
    ....
  51. ncbi request reprint Paroxetine CR augmentation for posttraumatic stress disorder refractory to prolonged exposure therapy
    Naomi M Simon
    Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 69:400-5. 2008
    ..This study prospectively examines the relative efficacy of augmentation of continued prolonged exposure therapy (PE) with paroxetine CR versus placebo for individuals remaining symptomatic despite a course of PE...
  52. ncbi request reprint The association of comorbid anxiety disorders with suicide attempts and suicidal ideation in outpatients with bipolar disorder
    Naomi M Simon
    Department of Psychiatry, Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Suite 2200, Boston, MA 02114, USA
    J Psychiatr Res 41:255-64. 2007
    ....
  53. ncbi request reprint Understanding the link between anxiety symptoms and suicidal ideation and behaviors in outpatients with bipolar disorder
    Naomi M Simon
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston MA 02114, United States
    J Affect Disord 97:91-9. 2007
    ..Prior studies suggest an association between anxiety comorbidity and suicidal ideation and behaviors in bipolar disorder. However, the nature of this association remains unclear...
  54. ncbi request reprint Psychotherapy, symptom outcomes, and role functioning over one year among patients with bipolar disorder
    David J Miklowitz
    Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
    Psychiatr Serv 57:959-65. 2006
    ..A one-year naturalistic-prospective design was used to examine the association between psychotherapy use and the symptomatic and functional outcomes of patients with bipolar disorder...
  55. pmc Intensive psychosocial intervention enhances functioning in patients with bipolar depression: results from a 9-month randomized controlled trial
    David J Miklowitz
    Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
    Am J Psychiatry 164:1340-7. 2007
    ..In a randomized trial, the authors examined the impact of intensive psychosocial treatment plus pharmacotherapy on the functional outcomes of patients with bipolar disorder over the 9 months following a depressive episode...
  56. ncbi request reprint Anxiety disorders among patients with co-occurring bipolar and substance use disorders
    Monika E Kolodziej
    The Alcohol and Drug Abuse Treatment Program, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Drug Alcohol Depend 80:251-7. 2005
    ..Our findings point to the importance of further investigating the ramifications of a trauma history among those who are dually diagnosed with bipolar and substance use disorders...
  57. ncbi request reprint Predictors of outcome following venlafaxine extended-release treatment of DSM-IV generalized anxiety disorder: a pooled analysis of short- and long-term studies
    Mark H Pollack
    Department of Psychiatry, Anxiety Disorders Program, Massachusetts General Hospital, WAC 812, 15 Parkman Street, Boston, MA 02215, USA
    J Clin Psychopharmacol 23:250-9. 2003
    ..The strongest trends emerged for history of substance abuse or dependence and symptoms of restlessness, sleep disturbance, and difficulty concentrating...
  58. ncbi request reprint Rationale, design, and methods of the systematic treatment enhancement program for bipolar disorder (STEP-BD)
    Gary S Sachs
    Partners Bipolar Treatment Center, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Biol Psychiatry 53:1028-42. 2003
    ....
  59. ncbi request reprint Cognitive-behavioral therapy for panic disorder: a review of treatment elements, strategies, and outcomes
    Nadine Recker Rayburn
    Cognitive Behavior Program, Department of Psychology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    CNS Spectr 8:356-62. 2003
    ..We also discuss some of the complex issues involved with combination-treatment strategies...
  60. ncbi request reprint A novel cognitive-behavioral approach for treatment-resistant drug dependence
    Mark H Pollack
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Subst Abuse Treat 23:335-42. 2002
    ..Reasons for differential performance by women and men and future directions for this new treatment are discussed...
  61. ncbi request reprint Treating medication-resistant panic disorder: predictors and outcome of cognitive-behavior therapy in a Brazilian public hospital
    Elizeth Heldt
    Anxiety Disorder Program, Hospital de Clinicas de Porto Alegre, RS, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Psychother Psychosom 72:43-8. 2003
    ..Studies have suggested that individual or group cognitive-behavior therapy (CBT) is an effective treatment strategy for panic patients who have failed to respond to pharmacotherapy...
  62. ncbi request reprint Predictors of psychological well-being in a diverse sample of HIV-positive patients receiving highly active antiretroviral therapy
    Steven A Safren
    Fenway Community Health, Boston, MA, USA
    Psychosomatics 43:478-85. 2002
    ..These results provide support for continued psychosocial interventions that target these variables among patients with HIV...
  63. ncbi request reprint Early improvement predicts endpoint remission status in sertraline and placebo treatments of panic disorder
    Mark H Pollack
    Anxiety Disorders Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, WAC 812, 15 Parkman Street, Boston, MA 02114, USA
    J Psychiatr Res 36:229-36. 2002
    ....
  64. ncbi request reprint History of childhood abuse in panic disorder, social phobia, and generalized anxiety disorder
    Steven A Safren
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, MGH Psychiatry, WACC 815, 15 Parkman Street, Boston, Massachusetts 02114, USA
    J Nerv Ment Dis 190:453-6. 2002
    ..These findings are discussed in terms of biological and behavioral factors that may influence the development of anxiety disorders after the experience of a traumatic event...
  65. ncbi request reprint Prevalence and predictors of premenstrual dysphoric disorder (PMDD) in older premenopausal women. The Harvard Study of Moods and Cycles
    Lee S Cohen
    Harvard Medical School, Boston, MA, USA
    J Affect Disord 70:125-32. 2002
    ..Consistent data on the prevalence and predictors of premenstrual dysphoric disorder (PMDD) in the general population are lacking...
  66. ncbi request reprint Hypothyroidism and hyperthyroidism in anxiety disorders revisited: new data and literature review
    Naomi M Simon
    Anxiety Disorders Program, Massachusetts General Hospital and Harvard Medical School, 15 Parkman Street, WAC 815, Boston, MA 02114, USA
    J Affect Disord 69:209-17. 2002
    ..The need for thyroid screening of patients presenting with panic disorder (PD), social phobia (SP) or generalized anxiety disorder (GAD) remains uncertain...
  67. ncbi request reprint Longitudinal outcome with pharmacotherapy in a naturalistic study of panic disorder
    Naomi M Simon
    Anxiety Disorders Program, Massachusetts General Hospital and Harvard Medical School, 15 Parkman Street, WAC 815, Boston, MA 02114, USA
    J Affect Disord 69:201-8. 2002
    ..It is critically important to obtain more information on the effectiveness of medications over time for patients who initially responded to pharmacotherapy for panic disorder...
  68. ncbi request reprint Effect of abrupt change from standard to low serum levels of lithium: a reanalysis of double-blind lithium maintenance data
    Roy H Perlis
    Department of Psychiatry, Massachusetts General Hospital, 50 Staniford Street, Boston, MA 02114, USA
    Am J Psychiatry 159:1155-9. 2002
    ..To assess the effect of abrupt change in lithium dose, the authors reanalyzed data from a previously reported, randomized, double-blind trial of standard- versus low-dose lithium for maintenance therapy in bipolar disorder...
  69. ncbi request reprint Combined paroxetine and clonazepam treatment strategies compared to paroxetine monotherapy for panic disorder
    Mark H Pollack
    Department of Psychiatry, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    J Psychopharmacol 17:276-82. 2003
    ..Initiating combined treatment followed by benzodiazepine taper after a few weeks may provide early benefit while avoiding the potential adverse consequences of long-term combination therapy...
  70. ncbi request reprint Exploring the psychometric properties and construct validity of the MCMI-III anxiety and avoidant personality scales
    Mark A Blais
    Department of Psychiatry, Blake 11, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    J Pers Assess 81:237-41. 2003
    ..We conclude that the MCMI-III measures of anxiety and avoidance are consistent with other measures of these constructs and may provide valuable clinical information in this regard...
  71. ncbi request reprint Psychosocial treatments for adults with attention-deficit/hyperactivity disorder
    Steven A Safren
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02115, USA
    Psychiatr Clin North Am 27:349-60. 2004
    ..Further research on these strategies in the context of well-controlled trials is an essential step for helping reduce disability and distress among this cohort of patients...
  72. ncbi request reprint Cognitive-behavioral therapy and the treatment of panic disorder: efficacy and strategies
    Michael W Otto
    Massachusetts General Hospital and Harvard Medical School, Boston, Mass, USA
    J Clin Psychiatry 66:28-32. 2005
    ..We review these findings as well as some newer developments in the field including research on emotional acceptance, the importance of context in extinction learning, and the use of CBT in combination with pharmacotherapy...
  73. ncbi request reprint Discussion: using benzodiazepines in clinical practice
    Samantha A Stewart
    J Clin Psychiatry 66:39-43; quiz 44-5. 2005
  74. ncbi request reprint Benzodiazepine use, cognitive impairment, and cognitive-behavioral therapy for anxiety disorders: issues in the treatment of a patient in need
    Michael W Otto
    Department of Psychology and Center for Anxiety and Related Disorders, Boston University, Boston, MA 02215, USA
    J Clin Psychiatry 66:34-8. 2005
    ..This article addresses this concern and asserts that CBT is a valuable treatment option in these cases...
  75. ncbi request reprint A pilot study of functional Cognitive Behavioral Therapy (fCBT) for schizophrenia
    Corinne Cather
    Schizophrenia Program of the Massachusetts General Hospital, Freedom Trail Clinic, 25 Staniford Street, Boston, MA 02114, USA
    Schizophr Res 74:201-9. 2005
    ..This represents the first treatment outcome study of CBT for psychosis with a manualized, active comparison condition...
  76. pmc CBT for Vietnamese refugees with treatment-resistant PTSD and panic attacks: a pilot study
    Devon E Hinton
    Southeast Asian Clinic, Arbour Counseling Services, Lowell, Massachusetts, USA
    J Trauma Stress 17:429-33. 2004
    ..2); and Hopkins Symptom Checklist-25, depression subscale (d = 2.0) scores. Likewise, the severity of (culturally related) headache-and orthostasis-cued panic attacks improved significantly across treatment..
  77. ncbi request reprint Anxiety disorder comorbidity in bipolar disorder patients: data from the first 500 participants in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
    Naomi M Simon
    Center for Anxiety and Traumatic Stress Related Disorders, Wang ACC 815, Massachusetts General Hospital, 15 Parkman St, Boston, MA 02114, USA
    Am J Psychiatry 161:2222-9. 2004
    ..The authors provide a detailed perspective on the correlates of comorbid anxiety in a large, well-characterized sample of bipolar disorder patients...
  78. ncbi request reprint Demographic and diagnostic characteristics of the first 1000 patients enrolled in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
    Jane N Kogan
    Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Bipolar Disord 6:460-9. 2004
    ..The current report provides a context for interpreting studies resulting from STEP-BD by summarizing the baseline demographic and diagnostic characteristics of the first 1000 enrolled...
  79. ncbi request reprint The role and impact of psychotherapy in the management of bipolar disorder
    Michael W Otto
    Department of Psychology, Center for Anxiety and Related Disorders, Boston University, 648 Beacon St, 6th Floor, Boston, MA 02215 2013, USA
    CNS Spectr 9:27-32. 2004
    ..The available evidence suggests that interventions delivered in individual, group, or family settings, can provide significant benefit to patients undergoing pharmacotherapy for bipolar disorder...
  80. ncbi request reprint Hypericum extract in patients with MDD and reversed vegetative signs: re-analysis from data of a double-blind, randomized trial of hypericum extract, fluoxetine, and placebo
    Harald Murck
    Lichtwer Pharma GmbH, Berlin, Germany
    Int J Neuropsychopharmacol 8:215-21. 2005
    ..These data are based on a small sample size and must be considered tentative. A characterization of vegetative features of patients with depression could lead to an overall increased effect size in the treatment with HE...
  81. ncbi request reprint Changes in anxiety sensitivity with pharmacotherapy for panic disorder
    Naomi M Simon
    Anxiety Disorders Program, Massachusetts General Hospital and Harvard Medical School, WACC 812, 15 Parkman Street, Boston, MA 02114, USA
    J Psychiatr Res 38:491-5. 2004
    ..Implications of these findings are discussed relative to optimizing pharmacologic treatment of panic disorder...
  82. ncbi request reprint Pharmacotherapy for bipolar disorder and comorbid conditions: baseline data from STEP-BD
    Naomi M Simon
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychopharmacol 24:512-20. 2004
    ..Our findings highlight the need for greater clinical guidance and treatment options for patients with bipolar disorder and comorbidity...
  83. ncbi request reprint Depression and its influence on reproductive endocrine and menstrual cycle markers associated with perimenopause: the Harvard Study of Moods and Cycles
    Bernard L Harlow
    Obstetrics and Gynecology Epidemiology Center, Brigham and Women s Hospital, 221 Longwood Ave, Boston, MA 02115, USA
    Arch Gen Psychiatry 60:29-36. 2003
    ..Few studies have determined the impact of a lifetime history of major depression on an early transition to menopause...
  84. ncbi request reprint Quality of life in social anxiety disorder compared with panic disorder and the general population
    Naomi M Simon
    Anxiety Disorders Program, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Psychiatr Serv 53:714-8. 2002
    ..Quality of life in a treatment-seeking cohort of patients with social anxiety disorder was compared with that of patients with panic disorder who were matched for age, comorbid illnesses, and gender and with population-based norms...