Research Topics
| M W OttoSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
| Collaborators
|
Detail Information
Publications
Psychoeducational and cognitive-behavioral strategies in the management of bipolar disorderMichael W Otto
Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
J Affect Disord 73:171-81. 2003....- Benzodiazepine discontinuation difficulties in panic disorder: conceptual model and outcome for cognitive-behavior therapyM W Otto
Harvard Medical School and Massachusetts General Hospital, 15 Parkman St, Boston, MA 02114, USA
Curr Pharm Des 8:75-80. 2002..Outcome studies are reviewed, and are placed in the context of other evidence for the efficacy of CBT in patients with this disorder... - Prevalence of body dysmorphic disorder in a community sample of womenM W Otto
Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Psychiatry 158:2061-3. 2001..In a large population-based study, the authors examined the prevalence and correlates of body dysmorphic disorder, a debilitating and chronic condition characterized by an imagined defect in appearance... - Internal cue exposure and the treatment of substance use disorders: lessons from the treatment of panic disorderMichael W Otto
Massachusetts General Hospital and Harvard Medical School, WACC 812, 15 Parkman St, Boston, MA 02114, USA
J Anxiety Disord 18:69-87. 2004.... - Empirically supported treatments for panic disorder: costs, benefits, and stepped careM W Otto
Massachusetts General Hospital, Boston 02114, USA
J Consult Clin Psychol 68:556-63. 2000..Analysis of the "services" data indicated that CBT was at least equal to pharmacotherapy in terms of pretreatment severity and acute treatment outcome and that CBT is an especially cost-effective treatment option... - An effect-size analysis of the relative efficacy and tolerability of serotonin selective reuptake inhibitors for panic disorderM W Otto
Massachusetts General Hospital, Boston, MA 02114, USA
Am J Psychiatry 158:1989-92. 2001..In this study the authors used an effect-size analysis to provide an initial comparison... - Cognitive-behavioral therapy for the treatment of anxiety disordersMichael W Otto
Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
J Clin Psychiatry 65:34-41. 2004..Relative to combination therapy, we review some of the conditions that may influence the longevity of treatment gains from CBT... - Treatment of pharmacotherapy-refractory posttraumatic stress disorder among Cambodian refugees: a pilot study of combination treatment with cognitive-behavior therapy vs sertraline aloneMichael W Otto
Massachusetts General Hospital and Harvard Medical School, WACC 812, 15 Parkman St, Boston, MA 02114, USA
Behav Res Ther 41:1271-6. 2003.... - Prevalence and predictors of depressive symptoms in older premenopausal women: the Harvard Study of Moods and CyclesB L Harlow
Harvard Medical School, Obstetrics and Gynecology Epidemiology Center, Brigham and Women s Hospital, Boston, Mass 02115, USA
Arch Gen Psychiatry 56:418-24. 1999..The Harvard Study of Moods and Cycles is a community-based cohort study designed to evaluate the relationship between major depression and changes in menstrual and ovarian function... - Prevalence of body dysmorphic disorder in patients with anxiety disordersS Wilhelm
OCD Clinic and Research Unit, Massachusetts General Hospital, Charlestown 02129, USA
J Anxiety Disord 11:499-502. 1997..In all cases, onset of social phobia preceded onset of BDD. Our findings draw attention to the prevalence of BDD in patients with social phobia. The potential etiologic significance of our findings is discussed... - Sertraline in the treatment of panic disorder: a flexible-dose multicenter trialM H Pollack
Anxiety Disorders Program, Department of Psychiatry, Massachusetts General Hospital, Boston 02114 3117, USA
Arch Gen Psychiatry 55:1010-6. 1998..We examined the efficacy and safety of the serotonin selective reuptake inhibitor sertraline hydrochloride in patients with panic disorder... - Rate of improvement during cognitive-behavioral group treatment for panic disorderS J Penava
Department of Psychiatry, Massachusetts General Hospital, Boston 02114, USA
Behav Res Ther 36:665-73. 1998..Information on rats of symptom improvement is valuable for providing patients with accurate expectations about potential treatment benefits and for helping to maintain motivation during initial treatment sessions... - Childhood history of anxiety disorders among adults with social phobia: rates, correlates, and comparisons with patients with panic disorderM W Otto
Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Depress Anxiety 14:209-13. 2001.... - Cognitive behavior group therapy for body dysmorphic disorder: a case seriesS Wilhelm
Massachusetts General Hospital, Charlestown, USA
Behav Res Ther 37:71-5. 1999..This finding adds to a nascent literature documenting the potential efficacy of short-term cognitive-behavior therapy for patients suffering from BDD... - Group cognitive-behavior therapy for patients failing to respond to pharmacotherapy for panic disorder: a clinical case seriesM W Otto
Massachusetts General Hospital, Boston, USA
Behav Res Ther 37:763-70. 1999.... - A comparison of the efficacy of clonazepam and cognitive-behavioral group therapy for the treatment of social phobiaM W Otto
Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
J Anxiety Disord 14:345-58. 2000.... - The anxiety sensitivity index: item analysis and suggestions for refinementM A Blais
Inpatient Psychiatry Service, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
J Pers Assess 77:272-94. 2001..The 11-item ASI appears to tap 2 primary aspects of anxiety sensitivity: fears of somatic sensations of anxiety and fears of loss of mental control. Suggestions for further development of the ASI are offered... - How do clinicians respond to patients who miss appointments?J W Smoller
Department of Psychiatry, Massachusetts General Hospital, Boston 02114, USA
J Clin Psychiatry 59:330-8; quiz 339-40. 1998..quot; In an effort to determine how clinicians customarily handle missed appointments, we surveyed mental health clinicians and internists at 2 academic hospitals: a private psychiatric hospital and an urban general hospital... - Nefazodone for social phobia: a clinical case seriesJ J Worthington
Anxiety Disorders Program, Massachusetts General Hospital, Boston, USA
Depress Anxiety 8:131-3. 1998..Results from this case series suggest that nefazodone may be an effective treatment for social phobia and that formal randomized trials are warranted... - Additional findings on the association between anxiety sensitivity and hypochondriacal concerns: examination of patients with major depressionM W Otto
Cognitive Behavior Therapy Program, Massachusetts General Hospital, Boston 02114, USA
J Anxiety Disord 12:225-32. 1998..Findings are discussed in relation to the role of catastrophic interpretations of somatic symptoms in depression, panic disorder, and hypochondriasis... - Two strategies to increase adherence to HIV antiretroviral medication: life-steps and medication monitoringS A Safren
Massachusetts General Hospital and Harvard Medical School, Boston MA 02114, USA
Behav Res Ther 39:1151-62. 2001..Both interventions yielded improvement in adherence from baseline, and the Life-Steps intervention showed faster improvements in adherence for persons with extant adherence problems... - Characteristics of women with premenstrual dysphoric disorder (PMDD) who did or did not report history of depression: a preliminary report from the Harvard Study of Moods and CyclesC N Soares
Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, Boston, MA 02114, USA
J Womens Health Gend Based Med 10:873-8. 2001.... - Cognitive-behavioral therapy for depression. Applications and outcomeT Deckersbach
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Psychiatr Clin North Am 23:795-809, VII. 2000..This article discusses cognitive-behavioral therapy for depression, including evidence for its efficacy and how to choose between this therapy and antidepressants. The use of this therapy to prevent relapse also is presented... - Anger-associated panic attacks in Cambodian refugees with PTSD; a multiple baseline examination of clinical dataD Hinton
Massachusetts General Hospital and Harvard Medical School, Revere, MA, USA
Behav Res Ther 41:647-54. 2003..Mechanisms for this high rate of fear of death during anger arousal are discussed with a focus on culture-specific catastrophic cognitions... - Is age at symptom onset associated with severity of memory impairment in adults with obsessive-compulsive disorder?A Henin
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129 2060, USA
Am J Psychiatry 158:137-9. 2001..Age at onset is a potentially important marker for neurobiological features of obsessive-compulsive disorder (OCD). This study examined the relationship between age at symptom onset and memory impairment in adults with OCD... - Prospective 12-month course of bipolar disorder in out-patients with and without comorbid anxiety disordersM W Otto
Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Br J Psychiatry 189:20-5. 2006..The impact of anxiety disorders has not been well delineated in prospective studies of bipolar disorder... - Psychosocial approaches to suicide prevention: applications to patients with bipolar disorderS M Gray
Partners Bipolar Treatment Center, Massachusetts General Hospital, Boston 02114, USA
J Clin Psychiatry 62:56-64. 2001..On the basis of their review of the literature, the authors make recommendations for suicide prevention for patients with bipolar disorder... - Do baseline client characteristics predict the therapeutic alliance in the treatment of schizophrenia?Shannon M Couture
University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27599 3270, USA
J Nerv Ment Dis 194:10-4. 2006..Low correlations between clients' and therapists' ratings of the alliance should be examined in future research... - Augmentation of exposure therapy with D-cycloserine for social anxiety disorderStefan G Hofmann
Department of Psychology and Center for Anxiety and Related Disorders, Boston University, Boston, MA 02215, USA
Arch Gen Psychiatry 63:298-304. 2006..Controlled effect sizes were in the medium to large range. CONCLUSION: The pilot data provide preliminary support for the use of short-term dosing of d-cycloserine as an adjunctive intervention to exposure therapy for SAD... - Risk for new onset of depression during the menopausal transition: the Harvard study of moods and cyclesLee S Cohen
Perinatal and Reproductive Psychiatry Clinical Research Program and Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, 02114, USA
Arch Gen Psychiatry 63:385-90. 2006..However, it is unclear whether this period is one of increased risk for major depressive disorder, particularly for women who have not had a previous episode of depression... - Quality of life and treatment outcome in panic disorder: cognitive behavior group therapy effects in patients refractory to medication treatmentElizeth Heldt
Program of Anxiety Disorders, , Porto Alegre, Brazil
Psychother Psychosom 75:183-6. 2006..094). CONCLUSIONS: CBGT was efficacious in the treatment of PD; the symptoms of anticipatory anxiety and avoidance appear to be more important than episodic panic episodes in affecting QoL... - Validity of the distinction between primary and secondary substance use disorder in patients with bipolar disorder: data from the first 1000 STEP-BD participantsMark D Fossey
Department of Psychiatry, University of Oklahoma College of Medicine Tulsa, Tulsa, Oklahoma 74135, USA
Am J Addict 15:138-43. 2006..The primary/secondary distinction for SUD is not valid when variations in the age of onset of the non-SUD are linked to course characteristics... - A Double-blind, randomized trial of St John's wort, fluoxetine, and placebo in major depressive disorderMaurizio Fava
Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
J Clin Psychopharmacol 25:441-7. 2005..This study looks to compare the antidepressant efficacy and safety of a standardized extract of St John's wort with both placebo and fluoxetine... - Rates of isolated sleep paralysis in outpatients with anxiety disordersMichael W Otto
Center for Anxiety and Related Disorders, Boston University, 648 Beacon St, Floor 6, Boston, MA 02114, USA
J Anxiety Disord 20:687-93. 2006..Results are discussed relative to other variables predicting variability in the occurrence of ISP... - One-year follow-up of pharmacotherapy-resistant patients with panic disorder treated with cognitive-behavior therapy: Outcome and predictors of remissionElizeth Heldt
Anxiety Disorders Program, , RS and Post-Graduate Program in Medical Sciences: Psychiatry, Universidade Federal do Rio Grande do Sul, Brazil
Behav Res Ther 44:657-65. 2006..Negative predictors of remission status included comorbid dysthymia, social phobia, and generalized anxiety disorder. These results provide additional evidence for the efficacy of CBT for medication non-responders with PD... - Does recovery from substance use disorder matter in patients with bipolar disorder?Roger D Weiss
Department of Psychiatry, Harvard Medical School, Boston, USA
J Clin Psychiatry 66:730-5; quiz 808-9. 2005..To examine the potential impact of recovery from substance use disorder (SUD) on the course of bipolar disorder among patients diagnosed with both bipolar and substance use disorders according to DSM-IV criteria... - Clinical and diagnostic implications of lifetime attention-deficit/hyperactivity disorder comorbidity in adults with bipolar disorder: data from the first 1000 STEP-BD participantsAndrew A Nierenberg
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Depression and Clinical Research Program ACC 812, Boston, Massachusetts 02114, USA
Biol Psychiatry 57:1467-73. 2005.... 
Influence of psychiatric comorbidity on recovery and recurrence in generalized anxiety disorder, social phobia, and panic disorder: a 12-year prospective studySteven E Bruce
Department of Psychiatry and Human Behavior, Brown University, RI 02906, USA
Am J Psychiatry 162:1179-87. 2005....- Cognitive-behavioral therapy for ADHD in medication-treated adults with continued symptomsSteven A Safren
Massachusetts General Hospital, MGH Psychiatry, Harvard Medical School, WACC 815, 15 Parkman Street, Boston, MA 02114, USA
Behav Res Ther 43:831-42. 2005..02). These data support the hypothesis that CBT for adults with ADHD with residual symptoms is a feasible, acceptable, and potentially efficacious next-step treatment approach, worthy of further testing... - Panic disorder and bipolar disorder: anxiety sensitivity as a potential mediator of panic during manic statesNaomi M Simon
Massachusetts General Hospital, WACC 815, 15 Parkman Street, Boston, Massachusetts 02114, United States
J Affect Disord 87:101-5. 2005..Anxiety sensitivity (AS), a risk factor for PD appears greater in bipolar disorder compared to unipolar depression, although the association of specific mood states with AS remains unknown... - Predictors of recurrence in bipolar disorder: primary outcomes from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)Roy H Perlis
Bipolar Clinical and Research Program, Massachusetts General Hospital, ACC 812, 15 Parkman Street, Boston, MA 02114, USA
Am J Psychiatry 163:217-24. 2006..The authors looked for the features associated with risk of recurrence... - Persistent posttraumatic stress disorder following September 11 in patients with bipolar disorderMark H Pollack
Department of Psychiatry, Massachusetts General Hospital, Boston, Mass, USA
J Clin Psychiatry 67:394-9. 2006.... - Cost-efficacy of individual and combined treatments for panic disorderR Kathryn McHugh
Department of Psychology, Center for Anxiety and Related Disorders, Boston University, Boston, MA 02215, USA
J Clin Psychiatry 68:1038-44. 2007..As psychosocial, pharmacologic, and combined treatments have all demonstrated efficacy in the treatment of panic disorder, cost-efficacy analysis provides an additional source of information to guide clinical decision making... - Defense mechanisms after brief cognitive-behavior group therapy for panic disorder: one-year follow-upElizeth Heldt
Anxiety Disorders Program, Hospital de Clinicas de Porto Alegre, Rio Grande do Sul, Brazil
J Nerv Ment Dis 195:540-3. 2007..359; p = 0.047). These findings are consistent with the hypothesis that defense styles are malleable in short-term treatment and are, at least partially, symptom-state dependent... - Novel treatment approaches for refractory anxiety disordersMark H Pollack
Harvard Medical School and Center for Anxiety and Traumatic Stress Related Disorders, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Depress Anxiety 25:467-76. 2008..Progress in the development of new treatments has great promise, but will only succeed through a concerted research effort that systematically evaluates potential areas of importance and properly uses scarce resources... - Psychosocial treatments for bipolar depression: a 1-year randomized trial from the Systematic Treatment Enhancement ProgramDavid J Miklowitz
Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
Arch Gen Psychiatry 64:419-26. 2007..Psychosocial interventions have been shown to enhance pharmacotherapy outcomes in bipolar disorder... - Effectiveness of adjunctive antidepressant treatment for bipolar depressionGary S Sachs
Bipolar Clinic and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
N Engl J Med 356:1711-22. 2007..Our study was designed to determine whether adjunctive antidepressant therapy reduces symptoms of bipolar depression without increasing the risk of mania... - Posttraumatic stress disorder symptoms following media exposure to tragic events: impact of 9/11 on children at risk for anxiety disordersMichael W Otto
Massachusetts General Hospital and Harvard Medical School, MA, United States
J Anxiety Disord 21:888-902. 2007..Given the links between PTSD symptoms and viewing habits, parental monitoring of media exposure may be important for younger children... - Clinical perspectives on the combination of D-cycloserine and cognitive-behavioral therapy for the treatment of anxiety disordersMichael W Otto
Center for Anxiety and Related Disorders, Department of Psychology, Boston University, Boston, MA 02215, USA
CNS Spectr 12:51-6, 59-61. 2007..This strategy is contrasted with the chronic-dosing applications of DCS for schizophrenia and Alzheimer's disease, and future directions for isolated-dosing strategies are discussed... - The relationship of anxiety disorders, anxiety sensitivity and pulmonary dysfunction with dyspnea-related distress and avoidanceNaomi M Simon
Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Nerv Ment Dis 194:951-7. 2006.... - Paroxetine CR augmentation for posttraumatic stress disorder refractory to prolonged exposure therapyNaomi M Simon
Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital, Boston, MA 02114, USA
J Clin Psychiatry 69:400-5. 2008..This study prospectively examines the relative efficacy of augmentation of continued prolonged exposure therapy (PE) with paroxetine CR versus placebo for individuals remaining symptomatic despite a course of PE... - The association of comorbid anxiety disorders with suicide attempts and suicidal ideation in outpatients with bipolar disorderNaomi M Simon
Department of Psychiatry, Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Suite 2200, Boston, MA 02114, USA
J Psychiatr Res 41:255-64. 2007.... - Understanding the link between anxiety symptoms and suicidal ideation and behaviors in outpatients with bipolar disorderNaomi M Simon
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston MA 02114, United States
J Affect Disord 97:91-9. 2007..Prior studies suggest an association between anxiety comorbidity and suicidal ideation and behaviors in bipolar disorder. However, the nature of this association remains unclear... - Psychotherapy, symptom outcomes, and role functioning over one year among patients with bipolar disorderDavid J Miklowitz
Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
Psychiatr Serv 57:959-65. 2006..A one-year naturalistic-prospective design was used to examine the association between psychotherapy use and the symptomatic and functional outcomes of patients with bipolar disorder... - Intensive psychosocial intervention enhances functioning in patients with bipolar depression: results from a 9-month randomized controlled trialDavid J Miklowitz
Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
Am J Psychiatry 164:1340-7. 2007..In a randomized trial, the authors examined the impact of intensive psychosocial treatment plus pharmacotherapy on the functional outcomes of patients with bipolar disorder over the 9 months following a depressive episode... - Anxiety disorders among patients with co-occurring bipolar and substance use disordersMonika E Kolodziej
The Alcohol and Drug Abuse Treatment Program, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Drug Alcohol Depend 80:251-7. 2005..Our findings point to the importance of further investigating the ramifications of a trauma history among those who are dually diagnosed with bipolar and substance use disorders... - Predictors of outcome following venlafaxine extended-release treatment of DSM-IV generalized anxiety disorder: a pooled analysis of short- and long-term studiesMark H Pollack
Department of Psychiatry, Anxiety Disorders Program, Massachusetts General Hospital, WAC 812, 15 Parkman Street, Boston, MA 02215, USA
J Clin Psychopharmacol 23:250-9. 2003..The strongest trends emerged for history of substance abuse or dependence and symptoms of restlessness, sleep disturbance, and difficulty concentrating... - Rationale, design, and methods of the systematic treatment enhancement program for bipolar disorder (STEP-BD)Gary S Sachs
Partners Bipolar Treatment Center, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Biol Psychiatry 53:1028-42. 2003.... - Cognitive-behavioral therapy for panic disorder: a review of treatment elements, strategies, and outcomesNadine Recker Rayburn
Cognitive-Behavior Program, Department of Psychology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
CNS Spectr 8:356-62. 2003..We also discuss some of the complex issues involved with combination-treatment strategies... - A novel cognitive-behavioral approach for treatment-resistant drug dependenceMark H Pollack
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
J Subst Abuse Treat 23:335-42. 2002..Reasons for differential performance by women and men and future directions for this new treatment are discussed... - Treating medication-resistant panic disorder: predictors and outcome of cognitive-behavior therapy in a Brazilian public hospitalElizeth Heldt
Anxiety Disorder Program, , RS, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
Psychother Psychosom 72:43-8. 2003..Among these patients, depression as well as neurotic defense style was associated with a poorer outcome. The use of CBT in Brazil for treatment-resistant and other panic patients is encouraged... - Predictors of psychological well-being in a diverse sample of HIV-positive patients receiving highly active antiretroviral therapySteven A Safren
Fenway Community Health, Boston, MA, USA
Psychosomatics 43:478-85. 2002..These results provide support for continued psychosocial interventions that target these variables among patients with HIV... - Early improvement predicts endpoint remission status in sertraline and placebo treatments of panic disorderMark H Pollack
Anxiety Disorders Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, WAC 812, 15 Parkman Street, Boston, MA 02114, USA
J Psychiatr Res 36:229-36. 2002.... - History of childhood abuse in panic disorder, social phobia, and generalized anxiety disorderSteven A Safren
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, MGH Psychiatry, WACC 815, 15 Parkman Street, Boston, Massachusetts 02114, USA
J Nerv Ment Dis 190:453-6. 2002..These findings are discussed in terms of biological and behavioral factors that may influence the development of anxiety disorders after the experience of a traumatic event... - Prevalence and predictors of premenstrual dysphoric disorder (PMDD) in older premenopausal women. The Harvard Study of Moods and CyclesLee S Cohen
Harvard Medical School, Boston, MA, USA
J Affect Disord 70:125-32. 2002..Consistent data on the prevalence and predictors of premenstrual dysphoric disorder (PMDD) in the general population are lacking... - Hypothyroidism and hyperthyroidism in anxiety disorders revisited: new data and literature reviewNaomi M Simon
Anxiety Disorders Program, Massachusetts General Hospital and Harvard Medical School, 15 Parkman Street, WAC 815, Boston, MA 02114, USA
J Affect Disord 69:209-17. 2002..The need for thyroid screening of patients presenting with panic disorder (PD), social phobia (SP) or generalized anxiety disorder (GAD) remains uncertain... - Longitudinal outcome with pharmacotherapy in a naturalistic study of panic disorderNaomi M Simon
Anxiety Disorders Program, Massachusetts General Hospital and Harvard Medical School, 15 Parkman Street, WAC 815, Boston, MA 02114, USA
J Affect Disord 69:201-8. 2002..It is critically important to obtain more information on the effectiveness of medications over time for patients who initially responded to pharmacotherapy for panic disorder... - Effect of abrupt change from standard to low serum levels of lithium: a reanalysis of double-blind lithium maintenance dataRoy H Perlis
Department of Psychiatry, Massachusetts General Hospital, 50 Staniford Street, Boston, MA 02114, USA
Am J Psychiatry 159:1155-9. 2002..To assess the effect of abrupt change in lithium dose, the authors reanalyzed data from a previously reported, randomized, double-blind trial of standard- versus low-dose lithium for maintenance therapy in bipolar disorder... - Combined paroxetine and clonazepam treatment strategies compared to paroxetine monotherapy for panic disorderMark H Pollack
Department of Psychiatry, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
J Psychopharmacol 17:276-82. 2003..Initiating combined treatment followed by benzodiazepine taper after a few weeks may provide early benefit while avoiding the potential adverse consequences of long-term combination therapy... - Exploring the psychometric properties and construct validity of the MCMI-III anxiety and avoidant personality scalesMark A Blais
Department of Psychiatry, Blake 11, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
J Pers Assess 81:237-41. 2003..We conclude that the MCMI-III measures of anxiety and avoidance are consistent with other measures of these constructs and may provide valuable clinical information in this regard... - Psychosocial treatments for adults with attention-deficit/hyperactivity disorderSteven A Safren
Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02115, USA
Psychiatr Clin North Am 27:349-60. 2004..Further research on these strategies in the context of well-controlled trials is an essential step for helping reduce disability and distress among this cohort of patients... - Cognitive-behavioral therapy and the treatment of panic disorder: efficacy and strategiesMichael W Otto
Massachusetts General Hospital and Harvard Medical School, Boston, Mass, USA
J Clin Psychiatry 66:28-32. 2005..We review these findings as well as some newer developments in the field including research on emotional acceptance, the importance of context in extinction learning, and the use of CBT in combination with pharmacotherapy... - Discussion: using benzodiazepines in clinical practiceSamantha A Stewart
J Clin Psychiatry 66:39-43; quiz 44-5. 2005 - Benzodiazepine use, cognitive impairment, and cognitive-behavioral therapy for anxiety disorders: issues in the treatment of a patient in needMichael W Otto
Department of Psychology and Center for Anxiety and Related Disorders, Boston University, Boston, MA 02215, USA
J Clin Psychiatry 66:34-8. 2005..This article addresses this concern and asserts that CBT is a valuable treatment option in these cases... - A pilot study of functional Cognitive Behavioral Therapy (fCBT) for schizophreniaCorinne Cather
Schizophrenia Program of the Massachusetts General Hospital, Freedom Trail Clinic, 25 Staniford Street, Boston, MA 02114, USA
Schizophr Res 74:201-9. 2005..This represents the first treatment outcome study of CBT for psychosis with a manualized, active comparison condition... - CBT for Vietnamese refugees with treatment-resistant PTSD and panic attacks: a pilot studyDevon E Hinton
Southeast Asian Clinic, Arbour Counseling Services, Lowell, Massachusetts, USA
J Trauma Stress 17:429-33. 2004..2); and Hopkins Symptom Checklist-25, depression subscale (d = 2.0) scores. Likewise, the severity of (culturally related) headache-and orthostasis-cued panic attacks improved significantly across treatment.. - Anxiety disorder comorbidity in bipolar disorder patients: data from the first 500 participants in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)Naomi M Simon
Center for Anxiety and Traumatic Stress Related Disorders, Wang ACC 815, Massachusetts General Hospital, 15 Parkman St, Boston, MA 02114, USA
Am J Psychiatry 161:2222-9. 2004..The authors provide a detailed perspective on the correlates of comorbid anxiety in a large, well-characterized sample of bipolar disorder patients... - Demographic and diagnostic characteristics of the first 1000 patients enrolled in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)Jane N Kogan
Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Bipolar Disord 6:460-9. 2004..The current report provides a context for interpreting studies resulting from STEP-BD by summarizing the baseline demographic and diagnostic characteristics of the first 1000 enrolled... - The role and impact of psychotherapy in the management of bipolar disorderMichael W Otto
Department of Psychology, Center for Anxiety and Related Disorders, Boston University, 648 Beacon St, 6th Floor, Boston, MA 02215-2013, USA
CNS Spectr 9:27-32. 2004..The available evidence suggests that interventions delivered in individual, group, or family settings, can provide significant benefit to patients undergoing pharmacotherapy for bipolar disorder... - Hypericum extract in patients with MDD and reversed vegetative signs: re-analysis from data of a double-blind, randomized trial of hypericum extract, fluoxetine, and placeboHarald Murck
Lichtwer Pharma GmbH, Berlin, Germany
Int J Neuropsychopharmacol 8:215-21. 2005..These data are based on a small sample size and must be considered tentative. A characterization of vegetative features of patients with depression could lead to an overall increased effect size in the treatment with HE... - Changes in anxiety sensitivity with pharmacotherapy for panic disorderNaomi M Simon
Anxiety Disorders Program, Massachusetts General Hospital and Harvard Medical School, WACC 812, 15 Parkman Street, Boston, MA 02114, USA
J Psychiatr Res 38:491-5. 2004..Implications of these findings are discussed relative to optimizing pharmacologic treatment of panic disorder... - Pharmacotherapy for bipolar disorder and comorbid conditions: baseline data from STEP-BDNaomi M Simon
Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
J Clin Psychopharmacol 24:512-20. 2004..Our findings highlight the need for greater clinical guidance and treatment options for patients with bipolar disorder and comorbidity... - Depression and its influence on reproductive endocrine and menstrual cycle markers associated with perimenopause: the Harvard Study of Moods and CyclesBernard L Harlow
Obstetrics and Gynecology Epidemiology Center, Brigham and Women s Hospital, 221 Longwood Ave, Boston, MA 02115, USA
Arch Gen Psychiatry 60:29-36. 2003..Few studies have determined the impact of a lifetime history of major depression on an early transition to menopause... - Quality of life in social anxiety disorder compared with panic disorder and the general populationNaomi M Simon
Anxiety Disorders Program, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
Psychiatr Serv 53:714-8. 2002..Quality of life in a treatment-seeking cohort of patients with social anxiety disorder was compared with that of patients with panic disorder who were matched for age, comorbid illnesses, and gender and with population-based norms...