Ebru Oral

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. doi request reprint Increasing irradiation temperature maximizes vitamin E grafting and wear resistance of ultrahigh molecular weight polyethylene
    Ebru Oral
    Harris Orthopaedic Laboratory, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Biomed Mater Res B Appl Biomater 101:436-40. 2013
  2. doi request reprint Surface cross-linked UHMWPE can enable the use of larger femoral heads in total joints
    Ebru Oral
    Harris Orthopaedic Laboratory, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Orthop Res 31:59-66. 2013
  3. doi request reprint A surface crosslinked UHMWPE stabilized by vitamin E with low wear and high fatigue strength
    Ebru Oral
    Massachusetts General Hospital, Department of Orthopaedic Surgery, Harris Orthopaedic Biomechanics and Biomaterials Laboratory, 55 Fruit Street, Boston, MA 02114, USA
    Biomaterials 31:7051-60. 2010
  4. pmc Vitamin E diffused, highly crosslinked UHMWPE: a review
    Ebru Oral
    Harris Orthopaedic Laboratory, Massachusetts General Hospital, 55 Fruit St GRJ 1206, Boston, MA 02114, USA
    Int Orthop 35:215-23. 2011
  5. pmc Effect of cross-link density on the high pressure crystallization of UHMWPE
    Ebru Oral
    Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Biomed Mater Res B Appl Biomater 90:720-9. 2009
  6. pmc Wear resistance and mechanical properties of highly cross-linked, ultrahigh-molecular weight polyethylene doped with vitamin E
    Ebru Oral
    Department of Orthopaedic Surgery, Orthopaedic Biomechanics and Biomaterials Laboratory, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Arthroplasty 21:580-91. 2006
  7. pmc Improved resistance to wear and fatigue fracture in high pressure crystallized vitamin E-containing ultra-high molecular weight polyethylene
    Ebru Oral
    Massachusetts General Hospital, Department of Orthopaedic Surgery, Boston, MA 02114, USA
    Biomaterials 30:1870-80. 2009
  8. pmc Diffusion of vitamin E in ultra-high molecular weight polyethylene
    Ebru Oral
    Department of Orthopaedic Surgery, Massachusetts General Hospital, 55 Fruit Street, GRJ 1206, Boston, MA 02114, USA
    Biomaterials 28:5225-37. 2007
  9. pmc Highly cross-linked ultrahigh molecular weight polyethylene with improved fatigue resistance for total joint arthroplasty: recipient of the 2006 Hap Paul Award
    Ebru Oral
    Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Arthroplasty 23:1037-44. 2008
  10. pmc The effects of high dose irradiation on the cross-linking of vitamin E-blended ultrahigh molecular weight polyethylene
    Ebru Oral
    Massachusetts General Hospital, Department of Orthopaedic Surgery, USA
    Biomaterials 29:3557-60. 2008

Collaborators

Detail Information

Publications23

  1. doi request reprint Increasing irradiation temperature maximizes vitamin E grafting and wear resistance of ultrahigh molecular weight polyethylene
    Ebru Oral
    Harris Orthopaedic Laboratory, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Biomed Mater Res B Appl Biomater 101:436-40. 2013
    ....
  2. doi request reprint Surface cross-linked UHMWPE can enable the use of larger femoral heads in total joints
    Ebru Oral
    Harris Orthopaedic Laboratory, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Orthop Res 31:59-66. 2013
    ..We believe that these materials can enable thinner implant forms and more anatomical designs in joint arthroplasty and may provide a feasible alternative to metal-on-metal implants...
  3. doi request reprint A surface crosslinked UHMWPE stabilized by vitamin E with low wear and high fatigue strength
    Ebru Oral
    Massachusetts General Hospital, Department of Orthopaedic Surgery, Harris Orthopaedic Biomechanics and Biomaterials Laboratory, 55 Fruit Street, Boston, MA 02114, USA
    Biomaterials 31:7051-60. 2010
    ..Such an implant has the potential of decreasing risk of fatigue fracture of total joint implants as well as expanding the use of UHMWPE to younger and more active patients...
  4. pmc Vitamin E diffused, highly crosslinked UHMWPE: a review
    Ebru Oral
    Harris Orthopaedic Laboratory, Massachusetts General Hospital, 55 Fruit St GRJ 1206, Boston, MA 02114, USA
    Int Orthop 35:215-23. 2011
    ..The clinical outcome of this material will be apparent from the results of prospective, randomised clinical studies...
  5. pmc Effect of cross-link density on the high pressure crystallization of UHMWPE
    Ebru Oral
    Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Biomed Mater Res B Appl Biomater 90:720-9. 2009
    ..Therefore, HPC can be used effectively for imparting oxidative stability while strength improvement can be achieved for irradiated UHMWPE with low to moderate cross-link density...
  6. pmc Wear resistance and mechanical properties of highly cross-linked, ultrahigh-molecular weight polyethylene doped with vitamin E
    Ebru Oral
    Department of Orthopaedic Surgery, Orthopaedic Biomechanics and Biomaterials Laboratory, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Arthroplasty 21:580-91. 2006
    ..The data indicate good in vitro wear properties and improved mechanical and fatigue properties for vitamin E-stabilized, cross-linked UHMWPE...
  7. pmc Improved resistance to wear and fatigue fracture in high pressure crystallized vitamin E-containing ultra-high molecular weight polyethylene
    Ebru Oral
    Massachusetts General Hospital, Department of Orthopaedic Surgery, Boston, MA 02114, USA
    Biomaterials 30:1870-80. 2009
    ..This suggested different mechanisms of wear reduction and fatigue crack propagation resistance in UHMWPE...
  8. pmc Diffusion of vitamin E in ultra-high molecular weight polyethylene
    Ebru Oral
    Department of Orthopaedic Surgery, Massachusetts General Hospital, 55 Fruit Street, GRJ 1206, Boston, MA 02114, USA
    Biomaterials 28:5225-37. 2007
    ..We developed an analytical model based on Fickian theory that closely predicted vitamin E concentration as a function of depth following doping and homogenization...
  9. pmc Highly cross-linked ultrahigh molecular weight polyethylene with improved fatigue resistance for total joint arthroplasty: recipient of the 2006 Hap Paul Award
    Ebru Oral
    Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Arthroplasty 23:1037-44. 2008
    ..The use of this material may be beneficial in total knee arthroplasty where its improved fatigue properties may be an advantage under high stresses...
  10. pmc The effects of high dose irradiation on the cross-linking of vitamin E-blended ultrahigh molecular weight polyethylene
    Ebru Oral
    Massachusetts General Hospital, Department of Orthopaedic Surgery, USA
    Biomaterials 29:3557-60. 2008
    ..The long-term oxidative stability of irradiated blends with low vitamin E concentrations has yet to be studied to determine an optimum between cross-link density and long-term oxidative stability...
  11. pmc Characterization of irradiated blends of alpha-tocopherol and UHMWPE
    Ebru Oral
    Department of Orthopaedic Surgery, Massachusetts General Hospital, 55 Fruit Street, GRJ 1206, Boston, MA 02114, USA
    Biomaterials 26:6657-63. 2005
    ..These results showed that alpha-tocopherol-blended 100-kGy irradiated UHMWPEs were not cross-linked to the same extent as the 100-kGy irradiated, virgin UHMWPE...
  12. pmc Migration stability of alpha-tocopherol in irradiated UHMWPE
    Ebru Oral
    Orthopaedic Biomechanics and Biomaterials Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital, 55 Fruit Street, GRJ 1206, Boston, MA 02114, USA
    Biomaterials 27:2434-9. 2006
    ..There was no change in the oxidative stability following 5 MC of hip simulator testing, indicating minimal elution during simulated normal gait...
  13. pmc The elimination of free radicals in irradiated UHMWPEs with and without vitamin E stabilization by annealing under pressure
    Ebru Oral
    Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Biomed Mater Res B Appl Biomater 97:167-74. 2011
    ....
  14. doi request reprint In vivo biological response to vitamin E and vitamin-E-doped polyethylene
    Bryan T Jarrett
    Harris Orthopaedic Biomechanics and Biomaterials Laboratory, Massachusetts General Hospital, 1125 Gray Jackson, 55 Fruit Street, Boston, MA 02115, USA
    J Bone Joint Surg Am 92:2672-81. 2010
    ..This study was done to determine the local tissue effects of free vitamin E and vitamin E eluted from ultra-high molecular weight polyethylene implants in the joint space...
  15. pmc The effect of alpha-tocopherol on the oxidation and free radical decay in irradiated UHMWPE
    Ebru Oral
    Harris Orthopaedic Biomechanics and Biomaterials Laboratory, Massachusetts General Hospital, 55 Fruit Street, GRJ 1206, Boston, MA 02114, USA
    Biomaterials 27:5580-7. 2006
    ..In summary, the real-time oxidation behavior of alpha-TPE was consistent with that observed using accelerated aging methods. This new UHMWPE is oxidation resistant and is expected to maintain its properties in the long term...
  16. doi request reprint Porous poly(vinyl alcohol)-hydrogel matrix-engineered biosynthetic cartilage
    David A Bichara
    Plastic Surgery Research Laboratory, Division of Plastic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Tissue Eng Part A 17:301-9. 2011
    ....
  17. doi request reprint A new mechanism of oxidation in ultrahigh molecular weight polyethylene caused by squalene absorption
    Ebru Oral
    Massachusetts General Hospital, Harris Orthopaedic Laboratory, Boston, Massachusetts 02114, USA
    J Biomed Mater Res B Appl Biomater 100:742-51. 2012
    ..This result represents a paradigm shift in our understanding of oxidative stability of UHMWPE and prompts further investigation of in vivo oxidation mechanisms as well as the development of relevant in vitro aging models...
  18. doi request reprint Comparative oxidative stability of α-tocopherol blended and diffused UHMWPEs at 3 years of real-time aging
    Shannon L Rowell
    Harris Orthopaedic Laboratory, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Orthop Res 29:773-80. 2011
    ..We also showed that current thermal accelerated aging methods were unable to differentiate among the oxidative stability of vitamin E-stabilized, radiation cross-linked UHMWPEs prepared by different processes...
  19. ncbi request reprint How have wear testing and joint simulator studies helped to discriminate among materials and designs?
    Harry A McKellop
    Department of Orthopaedic Surgery, UCLA Orthopaedic Hospital, Los Angeles, CA, USA
    J Am Acad Orthop Surg 16:S111-9. 2008
    ....
  20. pmc Mechanisms of decrease in fatigue crack propagation resistance in irradiated and melted UHMWPE
    Ebru Oral
    Department of Orthopaedic Surgery, Massachusetts General Hospital, 55 Fruit Street, GRJ 1206, Boston, MA 02114, USA
    Biomaterials 27:917-25. 2006
    ..Morphology of fracture surfaces revealed loss of ductility with increase in radiation dose and more detrimental effects on ductility at lower radiation doses after post-irradiation melting...
  21. doi request reprint The effect of an additional phosphite stabilizer on the properties of radiation cross-linked vitamin E blends of UHMWPE
    Ebru Oral
    Harris Orthopaedic Laboratory, Massachusetts General Hospital, Boston, Massachusetts Department of Orthopaedic Surgery, Harvard Medical School, Boston, Massachusetts
    J Orthop Res 32:757-61. 2014
    ..To our knowledge, this was the first attempt at using multiple stabilizers in medical grade UHMWPE. © 2014 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 32:757-761, 2014. ..
  22. ncbi request reprint The effect of polyethylene glycol on the stability of pores in polyvinyl alcohol hydrogels during annealing
    Hatice Bodugoz-Senturk
    Harris Orthopaedic Biomechanics and Biomaterials Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital, 55 Fruit Street, GRJ 1206, Boston, MA 02114, USA
    Biomaterials 29:141-9. 2008
    ..4%) when compared to the PEG-free hydrogels (17 +/- 3.7) under an initial contact stress of 0.45 MPa. EWC appeared to be strongly related to the creep resistance of annealed PVA theta-gels...
  23. ncbi request reprint Alpha-tocopherol-doped irradiated UHMWPE for high fatigue resistance and low wear
    Ebru Oral
    Orthopaedic Biomechanics and Biomaterials Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital, 55 Fruit Street, GRJ 1206, Boston, MA 02114, USA
    Biomaterials 25:5515-22. 2004
    ..The improved fatigue strength is attributed to the increase in plasticity of UHMWPE due to the lipophilic nature of alpha-T...