Research Topics
Genomes and GenesSpecies | Dost OngurSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Publications
Clinical characteristics influencing age at onset in psychotic disordersDost Ongur
McLean Hospital, Harvard Medical School, Boston, MA 02478, USA
Compr Psychiatry 50:13-9. 2009..Age at onset of psychosis may carry clinical significance across psychotic disorders and appears to be associated with specific genetic abnormalities...
Abnormal glutamatergic neurotransmission and neuronal-glial interactions in acute maniaDost Ongur
McLean Hospital, Belmont, Massachusetts 02478, USA
Biol Psychiatry 64:718-26. 2008..We examined the glutamine/glutamate ratio and levels of other metabolites in acute mania and schizophrenia in this exploratory study...- Creatine abnormalities in schizophrenia and bipolar disorderDost Ongur
McLean Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA, United States
Psychiatry Res 172:44-8. 2009..They also add to the literature on bioenergetic abnormalities in schizophrenia... - Default mode network abnormalities in bipolar disorder and schizophreniaDost Ongur
McLean Hospital, Belmont, MA and Harvard Medical School, Boston, MA, United States
Psychiatry Res 183:59-68. 2010..Further studies are needed to determine how these abnormalities are related to specific symptoms of each condition... - T2 relaxation time abnormalities in bipolar disorder and schizophreniaDost Ongur
McLean Hospital, Belmont, Massachusetts 02478, USA
Magn Reson Med 63:1-8. 2010.... - Elevated gamma-aminobutyric acid levels in chronic schizophreniaDost Ongur
McLean Hospital, Belmont, Massachusetts 02478, USA
Biol Psychiatry 68:667-70. 2010..We used proton magnetic resonance spectroscopy to measure tissue GABA levels in participants with schizophrenia and healthy control subjects in the anterior cingulate cortex and parieto-occipital cortex... 
Electroconvulsive seizures stimulate glial proliferation and reduce expression of Sprouty2 within the prefrontal cortex of ratsDost Ongur
Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, Massachusetts 02478, USA
Biol Psychiatry 62:505-12. 2007..In parallel, we examined if ECS also alters the expression of Sprouty2 (SPRY2), an inhibitor of cell proliferation...- The neural basis of relational memory deficits in schizophreniaDost Ongur
Schizophrenia and Bipolar Disorder Program, McLean Hospital and Harvard Medical School, Brain Imaging Center, Belmont, MA 02478, USA
Arch Gen Psychiatry 63:356-65. 2006..Memory deficits are common in schizophrenia. Recent studies have demonstrated that relational memory is particularly impaired... - Hippocampal activation during processing of previously seen visual stimulus pairsDost Ongur
Schizophrenia and Bipolar Disorder Program, McLean Hospital, 115 Mill St, AB 347, Belmont, MA, USA
Psychiatry Res 139:191-8. 2005..Right hippocampal activation during discrimination of previously seen pairs of objects was correlated with activity in the anteromedial thalamus, cingulate cortex, and contralateral hippocampus... - Obsessive-compulsive symptoms in schizophrenia: associated clinical features, cognitive function and medication statusDost Ongur
Schizophrenia Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Schizophr Res 75:349-62. 2005..To determine the prevalence and clinical significance of obsessive-compulsive (OC) symptoms among a group of stable outpatients with schizophrenia... - A role for glia in the action of electroconvulsive therapyDost Ongur
Schizophrenia and Bipolar Disorder Unit, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
Harv Rev Psychiatry 12:253-62. 2004..We suggest that the effectiveness of ECT is, in part, related to its effect on glial cells. This testable hypothesis may advance our understanding and treatment of psychiatric disorders... - Blockade of astrocytic glutamate uptake in the prefrontal cortex induces anhedoniaCatherine S John
Department of Psychiatry, Harvard Medical School McLean Hospital, Belmont, MA, USA
Neuropsychopharmacology 37:2467-75. 2012..Overall, these results suggest that blockade of astrocytic glutamate uptake in the PFC is sufficient to produce anhedonia, a core symptom of depression... - Distinct facial processing in schizophrenia and schizoaffective disordersYue Chen
McLean Hospital, United States
Schizophr Res 134:95-100. 2012..This pattern of results suggests distinct processing of face information in schizophrenia and schizoaffective disorders... - Visual and cognitive processing of face information in schizophrenia: detection, discrimination and working memoryYue Chen
McLean Hospital, Department of Psychiatry, Harvard Medical School, USA
Schizophr Res 107:92-8. 2009..This pattern of results indicates that greater signal strength is required for visual and cognitive processing of facial information in schizophrenia... - Rapid enhancement of glutamatergic neurotransmission in bipolar depression following treatment with riluzoleBrian P Brennan
Biological Psychiatry Laboratory, McLean Hospital, Belmont, MA 02478, USA
Neuropsychopharmacology 35:834-46. 2010..Further investigation of the Gln/Glu ratio as a possible early biomarker of response to glutamate-modulating therapies is warranted... - Auditory hallucinations in a cross-diagnostic sample of psychotic disorder patients: a descriptive, cross-sectional studyAnn K Shinn
Schizophrenia and Bipolar Disorder Program, McLean Hospital and Harvard Medical School, Department of Psychiatry, USA
Compr Psychiatry 53:718-26. 2012..Auditory hallucinations (AH) are a cardinal feature of schizophrenia spectrum disorders. They are not disease specific, however, and can occur in other conditions, including affective psychoses... - Water and metabolite transverse T2 relaxation time abnormalities in the white matter in schizophreniaFei Du
McLean Hospital, Belmont, MA 02478, USA
Schizophr Res 137:241-5. 2012..980, p=0.039). Prolongation of water T2 and shortening of NAA T2 is consistent with an impoverishment of white matter macromolecule structures (including myelin) and abnormal intra-axonal milieu and volume in SZ... - Relationship of neurocognitive deficits to diagnosis and symptoms across affective and non-affective psychosesKathryn E Lewandowski
Schizophrenia and Bipolar Disorder Program, McLean Hospital, 115 Mill St, Belmont, MA, 02478 USA
Schizophr Res 133:212-7. 2011..Additionally, we predicted that negative symptoms but not positive, general, or mood symptoms, would be associated with neurocognitive functioning... - Association of impaired facial affect recognition with basic facial and visual processing deficits in schizophreniaDaniel Norton
McLean Hospital, Belmont, Massachusetts, USA
Biol Psychiatry 65:1094-8. 2009..We examined whether and how poor facial emotion recognition in schizophrenia is related to basic visual processing and nonaffective face recognition... - Relationship between genetic variation in the glutaminase gene GLS1 and brain glutamine/glutamate ratio measured in vivoDost Ongur
McLean Hospital, Belmont, Massachusetts 02478, USA
Biol Psychiatry 70:169-74. 2011..Accumulating evidence suggests that the Gln/Glu ratio is a putative index of glutamatergic neurotransmission but interpretation of changes in the Gln/Glu ratio depends on the conditions of the system, including ammonia levels... - Categorical vs dimensional classifications of psychotic disordersMelissa Potuzak
Psychotic Disorders Division, McLean Hospital, 1125 Mill St, Belmont, MA 02478, USA
Compr Psychiatry 53:1118-29. 2012..This review examines the evidence on specific dimensions and categories that would best characterize psychoses... - Altered 'three-flash' illusion in response to two light pulses in schizophreniaDan Norton
McLean Hospital, United States
Schizophr Res 103:275-82. 2008..We examined the perceived interaction of two elementary visual events in schizophrenia patients, using a psychophysical approach... - Oral glycine administration increases brain glycine/creatine ratios in men: a proton magnetic resonance spectroscopy studyMarc J Kaufman
Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, United States
Psychiatry Res 173:143-9. 2009.... - Brain metabolite concentrations across cortical regions in healthy adultsBethany K Bracken
Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
Brain Res 1369:89-94. 2011..MRS may be a useful tool for studying physical properties of the living human brain... - Gray matter volume in schizophrenia and bipolar disorder with psychotic featuresCagri Yüksel
Psychotic Disorders Division, McLean Hospital, Belmont, MA, USA
Schizophr Res 138:177-82. 2012..We conclude that GM abnormality as measured by VBM analysis is less pronounced in psychotic BD compared to SZ. This may be due to disease-specific factors or medications used more commonly in BD... - Perceptual training strongly improves visual motion perception in schizophreniaDaniel J Norton
McLean Hospital, Massachusetts, United States
Brain Cogn 77:248-56. 2011..The large perceptual training effect in patients on the trained task suggests that perceptual plasticity is robust in schizophrenia and can be applied to develop bottom-up behavioral interventions... - Quantification of J-resolved proton spectra in two-dimensions with LCModel using GAMMA-simulated basis sets at 4 TeslaJ Eric Jensen
McLean Hospital, Belmont, MA 02478, USA
NMR Biomed 22:762-9. 2009..These novel methods have clear implications for clinical and research studies seeking to understand neurochemical dysfunction... - Personality disorders and the trimensional personality questionnaire factors in major depressive disorderAmy Farabaugh
Depression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
J Nerv Ment Dis 193:747-50. 2005..Certain temperament traits, especially HA and NS, appear to be associated with specific patterns of personality clusters among depressed patients... - Blockade of astrocytic glutamate uptake in rats induces signs of anhedonia and impaired spatial memoryAnita J Bechtholt-Gompf
Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
Neuropsychopharmacology 35:2049-59. 2010..These finding may have implications for the etiology of depression and other disorders that share the features of anhedonia and cognitive impairment... - Inefficient face detection in schizophreniaYue Chen
Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
Schizophr Bull 34:367-74. 2008..Higher levels of facial processing, such as recognition of the individuality and emotional expression of faces, are abnormal in schizophrenia. It is unknown, however, whether the visual detection of a face as face is impaired as well... - Safety and proof of principle study of cerebellar vermal theta burst stimulation in refractory schizophreniaAsli Demirtas-Tatlidede
Harvard Medical School, Boston, MA, United States
Schizophr Res 124:91-100. 2010..This proof of principle study aimed to test this hypothesis using noninvasive brain stimulation, and to explore the safety of this protocol in schizophrenia... - Altered center-surround motion inhibition in schizophreniaYue Chen
McLean Hospital, Department of Psychiatry, Harvard Medical School, Belmont, Massachusetts, USA
Biol Psychiatry 64:74-7. 2008..Center-surround interaction is a ubiquitous neural mechanism underlying the organization of visual information over different spatial locations... - Tactile, olfactory, and gustatory hallucinations in psychotic disorders: a descriptive studyKathryn E Lewandowski
McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
Ann Acad Med Singapore 38:383-5. 2009..The present study examined hallucinations across sensory modalities in patients with primary psychotic disorders by diagnosis and in association with mood and psychotic symptoms... - Anxiety disorder comorbidity in bipolar disorder, schizophrenia and schizoaffective disorderSarah Young
McLean Hospital, Belmont, Mass, USA
Psychopathology 46:176-85. 2013..Clinicians treating patients with SZA should evaluate for anxiety disorder comorbidity, especially as anxiety symptoms may not be reported at first presentation... - Catatonia in psychotic patients: clinical features and treatment responseMary L England
From Harvard Medical School, Schizophrenia and Bipolar Disorder Program, McLean Hospital, 115 Mill St, Belmont, MA 02478
J Neuropsychiatry Clin Neurosci 23:223-6. 2011..Electroconvulsive therapy, benzodiazepines, and clozapine had beneficial effects on catatonic features, whereas typical antipsychotics resulted in clinical worsening... - Delirious mania: clinical features and treatment responseRakesh Karmacharya
Schizophrenia and Bipolar Disorder Program, McLean Hospital, Belmont, MA 02478, USA
J Affect Disord 109:312-6. 2008..To examine clinical characteristics and treatment responses of patients presenting with delirium and mania to a psychiatric inpatient unit... - Cholesterol in mood and anxiety disorders: review of the literature and new hypothesesGeorge I Papakostas
Depression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, 15 Parkman Street, WACC 812, Boston, MA 02114, USA
Eur Neuropsychopharmacol 14:135-42. 2004..We then propose possible mechanisms that would account for the relationship between elevated cholesterol and treatment non-response in MDD... - Functional connectivity of left Heschl's gyrus in vulnerability to auditory hallucinations in schizophreniaAnn K Shinn
McLean Hospital, Psychotic Disorders Division, Belmont, MA, United States
Schizophr Res 143:260-8. 2013.... - Creatine kinase and ATP synthase reaction rates in human frontal lobe measured by ³¹P magnetization transfer spectroscopy at 4TFei Du
Neuroimaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
Magn Reson Imaging 31:102-8. 2013.... - Medication adherence and attitudes in patients with bipolar disorder and current versus past substance use disorderChristian J Teter
Division of Alcohol and Drug Abuse, McLean Hospital, Belmont, MA, USA
Psychiatry Res 190:253-8. 2011..In conclusion, patients with BD-C demonstrated poor medication adherence and attitudes concerning medication management. Helping patients with BD achieve remission from SUD may lead to a more successful course of BD pharmacotherapy... - Tridimensional personality questionnaire factors in major depressive disorder: relationship to anxiety disorder comorbidity and age of onsetDost Ongur
Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, WACC 812, Boston, MA 02114, USA
Psychother Psychosom 74:173-8. 2005..Higher levels of HA and lower levels of RD and NS were associated with an increased risk of anxiety disorder comorbidity in our sample. HA may also be related to early onset of depression... - CD-1 and Balb/cJ mice do not show enduring antidepressant-like effects of ketamine in tests of acute antidepressant efficacyAnita J Bechtholt-Gompf
Department of Psychiatry, Harvard Medical School McLean Hospital, 115 Mill Street, MRC 215, Belmont, MA 02478, USA
Psychopharmacology (Berl) 215:689-95. 2011..In patients, ketamine is a fast-acting antidepressant that can induce long-lasting symptom relief. Similar rapid effects have been reported in rodents, but reports of lasting effects are limited... - The special treatment of first rank auditory hallucinations and bizarre delusions in the diagnosis of schizophreniaAnn K Shinn
McLean Hospital, Schizophrenia and Bipolar Disorder Program, Belmont, MA, USA Harvard Medical School Department of Psychiatry, Boston, MA, USA Electronic address
Schizophr Res 146:17-21. 2013.... - Metabolic syndrome in psychiatrically hospitalized patients treated with antipsychotics and other psychotropicsFranca Centorrino
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
Hum Psychopharmacol 27:521-6. 2012..Although the literature on metabolic syndrome in psychiatry has expanded in recent years, we seek to elucidate some of the remaining gaps by examining a severely and chronically ill population heavily treated with pharmacological agents... - Architectonic subdivision of the human orbital and medial prefrontal cortexDost Ongur
Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Comp Neurol 460:425-49. 2003..The parallel organization of the OMPFC in monkeys and humans allows experimental data from monkeys to be applied to studies of the human cortex... - Differences in lymphocyte electron transport gene expression levels between subjects with bipolar disorder and normal controls in response to glucose deprivation stressAlipi V Naydenov
Laboratory of Neuroplasticity and Schizophrenia and Bipolar Disorders Program, McLean Hospital, Belmont, MA, USA
Arch Gen Psychiatry 64:555-64. 2007..Bipolar disorder (BPD) is among the top 10 causes of disability worldwide. Recent findings on the etiology of the disease point to a disturbed mitochondrial energy metabolism in the brain of subjects with BPD... - Probing myelin and axon abnormalities separately in psychiatric disorders using MRI techniquesFei Du
McLean Hospital Belmont, MA, USA Department of Psychiatry, Harvard Medical School Boston, MA, USA
Front Integr Neurosci 7:24. 2013..Work is ongoing to collect data that will answer some relevant questions using these techniques in schizophrenia and related conditions... - No effect of adjunctive, repeated-dose intranasal insulin treatment on psychopathology and cognition in patients with schizophreniaXiaoduo Fan
Psychotic Disorders Program, UMass Memorial Medical Center, Worcester, MA, USA
J Clin Psychopharmacol 33:226-30. 2013..This study examined the effect of adjunctive intranasal insulin therapy on psychopathology and cognition in patients with schizophrenia...