Dost Ongur

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. doi request reprint Clinical characteristics influencing age at onset in psychotic disorders
    Dost Ongur
    McLean Hospital, Harvard Medical School, Boston, MA 02478, USA
    Compr Psychiatry 50:13-9. 2009
  2. pmc Creatine abnormalities in schizophrenia and bipolar disorder
    Dost Ongur
    McLean Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA, United States
    Psychiatry Res 172:44-8. 2009
  3. pmc Abnormal glutamatergic neurotransmission and neuronal-glial interactions in acute mania
    Dost Ongur
    McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 64:718-26. 2008
  4. ncbi request reprint Electroconvulsive seizures stimulate glial proliferation and reduce expression of Sprouty2 within the prefrontal cortex of rats
    Dost Ongur
    Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 62:505-12. 2007
  5. ncbi request reprint The neural basis of relational memory deficits in schizophrenia
    Dost Ongur
    Schizophrenia and Bipolar Disorder Program, McLean Hospital and Harvard Medical School, Brain Imaging Center, Belmont, MA 02478, USA
    Arch Gen Psychiatry 63:356-65. 2006
  6. pmc Elevated gamma-aminobutyric acid levels in chronic schizophrenia
    Dost Ongur
    McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 68:667-70. 2010
  7. ncbi request reprint Hippocampal activation during processing of previously seen visual stimulus pairs
    Dost Ongur
    Schizophrenia and Bipolar Disorder Program, McLean Hospital, 115 Mill St, AB 347, Belmont, MA, USA
    Psychiatry Res 139:191-8. 2005
  8. ncbi request reprint Obsessive-compulsive symptoms in schizophrenia: associated clinical features, cognitive function and medication status
    Dost Ongur
    Schizophrenia Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Schizophr Res 75:349-62. 2005
  9. doi request reprint T2 relaxation time abnormalities in bipolar disorder and schizophrenia
    Dost Ongur
    McLean Hospital, Belmont, Massachusetts 02478, USA
    Magn Reson Med 63:1-8. 2010
  10. ncbi request reprint A role for glia in the action of electroconvulsive therapy
    Dost Ongur
    Schizophrenia and Bipolar Disorder Unit, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Harv Rev Psychiatry 12:253-62. 2004

Detail Information

Publications52

  1. doi request reprint Clinical characteristics influencing age at onset in psychotic disorders
    Dost Ongur
    McLean Hospital, Harvard Medical School, Boston, MA 02478, USA
    Compr Psychiatry 50:13-9. 2009
    ..Age at onset of psychosis may carry clinical significance across psychotic disorders and appears to be associated with specific genetic abnormalities...
  2. pmc Creatine abnormalities in schizophrenia and bipolar disorder
    Dost Ongur
    McLean Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA, United States
    Psychiatry Res 172:44-8. 2009
    ..They also add to the literature on bioenergetic abnormalities in schizophrenia...
  3. pmc Abnormal glutamatergic neurotransmission and neuronal-glial interactions in acute mania
    Dost Ongur
    McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 64:718-26. 2008
    ..We examined the glutamine/glutamate ratio and levels of other metabolites in acute mania and schizophrenia in this exploratory study...
  4. ncbi request reprint Electroconvulsive seizures stimulate glial proliferation and reduce expression of Sprouty2 within the prefrontal cortex of rats
    Dost Ongur
    Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 62:505-12. 2007
    ..In parallel, we examined if ECS also alters the expression of Sprouty2 (SPRY2), an inhibitor of cell proliferation...
  5. ncbi request reprint The neural basis of relational memory deficits in schizophrenia
    Dost Ongur
    Schizophrenia and Bipolar Disorder Program, McLean Hospital and Harvard Medical School, Brain Imaging Center, Belmont, MA 02478, USA
    Arch Gen Psychiatry 63:356-65. 2006
    ..Memory deficits are common in schizophrenia. Recent studies have demonstrated that relational memory is particularly impaired...
  6. pmc Elevated gamma-aminobutyric acid levels in chronic schizophrenia
    Dost Ongur
    McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 68:667-70. 2010
    ..We used proton magnetic resonance spectroscopy to measure tissue GABA levels in participants with schizophrenia and healthy control subjects in the anterior cingulate cortex and parieto-occipital cortex...
  7. ncbi request reprint Hippocampal activation during processing of previously seen visual stimulus pairs
    Dost Ongur
    Schizophrenia and Bipolar Disorder Program, McLean Hospital, 115 Mill St, AB 347, Belmont, MA, USA
    Psychiatry Res 139:191-8. 2005
    ..Right hippocampal activation during discrimination of previously seen pairs of objects was correlated with activity in the anteromedial thalamus, cingulate cortex, and contralateral hippocampus...
  8. ncbi request reprint Obsessive-compulsive symptoms in schizophrenia: associated clinical features, cognitive function and medication status
    Dost Ongur
    Schizophrenia Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Schizophr Res 75:349-62. 2005
    ..To determine the prevalence and clinical significance of obsessive-compulsive (OC) symptoms among a group of stable outpatients with schizophrenia...
  9. doi request reprint T2 relaxation time abnormalities in bipolar disorder and schizophrenia
    Dost Ongur
    McLean Hospital, Belmont, Massachusetts 02478, USA
    Magn Reson Med 63:1-8. 2010
    ....
  10. ncbi request reprint A role for glia in the action of electroconvulsive therapy
    Dost Ongur
    Schizophrenia and Bipolar Disorder Unit, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Harv Rev Psychiatry 12:253-62. 2004
    ..We suggest that the effectiveness of ECT is, in part, related to its effect on glial cells. This testable hypothesis may advance our understanding and treatment of psychiatric disorders...
  11. pmc Default mode network abnormalities in bipolar disorder and schizophrenia
    Dost Ongur
    McLean Hospital, Belmont, MA and Harvard Medical School, Boston, MA, United States
    Psychiatry Res 183:59-68. 2010
    ..Further studies are needed to determine how these abnormalities are related to specific symptoms of each condition...
  12. pmc Blockade of astrocytic glutamate uptake in the prefrontal cortex induces anhedonia
    Catherine S John
    Department of Psychiatry, Harvard Medical School McLean Hospital, Belmont, MA, USA
    Neuropsychopharmacology 37:2467-75. 2012
    ..Overall, these results suggest that blockade of astrocytic glutamate uptake in the PFC is sufficient to produce anhedonia, a core symptom of depression...
  13. pmc Distinct facial processing in schizophrenia and schizoaffective disorders
    Yue Chen
    McLean Hospital, United States
    Schizophr Res 134:95-100. 2012
    ..This pattern of results suggests distinct processing of face information in schizophrenia and schizoaffective disorders...
  14. pmc Rapid enhancement of glutamatergic neurotransmission in bipolar depression following treatment with riluzole
    Brian P Brennan
    Biological Psychiatry Laboratory, McLean Hospital, Belmont, MA 02478, USA
    Neuropsychopharmacology 35:834-46. 2010
    ..Further investigation of the Gln/Glu ratio as a possible early biomarker of response to glutamate-modulating therapies is warranted...
  15. pmc Visual and cognitive processing of face information in schizophrenia: detection, discrimination and working memory
    Yue Chen
    McLean Hospital, Department of Psychiatry, Harvard Medical School, USA
    Schizophr Res 107:92-8. 2009
    ..This pattern of results indicates that greater signal strength is required for visual and cognitive processing of facial information in schizophrenia...
  16. pmc Auditory hallucinations in a cross-diagnostic sample of psychotic disorder patients: a descriptive, cross-sectional study
    Ann K Shinn
    Schizophrenia and Bipolar Disorder Program, McLean Hospital and Harvard Medical School, Department of Psychiatry, USA
    Compr Psychiatry 53:718-26. 2012
    ..Auditory hallucinations (AH) are a cardinal feature of schizophrenia spectrum disorders. They are not disease specific, however, and can occur in other conditions, including affective psychoses...
  17. pmc Water and metabolite transverse T2 relaxation time abnormalities in the white matter in schizophrenia
    Fei Du
    McLean Hospital, Belmont, MA 02478, USA
    Schizophr Res 137:241-5. 2012
    ..980, p=0.039). Prolongation of water T2 and shortening of NAA T2 is consistent with an impoverishment of white matter macromolecule structures (including myelin) and abnormal intra-axonal milieu and volume in SZ...
  18. pmc Relationship of neurocognitive deficits to diagnosis and symptoms across affective and non-affective psychoses
    Kathryn E Lewandowski
    Schizophrenia and Bipolar Disorder Program, McLean Hospital, 115 Mill St, Belmont, MA, 02478 USA
    Schizophr Res 133:212-7. 2011
    ..Additionally, we predicted that negative symptoms but not positive, general, or mood symptoms, would be associated with neurocognitive functioning...
  19. doi request reprint Association of impaired facial affect recognition with basic facial and visual processing deficits in schizophrenia
    Daniel Norton
    McLean Hospital, Belmont, Massachusetts, USA
    Biol Psychiatry 65:1094-8. 2009
    ..We examined whether and how poor facial emotion recognition in schizophrenia is related to basic visual processing and nonaffective face recognition...
  20. pmc Relationship between genetic variation in the glutaminase gene GLS1 and brain glutamine/glutamate ratio measured in vivo
    Dost Ongur
    McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 70:169-74. 2011
    ..Accumulating evidence suggests that the Gln/Glu ratio is a putative index of glutamatergic neurotransmission but interpretation of changes in the Gln/Glu ratio depends on the conditions of the system, including ammonia levels...
  21. pmc The special treatment of first rank auditory hallucinations and bizarre delusions in the diagnosis of schizophrenia
    Ann K Shinn
    McLean Hospital, Schizophrenia and Bipolar Disorder Program, Belmont, MA, USA
    Schizophr Res 146:17-21. 2013
    ....
  22. pmc Categorical vs dimensional classifications of psychotic disorders
    Melissa Potuzak
    Psychotic Disorders Division, McLean Hospital, 1125 Mill St, Belmont, MA 02478, USA
    Compr Psychiatry 53:1118-29. 2012
    ..This review examines the evidence on specific dimensions and categories that would best characterize psychoses...
  23. pmc Altered 'three-flash' illusion in response to two light pulses in schizophrenia
    Dan Norton
    McLean Hospital, United States
    Schizophr Res 103:275-82. 2008
    ..We examined the perceived interaction of two elementary visual events in schizophrenia patients, using a psychophysical approach...
  24. pmc Functional connectivity of left Heschl's gyrus in vulnerability to auditory hallucinations in schizophrenia
    Ann K Shinn
    McLean Hospital, Psychotic Disorders Division, Belmont, MA, United States
    Schizophr Res 143:260-8. 2013
    ....
  25. pmc Oral glycine administration increases brain glycine/creatine ratios in men: a proton magnetic resonance spectroscopy study
    Marc J Kaufman
    Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, United States
    Psychiatry Res 173:143-9. 2009
    ....
  26. pmc Brain metabolite concentrations across cortical regions in healthy adults
    Bethany K Bracken
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    Brain Res 1369:89-94. 2011
    ..MRS may be a useful tool for studying physical properties of the living human brain...
  27. doi request reprint No effect of adjunctive, repeated-dose intranasal insulin treatment on psychopathology and cognition in patients with schizophrenia
    Xiaoduo Fan
    Psychotic Disorders Program, UMass Memorial Medical Center, Worcester, MA, USA
    J Clin Psychopharmacol 33:226-30. 2013
    ..This study examined the effect of adjunctive intranasal insulin therapy on psychopathology and cognition in patients with schizophrenia...
  28. pmc Gray matter volume in schizophrenia and bipolar disorder with psychotic features
    Cagri Yüksel
    Psychotic Disorders Division, McLean Hospital, Belmont, MA, USA
    Schizophr Res 138:177-82. 2012
    ..We conclude that GM abnormality as measured by VBM analysis is less pronounced in psychotic BD compared to SZ. This may be due to disease-specific factors or medications used more commonly in BD...
  29. pmc Perceptual training strongly improves visual motion perception in schizophrenia
    Daniel J Norton
    McLean Hospital, Massachusetts, United States
    Brain Cogn 77:248-56. 2011
    ..The large perceptual training effect in patients on the trained task suggests that perceptual plasticity is robust in schizophrenia and can be applied to develop bottom-up behavioral interventions...
  30. doi request reprint Quantification of J-resolved proton spectra in two-dimensions with LCModel using GAMMA-simulated basis sets at 4 Tesla
    J Eric Jensen
    McLean Hospital, Belmont, MA 02478, USA
    NMR Biomed 22:762-9. 2009
    ..These novel methods have clear implications for clinical and research studies seeking to understand neurochemical dysfunction...
  31. ncbi request reprint Personality disorders and the trimensional personality questionnaire factors in major depressive disorder
    Amy Farabaugh
    Depression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Nerv Ment Dis 193:747-50. 2005
    ..Certain temperament traits, especially HA and NS, appear to be associated with specific patterns of personality clusters among depressed patients...
  32. doi request reprint In Vivo Evidence for Cerebral Bioenergetic Abnormalities in Schizophrenia Measured Using 31P Magnetization Transfer Spectroscopy
    Fei Du
    Psychotic Disorders Division, McLean Hospital, Belmont, Massachusetts2Department of Psychiatry, Harvard Medical School, Boston, Massachusetts
    JAMA Psychiatry 71:19-27. 2014
    ..The similar phosphocreatine to ATP ratios in SZ and healthy controls suggest that the underlying bioenergetics abnormality is not associated with change in this metabolite ratio. ..
  33. pmc Creatine kinase and ATP synthase reaction rates in human frontal lobe measured by ³¹P magnetization transfer spectroscopy at 4T
    Fei Du
    Neuroimaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Magn Reson Imaging 31:102-8. 2013
    ....
  34. pmc Altered center-surround motion inhibition in schizophrenia
    Yue Chen
    McLean Hospital, Department of Psychiatry, Harvard Medical School, Belmont, Massachusetts, USA
    Biol Psychiatry 64:74-7. 2008
    ..Center-surround interaction is a ubiquitous neural mechanism underlying the organization of visual information over different spatial locations...
  35. pmc Blockade of astrocytic glutamate uptake in rats induces signs of anhedonia and impaired spatial memory
    Anita J Bechtholt-Gompf
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
    Neuropsychopharmacology 35:2049-59. 2010
    ..These finding may have implications for the etiology of depression and other disorders that share the features of anhedonia and cognitive impairment...
  36. pmc Safety and proof of principle study of cerebellar vermal theta burst stimulation in refractory schizophrenia
    Asli Demirtas-Tatlidede
    Harvard Medical School, Boston, MA, United States
    Schizophr Res 124:91-100. 2010
    ..This proof of principle study aimed to test this hypothesis using noninvasive brain stimulation, and to explore the safety of this protocol in schizophrenia...
  37. ncbi request reprint Tactile, olfactory, and gustatory hallucinations in psychotic disorders: a descriptive study
    Kathryn E Lewandowski
    McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
    Ann Acad Med Singapore 38:383-5. 2009
    ..The present study examined hallucinations across sensory modalities in patients with primary psychotic disorders by diagnosis and in association with mood and psychotic symptoms...
  38. pmc Inefficient face detection in schizophrenia
    Yue Chen
    Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Schizophr Bull 34:367-74. 2008
    ..Higher levels of facial processing, such as recognition of the individuality and emotional expression of faces, are abnormal in schizophrenia. It is unknown, however, whether the visual detection of a face as face is impaired as well...
  39. doi request reprint Anxiety disorder comorbidity in bipolar disorder, schizophrenia and schizoaffective disorder
    Sarah Young
    McLean Hospital, Belmont, MA, USA
    Psychopathology 46:176-85. 2013
    ..Reported rates of comorbid anxiety disorders in psychotic and mood disorders vary widely among studies...
  40. pmc Catatonia in psychotic patients: clinical features and treatment response
    Mary L England
    From Harvard Medical School, Schizophrenia and Bipolar Disorder Program, McLean Hospital, 115 Mill St, Belmont, MA 02478
    J Neuropsychiatry Clin Neurosci 23:223-6. 2011
    ..Electroconvulsive therapy, benzodiazepines, and clozapine had beneficial effects on catatonic features, whereas typical antipsychotics resulted in clinical worsening...
  41. doi request reprint Delirious mania: clinical features and treatment response
    Rakesh Karmacharya
    Schizophrenia and Bipolar Disorder Program, McLean Hospital, Belmont, MA 02478, USA
    J Affect Disord 109:312-6. 2008
    ..To examine clinical characteristics and treatment responses of patients presenting with delirium and mania to a psychiatric inpatient unit...
  42. ncbi request reprint Cholesterol in mood and anxiety disorders: review of the literature and new hypotheses
    George I Papakostas
    Depression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, 15 Parkman Street, WACC 812, Boston, MA 02114, USA
    Eur Neuropsychopharmacol 14:135-42. 2004
    ..We then propose possible mechanisms that would account for the relationship between elevated cholesterol and treatment non-response in MDD...
  43. pmc Myelin and axon abnormalities in schizophrenia measured with magnetic resonance imaging techniques
    Fei Du
    McLean Hospital, Belmont, MA 02478, USA
    Biol Psychiatry 74:451-7. 2013
    ..However, diffusion tensor imaging alone cannot currently pinpoint the biological basis of these abnormalities...
  44. pmc Neuropsychological functioning predicts community outcomes in affective and non-affective psychoses: a 6-month follow-up
    Kathryn E Lewandowski
    Schizophrenia and Bipolar Disorder Program, McLean Hospital, 115 Mill St, Belmont, MA 02478 USA
    Schizophr Res 148:34-7. 2013
    ..We examined neurocognitive, clinical, and community functioning in a cross-diagnostic sample of patients with psychotic disorders over a 6-month follow-up interval...
  45. pmc Medication adherence and attitudes in patients with bipolar disorder and current versus past substance use disorder
    Christian J Teter
    Division of Alcohol and Drug Abuse, McLean Hospital, Belmont, MA, USA
    Psychiatry Res 190:253-8. 2011
    ..In conclusion, patients with BD-C demonstrated poor medication adherence and attitudes concerning medication management. Helping patients with BD achieve remission from SUD may lead to a more successful course of BD pharmacotherapy...
  46. doi request reprint CD-1 and Balb/cJ mice do not show enduring antidepressant-like effects of ketamine in tests of acute antidepressant efficacy
    Anita J Bechtholt-Gompf
    Department of Psychiatry, Harvard Medical School McLean Hospital, 115 Mill Street, MRC 215, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 215:689-95. 2011
    ..In patients, ketamine is a fast-acting antidepressant that can induce long-lasting symptom relief. Similar rapid effects have been reported in rodents, but reports of lasting effects are limited...
  47. ncbi request reprint Tridimensional personality questionnaire factors in major depressive disorder: relationship to anxiety disorder comorbidity and age of onset
    Dost Ongur
    Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, WACC 812, Boston, MA 02114, USA
    Psychother Psychosom 74:173-8. 2005
    ..We used the Tridimensional Personality Questionnaire (TPQ) to study the relationship between temperamental traits and comorbid anxiety disorders as well as age of onset of major depressive disorder (MDD) in 263 patients with MDD...
  48. doi request reprint Neurophysiologic effect of GWAS derived schizophrenia and bipolar risk variants
    Mei Hua Hall
    Psychotic Disorders Division, Department of Psychiatry, McLean Hospital, Harvard Medical School, Boston, Massachusetts Department of Psychiatry, Psychology Research Laboratory, McLean Hospital, Harvard Medical School, Boston, Massachusetts Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts
    Am J Med Genet B Neuropsychiatr Genet 165:9-18. 2014
    ..These findings suggest a mechanism by which TCF4 may contribute to the neurobiological basis of psychotic illness. © 2013 Wiley Periodicals, Inc. ..
  49. doi request reprint Metabolic syndrome in psychiatrically hospitalized patients treated with antipsychotics and other psychotropics
    Franca Centorrino
    Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    Hum Psychopharmacol 27:521-6. 2012
    ..Although the literature on metabolic syndrome in psychiatry has expanded in recent years, we seek to elucidate some of the remaining gaps by examining a severely and chronically ill population heavily treated with pharmacological agents...
  50. ncbi request reprint Architectonic subdivision of the human orbital and medial prefrontal cortex
    Dost Ongur
    Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Comp Neurol 460:425-49. 2003
    ..The parallel organization of the OMPFC in monkeys and humans allows experimental data from monkeys to be applied to studies of the human cortex...
  51. ncbi request reprint Differences in lymphocyte electron transport gene expression levels between subjects with bipolar disorder and normal controls in response to glucose deprivation stress
    Alipi V Naydenov
    Laboratory of Neuroplasticity and Schizophrenia and Bipolar Disorders Program, McLean Hospital, Belmont, MA, USA
    Arch Gen Psychiatry 64:555-64. 2007
    ..Bipolar disorder (BPD) is among the top 10 causes of disability worldwide. Recent findings on the etiology of the disease point to a disturbed mitochondrial energy metabolism in the brain of subjects with BPD...
  52. pmc Probing myelin and axon abnormalities separately in psychiatric disorders using MRI techniques
    Fei Du
    McLean Hospital Belmont, MA, USA Department of Psychiatry, Harvard Medical School Boston, MA, USA
    Front Integr Neurosci 7:24. 2013
    ..Work is ongoing to collect data that will answer some relevant questions using these techniques in schizophrenia and related conditions...