Research Topics
| Olivia I OkerekeSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
| Collaborators
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Detail Information
Publications
Ten-year change in plasma amyloid beta levels and late-life cognitive declineOlivia I Okereke
Division of Aging and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, Third Floor, Boston, MA 02115, USA
Arch Neurol 66:1247-53. 2009..Plasma levels of amyloid beta peptide (Abeta) are potential biomarkers of early cognitive impairment and decline and of Alzheimer disease risk...- The SIST-M: predictive validity of a brief structured clinical dementia rating interviewOlivia I Okereke
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Alzheimer Dis Assoc Disord 26:225-31. 2012.... - Performance characteristics of plasma amyloid-beta 40 and 42 assaysOlivia I Okereke
Division of Aging, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
J Alzheimers Dis 16:277-85. 2009..While these preliminary findings suggest that measuring plasma Abeta(40) and Abeta(42) may be feasible in varied research settings, additional work in this area is necessary... - Fasting plasma insulin, C-peptide and cognitive change in older men without diabetes: results from the Physicians' Health Study IIOlivia I Okereke
Divisions of Aging, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Neuroepidemiology 34:200-7. 2010..We examined prospectively relations of fasting insulin levels and insulin secretion to cognitive decline among healthy, community-dwelling older men without diabetes... - The Structured Interview & Scoring Tool-Massachusetts Alzheimer's Disease Research Center (SIST-M): development, reliability, and cross-sectional validation of a brief structured clinical dementia rating interviewOlivia I Okereke
Department of Psychiatry, Gerontology Research Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Arch Neurol 68:343-50. 2011..The Clinical Dementia Rating (CDR) and CDR Sum-of-Boxes can be used to grade mild but clinically important cognitive symptoms of Alzheimer disease. However, sensitive clinical interview formats are lengthy... - A profile of impaired insulin degradation in relation to late-life cognitive decline: a preliminary investigationOlivia I Okereke
Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Int J Geriatr Psychiatry 24:177-82. 2009..In preliminary analyses, we considered the relation of combined lower insulin secretion (c-peptide) and higher insulin--possibly a phenotype for impaired insulin degradation--to cognitive decline... 
Type 2 diabetes mellitus and cognitive decline in two large cohorts of community-dwelling older adultsOlivia I Okereke
Division of Aging and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Am Geriatr Soc 56:1028-36. 2008..To relate diabetes mellitus (DM) status and duration to late-life cognitive impairment and decline in men and women...- Plasma C-peptide levels and rates of cognitive decline in older, community-dwelling women without diabetesOlivia I Okereke
Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
Psychoneuroendocrinology 33:455-61. 2008.... 
Plasma C-peptide and cognitive performance in older men without diabetesOlivia Okereke
Division of Aging, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA, USA
Am J Geriatr Psychiatry 14:1041-50. 2006..Emerging evidence suggests that type 2 diabetes may be related to diminished cognition, but little data are available directly regarding the role of insulin levels...- Midlife plasma insulin-like growth factor I and cognitive function in older menOlivia I Okereke
Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Endocrinol Metab 91:4306-12. 2006..Emerging biological and epidemiological evidence suggests possible benefits of higher IGF-I levels in cognitive aging... - Plasma IGF-I levels and cognitive performance in older womenOlivia Okereke
Division of Aging, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, 3rd Floor, 181 Longwood Avenue, Boston, MA 02115, USA
Neurobiol Aging 28:135-42. 2007..Emerging biologic and epidemiologic evidence suggests benefits of insulin-like growth factor-I (IGF-I) in cognitive aging... - Plasma C peptide level and cognitive function among older women without diabetes mellitusOlivia Okereke
Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
Arch Intern Med 165:1651-6. 2005..To help differentiate between the effects of diabetes and insulin, we examined the relation of insulin to cognitive function among nondiabetic participants of the Nurses' Health Study... - Dietary fat types and 4-year cognitive change in community-dwelling older womenOlivia I Okereke
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
Ann Neurol 72:124-34. 2012..A study was undertaken to relate dietary fat types to cognitive change in healthy community-based elders... - Relation between clinical depression risk and physical activity and time spent watching television in older women: a 10-year prospective follow-up studyMichel Lucas
Department of Nutrition, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
Am J Epidemiol 174:1017-27. 2011..13 (95% confidence interval: 1.00, 1.27; P(trend) = 0.01). Analyses simultaneously considering PA and television watching suggested that both contributed independently to depression risk... - Depression and incident stroke in womenAn Pan
Department of Nutrition and Epidemiology, Harvard School of Public Health, and Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
Stroke 42:2770-5. 2011..Depression has been associated with an increased risk of coronary heart disease, but prospective data for the association with stroke are limited... - Physical activity at midlife in relation to successful survival in women at age 70 years or olderQi Sun
Department of Nutrition, Harvard School of Public Health, 655 Huntington Ave, Boston, MA 02115, USA
Arch Intern Med 170:194-201. 2010..Physical activity is associated with reduced risks of chronic diseases and premature death. Whether physical activity is also associated with improved overall health among those who survive to older ages is unclear... - Plasma amyloid-β as a predictor of dementia and cognitive decline: a systematic review and meta-analysisAlain Koyama
Department of Psychiatry, University of California at San Francisco, USA
Arch Neurol 69:824-31. 2012.... - Relation between insulin, insulin-related factors, and plasma amyloid beta peptide levels at midlife in a population-based studyMary K Townsend
Department of Epidemiology, Harvard School of Public Health, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Alzheimer Dis Assoc Disord 26:50-4. 2012.... - Long-term adherence to the Mediterranean diet is associated with overall cognitive status, but not cognitive decline, in womenCecilia Samieri
Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
J Nutr 143:493-9. 2013..These associations were similar to those observed in women 1-1.5 y apart in age. In summary, long-term MeDi adherence was related to moderately better cognition but not with cognitive change in this very large cohort of older women... - Bidirectional association between depression and metabolic syndrome: a systematic review and meta-analysis of epidemiological studiesAn Pan
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
Diabetes Care 35:1171-80. 2012..However, the results have been inconsistent. This meta-analysis aimed to summarize the current evidence from cross-sectional and prospective cohort studies that evaluated this association... - Depression and risk of stroke morbidity and mortality: a meta-analysis and systematic reviewAn Pan
Department of Nutrition, Harvard School of Public Health, 655 Huntington Ave, Boston, MA 02115, USA
JAMA 306:1241-9. 2011..Several studies have suggested that depression is associated with an increased risk of stroke; however, the results are inconsistent... - Adiposity and weight change in mid-life in relation to healthy survival after age 70 in women: prospective cohort studyQi Sun
Department of Nutrition, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, United States
BMJ 339:b3796. 2009..To examine the hypothesis that mid-life adiposity is associated with a reduced probability of maintaining an optimal health status among those who survive to older ages... - High phobic anxiety is related to lower leukocyte telomere length in womenOlivia I Okereke
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 7:e40516. 2012..Yet, little is known about relations of anxiety to telomeres. We examined whether a typically chronic form of anxiety--phobic anxiety--is related to telomere length... - Coffee, caffeine, and risk of depression among womenMichel Lucas
Department of Nutrition, Harvard School of Public Health, and Department of Medicine, Brigham and Women s Hospital, 655 Huntington Ave, Boston, MA 02115, USA
Arch Intern Med 171:1571-8. 2011..However, studies that analyze prospectively the relationship between coffee or caffeine consumption and depression risk are scarce... - Physical activity levels and cognition in women with type 2 diabetesELIZABETH E DEVORE
Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Am J Epidemiol 170:1040-7. 2009..Results were similar for cognitive decline. These findings indicate little overall association between physical activity and cognition after adjustment for disability factors in older women with type 2 diabetes... - Fasting insulin levels and cognitive decline in older women without diabetesMarieke van Oijen
Department of Epidemiology Biostatistics and Neurology, Erasmus Medical Center, Rotterdam, The Netherlands
Neuroepidemiology 30:174-9. 2008..Type 2 diabetes has been associated with an increased risk of dementia. To assess possible independent effects of insulin, we investigated the relation of insulin levels to cognitive decline in nondiabetic women... - Medical comorbidity in geriatric psychiatryOlivia I Okereke
Am J Geriatr Psychiatry 13:177-9. 2005