R D Odze

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Diagnostic problems and advances in inflammatory bowel disease
    Robert Odze
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Mod Pathol 16:347-58. 2003
  2. ncbi request reprint Biologic properties of columnar epithelium underneath reepithelialized squamous mucosa in Barrett's esophagus
    Jason L Hornick
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 29:372-80. 2005
  3. pmc Multilayered epithelium in a rat model and human Barrett's esophagus: similar expression patterns of transcription factors and differentiation markers
    Xiaoxin Chen
    Cancer Research Program, Julius L, Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, 700 George Street, Durham, NC 27707, USA
    BMC Gastroenterol 8:1. 2008
  4. pmc IQGAP1 and IQGAP2 are reciprocally altered in hepatocellular carcinoma
    Colin D White
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    BMC Gastroenterol 10:125. 2010
  5. doi request reprint What the gastroenterologist needs to know about the histology of Barrett's esophagus
    Robert D Odze
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Curr Opin Gastroenterol 27:389-96. 2011
  6. doi request reprint Neoplasia without dysplasia: lessons from Barrett esophagus and other tubal gut neoplasms
    Robert D Odze
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Arch Pathol Lab Med 134:896-906. 2010
  7. doi request reprint Barrett esophagus: histology and pathology for the clinician
    Robert D Odze
    Department of Pathology, Harvard Medical School, Brigham and Women s Hospital, Boston, MA, USA
    Nat Rev Gastroenterol Hepatol 6:478-90. 2009
  8. doi request reprint Pathology of eosinophilic esophagitis: what the clinician needs to know
    Robert D Odze
    GI Pathology Division, Brigham and Women Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Gastroenterol 104:485-90. 2009
  9. doi request reprint Histopathology of Barrett's esophagus after ablation and endoscopic mucosal resection therapy
    R D Odze
    Gastrointestinal Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Endoscopy 40:1008-15. 2008
  10. doi request reprint Update on the diagnosis and treatment of Barrett esophagus and related neoplastic precursor lesions
    Robert D Odze
    GI Pathology Service, Brigham andWomen s Hospital, Harvard Medical School, Boston, Massachussetts 02115, USA
    Arch Pathol Lab Med 132:1577-85. 2008

Collaborators

Detail Information

Publications80

  1. ncbi request reprint Diagnostic problems and advances in inflammatory bowel disease
    Robert Odze
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Mod Pathol 16:347-58. 2003
    ..The surveillance and treatment options for patients with flat and elevated dysplasia in ulcerative colitis are reviewed in detail...
  2. ncbi request reprint Biologic properties of columnar epithelium underneath reepithelialized squamous mucosa in Barrett's esophagus
    Jason L Hornick
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 29:372-80. 2005
    ..Prospective studies of large numbers of patients with BUSI will be required to determine the magnitude of its risk of progression to cancer...
  3. pmc Multilayered epithelium in a rat model and human Barrett's esophagus: similar expression patterns of transcription factors and differentiation markers
    Xiaoxin Chen
    Cancer Research Program, Julius L, Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, 700 George Street, Durham, NC 27707, USA
    BMC Gastroenterol 8:1. 2008
    ..Invest. 2004;84:753-765). The purpose of this study was to compare the phenotype of rat MLE with human MLE, in order to gain insight into the nature of MLE and its potential role in the development of BE...
  4. pmc IQGAP1 and IQGAP2 are reciprocally altered in hepatocellular carcinoma
    Colin D White
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    BMC Gastroenterol 10:125. 2010
    ..We recently reported that IQGAP2 deficiency leads to the development of hepatocellular carcinoma (HCC) in mice. In the current study we extend these findings, and investigate IQGAP1 and IQGAP2 expression in human HCC...
  5. doi request reprint What the gastroenterologist needs to know about the histology of Barrett's esophagus
    Robert D Odze
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Curr Opin Gastroenterol 27:389-96. 2011
    ....
  6. doi request reprint Neoplasia without dysplasia: lessons from Barrett esophagus and other tubal gut neoplasms
    Robert D Odze
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Arch Pathol Lab Med 134:896-906. 2010
    ..Recent studies suggest that many important-and in some cases clonal-molecular abnormalities that lead to dysregulation of cell proliferation and differentiation (neoplasia) occur before morphologic expression of dysplasia...
  7. doi request reprint Barrett esophagus: histology and pathology for the clinician
    Robert D Odze
    Department of Pathology, Harvard Medical School, Brigham and Women s Hospital, Boston, MA, USA
    Nat Rev Gastroenterol Hepatol 6:478-90. 2009
    ..Close interaction between the clinician and the pathologist is essential for proper interpretation of biopsy results and to provide optimal surveillance or treatment strategies...
  8. doi request reprint Pathology of eosinophilic esophagitis: what the clinician needs to know
    Robert D Odze
    GI Pathology Division, Brigham and Women Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Gastroenterol 104:485-90. 2009
    ....
  9. doi request reprint Histopathology of Barrett's esophagus after ablation and endoscopic mucosal resection therapy
    R D Odze
    Gastrointestinal Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Endoscopy 40:1008-15. 2008
    ..On the other hand, anecdotal reports have suggested that buried dysplasia may progress to cancer in some instances...
  10. doi request reprint Update on the diagnosis and treatment of Barrett esophagus and related neoplastic precursor lesions
    Robert D Odze
    GI Pathology Service, Brigham andWomen s Hospital, Harvard Medical School, Boston, Massachussetts 02115, USA
    Arch Pathol Lab Med 132:1577-85. 2008
    ..At present, Barrett esophagus is the most common cause of esophageal adenocarcinoma. In the past 20 years, the incidence of esophageal adenocarcinoma in white males has exceeded that of tumors of the colorectum, lung, prostate, and skin...
  11. ncbi request reprint Cytokeratin 7/20 immunostaining: Barrett's oesophagus or gastric intestinal metaplasia?
    Robert Odze
    Department of Pathology, Brigham and Women Hospital, Harvard Medical School, Boston, MA 02115, USA
    Lancet 359:1711-3. 2002
  12. pmc Diagnosis and grading of dysplasia in Barrett's oesophagus
    R D Odze
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Pathol 59:1029-38. 2006
    ..In this review, the problematic areas in dysplasia interpretation are outlined and a specific approach to these issues is discussed...
  13. ncbi request reprint Pathology of dysplasia and cancer in inflammatory bowel disease
    Robert D Odze
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School Boston, MA 02115, USA
    Gastroenterol Clin North Am 35:533-52. 2006
    ..As a result, this article focuses mainly on the pathologic features, adjunctive diagnostic methods, and differential diagnosis of dysplasia in UC...
  14. ncbi request reprint Pathology of indeterminate colitis
    Robert D Odze
    GI Pathology Service, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Clin Gastroenterol 38:S36-40. 2004
    ....
  15. ncbi request reprint Long-term follow-up after polypectomy treatment for adenoma-like dysplastic lesions in ulcerative colitis
    Robert D Odze
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Clin Gastroenterol Hepatol 2:534-41. 2004
    ..The purpose of this study was to evaluate the long-term outcome of our previously defined group of UC patients, all with adenoma-like DALMs, who were treated by polypectomy...
  16. ncbi request reprint Pathology of the gastroesophageal junction
    Robert D Odze
    Gastrointestinal Pathology Service, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Semin Diagn Pathol 22:256-65. 2005
    ..pylori infection represents a columnar to columnar metaplastic reaction. This review will focus on the clinical, pathologic, and pathogenetic aspects of GERD and H. pylori-induced inflammation of the GEJ region...
  17. ncbi request reprint Microsatellite instability and hMLH1/hMSH2 expression in Barrett esophagus-associated adenocarcinoma
    M H Kulke
    Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cancer 91:1451-7. 2001
    ..This study sought to determine the prevalence of MSI in 80 primary Barrett esophagus-associated adenocarcinomas (BEAd) and to examine the relation of MSI with the clinical and pathologic features of the tumors...
  18. ncbi request reprint Phenotypic characteristics of a distinctive multilayered epithelium suggests that it is a precursor in the development of Barrett's esophagus
    J N Glickman
    Departments of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Surg Pathol 25:569-78. 2001
    ..The mucosal gland duct epithelium may contain progenitor cells that can give rise to ME...
  19. ncbi request reprint Expression of p53-related protein p63 in the gastrointestinal tract and in esophageal metaplastic and neoplastic disorders
    J N Glickman
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Hum Pathol 32:1157-65. 2001
    ..These data also indicate that multilayered epithelium is phenotypically similar to, and may share a lineage relationship with, mucosal gland duct epithelium...
  20. ncbi request reprint Phenotype of Barrett's esophagus and intestinal metaplasia of the distal esophagus and gastroesophageal junction: an immunohistochemical study of cytokeratins 7 and 20, Das-1 and 45 MI
    J N Glickman
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Am J Surg Pathol 25:87-94. 2001
    ..This may indicate that IM in LSBE, SSBE and at the GEJ have similar biologic properties. Based on our data, SSBE and IMGEJ cannot be distinguished on the basis of their immunophenotype...
  21. ncbi request reprint Gastric dysplasia-like epithelial atypia associated with chemoradiotherapy for esophageal cancer: a clinicopathologic and immunohistochemical study of 15 cases
    T P Brien
    Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Mod Pathol 14:389-96. 2001
    ..Pathologists should be aware of this entity and its histologic and immunohistochemical features to avoid misinterpretation and prevent unnecessary treatment...
  22. ncbi request reprint Cytokeratin 7 and 20 and thyroid transcription factor 1 can help distinguish pulmonary from gastrointestinal carcinoid and pancreatic endocrine tumors
    Y C Cai
    Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA
    Hum Pathol 32:1087-93. 2001
    ..Expression of CK7 and CK20, and particularly TTF-1, may be useful in distinguishing pulmonary from GI carcinoid tumors and PETs, especially when evaluated as a panel of markers. TTF-1 is highly specific for pulmonary carcinoid tumors...
  23. ncbi request reprint Hyperplastic polyp with epithelial misplacement (inverted hyperplastic polyp): a clinicopathologic and immunohistochemical study of 19 cases
    R K Yantiss
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Mod Pathol 14:869-75. 2001
    ..Pathologists should be aware of this entity to avoid diagnostic confusion with other, more serious lesions, such as adenomas with pseudoinvasion or well-differentiated adenocarcinoma...
  24. ncbi request reprint Genetic alterations in chronic ulcerative colitis-associated adenoma-like DALMs are similar to non-colitic sporadic adenomas
    R D Odze
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Surg Pathol 24:1209-16. 2000
    ..Our data also suggests that the latter two groups of neoplasms may in fact represent a similar, if not identical, pathogenetic entity...
  25. ncbi request reprint Diagnostic difficulties in inflammatory bowel disease pathology
    R K Yantiss
    Department of Pathology, Weill Medical College of Cornell University, New York, NY, USA
    Histopathology 48:116-32. 2006
    ..The clinical and pathological features that aid in the distinction between these entities, and others, are covered in detail in this review...
  26. pmc Allelic loss of 10q23, the PTEN tumour suppressor gene locus, in Barrett's oesophagus-associated adenocarcinoma
    M H Kulke
    Department of Adult Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
    Br J Cancer 84:748-53. 2001
    ..It is possible that PTEN is inactivated through other mechanisms in BOAd...
  27. doi request reprint A Balancing view: Pathologist-clinician interaction is essential
    Robert Odze
    Department of Pathology, Brigham Women s Hospital, Boston, MA 02115, USA
    Am J Gastroenterol 103:1331-3. 2008
  28. pmc Deletion at fragile sites is a common and early event in Barrett's esophagus
    Lisa A Lai
    Department of Pathology, University of Washington, Seattle, WA, USA
    Mol Cancer Res 8:1084-94. 2010
    ..Deletion and genomic instability at FRA3B and other fragile sites could thus be a biomarker of genetic damage in BE patients and a potential biomarker of cancer risk...
  29. ncbi request reprint Filiform serrated adenomas: a clinicopathologic and immunophenotypic study of 18 cases
    Rhonda K Yantiss
    Weill Medical College of Cornell University, Department of Pathology, New York, NY 10021, USA
    Am J Surg Pathol 31:1238-45. 2007
    ..We conclude that filiform SA potentially represents an unusual variant of SA with a predilection for the left colon, particularly the rectum...
  30. ncbi request reprint Variability in the diagnosis and management of adenoma-like and non-adenoma-like dysplasia-associated lesions or masses in inflammatory bowel disease: an Internet-based study
    Francis A Farraye
    Section of Gastroenterology Center for Digestive Disorders, Boston Medical Center, Boston, Massachusetts 02118, USA
    Gastrointest Endosc 66:519-29. 2007
    ..Dysplasia-associated lesions or masses (DALMs) in inflammatory bowel disease (IBD) are a heterogeneous group of tumors with different natural histories...
  31. ncbi request reprint Extent of low-grade dysplasia is a risk factor for the development of esophageal adenocarcinoma in Barrett's esophagus
    Amitabh Srivastava
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Gastroenterol 102:483-93; quiz 694. 2007
    ..The aim of this discovery study was to evaluate the hypothesis that extent of LGD and HGD are risk factors for progression to EA...
  32. ncbi request reprint Increasing genomic instability during premalignant neoplastic progression revealed through high resolution array-CGH
    Lisa A Lai
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Genes Chromosomes Cancer 46:532-42. 2007
    ....
  33. pmc NSAIDs modulate CDKN2A, TP53, and DNA content risk for progression to esophageal adenocarcinoma
    Patricia C Galipeau
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Med 4:e67. 2007
    ..We aimed to evaluate somatic genetic abnormalities with NSAIDs as predictors of EA in a prospective cohort study of patients with BE...
  34. ncbi request reprint Pitfalls in the interpretation of nonneoplastic mucosal biopsies in inflammatory bowel disease
    Rhonda K Yantiss
    Department of Pathology and Laboratory Medicine of the Weill Medical College of Cornell University, New York, New York, USA
    Am J Gastroenterol 102:890-904. 2007
    ..The potential diagnostic pitfalls faced by physicians, as well as features that aid in the distinction among these entities, are discussed in detail in this review...
  35. ncbi request reprint Squamous dysplasia and other precursor lesions related to esophageal squamous cell carcinoma
    Michio Shimizu
    Department of Pathology, Saitama Medical University International Medical Center, 1397 1 Yamane, Hidaka City, Saitama 350 1298, Japan
    Gastroenterol Clin North Am 36:797-811, v-vi. 2007
    ..This article discusses squamous dysplasia in detail, which is the most important and well-described risk factor for squamous cell carcinoma of the esophagus...
  36. ncbi request reprint Clinicopathologic and immunohistochemical study of small apparently "de novo" colorectal adenocarcinomas
    Jason L Hornick
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 31:207-15. 2007
    ....
  37. ncbi request reprint EMR for Barrett's esophagus-related superficial neoplasms offers better diagnostic reproducibility than mucosal biopsy
    Mari Mino-Kenudson
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Gastrointest Endosc 66:660-6; quiz 767, 769. 2007
    ..It also allows for better pathologic grading compared with mucosal biopsy specimens. However, the interobserver variation in the interpretation of EMR specimens has not been tested...
  38. ncbi request reprint Genetic alterations in serrated adenomas: comparison to conventional adenomas and hyperplastic polyps
    Franz Fogt
    Department of Pathology, Presbyterian Medical Center, University of Pennsylvania, Philadelphia, PA 19104, USA
    Hum Pathol 33:87-91. 2002
    ..05). These results support the hypothesis that serrated adenomas represent a biologically similar morphologic variant of conventional adenomas...
  39. doi request reprint DNA ploidy abnormalities in basal and superficial regions of the crypts in Barrett's esophagus and associated neoplastic lesions
    Xiaoqi Zhang
    Departments of Medicine, Veterans Affairs Boston Healthcare System, Harvard Medical School, West Roxbury, MA 02132, USA
    Am J Surg Pathol 32:1327-35. 2008
    ..These results suggest that with neoplastic progression, dysplastic changes in BE begin in the basal crypt cells and then extend further up the crypts, and BCD represents a true early form of dysplasia limited to the crypt bases...
  40. pmc Dietary supplement use and risk of neoplastic progression in esophageal adenocarcinoma: a prospective study
    Linda M Dong
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, and Department of Epidemiology, University of Washington, Seattle, WA 98109, USA
    Nutr Cancer 60:39-48. 2008
    ..10-0.60). In this cohort study, use of multivitamins and single antioxidant supplements was associated with a significantly reduced risk of EA and markers of neoplastic progression among individuals with Barrett's esophagus...
  41. doi request reprint Alterations in the immunohistochemical expression of Das-1 and CG-3 in colonic mucosal biopsy specimens helps distinguish ulcerative colitis from Crohn disease and from other forms of colitis
    Rhonda K Yantiss
    Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY
    Am J Surg Pathol 32:844-50. 2008
    ..003 for all comparisons). We conclude that the patterns of Das-1 and CG-3 staining in colonic mucosal biopsies may be clinically useful in distinguishing UC from CD and from other colitidies...
  42. doi request reprint Hyperplastic/serrated polyposis in inflammatory bowel disease: a case series of a previously undescribed entity
    Amitabh Srivastava
    Department of Pathology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03755
    Am J Surg Pathol 32:296-303. 2008
    ....
  43. doi request reprint Vascular and lymphatic properties of the superficial and deep lamina propria in Barrett esophagus
    Hejin P Hahn
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 32:1454-61. 2008
    ..quot; Further outcome studies are needed to evaluate the risk of vascular/lymphatic metastasis in BE patients with different levels of LP invasion...
  44. ncbi request reprint Leukocyte telomere length predicts cancer risk in Barrett's esophagus
    Rosa Ana Risques
    Department of Pathology, University of Washington, Seattle, WA 98195 7705, USA
    Cancer Epidemiol Biomarkers Prev 16:2649-55. 2007
    ..Patients and..
  45. ncbi request reprint Buried Barrett's epithelium following photodynamic therapy shows reduced crypt proliferation and absence of DNA content abnormalities
    Jason L Hornick
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Gastroenterol 103:38-47. 2008
    ..The neoplastic potential of buried BE is poorly understood. The aim of this study was to evaluate the biological characteristics of nonburied and buried BE in patients treated with PDT...
  46. ncbi request reprint A comprehensive study of nondysplastic and dysplastic serrated polyps of the vermiform appendix
    Rhonda K Yantiss
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10021, USA
    Am J Surg Pathol 31:1742-53. 2007
    ..These features, including BRAF mutations, may be more closely related to a serrated morphology in appendiceal polyps rather than biologically important changes...
  47. ncbi request reprint Morphologic features are useful in distinguishing Barrett esophagus from carditis with intestinal metaplasia
    Amitabh Srivastava
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02114, USA
    Am J Surg Pathol 31:1733-41. 2007
    ..Larger prospective studies need to be performed to validate these findings and evaluate the reproducibility of this approach in routine clinical practice...
  48. ncbi request reprint Longitudinal study of insulin-like growth factor, insulin-like growth factor binding protein-3, and their polymorphisms: risk of neoplastic progression in Barrett's esophagus
    Sid H Siahpush
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 16:2387-95. 2007
    ..IGF-I and its main binding protein, IGF binding protein-3 (IGFBP-3), and their polymorphisms have been investigated in relation to risk of many cancers, but not esophageal adenocarcinoma...
  49. ncbi request reprint Neoplastic precursor lesions in Barrett's esophagus
    Jason L Hornick
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Gastroenterol Clin North Am 36:775-96, v. 2007
    ..This article focuses on dysplasia in Barrett's esophagus in terms of its classification, pathologic diagnostic criteria, limitations, natural history, and treatment...
  50. ncbi request reprint Low-grade dysplasia in Barrett's esophagus
    Robert D Odze
    Clin Gastroenterol Hepatol 4:1419-20; author reply 1420. 2006
  51. ncbi request reprint Mucin core polypeptide expression in the progression of neoplasia in Barrett's esophagus
    Jonathan N Glickman
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Hum Pathol 37:1304-15. 2006
    ..Alterations in MUC expression occur in the progression of dysplasia in BE. However, none of these markers helps identify a subgroup of patients at increased risk for neoplasia...
  52. ncbi request reprint Cell proliferation and differentiation in familial adenomatous polyposis
    Robert D Odze
    Hum Pathol 35:1430-1. 2004
  53. ncbi request reprint The clinical significance of right-sided colonic inflammation in patients with left-sided chronic ulcerative colitis
    Muthoka L Mutinga
    Brigham and Women s Hospital, Boston University Medical Center, and Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Inflamm Bowel Dis 10:215-9. 2004
    ....
  54. ncbi request reprint Histologic predictors of pouchitis in patients with chronic ulcerative colitis
    Rhonda K Yantiss
    Department of Pathology of the University of Massachusetts Medical School UMass Memorial Health Care, 55 Lake Avenue North, Worcester, MA 01655, USA
    Am J Surg Pathol 28:999-1006. 2004
    ..Of these features, appendiceal ulceration is highly associated with pouchitis...
  55. ncbi request reprint Prognostic significance of vascular endothelial growth factor and cyclooxygenase 2 expression in patients receiving preoperative chemoradiation for esophageal cancer
    Matthew H Kulke
    Department of Adult Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Thorac Cardiovasc Surg 127:1579-86. 2004
    ....
  56. ncbi request reprint Pediatric patients with untreated ulcerative colitis may present initially with unusual morphologic findings
    Jonathan N Glickman
    Department of Pathology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Am J Surg Pathol 28:190-7. 2004
    ..Therefore, the objectives of this study were to determine the clinical and pathologic features of new-onset UC in children and to compare the initial presentation of UC in this group with a control group of adults...
  57. ncbi request reprint Mucin core peptide expression can help differentiate Barrett's esophagus from intestinal metaplasia of the stomach
    Jonathan N Glickman
    Department of Pathology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Am J Surg Pathol 27:1357-65. 2003
    ..Columnar epithelium in the "normal" gastric cardia has a partially intestinalized phenotype and, as a result, may represent an early form of metaplastic epithelium...
  58. ncbi request reprint Management of neoplastic polyps in inflammatory bowel disease
    Sonia Friedman
    Gastroenterology Division, Harvard Medical School, Brigham and Women s Hospital, ASBII, Boston, Massachusetts, U S A
    Inflamm Bowel Dis 9:260-6. 2003
    ..As long as there is no flat dysplasia or adenocarcinoma elsewhere in the colon, a colectomy is not required. However, this group of patients requires increased colonoscopic surveillance...
  59. ncbi request reprint Pathologic features of reflux and Helicobacter pylori-associated carditis: a comparative study
    Tad J Wieczorek
    Department of Pathology, Brigham and Women s Hospital, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Surg Pathol 27:960-8. 2003
    ....
  60. ncbi request reprint The terminal ileum is affected in patients with lymphocytic or collagenous colitis
    Heidi Sapp
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Am J Surg Pathol 26:1484-92. 2002
    ..The results suggest that the terminal ileum may be involved by a similar pathogenic process as the colon in LC and CC...
  61. ncbi request reprint Prevalence and significance of inflammatory bowel disease-like morphologic features in collagenous and lymphocytic colitis
    Gamze Ayata
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    Am J Surg Pathol 26:1414-23. 2002
    ....
  62. ncbi request reprint Morphology of the cardia and significance of carditis in pediatric patients
    Jonathan N Glickman
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Surg Pathol 26:1032-9. 2002
    ....
  63. ncbi request reprint Molecular alterations in chronic ulcerative colitis-associated and sporadic hyperplastic polyps: a comparative analysis
    Robert D Odze
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Gastroenterol 97:1235-42. 2002
    ..The aim of this study was to evaluate and compare the molecular profile of CUC-associated hyperplastic polyps with sporadic hyperplastic polyps of the colon...
  64. ncbi request reprint Interinstitutional variability and effect of tissue fixative on the interpretation of a Barrett cytokeratin 7/20 immunoreactivity pattern in Barrett esophagus
    Jonathan N Glickman
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Hum Pathol 36:58-65. 2005
    ..Nevertheless, specific criteria for interpretation of CK7/20 staining can be successfully applied between institutions and need to be developed before use of this technique in clinical practice...
  65. ncbi request reprint Support for hMLH1 and MGMT silencing as a mechanism of tumorigenesis in the hyperplastic-adenoma-carcinoma (serrated) carcinogenic pathway in the colon
    Kirstine Oh
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School Boston, MA 02115, USA
    Hum Pathol 36:101-11. 2005
    ....
  66. ncbi request reprint Chromosomal instability in Barrett's esophagus is related to telomere shortening
    Jennifer C Finley
    Department of Pathology, University of Washington, Box 357705, Seattle, WA 98195 7705, USA
    Cancer Epidemiol Biomarkers Prev 15:1451-7. 2006
    ....
  67. ncbi request reprint AMACR immunostaining is useful in detecting dysplastic epithelium in Barrett's esophagus, ulcerative colitis, and Crohn's disease
    Russell Dorer
    Department of Pathology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Am J Surg Pathol 30:871-7. 2006
    ..AMACR is involved in the neoplastic progression in BE and IBD. The high degree of specificity of AMACR for dysplasia/carcinoma in BE and IBD suggests that it may be useful to detect neoplastic epithelium in these conditions...
  68. ncbi request reprint Crypt dysplasia with surface maturation: a clinical, pathologic, and molecular study of a Barrett's esophagus cohort
    Leslie C Lomo
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 30:423-35. 2006
    ..Based on these findings, BCDA warrants further investigation as a possible subtype of true dysplasia despite the morphologic appearance of surface maturation...
  69. ncbi request reprint Genetic mechanisms of TP53 loss of heterozygosity in Barrett's esophagus: implications for biomarker validation
    V Jon Wongsurawat
    Divisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 15:509-16. 2006
    ..If an alternative biomarker assay, such as fluorescence in situ hybridization (FISH), provided equivalent results, then translation to the clinic might be accelerated, because LOH genotyping is presently limited to research centers...
  70. ncbi request reprint Prognostic significance of superficial fissuring ulceration in patients with severe "indeterminate" colitis
    Rhonda K Yantiss
    Department of Pathology, University of Massachusetts Medical School UMass Memorial Health Care, Worcester, MA, USA
    Am J Surg Pathol 30:165-70. 2006
    ..Nevertheless, the presence of superficial fissuring-type ulcers in patients with severe chronic active UC denotes a subgroup with a higher risk of pouchitis following surgical resection...
  71. ncbi request reprint Prevalence and significance of prominent mucin pools in the esophagus post neoadjuvant chemoradiotherapy for Barrett's-associated adenocarcinoma
    Jason L Hornick
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Am J Surg Pathol 30:28-35. 2006
    ....
  72. ncbi request reprint Non-steroidal anti-inflammatory drugs and risk of neoplastic progression in Barrett's oesophagus: a prospective study
    Thomas L Vaughan
    Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, Seattle, WA 98109, USA
    Lancet Oncol 6:945-52. 2005
    ..We aimed to assess the role of NSAID in the development of oesophageal adenocarcinoma and precursor lesions in people with Barrett's oesophagus--a metaplastic disorder that confers a high risk of oesophageal adenocarcinoma...
  73. ncbi request reprint Low-fat, high fruit and vegetable diets and weight loss do not affect biomarkers of cellular proliferation in Barrett esophagus
    Alan R Kristal
    Fred Hutchinson Cancer Research Center, Cancer Prevention Program, M4 B402, P O Box 19024, Seattle, WA, USA
    Cancer Epidemiol Biomarkers Prev 14:2377-83. 2005
    ..We conclude that substantial dietary change has no short-term effects on biomarkers of cellular proliferation in Barrett esophagus or on clinical observations of the Barrrett segment...
  74. ncbi request reprint Unraveling the mystery of the gastroesophageal junction: a pathologist's perspective
    Robert D Odze
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Gastroenterol 100:1853-67. 2005
    ..Further prospective trials are needed to adequately evaluate the different etiologic and pathogenetic mechanisms and, most importantly, the risk of malignancy in these two conditions...
  75. ncbi request reprint Significance of squamous metaplasia-like change in the esophagus
    Robert D Odze
    Am J Surg Pathol 29:1259-61; author reply 1261-3. 2005
  76. ncbi request reprint Immunohistochemistry can help distinguish metastatic pancreatic adenocarcinomas from bile duct adenomas and hamartomas of the liver
    Jason L Hornick
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Surg Pathol 29:381-9. 2005
    ..Although p63 and AMACR are also specific for pancreatic adenocarcinoma, their low sensitivity limits their use in clinical practice...
  77. ncbi request reprint Utility of MMP-1, p53, E-cadherin, and collagen IV immunohistochemical stains in the differential diagnosis of adenomas with misplaced epithelium versus adenomas with invasive adenocarcinoma
    Rhonda K Yantiss
    Department of Pathology, UMass Memorial Health Care, Worcester, Massachusetts, U S A
    Am J Surg Pathol 26:206-15. 2002
    ....
  78. ncbi request reprint Inflammatory fibroid polyps are not inflammatory myofibroblastic tumors
    Liron Pantanowitz
    Diagn Cytopathol 31:131. 2004
  79. ncbi request reprint Utility of immunohistochemistry in distinguishing primary adenocarcinomas from metastatic breast carcinomas in the gastrointestinal tract
    Fionnuala P O'Connell
    Department of Pathology, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Arch Pathol Lab Med 129:338-47. 2005
    ..Breast carcinoma often metastasizes to the gastrointestinal tract, especially the stomach, where it is frequently difficult to distinguish from a primary gastric carcinoma...
  80. ncbi request reprint Prevalence and prognostic significance of acinar cell differentiation in pancreatic endocrine tumors
    Rhonda K Yantiss
    Department of Pathology, University of Massachusetts Memorial Medical Center, Worcester 01655, USA
    Am J Surg Pathol 26:893-901. 2002
    ..However, in addition to tumor stage, location in the pancreatic tail and the immunohistochemical expression of synaptophysin and/or Leu-7 may be useful prognostic indicators in patients with these lesions...