Michelle L O'Donoghue

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Utility of amino-terminal pro-brain natriuretic peptide testing for prediction of 1-year mortality in patients with dyspnea treated in the emergency department
    James L Januzzi
    Department of Internal Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Arch Intern Med 166:315-20. 2006
  2. doi request reprint Association between baseline neutrophil count, clopidogrel therapy, and clinical and angiographic outcomes in patients with ST-elevation myocardial infarction receiving fibrinolytic therapy
    Michelle O'Donoghue
    TIMI Study Group, Cardiovascular Division, Brigham and Women s Hospital, 350 Longwood Avenue, 1st Floor, Boston, MA 02115, USA
    Eur Heart J 29:984-91. 2008
  3. pmc Lipoprotein(a) for risk assessment in patients with established coronary artery disease
    Michelle L O'Donoghue
    TIMI Study Group, Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts Electronic address
    J Am Coll Cardiol 63:520-7. 2014
  4. doi request reprint An invasive or conservative strategy in patients with diabetes mellitus and non-ST-segment elevation acute coronary syndromes: a collaborative meta-analysis of randomized trials
    Michelle L O'Donoghue
    TIMI Study Group, Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Am Coll Cardiol 60:106-11. 2012
  5. doi request reprint Atopaxar and its effects on markers of platelet activation and inflammation: results from the LANCELOT CAD program
    Michelle L O'Donoghue
    Cardiovascular Division and TIMI Study Group, Brigham and Women s Hospital, 350 Longwood Avenue, 1st Floor, Boston, MA 02115, USA
    J Thromb Thrombolysis 34:36-43. 2012
  6. doi request reprint Early invasive vs conservative treatment strategies in women and men with unstable angina and non-ST-segment elevation myocardial infarction: a meta-analysis
    Michelle O'Donoghue
    TIMI Study Group, Brigham and Women s Hospital, 350 Longwood Ave, First Floor, Boston, MA 02115, USA
    JAMA 300:71-80. 2008
  7. ncbi request reprint Usefulness of aminoterminal pro-brain natriuretic peptide testing for the diagnostic and prognostic evaluation of dyspneic patients with diabetes mellitus seen in the emergency department (from the PRIDE Study)
    Michelle O'Donoghue
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Am J Cardiol 100:1336-40. 2007
  8. doi request reprint Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: an analysis of two randomised trials
    Michelle L O'Donoghue
    TIMI Study Group, Brigham and Women s Hospital, Boston, MA 02115, USA
    Lancet 374:989-97. 2009
  9. doi request reprint Safety and tolerability of atopaxar in the treatment of patients with acute coronary syndromes: the lessons from antagonizing the cellular effects of Thrombin–Acute Coronary Syndromes Trial
    Michelle L O'Donoghue
    Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 123:1843-53. 2011
  10. pmc Prognostic utility of secretory phospholipase A(2) in patients with stable coronary artery disease
    Michelle L O'Donoghue
    TIMI Study Group, Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02215, USA
    Clin Chem 57:1311-7. 2011

Detail Information

Publications31

  1. ncbi request reprint Utility of amino-terminal pro-brain natriuretic peptide testing for prediction of 1-year mortality in patients with dyspnea treated in the emergency department
    James L Januzzi
    Department of Internal Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Arch Intern Med 166:315-20. 2006
    ..Amino-terminal pro-brain natriuretic peptide (NT-proBNP) is useful for diagnosis and triage of patients with dyspnea, but its role for predicting outcomes in such patients remains undefined...
  2. doi request reprint Association between baseline neutrophil count, clopidogrel therapy, and clinical and angiographic outcomes in patients with ST-elevation myocardial infarction receiving fibrinolytic therapy
    Michelle O'Donoghue
    TIMI Study Group, Cardiovascular Division, Brigham and Women s Hospital, 350 Longwood Avenue, 1st Floor, Boston, MA 02115, USA
    Eur Heart J 29:984-91. 2008
    ..To investigate the association between neutrophil count, outcomes, and benefit of clopidogrel therapy in ST-elevation myocardial infarction (STEMI)...
  3. pmc Lipoprotein(a) for risk assessment in patients with established coronary artery disease
    Michelle L O'Donoghue
    TIMI Study Group, Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts Electronic address
    J Am Coll Cardiol 63:520-7. 2014
    ..The purpose of this study was to assess the prognostic utility of lipoprotein(a) [Lp(a)] in individuals with coronary artery disease (CAD)...
  4. doi request reprint An invasive or conservative strategy in patients with diabetes mellitus and non-ST-segment elevation acute coronary syndromes: a collaborative meta-analysis of randomized trials
    Michelle L O'Donoghue
    TIMI Study Group, Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Am Coll Cardiol 60:106-11. 2012
    ..The purpose of this study was to conduct a meta-analysis to examine an invasive or conservative strategy in diabetic versus nondiabetic patients...
  5. doi request reprint Atopaxar and its effects on markers of platelet activation and inflammation: results from the LANCELOT CAD program
    Michelle L O'Donoghue
    Cardiovascular Division and TIMI Study Group, Brigham and Women s Hospital, 350 Longwood Avenue, 1st Floor, Boston, MA 02115, USA
    J Thromb Thrombolysis 34:36-43. 2012
    ..Although atopaxar increased the concentration of Lp-PLA(2) and IL-18, the clinical relevance of these findings remains unknown and warrants further investigation and validation...
  6. doi request reprint Early invasive vs conservative treatment strategies in women and men with unstable angina and non-ST-segment elevation myocardial infarction: a meta-analysis
    Michelle O'Donoghue
    TIMI Study Group, Brigham and Women s Hospital, 350 Longwood Ave, First Floor, Boston, MA 02115, USA
    JAMA 300:71-80. 2008
    ..Although an invasive strategy is frequently used in patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS), data from some trials suggest that this strategy may not benefit women...
  7. ncbi request reprint Usefulness of aminoterminal pro-brain natriuretic peptide testing for the diagnostic and prognostic evaluation of dyspneic patients with diabetes mellitus seen in the emergency department (from the PRIDE Study)
    Michelle O'Donoghue
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Am J Cardiol 100:1336-40. 2007
    ..09 to 10.7, p <0.001). In conclusion, NT-pro-BNP testing offers valuable diagnostic and prognostic information in the evaluation of dyspneic patients with DM in the ED, using identical cutpoints as the population as whole...
  8. doi request reprint Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: an analysis of two randomised trials
    Michelle L O'Donoghue
    TIMI Study Group, Brigham and Women s Hospital, Boston, MA 02115, USA
    Lancet 374:989-97. 2009
    ..Conflicting data exist as to whether PPIs diminish the efficacy of clopidogrel. We assessed the association between PPI use, measures of platelet function, and clinical outcomes for patients treated with clopidogrel or prasugrel...
  9. doi request reprint Safety and tolerability of atopaxar in the treatment of patients with acute coronary syndromes: the lessons from antagonizing the cellular effects of Thrombin–Acute Coronary Syndromes Trial
    Michelle L O'Donoghue
    Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 123:1843-53. 2011
    ..The primary objective of the Lessons From Antagonizing the Cellular Effects of Thrombin-Acute Coronary Syndromes (LANCELOT—ACS) trial was to evaluate the safety and tolerability of atopaxar in patients with ACS...
  10. pmc Prognostic utility of secretory phospholipase A(2) in patients with stable coronary artery disease
    Michelle L O'Donoghue
    TIMI Study Group, Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02215, USA
    Clin Chem 57:1311-7. 2011
    ..Secretory phospholipase A(2) (sPLA(2)) may contribute to atherogenesis. To date, few prospective studies have examined the utility of sPLA(2) for risk stratification in coronary artery disease (CAD)...
  11. doi request reprint The efficacy and safety of prasugrel with and without a glycoprotein IIb/IIIa inhibitor in patients with acute coronary syndromes undergoing percutaneous intervention: a TRITON-TIMI 38 (Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Pla
    Michelle O'Donoghue
    TIMI Study Group, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Am Coll Cardiol 54:678-85. 2009
    ..We evaluated the efficacy and safety of prasugrel and clopidogrel in the setting of a glycoprotein (GP) IIb/IIIa inhibitor...
  12. doi request reprint Randomized trial of atopaxar in the treatment of patients with coronary artery disease: the lessons from antagonizing the cellular effect of Thrombin–Coronary Artery Disease Trial
    Stephen D Wiviott
    Cardiovascular Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Circulation 123:1854-63. 2011
    ..The phase II Lessons From Antagonizing the Cellular Effect of Thrombin-Coronary Artery Disease (LANCELOT-CAD) trial examined the safety and tolerability of prolonged therapy with atopaxar in subjects with CAD...
  13. ncbi request reprint The effects of ejection fraction on N-terminal ProBNP and BNP levels in patients with acute CHF: analysis from the ProBNP Investigation of Dyspnea in the Emergency Department (PRIDE) study
    Michelle O'Donoghue
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Card Fail 11:S9-14. 2005
    ..Limited data exist regarding the impact of left ventricular ejection fraction (LVEF) on N-terminal pro-brain natriuretic peptide (NT-proBNP) and B-type natriuretic peptide (BNP) levels in patients with acute congestive heart failure (CHF)...
  14. doi request reprint Impact of smoking on antiplatelet effect of clopidogrel and prasugrel after loading dose and on maintenance therapy
    Willibald Hochholzer
    TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am Heart J 162:518-26.e5. 2011
    ..The aims of this analysis were to evaluate the impact of smoking on the antiplatelet effect of clopidogrel and prasugrel and to test the potential interaction of smoking with the treatment effect of these drugs...
  15. doi request reprint AMG145, a monoclonal antibody against proprotein convertase subtilisin kexin type 9, significantly reduces lipoprotein(a) in hypercholesterolemic patients receiving statin therapy: an analysis from the LDL-C Assessment with Proprotein Convertase Subtilisi
    Nihar R Desai
    TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circulation 128:962-9. 2013
    ..Currently, there are few available therapies to lower Lp(a). We sought to evaluate the impact of AMG145, a monoclonal antibody against proprotein convertase subtilisin kexin type 9 (PCSK9), on Lp(a)...
  16. doi request reprint Concomitant administration of clopidogrel with statins or calcium-channel blockers: insights from the TRITON-TIMI 38 (trial to assess improvement in therapeutic outcomes by optimizing platelet inhibition with prasugrel-thrombolysis in myocardial infarctio
    Oluseyi Ojeifo
    Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts
    JACC Cardiovasc Interv 6:1275-81. 2013
    ..This study sought to evaluate the clinical relevance of potential clopidogrel drug-drug interactions...
  17. ncbi request reprint The incidence of kidney injury for patients treated with a high-potency versus moderate-potency statin regimen after an acute coronary syndrome
    Amy Sarma
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA
    J Am Heart Assoc 3:e000784. 2014
    ..Observational studies have raised concerns that high-potency statins increase the risk of acute kidney injury. We therefore examined the incidence of kidney injury across 2 randomized trials of statin therapy...
  18. doi request reprint Clinical uncertainty, diagnostic accuracy, and outcomes in emergency department patients presenting with dyspnea
    Sandy M Green
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Yawkey 5984, 55 Fruit St, Boston, MA 02114, USA
    Arch Intern Med 168:741-8. 2008
    ..We hypothesized that diagnostic uncertainty in this setting is associated with adverse outcomes, and amino-terminal pro-B-type natriuretic peptide (NT-proBNP) testing would improve diagnostic accuracy and reduce diagnostic uncertainty...
  19. ncbi request reprint Effect of body mass index on natriuretic peptide levels in patients with acute congestive heart failure: a ProBNP Investigation of Dyspnea in the Emergency Department (PRIDE) substudy
    Daniel G Krauser
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Am Heart J 149:744-50. 2005
    ..Neither the mechanism of natriuretic peptide suppression in the obese patient nor whether obesity affects natriuretic peptide levels among patients with acute CHF is known...
  20. ncbi request reprint Neither race nor gender influences the usefulness of amino-terminal pro-brain natriuretic peptide testing in dyspneic subjects: a ProBNP Investigation of Dyspnea in the Emergency Department (PRIDE) substudy
    Daniel G Krauser
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Card Fail 12:452-7. 2006
    ..Little is known about the effect of race on NT-proBNP concentrations. Also, NT-proBNP levels may be higher in apparently well women, but the effect of gender on NT-proBNP concentrations in dyspneic patients is not known...
  21. ncbi request reprint Renal function, congestive heart failure, and amino-terminal pro-brain natriuretic peptide measurement: results from the ProBNP Investigation of Dyspnea in the Emergency Department (PRIDE) Study
    Saif Anwaruddin
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Am Coll Cardiol 47:91-7. 2006
    ..Even in the presence of renal insufficiency, NT-proBNP remained a valuable tool for the diagnosis of acute congestive heart failure and it provides important prognostic information...
  22. ncbi request reprint A validated clinical and biochemical score for the diagnosis of acute heart failure: the ProBNP Investigation of Dyspnea in the Emergency Department (PRIDE) Acute Heart Failure Score
    Aaron L Baggish
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Am Heart J 151:48-54. 2006
    ..No method integrating amino-terminal pro-brain natriuretic peptide (NT-proBNP) testing with clinical assessment for the evaluation of patients with suspected acute heart failure (HF) has been described...
  23. pmc Natriuretic peptide testing for the evaluation of critically ill patients with shock in the intensive care unit: a prospective cohort study
    James L Januzzi
    Division of Cardiology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Crit Care 10:R37. 2006
    ..Amino-terminal pro-brain natriuretic peptide (NT-proBNP) is useful in evaluating heart failure, but its role in evaluating patients with shock in the intensive care unit (ICU) is not clear...
  24. ncbi request reprint NT-proBNP levels, echocardiographic findings, and outcomes in breathless patients: results from the ProBNP Investigation of Dyspnoea in the Emergency Department (PRIDE) echocardiographic substudy
    Annabel A Chen
    Division of Cardiology, Cardiac Ultrasound Laboratory, and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, USA
    Eur Heart J 27:839-45. 2006
    ..The objective of this study was to determine the integrative utility of measuring plasma NT-proBNP levels with echocardiography in the evaluation of dyspnoeic patients...
  25. ncbi request reprint Combination of D-dimer and amino-terminal pro-B-type natriuretic Peptide testing for the evaluation of dyspneic patients with and without acute pulmonary embolism
    Stacy E F Melanson
    Department of Pathology, Division of Clinical Laboratories, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    Arch Pathol Lab Med 130:1326-9. 2006
    ..However, clinicians frequently order unnecessary supplemental testing in patients with low concentrations of D-dimer. Elevations in natriuretic peptides have also been described in the setting of pulmonary embolism...
  26. ncbi request reprint The N-terminal Pro-BNP investigation of dyspnea in the emergency department (PRIDE) study
    James L Januzzi
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Cardiol 95:948-54. 2005
    ..NT-proBNP measurement is a valuable addition to standard clinical assessment for the identification and exclusion of acute CHF in the emergency department setting...
  27. ncbi request reprint Evaluation of the diagnostic performance of heart-type fatty acid binding protein in the BWH-TIMI ED chest pain study
    Christian T Ruff
    TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 350 Longwood Avenue, 1st Floor Offices, Boston, MA, 02115, USA
    J Thromb Thrombolysis 36:361-7. 2013
    ..Further studies are needed to determine the utility a very rapid "rule out" of MI with a single blood draw of troponin and H-FABP at presentation...
  28. doi request reprint Study design and rationale for the Stabilization of pLaques usIng Darapladib-Thrombolysis in Myocardial Infarction (SOLID-TIMI 52) trial in patients after an acute coronary syndrome
    Michelle L O'Donoghue
    TIMI Study Group, Cardiovascular Division, Brigham and Women s Hospital, Boston, MA, USA
    Am Heart J 162:613-619.e1. 2011
    ..Darapladib inhibits Lp-PLA(2) activity in plasma and in arterial plaques and may confer clinical benefit in preventing cardiovascular events...
  29. doi request reprint Biomarkers in ACS and heart failure: should men and women be interpreted differently?
    Shweta R Motiwala
    Department of Medicine, Massachusetts General Hospital, Boston, MA
    Clin Chem 60:35-43. 2014
    ..However, to date, few studies have compared the diagnostic and prognostic utility of these markers in men vs women...
  30. ncbi request reprint Response to "Getting the right message"
    James L Januzzi
    Ann Emerg Med 49:381-3; discussion 383; author reply 384. 2007
  31. ncbi request reprint Letter regarding article by Brueckmann et al, "prognostic value of plasma N-terminal pro-brain natriuretic peptide in patients with severe sepsis"
    James L Januzzi
    Circulation 113:e25; author reply e25. 2006