Caroline C O'Brien

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. pmc Impact of flow pulsatility on arterial drug distribution in stent-based therapy
    Caroline C O'Brien
    Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia
    J Control Release 168:115-24. 2013
  2. doi request reprint Analysis of drug distribution from a simulated drug-eluting stent strut using an in vitro framework
    Caroline C O'Brien
    Graduate School of Biomedical Engineering, University of New South Wales, Sydney, NSW, Australia
    Ann Biomed Eng 40:2687-96. 2012
  3. doi request reprint Development of an in vitro method for modeling drug release and subsequent tissue drug uptake and deposition in a pulsatile flow network
    Caroline C O'Brien
    Graduate School of Biomedical Engineering, The University of New South Wales, Sydney, UNSW, Australia 2052
    Conf Proc IEEE Eng Med Biol Soc 2011:3262-5. 2011

Detail Information

Publications3

  1. pmc Impact of flow pulsatility on arterial drug distribution in stent-based therapy
    Caroline C O'Brien
    Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia
    J Control Release 168:115-24. 2013
    ..Our results indicate that factors governing pulsatile luminal flow on arterial drug deposition should be carefully considered in conjunction with device deployment settings for better utilization of drug-eluting stent therapy...
  2. doi request reprint Analysis of drug distribution from a simulated drug-eluting stent strut using an in vitro framework
    Caroline C O'Brien
    Graduate School of Biomedical Engineering, University of New South Wales, Sydney, NSW, Australia
    Ann Biomed Eng 40:2687-96. 2012
    ..Results confirm the existence of inhomogeneous and asymmetric arterial drug distributions, with this distribution shown to be sensitive to the flow field surrounding the strut...
  3. doi request reprint Development of an in vitro method for modeling drug release and subsequent tissue drug uptake and deposition in a pulsatile flow network
    Caroline C O'Brien
    Graduate School of Biomedical Engineering, The University of New South Wales, Sydney, UNSW, Australia 2052
    Conf Proc IEEE Eng Med Biol Soc 2011:3262-5. 2011
    ..Furthermore, these results showed that the novel method could be used to study the effects of luminal flow in the presence of single or multiple struts. The method could also be used to explore more complex drug release strategies...