- Impact of flow pulsatility on arterial drug distribution in stent-based therapyCaroline C O'Brien
Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia
J Control Release 168:115-24. 2013..Our results indicate that factors governing pulsatile luminal flow on arterial drug deposition should be carefully considered in conjunction with device deployment settings for better utilization of drug-eluting stent therapy...
- Analysis of drug distribution from a simulated drug-eluting stent strut using an in vitro frameworkCaroline C O'Brien
Graduate School of Biomedical Engineering, University of New South Wales, Sydney, NSW, Australia
Ann Biomed Eng 40:2687-96. 2012..Results confirm the existence of inhomogeneous and asymmetric arterial drug distributions, with this distribution shown to be sensitive to the flow field surrounding the strut...
- Development of an in vitro method for modeling drug release and subsequent tissue drug uptake and deposition in a pulsatile flow networkCaroline C O'Brien
Graduate School of Biomedical Engineering, The University of New South Wales, Sydney, UNSW, Australia 2052
Conf Proc IEEE Eng Med Biol Soc 2011:3262-5. 2011..Furthermore, these results showed that the novel method could be used to study the effects of luminal flow in the presence of single or multiple struts. The method could also be used to explore more complex drug release strategies...