A L Oaklander

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi Patients with Ehlers Danlos syndrome and CRPS: a possible association?
    Joan M Stoler
    Genetics and Teratology Unit, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Pain 123:204-9. 2006
  2. ncbi The density of remaining nerve endings in human skin with and without postherpetic neuralgia after shingles
    A L Oaklander
    Department of Neurological Surgery, Johns Hopkins Medical Institutions, Boston, MA, USA
    Pain 92:139-45. 2001
  3. ncbi Intractable postherpetic itch and cutaneous deafferentation after facial shingles
    Anne Louise Oaklander
    Neuropathic Pain Study Group, Department of Anesthesiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Pain 96:9-12. 2002
  4. ncbi Herpes zoster itch: preliminary epidemiologic data
    Anne Louise Oaklander
    Nerve Injury Unit, Department of Anesthesiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Pain 4:338-43. 2003
  5. ncbi Evidence of focal small-fiber axonal degeneration in complex regional pain syndrome-I (reflex sympathetic dystrophy)
    Anne Louise Oaklander
    Nerve Injury Unit, Departments of Anesthesiology, Neurology, and Neuropathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Pain 120:235-43. 2006
  6. pmc Objective evidence that small-fiber polyneuropathy underlies some illnesses currently labeled as fibromyalgia
    Anne Louise Oaklander
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA Department of Pathology Neuropathology, Massachusetts General Hospital, Boston, MA, USA Electronic address
    Pain 154:2310-6. 2013
  7. doi Evidence of small-fiber polyneuropathy in unexplained, juvenile-onset, widespread pain syndromes
    Anne Louise Oaklander
    Department of Neurology, Massachusetts General Hospital, 275 Charles St Warren 310, Boston, MA 02114, USA
    Pediatrics 131:e1091-100. 2013
  8. doi Common neuropathic itch syndromes
    Anne Louise Oaklander
    Nerve Injury Unit, Department of Neurology, Massachusetts General Hospital, Boston, 02114, USA
    Acta Derm Venereol 92:118-25. 2012
  9. ncbi Cutaneous innervation: form and function
    Anne Louise Oaklander
    Department of Anesthesiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Am Acad Dermatol 53:1027-37. 2005
  10. doi Mechanisms of pain and itch caused by herpes zoster (shingles)
    Anne Louise Oaklander
    Departments of Neurology and Pathology, Massachusetts General Hospital, Harvard Medical School, 275 Charles Street, Boston, MA 02114, USA
    J Pain 9:S10-8. 2008

Research Grants

  1. Neurite density in skin as a marker for neuropathic pain
    Anne Louise Oaklander; Fiscal Year: 2005

Detail Information

Publications33

  1. ncbi Patients with Ehlers Danlos syndrome and CRPS: a possible association?
    Joan M Stoler
    Genetics and Teratology Unit, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Pain 123:204-9. 2006
    ..We review the clinical presentation of the different Ehlers Danlos syndromes and provide clinical criteria that can be used to screen CRPS patients for EDS for clinical or research purposes...
  2. ncbi The density of remaining nerve endings in human skin with and without postherpetic neuralgia after shingles
    A L Oaklander
    Department of Neurological Surgery, Johns Hopkins Medical Institutions, Boston, MA, USA
    Pain 92:139-45. 2001
    ....
  3. ncbi Intractable postherpetic itch and cutaneous deafferentation after facial shingles
    Anne Louise Oaklander
    Neuropathic Pain Study Group, Department of Anesthesiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Pain 96:9-12. 2002
    ....
  4. ncbi Herpes zoster itch: preliminary epidemiologic data
    Anne Louise Oaklander
    Nerve Injury Unit, Department of Anesthesiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Pain 4:338-43. 2003
    ..These findings indicate a need for research on zoster-associated itch, including prospective studies on frequency, impact, and treatment...
  5. ncbi Evidence of focal small-fiber axonal degeneration in complex regional pain syndrome-I (reflex sympathetic dystrophy)
    Anne Louise Oaklander
    Nerve Injury Unit, Departments of Anesthesiology, Neurology, and Neuropathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Pain 120:235-43. 2006
    ..These results support the hypothesis that CRPS-I is specifically associated with post-traumatic focal MDNI affecting nociceptive small-fibers. This type of nerve injury will remain undetected in most clinical settings...
  6. pmc Objective evidence that small-fiber polyneuropathy underlies some illnesses currently labeled as fibromyalgia
    Anne Louise Oaklander
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA Department of Pathology Neuropathology, Massachusetts General Hospital, Boston, MA, USA Electronic address
    Pain 154:2310-6. 2013
    ..These findings suggest that some patients with chronic pain labeled as fibromyalgia have unrecognized SFPN, a distinct disease that can be tested for objectively and sometimes treated definitively...
  7. doi Evidence of small-fiber polyneuropathy in unexplained, juvenile-onset, widespread pain syndromes
    Anne Louise Oaklander
    Department of Neurology, Massachusetts General Hospital, 275 Charles St Warren 310, Boston, MA 02114, USA
    Pediatrics 131:e1091-100. 2013
    ..We tested the hypothesis that acquired small-fiber polyneuropathy (SFPN), previously uncharacterized in children, contributes to unexplained pediatric widespread pain syndromes...
  8. doi Common neuropathic itch syndromes
    Anne Louise Oaklander
    Nerve Injury Unit, Department of Neurology, Massachusetts General Hospital, Boston, 02114, USA
    Acta Derm Venereol 92:118-25. 2012
    ..This review summarizes current knowledge, admittedly incomplete, on neuropathic itch caused by diseases of the brain, spinal cord, cranial or spinal nerve-roots, and peripheral nerves...
  9. ncbi Cutaneous innervation: form and function
    Anne Louise Oaklander
    Department of Anesthesiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Am Acad Dermatol 53:1027-37. 2005
    ..We review the innervation of the skin and update readers about recent neuroscientific discoveries...
  10. doi Mechanisms of pain and itch caused by herpes zoster (shingles)
    Anne Louise Oaklander
    Departments of Neurology and Pathology, Massachusetts General Hospital, Harvard Medical School, 275 Charles Street, Boston, MA 02114, USA
    J Pain 9:S10-8. 2008
    ..Further human study, by electrophysiological recording, by structural and functional imaging, and by autopsy, should continue to provide much-needed insights...
  11. doi Is reflex sympathetic dystrophy/complex regional pain syndrome type I a small-fiber neuropathy?
    Anne Louise Oaklander
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Ann Neurol 65:629-38. 2009
    ..Restoring the interest of neurologists in RSD/CRPS should improve patient care and broaden our knowledge of small-fiber functions...
  12. pmc Neuropathic itch
    Anne Louise Oaklander
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Semin Cutan Med Surg 30:87-92. 2011
    ..Current treatment recommendations include local or systemic administration of inhibitors of neuronal excitability (especially local anesthetics) and barriers to reduce scratching...
  13. ncbi Pregabalin-withdrawal encephalopathy and splenial edema: a link to high-altitude illness?
    Anne Louise Oaklander
    Nerve Injury Unit, Department of Anesthesiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Ann Neurol 58:309-12. 2005
    ..The similarity of this syndrome to high-altitude cerebral edema suggests a possible common pathophysiology and offers potential therapies...
  14. ncbi Progression of dystonia in complex regional pain syndrome
    Anne Louise Oaklander
    Massachusetts General Hospital, 55 Fruit Street, Clinics 3, Boston, MA 02114, USA
    Neurology 63:751. 2004
  15. ncbi Unilateral nerve injury produces bilateral loss of distal innervation
    Anne Louise Oaklander
    Nerve Injury Unit, Department of Anesthesiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Ann Neurol 55:639-44. 2004
    ..They discredit the practice of using tissues contralateral to an injury to provide normative controls and suggest the possibility of rapid, transmedian postinjury signals between homologous mirror-image neurons...
  16. pmc Endoneurial pathology of the needlestick-nerve-injury model of Complex Regional Pain Syndrome, including rats with and without pain behaviors
    M M Klein
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Eur J Pain 16:28-37. 2012
    ..Spread of pathological changes to nearby ipsilateral and contralateral nerves might potentially contribute to extraterritorial pain in CRPS...
  17. ncbi Small-fiber neuropathy: answering the burning questions
    Ezekiel Fink
    Department of Anesthesiology, Neurology, and Neuropathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Sci Aging Knowledge Environ 2006:pe7. 2006
    ..Infrequently, the underlying cause of small-fiber dysfunction is identified and disease-modifying therapy can be instituted. More commonly, the treatments for small-fiber neuropathy involve symptomatic treatment of neuropathic pain...
  18. ncbi Number of Langerhans immune cells in painful and non-painful human skin after shingles
    Anne Louise Oaklander
    Department of Neurosurgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Arch Dermatol Res 294:529-35. 2003
    ....
  19. ncbi Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 16-2004. A 76-year-old woman with numbness and pain in the feet and legs
    Anthony A Amato
    Department of Neurology, Division of Neuromuscular Medicine, Brigham and Women s Hospital, Boston, USA
    N Engl J Med 350:2181-9. 2004
  20. pmc Effects of distal nerve injuries on dorsal-horn neurons and glia: relationships between lesion size and mechanical hyperalgesia
    J W Lee
    Departments of Neurology and Pathology, Massachusetts General Hospital, Harvard Medical School, 275 Charles Street, Warren 310, Boston, MA 02114, USA
    Neuroscience 158:904-14. 2009
    ..However, the presence of similar dorsal-horn changes in rats without pain behaviors suggests that not all transcellular responses to axotomy are pain-specific...
  21. ncbi Neuropathic pain associated with non-surgical treatment of breast cancer
    Beth F Jung
    Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 604, Rochester, NY 14642, USA
    Pain 118:10-4. 2005
  22. ncbi Postherpetic neuralgia after shingles: an under-recognized cause of chronic vulvar pain
    Anne Louise Oaklander
    Neuropathic Pain Study Group, Departments of Anesthesiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Obstet Gynecol 99:625-8. 2002
    ..5 million American women during their lifetime and leaves about 150,000 with postherpetic neuralgia, a chronic neuropathic pain syndrome. Prompt diagnosis and treatment can minimize pain severity and duration...
  23. pmc Single-agent bortezomib in previously untreated multiple myeloma: efficacy, characterization of peripheral neuropathy, and molecular correlations with response and neuropathy
    Paul G Richardson
    Dana Farber Cancer Institute, 44 Binney St, Dana 1B02, Boston, MA 02115, USA
    J Clin Oncol 27:3518-25. 2009
    ..Baseline myeloma-associated neuropathy seems more common than previously reported, and bortezomib-associated neuropathy, although a common toxicity, is reversible in most patients...
  24. ncbi Central neuropathic itch from spinal-cord cavernous hemangioma: a human case, a possible animal model, and hypotheses about pathogenesis
    Dennis Daniel Dey
    Anesthesia, Neurology and Pathology, Massachusetts General Hospital, 55 Fruit St, Clinics 3, Boston, MA 02114, USA
    Pain 113:233-7. 2005
    ..Study of quisqualate-injected rats may provide leads towards new treatments for neuropathic itch...
  25. ncbi Complex regional pain syndrome: a review of evidence-supported treatment options
    E Daniela Hord
    Massachusetts General Hospital, 55 Fruit Street, Clinics 3, Boston, MA 02114, USA
    Curr Pain Headache Rep 7:188-96. 2003
    ..Other treatments with encouraging published results (eg, neural stimulators) are not used often enough. We hope to encourage clinicians to rely more on evidence-supported treatments for complex regional pain syndrome...
  26. ncbi Needlestick distal nerve injury in rats models symptoms of complex regional pain syndrome
    Sandra M Siegel
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Anesth Analg 105:1820-9, table of contents. 2007
    ..Therefore, we, prospectively investigated whether DNIs are sufficient to cause CRPS-like abnormalities in animals. We used needlestick, a cause of human CRPS, to evaluate lesion-size effects...
  27. ncbi A retrospective analysis of reasons for reoperation following initially successful peripheral nerve stimulation
    Kelly Ishizuka
    Department of Neurological Surgery, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    J Neurosurg 106:388-90. 2007
    ..The authors investigated the causes for surgical reexploration in patients with complex regional pain syndrome Type II who received initial relief of pain from implantation of a peripheral nerve stimulator (PNS)...
  28. ncbi Recommendations for the management of herpes zoster
    Robert H Dworkin
    Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642, USA
    Clin Infect Dis 44:S1-26. 2007
    ..Specific recommendations for the use of these medications are provided. In addition, suggestions are made for treatments that, when used in combination with antiviral therapy, may further reduce pain and other complications of HZ...
  29. ncbi Defining a treatable cause of erythromelalgia: acute adolescent autoimmune small-fiber axonopathy
    Joshua Paticoff
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Anesth Analg 104:438-41. 2007
    ..Similarities to other cases allowed us to tentatively characterize a new treatable cause of erythromelalgia; acute adolescent autoimmune small-fiber axonopathy. In this report we evaluate various options for diagnosis and treatment...
  30. doi Diagnosis and assessment of pain associated with herpes zoster and postherpetic neuralgia
    Robert H Dworkin
    Department of Anesthesiology and Neurology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Pain 9:S37-44. 2008
    ..We review the results of recent research to identify the essential components that must be considered in developing an evidence-based description of pain associated with herpes zoster and PHN...
  31. ncbi Congenital insensitivity to pain: an update
    Elna M Nagasako
    Washington University School of Medicine, St Louis, MO, USA
    Pain 101:213-9. 2003
  32. ncbi Response to "Pain" editorial re: Oaklander et al. (2006)
    Anne Louise Oaklander
    Pain 123:217-8. 2006
  33. ncbi Reply to Prilipko et al
    Anne Louise Oaklander
    Ann Neurol 59:724-5. 2006

Research Grants5

  1. Neurite density in skin as a marker for neuropathic pain
    Anne Louise Oaklander; Fiscal Year: 2005
    ..abstract_text> ..