A A Nierenberg

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi The absence of depressive symptoms is not the presence of wellness: validation of the Clinical Positive Affect Scale
    Andrew A Nierenberg
    Bipolar Clinic and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    Aust N Z J Psychiatry 46:1165-72. 2012
  2. ncbi Mitochondrial modulators for bipolar disorder: a pathophysiologically informed paradigm for new drug development
    Andrew A Nierenberg
    Massachusetts General Hospital, Boston, MA 02114, USA
    Aust N Z J Psychiatry 47:26-42. 2013
  3. ncbi Lithium treatment moderate-dose use study (LiTMUS) for bipolar disorder: a randomized comparative effectiveness trial of optimized personalized treatment with and without lithium
    Andrew A Nierenberg
    Massachusetts General Hospital, Boston, USA
    Am J Psychiatry 170:102-10. 2013
  4. ncbi A brief review of antidepressant efficacy, effectiveness, indications, and usage for major depressive disorder
    Andrew A Nierenberg
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    J Occup Environ Med 50:428-36. 2008
  5. ncbi Treatment-resistant bipolar depression: a STEP-BD equipoise randomized effectiveness trial of antidepressant augmentation with lamotrigine, inositol, or risperidone
    Andrew A Nierenberg
    Massachusetts General Hospital Bipolar Clinic and Research Program, Suite 580, 50 Staniford Street, Boston, MA 02114, USA
    Am J Psychiatry 163:210-6. 2006
  6. ncbi Clinical and diagnostic implications of lifetime attention-deficit/hyperactivity disorder comorbidity in adults with bipolar disorder: data from the first 1000 STEP-BD participants
    Andrew A Nierenberg
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Depression and Clinical Research Program ACC 812, Boston, Massachusetts 02114, USA
    Biol Psychiatry 57:1467-73. 2005
  7. ncbi Suicide risk management for the sequenced treatment alternatives to relieve depression study: applied NIMH guidelines
    Andrew A Nierenberg
    Clinical Research Program, Clinical Psychopharmacology Unit, Massachusetts General Hospital, ACC 812, 15 Parkman Street, Boston, MA 01224, USA
    J Psychiatr Res 38:583-9. 2004
  8. ncbi Placebo-controlled continuation treatment with mirtazapine: acute pattern of response predicts relapse
    Andrew A Nierenberg
    Havard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Neuropsychopharmacology 29:1012-8. 2004
  9. ncbi Prevention of relapse and recurrence in depression: the role of long-term pharmacotherapy and psychotherapy
    Andrew A Nierenberg
    Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 64:13-7. 2003
  10. ncbi Predictors of response to antidepressants general principles and clinical implications
    Andrew A Nierenberg
    Massachusetts General Hospital, WACC 812, 15 Parkman Street, Boston, MA 02114, USA
    Psychiatr Clin North Am 26:345-52, viii. 2003

Research Grants

  1. Pharmacotherapy for Minor Depression
    Andrew Nierenberg; Fiscal Year: 2004
  2. Comparative Effectiveness Study for Bipolar Disorder
    Andrew A Nierenberg; Fiscal Year: 2010

Detail Information

Publications110 found, 100 shown here

  1. ncbi The absence of depressive symptoms is not the presence of wellness: validation of the Clinical Positive Affect Scale
    Andrew A Nierenberg
    Bipolar Clinic and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    Aust N Z J Psychiatry 46:1165-72. 2012
    ..Currently, no clinically useful scale has been developed to measure positive affect. To fill this gap, we developed the Clinical Positive Affect Scale (CPAS)...
  2. ncbi Mitochondrial modulators for bipolar disorder: a pathophysiologically informed paradigm for new drug development
    Andrew A Nierenberg
    Massachusetts General Hospital, Boston, MA 02114, USA
    Aust N Z J Psychiatry 47:26-42. 2013
    ..Based on recent research of the pathophysiology of bipolar disorder, we review the evidence for mitochondrial dysregulation and selected mitochondrial modulators (MM) as potential treatments...
  3. ncbi Lithium treatment moderate-dose use study (LiTMUS) for bipolar disorder: a randomized comparative effectiveness trial of optimized personalized treatment with and without lithium
    Andrew A Nierenberg
    Massachusetts General Hospital, Boston, USA
    Am J Psychiatry 170:102-10. 2013
    ..The authors investigated the comparative effectiveness of more tolerable dosages of lithium as part of optimized personalized treatment (OPT)...
  4. ncbi A brief review of antidepressant efficacy, effectiveness, indications, and usage for major depressive disorder
    Andrew A Nierenberg
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    J Occup Environ Med 50:428-36. 2008
    ..Antidepressants treat major depressive disorder (MDD) with the burden of associated side effects and difficulties with compliance. The purpose of this article is to review the efficacy and effectiveness of antidepressants for MDD...
  5. ncbi Treatment-resistant bipolar depression: a STEP-BD equipoise randomized effectiveness trial of antidepressant augmentation with lamotrigine, inositol, or risperidone
    Andrew A Nierenberg
    Massachusetts General Hospital Bipolar Clinic and Research Program, Suite 580, 50 Staniford Street, Boston, MA 02114, USA
    Am J Psychiatry 163:210-6. 2006
    ..This study represents the first randomized trial of competing options for treatment-resistant bipolar depression and assesses the effectiveness and safety of antidepressant augmentation with lamotrigine, inositol, and risperidone...
  6. ncbi Clinical and diagnostic implications of lifetime attention-deficit/hyperactivity disorder comorbidity in adults with bipolar disorder: data from the first 1000 STEP-BD participants
    Andrew A Nierenberg
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Depression and Clinical Research Program ACC 812, Boston, Massachusetts 02114, USA
    Biol Psychiatry 57:1467-73. 2005
    ....
  7. ncbi Suicide risk management for the sequenced treatment alternatives to relieve depression study: applied NIMH guidelines
    Andrew A Nierenberg
    Clinical Research Program, Clinical Psychopharmacology Unit, Massachusetts General Hospital, ACC 812, 15 Parkman Street, Boston, MA 01224, USA
    J Psychiatr Res 38:583-9. 2004
    ..This paper describes methods derived from the NIMH guidelines used to manage suicidal risk in STAR*D including the use of an interactive voice response system to alert clinicians, regional center directors, and safety officers...
  8. ncbi Placebo-controlled continuation treatment with mirtazapine: acute pattern of response predicts relapse
    Andrew A Nierenberg
    Havard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Neuropsychopharmacology 29:1012-8. 2004
    ..The low relapse rate for patients with an acute placebo pattern switched to placebo suggests specific drug effect played a smaller role in their initial improvement...
  9. ncbi Prevention of relapse and recurrence in depression: the role of long-term pharmacotherapy and psychotherapy
    Andrew A Nierenberg
    Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 64:13-7. 2003
    ..In addition, psychotherapy, alone or combined with medication, has been shown to be effective in preventing further episodes of depression...
  10. ncbi Predictors of response to antidepressants general principles and clinical implications
    Andrew A Nierenberg
    Massachusetts General Hospital, WACC 812, 15 Parkman Street, Boston, MA 02114, USA
    Psychiatr Clin North Am 26:345-52, viii. 2003
    ..This article reviews methodologic issues that have been neglected in the pursuit of predictors to antidepressant response and proposes improved requirements for predictor research that would impact clinical practice...
  11. ncbi Nortriptyline for treatment-resistant depression
    Andrew A Nierenberg
    Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, USA
    J Clin Psychiatry 64:35-9. 2003
    ..This study assesses the efficacy of nortriptyline for patients with treatment-resistant major depression...
  12. ncbi Lithium augmentation of nortriptyline for subjects resistant to multiple antidepressants
    Andrew A Nierenberg
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychopharmacol 23:92-5. 2003
    ..More definitive data await the outcome of the NIMH Sequential Treatment Alternatives to Relieve Depression (STAR*D) study...
  13. ncbi The integration of measurement and management for the treatment of bipolar disorder: a STEP-BD model of collaborative care in psychiatry
    Andrew A Nierenberg
    Bipolar Clinic and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 67:3-7. 2006
    ..This method was shown to be successful in the National Institute of Mental Health (NIMH) Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)...
  14. ncbi Family history of mood disorder and characteristics of major depressive disorder: a STAR*D (sequenced treatment alternatives to relieve depression) study
    Andrew A Nierenberg
    Depression Clinical and Research Program, ACC 812, Massachusetts General Hospital, 15 Parkman Street, Boston, MA 01224, USA
    J Psychiatr Res 41:214-21. 2007
    ....
  15. ncbi Deficits in psychological well-being and quality-of-life in minor depression: implications for DSM-V
    Andrew A Nierenberg
    Bipolar Clinic and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    CNS Neurosci Ther 16:208-16. 2010
    ..To examine deficits in psychological well-being (PWB) and quality-of-life (QOL) in minor depressive disorder (Min D)...
  16. ncbi Lithium treatment -- moderate dose use study (LiTMUS) for bipolar disorder: rationale and design
    Andrew A Nierenberg
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin Trials 6:637-48. 2009
    ..Recent data indicate that lithium use for bipolar disorder has declined over the last decade and that lithium largely has been replaced with alternate, commercially promoted medications that may or may not result in better outcomes...
  17. ncbi An analysis of the efficacy of treatments for bipolar depression
    Andrew A Nierenberg
    Department of Psychiatry, Harvard Medical School and Depression Clinical and Research Program and Bipolar Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 69:4-8. 2008
    ..This article reviews multiple pharmacologic options that should be considered by clinicians treating bipolar disorder in both acute and maintenance phases...
  18. ncbi Vagus nerve stimulation: 2-year outcomes for bipolar versus unipolar treatment-resistant depression
    Andrew A Nierenberg
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Biol Psychiatry 64:455-60. 2008
    ..This study describes the outcome of VNS for bipolar TRD patients participating in the acute and longitudinal pivotal trials and compares their outcome with unipolar TRD patients in the same trials...
  19. ncbi Critical thinking about adverse drug effects: lessons from the psychology of risk and medical decision-making for clinical psychopharmacology
    Andrew A Nierenberg
    Depression and Bipolar Clinical and Research Programs, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Psychother Psychosom 77:201-8. 2008
    ..Our purpose is to increase the awareness of how pharmaceutical companies may influence physicians by framing the risk of medication side effects to favor their products...
  20. ncbi Family history of completed suicide and characteristics of major depressive disorder: a STAR*D (sequenced treatment alternatives to relieve depression) study
    Andrew A Nierenberg
    Depression Clinical and Research Program, Massachusetts General Hospital Harvard Medical School, Boston, MA 01224, USA
    J Affect Disord 108:129-34. 2008
    ..It is unknown, however, whether patients with a family member who committed suicide differ from those without such a history...
  21. ncbi A critical overview of the pharmacologic management of treatment-resistant depression
    Andrew A Nierenberg
    Depression Clinical and Research Program, Massachusetts General Hospital, 50 Staniford Street, Boston, MA 02114, USA
    Psychiatr Clin North Am 30:13-29. 2007
    ....
  22. ncbi A comparison of lithium and T(3) augmentation following two failed medication treatments for depression: a STAR*D report
    Andrew A Nierenberg
    Massachusetts General Hospital, 50 Staniford St, Boston, MA 02114, USA
    Am J Psychiatry 163:1519-30; quiz 1665. 2006
    ..This study compared the effectiveness of lithium versus triiodothyronine (T(3)) augmentation as a third-step treatment for patients with major depressive disorder...
  23. ncbi Body dysmorphic disorder in outpatients with major depression
    Andrew A Nierenberg
    Depression Research Program, Clinical Psychopharmacology Unit, Massachusetts General Hospital and The Consolidated Department of Psychiatry, Harvard Medical School, Boston, MA 02114, USA
    J Affect Disord 69:141-8. 2002
    ..The purpose of this study was to evaluate the rate of BDD in a cohort of consecutive outpatients with typical and atypical major depressive disorder...
  24. ncbi Definitions of antidepressant treatment response, remission, nonresponse, partial response, and other relevant outcomes: a focus on treatment-resistant depression
    A A Nierenberg
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston 02114, USA
    J Clin Psychiatry 62:5-9. 2001
    ..This article reviews the definitions of these terms and their relevance for the study of treatment-resistant depression...
  25. ncbi Residual symptoms after remission of major depressive disorder with citalopram and risk of relapse: a STAR*D report
    A A Nierenberg
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    Psychol Med 40:41-50. 2010
    ..We describe the types and frequency of residual depressive symptoms and their relationship to subsequent depressive relapse after treatment with citalopram in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial...
  26. ncbi Mood disorders and suicide
    A A Nierenberg
    Bipolar Programs, Massachusetts General Hospital, Boston 02114, USA
    J Clin Psychiatry 62:27-30. 2001
    ..Widespread underdiagnosis and undertreatment of major depression and bipolar disorder contribute to an unacceptable risk of suicide, a preventable tragedy...
  27. ncbi Long-term management of chronic depression
    A A Nierenberg
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston 02114, USA
    J Clin Psychiatry 62:17-21. 2001
    ..This article will review data relevant to the long-term management of chronic major depression...
  28. ncbi Timing of onset of antidepressant response with fluoxetine treatment
    A A Nierenberg
    Depression and Clinical Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 157:1423-8. 2000
    ..The purpose of this study was to assess the time until onset of antidepressant response with fluoxetine treatment...
  29. ncbi Do some antidepressants work faster than others?
    A A Nierenberg
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    J Clin Psychiatry 62:22-5. 2001
    ....
  30. ncbi Course and treatment of atypical depression
    A A Nierenberg
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston 02114, USA
    J Clin Psychiatry 59:5-9. 1998
    ..A review and critique of the relevant literature on atypical depression will be presented...
  31. ncbi Factors associated with health-related quality of life among outpatients with major depressive disorder: a STAR*D report
    Madhukar H Trivedi
    Department of Psychiatry, University of Texas UT Southwestern Medical Center, Dallas 75390 9119, and the Clinical Psychopharmacology Unit, Massachusetts General Hospital, Boston, USA
    J Clin Psychiatry 67:185-95. 2006
    ..The aim of this study was to examine sociodemographic and clinical correlates of HRQOL in a large cohort of outpatients with MDD...
  32. ncbi Hypochondriacal concerns in depressed outpatients
    C Demopulos
    Depression Research Program, Massachusetts General Hospital, Boston 02114, USA
    Psychosom Med 58:314-20. 1996
    ....
  33. ncbi Personality disorders and depression
    M Fava
    Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Psychol Med 32:1049-57. 2002
    ..These findings suggest that the lack of stability of PD diagnoses among patients with current MDD may be attributable in part to a direct effect of antidepressant treatment on behaviours and attitudes that comprise PDs...
  34. ncbi Clinical and sociodemographic predictors of response to augmentation, or dose increase among depressed outpatients resistant to fluoxetine 20 mg/day
    R H Perlis
    Depression Clinical and Research Program, Massachusetts General Hospital, WACC 812, 15 Parkman Street, Boston, MA 02114, USA
    Acta Psychiatr Scand 108:432-8. 2003
    ..Factors moderating response to these next-step interventions are not well-studied...
  35. ncbi Income and attrition in the treatment of depression: a STAR*D report
    Diane Warden
    Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9086, USA
    Depress Anxiety 26:622-33. 2009
    ..This report assessed whether attrition rates and predictors of attrition differed among depressed outpatients with different income levels...
  36. ncbi Selecting among second-step antidepressant medication monotherapies: predictive value of clinical, demographic, or first-step treatment features
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Arch Gen Psychiatry 65:870-80. 2008
    ..Little is known about selecting among second-step medications for major depressive disorder after intolerance or lack of remission with an initial selective serotonin reuptake inhibitor...
  37. ncbi T3 blood levels and treatment outcome in depression
    D V Iosifescu
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Int J Psychiatry Med 31:367-73. 2001
    ..CONCLUSION: Abnormal T3-RU levels are rather uncommon in outpatient depression and do not correlate with the response to antidepressant treatment or lack thereof...
  38. ncbi Outcome definitions and predictors in depression
    J Tedlow
    Depression Research Program, Clinical Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Psychother Psychosom 67:266-70. 1998
    ..We therefore wanted to investigate possible relationships between baseline severity of depression and anxiety, and different definitions of outcome among outpatients with major depressive disorder undergoing antidepressant treatment...
  39. ncbi Family history of depression and therapeutic outcome: findings from STAR*D
    Mustafa M Husain
    Department of Psychiatry, University of Texas Southwestern Medical School, Dallas, TX 75390 8898, USA
    J Clin Psychiatry 70:185-95. 2009
    ....
  40. ncbi Long-term implications of early onset in bipolar disorder: data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD)
    Roy H Perlis
    Partners Bipolar Treatment Center at Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 55:875-81. 2004
    ..CONCLUSIONS: Very early or early onset of bipolar disorder might herald a more severe disease course in terms of chronicity and comorbidity. Whether early intervention might modify this risk merits further investigation...
  41. ncbi Sociodemographic, clinical, and treatment characteristics associated with worsened depression during treatment with citalopram: results of the NIMH STAR(*)D trial
    Edward S Friedman
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Depress Anxiety 26:612-21. 2009
    ..But nonresponse can include depression that worsened over the course of treatment, an outcome that has received scant attention...
  42. ncbi Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice
    Madhukar H Trivedi
    Department of Psychiatry, University of Texas Southwestern Medical Center, Exchange Park Express, American General Tower, 6363 Forest Park Rd, Suite 1300, Dallas, TX 75390 9119, USA
    Am J Psychiatry 163:28-40. 2006
    ....
  43. ncbi Does recovery from substance use disorder matter in patients with bipolar disorder?
    Roger D Weiss
    Department of Psychiatry, Harvard Medical School, Boston, USA
    J Clin Psychiatry 66:730-5; quiz 808-9. 2005
    ..To examine the potential impact of recovery from substance use disorder (SUD) on the course of bipolar disorder among patients diagnosed with both bipolar and substance use disorders according to DSM-IV criteria...
  44. ncbi Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9086, USA
    Am J Psychiatry 163:1905-17. 2006
    ..This report describes the participants and compares the acute and longer-term treatment outcomes associated with each of four successive steps in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial...
  45. ncbi Hopelessness and suicidal ideation in outpatients with treatment-resistant depression: prevalence and impact on treatment outcome
    George I Papakostas
    Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, WACC 812, 15 Parkman Street, Boston, Massachusetts, 02114, USA
    J Nerv Ment Dis 191:444-9. 2003
    ..Furthermore, a full 6-week trial of NT, a relatively noradrenergic tricyclic antidepressant, may be particularly useful in patients who have failed to respond to several antidepressants and also report significant hopelessness...
  46. ncbi What predicts attrition in second step medication treatments for depression?: a STAR*D Report
    Diane Warden
    Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9119, USA
    Int J Neuropsychopharmacol 12:459-73. 2009
    ..Focus on patients with attrition risk factors for medication augmentation or switch strategies may enhance retention and improve outcomes...
  47. ncbi Cognitive therapy versus medication in augmentation and switch strategies as second-step treatments: a STAR*D report
    Michael E Thase
    Department of Psychiatry, University of Pittsburgh Medical Center, 3811 OHara St, Pittsburgh, PA 15213 2593, and Massachusetts General Hospital, USA
    Am J Psychiatry 164:739-52. 2007
    ..Cognitive therapy was compared with medication augmentation and switch strategies...
  48. ncbi Sequenced treatment alternatives to relieve depression (STAR*D): rationale and design
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9086, USA
    Control Clin Trials 25:119-42. 2004
    ..Participants with an adequate symptomatic response may enter the 12-month naturalistic follow-up phase with brief monthly and more complete quarterly assessments...
  49. ncbi Tryptophan depletion in SSRI-recovered depressed outpatients
    M K Spillmann
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    Psychopharmacology (Berl) 155:123-7. 2001
    ..No other predicting or mediating factors were identified, although the variable "history of response pattern to medication" deserves further study...
  50. ncbi Management of major depression in the primary care setting
    D Mischoulon
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA, USA
    Psychother Psychosom 70:103-7. 2001
    ..We wished to determine how PCPs in a community clinic setting initially manage patients newly diagnosed with major depression...
  51. ncbi Volume reduction in the caudate nucleus following stereotactic placement of lesions in the anterior cingulate cortex in humans: a morphometric magnetic resonance imaging study
    S L Rauch
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    J Neurosurg 93:1019-25. 2000
    ..The goal of this study was to test hypotheses regarding changes in volume in subcortical structures following anterior cingulotomy...
  52. ncbi Personality and bipolar disorder: dissecting state and trait associations between mood and personality
    J H Barnett
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, and Psychiatric Genetics Program in Mood and Anxiety Disorders, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
    Psychol Med 41:1593-604. 2011
    ..This study aimed to determine whether there is a characteristic personality profile in BD, and whether associations between BD and personality are best explained by state or trait effects...
  53. ncbi Response to a selective serotonin reuptake inhibitor (citalopram) in major depressive disorder with melancholic features: a STAR*D report
    Patrick J McGrath
    Department of Psychiatry, College of Physicians and Surgeons of Columbia University and New York State Psychiatric Institute, New York, NY 10032, USA
    J Clin Psychiatry 69:1847-55. 2008
    ....
  54. ncbi Diagnosing and treating patients with symptoms of depression
    Andrew A Nierenberg
    Depression Clinical and Research Program and the Bipolar Clinic and Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    J Clin Psychiatry 70:e05. 2009
    ..After a patient has been stabilized, long-term treatment is necessary to prevent episode recurrence and to control subsyndromal symptoms...
  55. ncbi Medication augmentation after the failure of SSRIs for depression
    Madhukar H Trivedi
    Mood Disorder Program and Clinic, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9119, USA
    N Engl J Med 354:1243-52. 2006
    ..Although clinicians frequently add a second medication to an initial, ineffective antidepressant drug, no randomized controlled trial has compared the efficacy of this approach...
  56. ncbi Effect of age at onset on the course of major depressive disorder
    Sidney Zisook
    Department of Psychiatry, University of California, San Diego, CA 92093, USA
    Am J Psychiatry 164:1539-46. 2007
    ..This report assesses whether age at onset defines a specific subgroup of major depressive disorder in 4,041 participants who entered the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study...
  57. ncbi Treatment resistant depression and axis I co-morbidity
    T Petersen
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston 02114, USA
    Psychol Med 31:1223-9. 2001
    ..In fact, the only statistical difference showed non-TRD patients with higher co-morbidity rates...
  58. ncbi Strategies for managing depression refractory to selective serotonin reuptake inhibitor treatment: a survey of clinicians
    D Mischoulon
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston 02114, USA
    Can J Psychiatry 45:476-81. 2000
    ..To examine treatment practices in cases where selective serotonin reuptake inhibitors (SSRIs) are ineffective...
  59. ncbi Folate, vitamin B12, and homocysteine in major depressive disorder
    M Fava
    Depression Clinical and Research Program, Clinical Psychopharmacology Unit, Massachusetts General Hospital, Boston 02114, USA
    Am J Psychiatry 154:426-8. 1997
    ..The authors examined the relationships between levels of three metabolites (folate, vitamin B12, and homocysteine) and both depressive subtype and response to fluoxetine treatment in depressed patients...
  60. ncbi Prospective 12-month course of bipolar disorder in out-patients with and without comorbid anxiety disorders
    M W Otto
    Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Br J Psychiatry 189:20-5. 2006
    ..The impact of anxiety disorders has not been well delineated in prospective studies of bipolar disorder...
  61. ncbi Anxiety is associated with impulsivity in bipolar disorder
    Charles T Taylor
    Department of Psychiatry, Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Anxiety Disord 22:868-76. 2008
    ..These data demonstrate that anxiety is positively associated with impulsivity in patients with BD. Further studies are needed to elucidate the implications of and reasons for this association...
  62. ncbi Inositol augmentation of lithium or valproate for bipolar depression
    A Eden Evins
    Harvard Bipolar Research Program and Department of Psychiatry of the Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Bipolar Disord 8:168-74. 2006
    ..Up to half of patients do not respond adequately to currently approved treatments. This study evaluated the efficacy of adjunctive inositol for bipolar depression...
  63. ncbi Suicidal ideation and depressive symptoms among bipolar patients as predictors of the health and well-being of caregivers
    Cheryl A Chessick
    Department of Psychiatry, University of Colorado Denver School of Medicine, Denver, CO 80045, USA
    Bipolar Disord 11:876-84. 2009
    ..This study examined whether caregivers' health is associated with changes in suicidal ideation and depressive symptoms among bipolar patients observed over one year...
  64. ncbi Duloxetine versus escitalopram and placebo in the treatment of patients with major depressive disorder: onset of antidepressant action, a non-inferiority study
    Andrew A Nierenberg
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA, USA
    Curr Med Res Opin 23:401-16. 2007
    ..The purpose of this non-inferiority study was to compare the speed of onset of antidepressant efficacy for duloxetine (a dual serotonin and norepinephrine reuptake inhibitor) and escitalopram (a selective serotonin reuptake inhibitor)...
  65. ncbi Bupropion-SR, sertraline, or venlafaxine-XR after failure of SSRIs for depression
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9086, USA
    N Engl J Med 354:1231-42. 2006
    ..After unsuccessful treatment for depression with a selective serotonin-reuptake inhibitor (SSRI), it is not known whether switching to one antidepressant is more effective than switching to another...
  66. ncbi Vagus nerve stimulation for treatment-resistant depression: a randomized, controlled acute phase trial
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Biol Psychiatry 58:347-54. 2005
    ..Vagus nerve stimulation (VNS) alters both concentrations of neurotransmitters or their metabolites and functional activity of central nervous system regions dysregulated in mood disorders. An open trial has suggested efficacy...
  67. ncbi Background and rationale for the sequenced treatment alternatives to relieve depression (STAR*D) study
    Maurizio Fava
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
    Psychiatr Clin North Am 26:457-94, x. 2003
    ..This article provides the overall rationale for STAR*D and details the rationale for key design, measurement, and analytic features of the study...
  68. ncbi Fenfluramine challenge in unipolar depression with and without anger attacks
    M Fava
    Depression Clinical and Research Program, WACC 812, Massachusetts General Hospital, 15 Parkman Street, Boston, MA 02114, USA
    Psychiatry Res 94:9-18. 2000
    ....
  69. ncbi Emergence of adverse events following discontinuation of treatment with extended-release venlafaxine
    M Fava
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 154:1760-2. 1997
    ..The rate of adverse events following discontinuation of treatment with extended-release venlafaxine was compared with the rate associated with discontinuation of placebo administration...
  70. ncbi Use of the five-factory inventory in characterizing patients with major depressive disorder
    T Petersen
    Department of Psychiatry, Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    Compr Psychiatry 42:488-93. 2001
    ..Future studies should examine how such personality factors affect response to treatment and course of illness...
  71. ncbi An open trial of oral sildenafilin antidepressant-induced sexual dysfunction
    M Fava
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, Mass 02114, USA
    Psychother Psychosom 67:328-31. 1998
    ..The goal of our study was to evaluate its efficacy in a small sample of outpatients with antidepressant-induced sexual dysfunction...
  72. ncbi Health-related quality of life in depression: a STAR*D report
    Ella J Daly
    Department of Psychiatry, University of Texas Southwestern Medical School at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9119, USA
    Ann Clin Psychiatry 22:43-55. 2010
    ..This report examined the psychological, physical, and social domains in a large sample of outpatients who entered the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial...
  73. ncbi Tachyphylaxis after repeated antidepressant drug exposure in patients with recurrent major depressive disorder
    Jay D Amsterdam
    Depression Research Unit, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 3309, USA
    Neuropsychobiology 59:227-33. 2009
    ..The aim of this post hoc analysis was to examine whether tachyphylaxis occurs after repeated courses of antidepressant drug therapy...
  74. ncbi Predictors of attrition during initial (citalopram) treatment for depression: a STAR*D report
    Diane Warden
    Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9086, USA
    Am J Psychiatry 164:1189-97. 2007
    ..The purpose of this study was to identify the pretreatment predictors of attrition during acute treatment with citalopram in a large, "real world" clinical trial...
  75. ncbi Illness beliefs of depressed Chinese American patients in primary care
    Albert Yeung
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    J Nerv Ment Dis 192:324-7. 2004
    ..5%) for their depressive symptoms. The results suggest that many Chinese Americans do not consider depressed mood a symptom to report to their physicians, and many are unfamiliar with depression as a treatable psychiatric disorder...
  76. ncbi An evaluation of the quick inventory of depressive symptomatology and the hamilton rating scale for depression: a sequenced treatment alternatives to relieve depression trial report
    A John Rush
    Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9086, USA
    Biol Psychiatry 59:493-501. 2006
    ..This report compares the performance of these three versions of the QIDS and the 17-item Hamilton Rating Scale for Depression (HRSD17)...
  77. ncbi Major depressive disorder with anger attacks and subcortical MRI white matter hyperintensities
    Dan V Iosifescu
    Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Nerv Ment Dis 195:175-8. 2007
    ..Atypical and melancholic MDD subtypes were not significantly associated with brain WMH. In conclusion, subcortical brain vascular lesions may be more prevalent or severe in MDD with anger attacks...
  78. ncbi Aims and results of the NIMH systematic treatment enhancement program for bipolar disorder (STEP-BD)
    C L Bowden
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    CNS Neurosci Ther 18:243-9. 2012
    ..STEP-BD has established procedures that are relevant to future collaborative research programs aimed at the systematic study of the complex, intrinsically important elements of bipolar disorders...
  79. ncbi Efficacy of mirtazapine for prevention of depressive relapse: a placebo-controlled double-blind trial of recently remitted high-risk patients
    M E Thase
    University of Pittsburgh School of Medicine, Department of Psychiatry, Western Psychiatric Institute and Clinic, PA 15213 2593, USA
    J Clin Psychiatry 62:782-8. 2001
    ..The current study was performed to evaluate the efficacy and safety of up to 1 year of mirtazapine therapy, using a more rigorous, randomized, placebo-controlled discontinuation design...
  80. ncbi Bipolar disorder with frequent mood episodes in the national comorbidity survey replication (NCS-R)
    A A Nierenberg
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
    Mol Psychiatry 15:1075-87. 2010
    ..Whether these indicators of severity merely reflect attenuated effects of rapid cycling or independent effects of sub-threshold rapid cycling warrants further study given the high proportion of lifetime cases who met criteria for FME...
  81. ncbi Correlates of subjective and objective burden among caregivers of patients with bipolar disorder
    M J Ostacher
    Massachusetts General Hospital, Bipolar Clinic and Research Program, Boston, MA, and Department of Psychiatry, Harvard Medical School, Boston, MA 02114, USA
    Acta Psychiatr Scand 118:49-56. 2008
    ..We examined the relationship between mood symptoms and episodes in patients with bipolar disorder and burden reported by their primary caregivers...
  82. ncbi Use of the Chinese version of the Beck Depression Inventory for screening depression in primary care
    Albert Yeung
    Depression Clinical and Research Program, Massachusetts General Hospital, 50 Staniford St, Suite 401, Boston, Massachusetts 02114, USA
    J Nerv Ment Dis 190:94-9. 2002
    ..Lack of interest among Chinese-American patients in using the CBDI as a self-rating instrument has limited its use for depression screening in primary care settings...
  83. ncbi Primary versus specialty care outcomes for depressed outpatients managed with measurement-based care: results from STAR*D
    Bradley N Gaynes
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    J Gen Intern Med 23:551-60. 2008
    ..Whether the acute outcomes of major depressive disorder (MDD) treated in primary (PC) or specialty care (SC) settings are different is unknown...
  84. ncbi Brain MRI white matter hyperintensities and one-carbon cycle metabolism in non-geriatric outpatients with major depressive disorder (Part II)
    George I Papakostas
    Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Psychiatry Res 140:301-7. 2005
    ....
  85. ncbi Clinical and demographic factors associated with DSM-IV melancholic depression
    Ahsan Y Khan
    University of Kansas School of Medicine Wichita, Department of Psychiatry, Wichita, KS, USA
    Ann Clin Psychiatry 18:91-8. 2006
    ..The purpose of this paper is to use demographic and clinical data from a large diverse group of outpatients diagnosed with non-psychotic major depression to investigate the validity of the DSM-IV concept of melancholic depression...
  86. ncbi Case records of the Massachusetts General Hospital. Case 14-2008. A 78-year-old man with anergia and anhedonia associated with cardiovascular surgery
    Jeffery C Huffman
    Department of Psychiatry, Massachusetts General Hospital, USA
    N Engl J Med 358:2051-9. 2008
  87. ncbi Brain white-matter hyperintensities and treatment outcome in major depressive disorder
    Dan V Iosifescu
    Massachusetts General Hospital, 50 Staniford Street, Suite 401, Boston, Massachusetts 02114, USA
    Br J Psychiatry 188:180-5. 2006
    ..CONCLUSIONS: Subcortical white-matter hyperintensities in the left hemisphere (but notin other brain areas) maybe associated with poor response to antidepressant treatment in major depression...
  88. ncbi A detailed examination of cytokine abnormalities in Major Depressive Disorder
    N M Simon
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Eur Neuropsychopharmacol 18:230-3. 2008
    ..These data support a generalized chronic inflammatory state in MDD, and implicate additional cytokines and chemokines previously linked to cardiovascular disease...
  89. ncbi Persistent posttraumatic stress disorder following September 11 in patients with bipolar disorder
    Mark H Pollack
    Department of Psychiatry, Massachusetts General Hospital, Boston, Mass, USA
    J Clin Psychiatry 67:394-9. 2006
    ....
  90. ncbi Somatic symptoms in treatment-resistant depression
    George I Papakostas
    Department of Psychiatry, Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Psychiatry Res 118:39-45. 2003
    ..The overwhelming majority of patients with TRD presented with somatic symptoms. In addition, a greater number of somatic symptoms during the screen visit placed patients at risk for further treatment resistance...
  91. ncbi Effectiveness of adjunctive antidepressant treatment for bipolar depression
    Gary S Sachs
    Bipolar Clinic and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    N Engl J Med 356:1711-22. 2007
    ..Our study was designed to determine whether adjunctive antidepressant therapy reduces symptoms of bipolar depression without increasing the risk of mania...
  92. ncbi Treatment-resistant depression and Axis II comorbidity
    Timothy Petersen
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, Mass 02114, USA
    Psychother Psychosom 71:269-74. 2002
    ....
  93. ncbi S-adenosyl-L-methionine (SAMe) as an adjunct for resistant major depressive disorder: an open trial following partial or nonresponse to selective serotonin reuptake inhibitors or venlafaxine
    Jonathan E Alpert
    Depression Clinical and Research Program, Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychopharmacol 24:661-4. 2004
    ..The purpose of this open trial was to evaluate the safety, tolerability, and efficacy of oral S-adenosyl-L-methionine as an antidepressant adjunct among partial and nonresponders to serotonin reuptake inhibitors or venlafaxine...
  94. ncbi Somatic symptoms in outpatients with major depressive disorder treated with fluoxetine
    John W Denninger
    Massachusetts General Hospital, Depression Clinical and Research Program, Dept of Psychiatry, 50 Staniford St, Suite 401, Boston, MA 02114 2541, USA
    Psychosomatics 47:348-52. 2006
    ..Taken together, these findings suggest that developing treatment strategies that successfully target somatic symptoms of depression may further improve the ability to treat depression to remission...
  95. ncbi Is unrecognized bipolar disorder a frequent contributor to apparent treatment resistant depression?
    R Correa
    Department of Psychiatry, University of California San Diego UCSD, USA
    J Affect Disord 127:10-8. 2010
    ..This review attempts to assess the degree to which prevailing empirical data supports that view...
  96. ncbi Screening for major depression in Asian-Americans: a comparison of the Beck and the Chinese Depression Inventory
    A Yeung
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, Massachusetts, USA
    Acta Psychiatr Scand 105:252-7. 2002
    ..This study compares the effectiveness of the Chinese version of the Beck Depression Inventory (CBDI) and the Chinese Depression Inventory (CDI) in screening for depression among Chinese Americans...
  97. ncbi Cerebral metabolic correlates as potential predictors of response to anterior cingulotomy for obsessive compulsive disorder
    S L Rauch
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 50:659-67. 2001
    ..Further research, utilizing a prospective design, is indicated to determine the validity and reliability of this finding. If confirmed, an index for noninvasively predicting response to cingulotomy for OCD would be of great value...
  98. ncbi Psychotherapy and medication in the treatment of adult and geriatric depression: which monotherapy or combined treatment?
    Steven D Hollon
    Department of Psychology, Vanderbilt University, Nashville, TN 37203, USA
    J Clin Psychiatry 66:455-68. 2005
    ..The authors reviewed the literature with respect to the relative efficacy of medications and psychotherapy alone and in combination in the treatment of depression...
  99. ncbi Hypericum extract in patients with MDD and reversed vegetative signs: re-analysis from data of a double-blind, randomized trial of hypericum extract, fluoxetine, and placebo
    Harald Murck
    Lichtwer Pharma GmbH, Berlin, Germany
    Int J Neuropsychopharmacol 8:215-21. 2005
    ..These data are based on a small sample size and must be considered tentative. A characterization of vegetative features of patients with depression could lead to an overall increased effect size in the treatment with HE...
  100. ncbi Addition of atomoxetine for depression incompletely responsive to sertraline: a randomized, double-blind, placebo-controlled study
    David Michelson
    Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, Ind, USA
    J Clin Psychiatry 68:582-7. 2007
    ..Addition of a noradrenergic intervention in patients poorly or partially responsive to SSRIs may improve outcomes, but few well-controlled studies testing this hypothesis have been reported...
  101. ncbi Presenting characteristics of depressed outpatients as a function of recurrence: preliminary findings from the STAR*D clinical trial
    Steven D Hollon
    Department of Psychology, Vanderbilt University, 306 Wilson Hall, Nashville, TN 37203, United States
    J Psychiatr Res 40:59-69. 2006
    ..Recurrent depression predicts risk for subsequent episodes, but it is unclear how it relates to demographic features, course of illness, and clinical presentation...

Research Grants6

  1. Pharmacotherapy for Minor Depression
    Andrew Nierenberg; Fiscal Year: 2004
    ..The results of this study will have profound public health implications by improving our understanding of the efficacy of SJW and standard antidepressants for the treatment of MinorD. ..
  2. Comparative Effectiveness Study for Bipolar Disorder
    Andrew A Nierenberg; Fiscal Year: 2010
    ..The two treatments will be the second generation antipsychotic mood stabilizer quetiapine and the classic mood stabilizer lithium. In addition to quetiapine or lithium, participants can be treated with other medications as needed. ..