Christopher Newton-Cheh

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study
    Christopher Newton-Cheh
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S7. 2007
  2. ncbi Common genetic variation in KCNH2 is associated with QT interval duration: the Framingham Heart Study
    Christopher Newton-Cheh
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
    Circulation 116:1128-36. 2007
  3. ncbi Genetic determinants of QT interval variation and sudden cardiac death
    Christopher Newton-Cheh
    Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, NHLBI s Framingham Heart Study, Cardiology Division, Massachusetts General Hospital, Boston, MA 02114, USA
    Curr Opin Genet Dev 17:213-21. 2007
  4. ncbi Clinical and genetic correlates of aldosterone-to-renin ratio and relations to blood pressure in a community sample
    Christopher Newton-Cheh
    Framingham Heart Study of the National Heart Lung and Blood Institute and Boston University School of Medicine, Framingham, MA 01702 5827, USA
    Hypertension 49:846-56. 2007
  5. ncbi Common genetic variation at the endothelial nitric oxide synthase locus and relations to brachial artery vasodilator function in the community
    Sekar Kathiresan
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA
    Circulation 112:1419-27. 2005
  6. ncbi Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level
    Sekar Kathiresan
    Framingham Heart Study, Framingham, MA 01702 5827, USA
    Circulation 113:1415-23. 2006
  7. pmc Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study
    Ramachandran S Vasan
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S2. 2007
  8. pmc Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness
    Daniel Levy
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S3. 2007
  9. pmc Common variants in cardiac ion channel genes are associated with sudden cardiac death
    Christine M Albert
    Center for Arrhythmia Prevention, Division of Preventive Medicine, Cardiovascular Division, Channing Laboratory, and Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115 1204, USA
    Circ Arrhythm Electrophysiol 3:222-9. 2010
  10. ncbi Multiple biomarkers for the prediction of first major cardiovascular events and death
    Thomas J Wang
    Framingham Heart Study, Framingham, MA, USA
    N Engl J Med 355:2631-9. 2006

Research Grants

  1. Genetic determinants of cardiac repolarization
    Christopher Newton Cheh; Fiscal Year: 2007
  2. Genetic determinants of cardiac repolarization
    Christopher Newton Cheh; Fiscal Year: 2008

Detail Information

Publications56

  1. pmc Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study
    Christopher Newton-Cheh
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S7. 2007
    ..We report the results of a community-based genomewide association study of six ECG and HRV intermediate traits...
  2. ncbi Common genetic variation in KCNH2 is associated with QT interval duration: the Framingham Heart Study
    Christopher Newton-Cheh
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
    Circulation 116:1128-36. 2007
    ..We tested common KCNH2 variants for association with continuous QT interval duration...
  3. ncbi Genetic determinants of QT interval variation and sudden cardiac death
    Christopher Newton-Cheh
    Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, NHLBI s Framingham Heart Study, Cardiology Division, Massachusetts General Hospital, Boston, MA 02114, USA
    Curr Opin Genet Dev 17:213-21. 2007
    ..Identification of genetic variation underlying myocardial repolarization could have important implications for the prevention of both sporadic and drug-induced arrhythmias...
  4. ncbi Clinical and genetic correlates of aldosterone-to-renin ratio and relations to blood pressure in a community sample
    Christopher Newton-Cheh
    Framingham Heart Study of the National Heart Lung and Blood Institute and Boston University School of Medicine, Framingham, MA 01702 5827, USA
    Hypertension 49:846-56. 2007
    ..16; 95% CI: 1.00 to 1.33). ARR is a heritable trait influenced by clinical and genetic factors. There is a continuous gradient of increasing risk of BP progression across ARR levels in nonhypertensive individuals...
  5. ncbi Common genetic variation at the endothelial nitric oxide synthase locus and relations to brachial artery vasodilator function in the community
    Sekar Kathiresan
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA
    Circulation 112:1419-27. 2005
    ..Sequence variants at the endothelial nitric oxide synthase (NOS3) locus have been associated with endothelial function measures, but replication has been limited...
  6. ncbi Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level
    Sekar Kathiresan
    Framingham Heart Study, Framingham, MA 01702 5827, USA
    Circulation 113:1415-23. 2006
    ..Serum C-reactive protein (CRP) level is a heritable complex trait that predicts incident cardiovascular disease. We investigated the clinical and genetic sources of interindividual variability in serum CRP...
  7. pmc Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study
    Ramachandran S Vasan
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S2. 2007
    ..We conducted a genome-wide association study (GWAS) in the community-based Framingham Heart Study...
  8. pmc Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness
    Daniel Levy
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S3. 2007
    ..Increased arterial stiffness is a key factor in the pathogenesis of systolic hypertension and cardiovascular disease. Substantial heritability of blood-pressure (BP) and arterial-stiffness suggests important genetic contributions...
  9. pmc Common variants in cardiac ion channel genes are associated with sudden cardiac death
    Christine M Albert
    Center for Arrhythmia Prevention, Division of Preventive Medicine, Cardiovascular Division, Channing Laboratory, and Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115 1204, USA
    Circ Arrhythm Electrophysiol 3:222-9. 2010
    ....
  10. ncbi Multiple biomarkers for the prediction of first major cardiovascular events and death
    Thomas J Wang
    Framingham Heart Study, Framingham, MA, USA
    N Engl J Med 355:2631-9. 2006
    ..Few investigations have evaluated the incremental usefulness of multiple biomarkers from distinct biologic pathways for predicting the risk of cardiovascular events...
  11. pmc Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes
    Martin G Larson
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S5. 2007
    ..Prior investigations have reported several single gene variants associated with CHD, stroke, HF, and AF. We report a community-based genome-wide association study of major CVD outcomes...
  12. pmc Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure
    Christopher Newton-Cheh
    Center for Human Genetic Research, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Nat Genet 41:348-53. 2009
    ..85-0.95, P = 2 x 10(-4), respectively). Common genetic variants at the NPPA-NPPB locus found to be associated with circulating natriuretic peptide concentrations contribute to interindividual variation in blood pressure and hypertension...
  13. pmc Cardiac natriuretic peptides, obesity, and insulin resistance: evidence from two community-based studies
    Abigail May Khan
    Cardiology Division, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 96:3242-9. 2011
    ..It has been suggested that obesity promotes a relative natriuretic peptide deficiency, but this has been a variable finding in prior studies and the cause is unknown...
  14. pmc QT interval and long-term mortality risk in the Framingham Heart Study
    Peter A Noseworthy
    Cardiovascular Research Center and Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Ann Noninvasive Electrocardiol 17:340-8. 2012
    ..We examined the QT-mortality relationship in the Framingham Heart Study (FHS)...
  15. pmc Common variants at ten loci influence QT interval duration in the QTGEN Study
    Christopher Newton-Cheh
    Center for Human Genetic Research, Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA
    Nat Genet 41:399-406. 2009
    ..5% of the variation in QT interval. These results, together with an accompanying paper, offer insights into myocardial repolarization and suggest candidate genes that could predispose to sudden cardiac death and drug-induced arrhythmias...
  16. pmc Relations of inflammatory biomarkers and common genetic variants with arterial stiffness and wave reflection
    Renate Schnabel
    National Heart Lung and Blood Institute Framingham Study, Framingham, Mass, USA
    Hypertension 51:1651-7. 2008
    ..Additional studies are needed to determine whether variation in inflammatory marker genes is associated with tonometry measures...
  17. pmc Association of parental hypertension with concentrations of select biomarkers in nonhypertensive offspring
    Wolfgang Lieb
    Framingham Heart Study, 73 Mount Wayte Ave, Framingham, MA 01702 5803, USA
    Hypertension 52:381-6. 2008
    ..In conclusion, serum C-reactive protein concentrations are higher in nonhypertensive offspring of parents with hypertension. These data suggest that inflammation may partly mediate the familial influences on hypertension risk...
  18. pmc Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes
    Jason Flannick
    1 Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology MIT, Cambridge, Massachusetts, USA 2 Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA 3 Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts, USA 4
    Nat Genet 45:1380-5. 2013
    ..Accurate estimates of variant effect sizes from population-based sequencing are needed to avoid falsely predicting a substantial fraction of individuals as being at risk for MODY or other Mendelian diseases...
  19. ncbi Plasma renin and risk of cardiovascular disease and mortality: the Framingham Heart Study
    Nisha I Parikh
    Framingham Heart Study, Boston University School of Medicine, 73 Mount Wayte Avenue, Suite 2, Framingham, MA 01702 5803, USA
    Eur Heart J 28:2644-52. 2007
    ..We related plasma renin to incidence of CVD and mortality in 3408 individuals (mean age 59; 53% women) and in a hypertensive subset (n = 1413)...
  20. ncbi Multiple biomarkers and the risk of incident hypertension
    Thomas J Wang
    Framingham Heart Study, Framingham, Mass, USA
    Hypertension 49:432-8. 2007
    ..These data support the premise that abnormalities in multiple biological pathways antedate the onset of overt hypertension...
  21. pmc Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
    Sekar Kathiresan
    Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Genet 40:189-97. 2008
    ..Understanding the molecular, cellular and clinical consequences of the newly identified loci may inform therapy and clinical care...
  22. pmc Effects of subacute dietary salt intake and acute volume expansion on diastolic function in young normotensive individuals
    Gary S Mak
    Cardiac Ultrasound Laboratory and Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Eur Heart J Cardiovasc Imaging 14:1092-8. 2013
    ..Effects of subacute sodium loading with excess dietary salt on diastolic function in normotensive individuals have been conflicting and the mechanisms are poorly understood...
  23. pmc Increased burden of cardiovascular disease in carriers of APOL1 genetic variants
    Kaoru Ito
    From the Department of Genetics, Harvard Medical School, Boston, MA K I, A G B, M G P, S R D, J N H, J G S, C S Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge K I, A G B, J F, G G, N G, S B G, C N C, S K, J N H, D M A, M R P, J G S, C S Center for Human Genetic Research, Massachusetts General Hospital, Boston J F, C N C, S K, D M A Division of Nephrology, Department of Medicine D J F, G G, M R P and Center for Vascular Biology Research, Department of Medicine D J F, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston
    Circ Res 114:845-50. 2014
    ..Approximately 14% of Americans with African ancestry carry 2 APOL1 risk alleles, accounting for the high chronic kidney disease burden in this population...
  24. doi Polymorphisms associated with cholesterol and risk of cardiovascular events
    Sekar Kathiresan
    Cardiovascular Disease Prevention Center, Cardiology Division, Massachusetts General Hospital, MA 02114, USA
    N Engl J Med 358:1240-9. 2008
    ..We tested the hypothesis that a combination of such SNPs contributes to the risk of cardiovascular disease...
  25. pmc The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports
    L Adrienne Cupples
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S1. 2007
    ....
  26. pmc A meta-analysis of genome-wide association studies of the electrocardiographic early repolarization pattern
    Moritz F Sinner
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA, USA
    Heart Rhythm 9:1627-34. 2012
    ..The early repolarization pattern (ERP) is common and associated with risk of sudden cardiac death. ERP is heritable, and mutations have been described in syndromatic cases...
  27. pmc Resequencing and clinical associations of the 9p21.3 region: a comprehensive investigation in the Framingham heart study
    Andrew D Johnson
    National Institutes of Health National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    Circulation 127:799-810. 2013
    ..3 region followed by a comprehensive study of genetic associations with clinical and subclinical cardiovascular disease and its risk factors, as well as with copy number variation and gene expression, in the Framingham Heart Study (FHS)...
  28. pmc Common variants in KCNN3 are associated with lone atrial fibrillation
    Patrick T Ellinor
    1 Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA 2 Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, Massachusetts, USA 3 Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA 4 These authors contributed equally to this work
    Nat Genet 42:240-4. 2010
    ..52, 95% CI 1.40-1.64; P = 1.83 x 10(-21)). rs13376333 is intronic to KCNN3, which encodes a potassium channel protein involved in atrial repolarization...
  29. pmc Long-term outcomes in individuals with prolonged PR interval or first-degree atrioventricular block
    Susan Cheng
    Framingham Heart Study, Framingham, Massachusetts, USA
    JAMA 301:2571-7. 2009
    ..Prolongation of the electrocardiographic PR interval, known as first-degree atrioventricular block when the PR interval exceeds 200 milliseconds, is frequently encountered in clinical practice...
  30. ncbi Heritability, linkage, and genetic associations of exercise treadmill test responses
    Erik Ingelsson
    Framingham Study, Framingham, Mass, USA
    Circulation 115:2917-24. 2007
    ..The blood pressure (BP) and heart rate responses to exercise treadmill testing predict incidence of cardiovascular disease, but the genetic determinants of hemodynamic and chronotropic responses to exercise are largely unknown...
  31. pmc Development of a risk score for atrial fibrillation (Framingham Heart Study): a community-based cohort study
    Renate B Schnabel
    Framingham Heart Study, Framingham, MA, USA Department of Medicine II, Johannes Gutenberg University, Mainz, Germany
    Lancet 373:739-45. 2009
    ..We aimed to develop a risk score to predict individuals' absolute risk of developing the condition, and to provide a framework for researchers to assess new risk markers...
  32. pmc Common genetic variants, QT interval, and sudden cardiac death in a Finnish population-based study
    Peter A Noseworthy
    Cardiovascular Research Center and Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Circ Cardiovasc Genet 4:305-11. 2011
    ..The QT interval appears to have a graded relationship to SCD, and 35% to 45% of its variation is heritable. We examined the relationship among recently reported common genetic variants, QT interval, and SCD...
  33. pmc Effects of transdermal testosterone on natriuretic peptide levels in women: a randomized placebo-controlled pilot study
    Eleanor Lin
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Fertil Steril 97:489-93. 2012
    ..To investigate whether testosterone administration alters natriuretic peptide levels in women...
  34. pmc Large-scale candidate gene analysis in whites and African Americans identifies IL6R polymorphism in relation to atrial fibrillation: the National Heart, Lung, and Blood Institute's Candidate Gene Association Resource (CARe) project
    Renate B Schnabel
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    Circ Cardiovasc Genet 4:557-64. 2011
    ..The genetic background of atrial fibrillation (AF) in whites and African Americans is largely unknown. Genes in cardiovascular pathways have not been systematically investigated...
  35. pmc Association of hypertension drug target genes with blood pressure and hypertension in 86,588 individuals
    Andrew D Johnson
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA 01702, USA
    Hypertension 57:903-10. 2011
    ..Our findings suggest that these genes warrant further studies of their genetic effects on blood pressure, including pharmacogenetic interactions...
  36. pmc Genome-wide association study identifies eight loci associated with blood pressure
    Christopher Newton-Cheh
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA
    Nat Genet 41:666-76. 2009
    ..These associations between common variants and blood pressure and hypertension offer mechanistic insights into the regulation of blood pressure and may point to novel targets for interventions to prevent cardiovascular disease...
  37. pmc Influence of sex and hormone status on circulating natriuretic peptides
    Carolyn S P Lam
    Framingham Heart Study, Framingham, Massachusetts, USA
    J Am Coll Cardiol 58:618-26. 2011
    ..The aim of this study was to assess the relationship between sex hormones and natriuretic peptide levels in community-based adults...
  38. ncbi Cross-sectional relations of multiple biomarkers from distinct biological pathways to brachial artery endothelial function
    Sekar Kathiresan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702 5827, USA
    Circulation 113:938-45. 2006
    ..We evaluated the relative contributions of distinct biological pathways to interindividual variation in endothelial function by relating prototype biomarkers (representing these pathways) to brachial artery vasodilator function...
  39. pmc Development and application of a longitudinal electrocardiogram repository: the Framingham Heart Study
    Jared W Magnani
    National Heart, Lung and Blood Institute s and Boston University s Framingham Heart Study, Framingham, MA, USA
    J Electrocardiol 45:673-6. 2012
    ..Such a resource will complement the phenotypic and genotypic characterization of FHS, facilitating novel investigations of cardiovascular epidemiology...
  40. pmc Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae
    J Gustav Smith
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Heart Rhythm 6:634-41. 2009
    ..Cardiac conduction, as assessed by electrocardiographic PR interval and QRS duration, is an important electrophysiological trait and a determinant of arrhythmia risk...
  41. pmc A common variant at 9p21 is associated with sudden and arrhythmic cardiac death
    Christopher Newton-Cheh
    MPH, Center for Arrhythmia Prevention, Division of Preventive Medicine, Cardiovascular Division, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02115 1204, USA
    Circulation 120:2062-8. 2009
    ..We hypothesized that a common variant at chromosome 9p21 related to myocardial infarction would influence SCD risk...
  42. pmc Atrial natriuretic peptide is negatively regulated by microRNA-425
    Pankaj Arora
    Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Invest 123:3378-82. 2013
    ..This study identifies miR-425 as a regulator of ANP production, raising the possibility that miR-425 antagonists could be used to treat disorders of salt overload, including hypertension and heart failure. ..
  43. ncbi QT interval is a heritable quantitative trait with evidence of linkage to chromosome 3 in a genome-wide linkage analysis: The Framingham Heart Study
    Christopher Newton-Cheh
    National Heart, Lung and Blood Institute s Framingham Heart Study, Massachusetts 01702, USA
    Heart Rhythm 2:277-84. 2005
    ..To identify genomic regions linked to QT interval duration in an unselected population...
  44. pmc Early repolarization pattern in competitive athletes: clinical correlates and the effects of exercise training
    Peter A Noseworthy
    Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA
    Circ Arrhythm Electrophysiol 4:432-40. 2011
    ..Although ERP is common among athletes, prevalence, ECG lead distribution, clinical characteristics, and effects of physical training remain uncertain. We sought to examine the nonanterior ERP in competitive athletes...
  45. ncbi Conserved noncoding sequences are selectively constrained and not mutation cold spots
    Jared A Drake
    Program in Genomics and Division of Endocrinology, Children s Hospital, Boston, Massachusetts 02115, USA
    Nat Genet 38:223-7. 2006
    ..Thus, conserved noncoding variants are more likely to be functional. Allele frequency distributions highlight selectively constrained genomic regions that should be intensively surveyed for functionally important variation...
  46. pmc Therapeutic hypothermia for cardiac arrest: real-world utilization trends and hospital mortality
    Anupam B Jena
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    J Hosp Med 7:684-9. 2012
    ..Therapeutic hypothermia (TH) improves outcomes following cardiac arrest in small clinical trials...
  47. pmc Blood pressure and human genetic variation in the general population
    Pankaj Arora
    Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Curr Opin Cardiol 25:229-37. 2010
    ..Association studies to identify common variants have been limited in the past by small sample sizes and most findings have lacked replication...
  48. pmc Burden of rare sarcomere gene variants in the Framingham and Jackson Heart Study cohorts
    Alexander G Bick
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Am J Hum Genet 91:513-9. 2012
    ..3) in the FHS cohort, suggesting that cardiovascular risk assessment in the general population can benefit from rare variant analysis...
  49. ncbi The electrocardiographic early repolarization pattern in athletes: normal variant or sudden death risk factor?
    Varsha Keelara Tanguturi
    Department of Medicine, Brigham and Womens Hospital, Boston, MA, USA
    Sports Med 42:359-66. 2012
    ..This review will describe the evolving understanding of the ERP and will explore the relevance of the ERP for the care of athletes...
  50. pmc A common variant in the β2-adrenergic receptor and risk of sudden cardiac death
    Michael C Gavin
    Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Heart Rhythm 8:704-10. 2011
    ..Homozygosity for a common nonsynonymous single nucleotide polymorphism (Gln27Glu) in the β(2)-adrenergic receptor gene (ADRB2) has been inconsistently associated with sudden cardiac death (SCD) in individual studies of small sample size...
  51. pmc Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry
    Emelia J Benjamin
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Nat Genet 41:879-81. 2009
    ..19; P = 2.3 x 10(-7)). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 x 10(-11); combined RR = 1.25; combined P = 1.8 x 10(-15))...
  52. ncbi Genetic association studies of complex traits: design and analysis issues
    Christopher Newton-Cheh
    Broad Institute of Harvard and MIT, One Kendall Square, Building 300, Cambridge, MA 02139, USA
    Mutat Res 573:54-69. 2005
    ..Heritable and accurately measured phenotypes, carefully matched large samples, well-chosen genetic markers, and adequate standards in genotyping, analysis, and interpretation are all integral parts of a high-quality association study...
  53. doi Genome-wide association study in humans
    J Gustav Smith
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA
    Methods Mol Biol 573:231-58. 2009
    ..Here, we describe the different steps of genome-wide association studies and use a recent study as example...
  54. pmc The early repolarization pattern in the general population: clinical correlates and heritability
    Peter A Noseworthy
    Cardiovascular Research Center and Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Am Coll Cardiol 57:2284-9. 2011
    ..This study sought to describe the clinical correlates and heritability of the early repolarization pattern (ERP) in 2 large, population-based cohorts...
  55. pmc Variation in the 4q25 chromosomal locus predicts atrial fibrillation after coronary artery bypass graft surgery
    Simon C Body
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circ Cardiovasc Genet 2:499-506. 2009
    ..However, their role in postoperative AF is unknown. We hypothesized that genetic variants in the 4q25 chromosomal region are independently associated with postoperative AF after coronary artery bypass graft surgery...
  56. pmc Effect of weight loss after weight loss surgery on plasma N-terminal pro-B-type natriuretic peptide levels
    Annabel Chen-Tournoux
    Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 106:1450-5. 2010
    ..These findings suggest a direct, reversible relation between obesity and reduced natriuretic peptide levels...

Research Grants2

  1. Genetic determinants of cardiac repolarization
    Christopher Newton Cheh; Fiscal Year: 2007
    ..Through the proposed research and educational training, Dr. Newton-Cheh will acquire the skills needed to pursue independent cardiovascular research at the cutting edge of genomic science. ..
  2. Genetic determinants of cardiac repolarization
    Christopher Newton Cheh; Fiscal Year: 2008
    ..Through the proposed research and educational training, Dr. Newton-Cheh will acquire the skills needed to pursue independent cardiovascular research at the cutting edge of genomic science. ..