- Bilateral neck exploration decreases operative time compared to minimally invasive parathyroidectomy in patients with discordant imagingMatthew A Nehs
Department of Surgery, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
World J Surg 37:1614-7. 2013....
- Thyroid-specific knockout of the tumor suppressor mitogen-inducible gene 6 activates epidermal growth factor receptor signaling pathways and suppresses nuclear factor-κB activityChi Iou Lin
Department of Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
Surgery 150:1295-302. 2011..Mitogen-inducible gene 6 (Mig-6) is a putative tumor suppressor gene and prognostic biomarker in papillary thyroid cancer. We hypothesized that Mig-6 knockout would activate pro-oncogenic signaling in mouse thyrocytes...
- Necroptosis is a novel mechanism of radiation-induced cell death in anaplastic thyroid and adrenocortical cancersMatthew A Nehs
Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Surgery 150:1032-9. 2011..Necroptosis is a recently described mechanism of programmed cellular death. We hypothesize that necroptosis plays an important role in radiation-induced cell death in endocrine cancers...
- Late intervention with anti-BRAF(V600E) therapy induces tumor regression in an orthotopic mouse model of human anaplastic thyroid cancerMatthew A Nehs
Thyroid Cancer Research Laboratory, Endocrine Surgery Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Endocrinology 153:985-94. 2012..PLX4720 treatment inhibited cell cycle progression from 28 d to 49 d in vivo. PLX4720 induces striking tumor regression and reversal of cachexia in an in vivo model of advanced thyroid cancer that harbors the BRAF(V600E) mutation...