D M Nathan

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Acute angle closure glaucoma following rapid correction of hyperglycemia
    Deirdre R Blake
    Diabetes Care 26:3197-8. 2003
  2. ncbi request reprint Impaired fasting glucose and impaired glucose tolerance: implications for care
    David M Nathan
    Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 30:753-9. 2007
  3. pmc ANGPTL4 variants E40K and T266M are associated with lower fasting triglyceride levels in Non-Hispanic White Americans from the Look AHEAD Clinical Trial
    Melissa C Smart-Halajko
    Division of Cardiovascular Genetics, British Heart Foundation Laboratories, Department of Medicine, Royal Free and UCL Medical School, London, UK
    BMC Med Genet 12:89. 2011
  4. pmc Changes in glycemic control from 1996 to 2006 among adults with type 2 diabetes: a longitudinal cohort study
    Karen J Blumenthal
    The Diabetes Center, Massachusetts General Hospital, 50 Staniford Street, Boston, MA 02114, USA
    BMC Health Serv Res 10:158. 2010
  5. ncbi request reprint Management of hyperglycaemia in type 2 diabetes mellitus: a consensus algorithm for the initiation and adjustment of therapy. Update regarding the thiazolidinediones
    D M Nathan
    Diabetes Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Diabetologia 51:8-11. 2008
  6. doi request reprint Management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: update regarding thiazolidinediones: a consensus statement from the American Diabetes Association and the European Association for the Stud
    David M Nathan
    Diabetes Center, Massachusetts General Hospital, Boston, MA 02114, USA
    Diabetes Care 31:173-5. 2008
  7. ncbi request reprint Impaired glucose tolerance, but not impaired fasting glucose, is associated with increased levels of coronary heart disease risk factors: results from the Baltimore Longitudinal Study on Aging
    Deirdre R Blake
    Diabetes Unit, Diabetes Center and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Diabetes 53:2095-100. 2004
  8. ncbi request reprint Isolated pancreas transplantation for type 1 diabetes: a doctor's dilemma
    David M Nathan
    Diabetes Center and General Clinical Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    JAMA 290:2861-3. 2003
  9. pmc Modern-day clinical course of type 1 diabetes mellitus after 30 years' duration: the diabetes control and complications trial/epidemiology of diabetes interventions and complications and Pittsburgh epidemiology of diabetes complications experience (1983-2
    David M Nathan
    Diabetes Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114 2698, USA
    Arch Intern Med 169:1307-16. 2009
  10. pmc Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes
    David M Nathan
    Diabetes Center, Massachusetts General Hospital, Boston, Massachusetts, USA
    Diabetes Care 32:193-203. 2009

Research Grants

  1. Post-DPP Followup Study
    David Nathan; Fiscal Year: 2007
  2. Action for Health in Diabetes (Look AHEAD)
    David Nathan; Fiscal Year: 2007

Detail Information

Publications100

  1. ncbi request reprint Acute angle closure glaucoma following rapid correction of hyperglycemia
    Deirdre R Blake
    Diabetes Care 26:3197-8. 2003
  2. ncbi request reprint Impaired fasting glucose and impaired glucose tolerance: implications for care
    David M Nathan
    Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 30:753-9. 2007
  3. pmc ANGPTL4 variants E40K and T266M are associated with lower fasting triglyceride levels in Non-Hispanic White Americans from the Look AHEAD Clinical Trial
    Melissa C Smart-Halajko
    Division of Cardiovascular Genetics, British Heart Foundation Laboratories, Department of Medicine, Royal Free and UCL Medical School, London, UK
    BMC Med Genet 12:89. 2011
    ....
  4. pmc Changes in glycemic control from 1996 to 2006 among adults with type 2 diabetes: a longitudinal cohort study
    Karen J Blumenthal
    The Diabetes Center, Massachusetts General Hospital, 50 Staniford Street, Boston, MA 02114, USA
    BMC Health Serv Res 10:158. 2010
    ..Our objectives were to examine temporal changes in HbA1c and lipid levels over a 10-year period and to identify predictors of metabolic control in a longitudinal patient cohort...
  5. ncbi request reprint Management of hyperglycaemia in type 2 diabetes mellitus: a consensus algorithm for the initiation and adjustment of therapy. Update regarding the thiazolidinediones
    D M Nathan
    Diabetes Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Diabetologia 51:8-11. 2008
  6. doi request reprint Management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: update regarding thiazolidinediones: a consensus statement from the American Diabetes Association and the European Association for the Stud
    David M Nathan
    Diabetes Center, Massachusetts General Hospital, Boston, MA 02114, USA
    Diabetes Care 31:173-5. 2008
  7. ncbi request reprint Impaired glucose tolerance, but not impaired fasting glucose, is associated with increased levels of coronary heart disease risk factors: results from the Baltimore Longitudinal Study on Aging
    Deirdre R Blake
    Diabetes Unit, Diabetes Center and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Diabetes 53:2095-100. 2004
    ..The differences in CHD risk factors among prediabetic groups may have clinical implications for screening strategies and CHD risk stratification of individuals with IFG and IGT...
  8. ncbi request reprint Isolated pancreas transplantation for type 1 diabetes: a doctor's dilemma
    David M Nathan
    Diabetes Center and General Clinical Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    JAMA 290:2861-3. 2003
  9. pmc Modern-day clinical course of type 1 diabetes mellitus after 30 years' duration: the diabetes control and complications trial/epidemiology of diabetes interventions and complications and Pittsburgh epidemiology of diabetes complications experience (1983-2
    David M Nathan
    Diabetes Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114 2698, USA
    Arch Intern Med 169:1307-16. 2009
    ..There have been few longitudinal studies to describe the clinical course of T1DM in the age of intensive therapy. Our objective was to describe the current-day clinical course of T1DM...
  10. pmc Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes
    David M Nathan
    Diabetes Center, Massachusetts General Hospital, Boston, Massachusetts, USA
    Diabetes Care 32:193-203. 2009
    ..In this revision, we focus on the new classes of medications that now have more clinical data and experience...
  11. pmc Translating the A1C assay into estimated average glucose values
    David M Nathan
    Diabetes Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Diabetes Care 31:1473-8. 2008
    ..We sought to define the mathematical relationship between A1C and average glucose (AG) levels and determine whether A1C could be expressed and reported as AG in the same units as used in self-monitoring...
  12. ncbi request reprint Relationship between glycated haemoglobin levels and mean glucose levels over time
    D M Nathan
    Diabetes Center, Department of Biostatistics, Massachusetts General Hospital, 50 Staniford Street, Suite 340, Boston, MA 02114, USA
    Diabetologia 50:2239-44. 2007
    ..We determined the relationship between an accurate measure of mean glucose levels over time and the HbA(1c) level, and whether HbA(1c) can be expressed in the same units as self-monitoring results...
  13. pmc Intensive diabetes therapy and carotid intima-media thickness in type 1 diabetes mellitus
    David M Nathan
    DCCT EDIC Research Group at Box NDIC DCCT, Bethesda, MD 20892, USA
    N Engl J Med 348:2294-303. 2003
    ..We examined the progression of carotid intima-media thickness, a measure of atherosclerosis, in a population with type 1 diabetes...
  14. pmc Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes
    David M Nathan
    N Engl J Med 353:2643-53. 2005
    ..We studied whether the use of intensive therapy as compared with conventional therapy during the Diabetes Control and Complications Trial (DCCT) affected the long-term incidence of cardiovascular disease...
  15. ncbi request reprint Management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes
    David M Nathan
    Diabetes Center, Massachusetts General Hospital, Boston, 02114, USA
    Diabetes Care 29:1963-72. 2006
  16. ncbi request reprint Management of hyperglycaemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes
    D M Nathan
    Diabetes Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Diabetologia 49:1711-21. 2006
  17. ncbi request reprint Counterpoint: No time to inhale: arguments against inhaled insulin in 2007
    David M Nathan
    MGH Diabetes Center, 50 Staniford Street, Boston, MA 02114, USA
    Diabetes Care 30:442-3. 2007
  18. doi request reprint Medical management of hyperglycaemia in type 2 diabetes mellitus: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes
    D M Nathan
    Diabetes Center, Massachusetts General Hospital, Boston, MA 02114, USA
    Diabetologia 52:17-30. 2009
    ..In this revision, we focus on the new classes of medications that now have more clinical data and experience...
  19. doi request reprint Determining stability of stored samples retrospectively: the validation of glycated albumin
    David M Nathan
    The Diabetes Center, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Clin Chem 57:286-90. 2011
    ....
  20. ncbi request reprint Metabolic risk factors worsen continuously across the spectrum of nondiabetic glucose tolerance. The Framingham Offspring Study
    J B Meigs
    Massachusetts General Hospital, Harvard Medical School, Boston University School of Public Health, 02114, USA
    Ann Intern Med 128:524-33. 1998
    ..Categorical definitions for glucose intolerance imply that risk thresholds exist, but metabolic risk for type 2 diabetes mellitus or cardiovascular disease may increase continuously as glucose intolerance increases...
  21. ncbi request reprint Hyperinsulinemia, hyperglycemia, and impaired hemostasis: the Framingham Offspring Study
    J B Meigs
    General Medicine Division and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Institute for Prevention of Cardiovascular Disease, Boston 02114, USA
    JAMA 283:221-8. 2000
    ..Hyperinsulinemia associated with glucose intolerance may increase risk directly, or its effect could be mediated through impaired hemostatic function...
  22. ncbi request reprint Risk variable clustering in the insulin resistance syndrome. The Framingham Offspring Study
    J B Meigs
    General Internal Medicine Unit, Massachusetts General Hospital, Boston 02114, USA
    Diabetes 46:1594-600. 1997
    ..Insulin resistance (reflected by hyperinsulinemia) alone did not appear to underlie all features of the insulin resistance syndrome...
  23. ncbi request reprint Fasting plasma homocysteine levels in the insulin resistance syndrome: the Framingham offspring study
    J B Meigs
    General Medicine Division and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Diabetes Care 24:1403-10. 2001
    ..We examined relationships between homocysteine levels and features of insulin resistance syndrome (IRS)...
  24. ncbi request reprint Immediate feedback of HbA1c levels improves glycemic control in type 1 and insulin-treated type 2 diabetic patients
    E Cagliero
    Diabetes Center, Massachusetts General Hospital, Boston 02114, USA
    Diabetes Care 22:1785-9. 1999
    ..We tested the hypothesis that immediately available HbA1c results could improve glycemic control by changing physician or patient behavior or both...
  25. ncbi request reprint Comparison of hyperglycemia, hypertension, and hypercholesterolemia management in patients with type 2 diabetes
    Richard W Grant
    General Medicine Division, Department of Medicine, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Am J Med 112:603-9. 2002
    ..We compared hyperglycemia management with the management of the cardiovascular disease risk factors hypertension and hypercholesterolemia in a cohort of type 2 diabetes patients...
  26. ncbi request reprint Apolipoprotein E isoform polymorphisms are not associated with insulin resistance: the Framingham Offspring Study
    J B Meigs
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Diabetes Care 23:669-74. 2000
    ..We examined the relationship between insulin resistance and apo(e) polymorphisms among participants in the Framingham Offspring Study...
  27. doi request reprint Disparity in management of diabetes and coronary heart disease risk factors by sex in DCCT/EDIC
    M E Larkin
    Massachusetts General Hospital Diabetes Center, Boston, MA 02114, USA
    Diabet Med 27:451-8. 2010
    ..Sex disparity in the treatment of modifiable CHD risk factors in patients with Type 2 diabetes has been reported previously; however, there is little comparable information in Type 1 diabetes...
  28. pmc Association of diet with glycated hemoglobin during intensive treatment of type 1 diabetes in the Diabetes Control and Complications Trial
    Linda M Delahanty
    Massachusetts General Hospital Diabetes Center and Harvard Medical School, Boston, MA 02114, USA
    Am J Clin Nutr 89:518-24. 2009
    ..Persons with type 1 diabetes have received widely varying dietary advice based on putative effects on glycemic control...
  29. ncbi request reprint Effect of intensive glycemic control on levels of markers of inflammation in type 1 diabetes mellitus in the diabetes control and complications trial
    Debra A Schaumberg
    Division of Preventive Medicine, Brigham and Womens Hospital, Boston, Mass, USA
    Circulation 111:2446-53. 2005
    ..The present study examined the effect of intensive therapy on levels of several markers of inflammation that have been linked to risk of CVD...
  30. pmc The effect of intensive glycemic treatment on coronary artery calcification in type 1 diabetic participants of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study
    Patricia A Cleary
    Diabetes Unit, Massachusetts General Hospital, 32 Fruit St, Boston, MA 02114 2698, USA
    Diabetes 55:3556-65. 2006
    ..Prior intensive diabetes treatment during the DCCT was associated with less atherosclerosis, largely because of reduced levels of A1C during the DCCT...
  31. ncbi request reprint Randomized controlled community-based nutrition and exercise intervention improves glycemia and cardiovascular risk factors in type 2 diabetic patients in rural Costa Rica
    Jeremy D Goldhaber-Fiebert
    Harvard Medical School, Boston, Massachusetts 02115, USA
    Diabetes Care 26:24-9. 2003
    ....
  32. pmc Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program
    Allan F Moore
    Center for Human Genetic Research, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Diabetes 57:2503-10. 2008
    ....
  33. ncbi request reprint Insulin sensitivity during combined androgen blockade for prostate cancer
    Matthew R Smith
    Massachusetts General Hospital, Cox 640, 100 Blossom Street, Boston, MA 02114, USA
    J Clin Endocrinol Metab 91:1305-8. 2006
    ..GnRH agonists markedly increase fat mass in men with prostate cancer, but little is known about the effects of treatment on insulin sensitivity...
  34. ncbi request reprint Tests of glycemia for the diagnosis of type 2 diabetes mellitus
    R Graham Barr
    Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Ann Intern Med 137:263-72. 2002
    ..The glycemic threshold for type 2 diabetes should be established by cost-effectiveness analysis. The clinical diagnosis of diabetes mellitus could be streamlined by incorporation of hemoglobin A1c into established criteria...
  35. pmc Prolonged effect of intensive therapy on the risk of retinopathy complications in patients with type 1 diabetes mellitus: 10 years after the Diabetes Control and Complications Trial
    Neil H White
    Diabetes Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Arch Ophthalmol 126:1707-15. 2008
    ..In the DCCT, intensive therapy aimed at near-normal glycemia reduced the risk of microvascular complications of type 1 diabetes mellitus compared with conventional therapy...
  36. pmc Intensification of diabetes medication and risk for 30-day readmission
    N J Wei
    Massachusetts General Hospital, Diabetes Center Harvard Medical School, Boston, MA, USA
    Diabet Med 30:e56-62. 2013
    ..To examine the association of in-hospital diabetes regimen intensification with subsequent 30-day risk for unplanned readmission/emergency department admission...
  37. ncbi request reprint C-reactive protein gene variation and type 2 diabetes mellitus: a case-control study
    Robert Y L Zee
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Atherosclerosis 197:931-6. 2008
    ..C-reactive protein (CRP) gene variation, in particular an rs2794521 variant was recently associated with type 2 diabetes mellitus (T2DM) in Pima Indians...
  38. pmc Implications of the diabetes prevention program and Look AHEAD clinical trials for lifestyle interventions
    Linda M Delahanty
    MGH Diabetes Center, Massachusetts General Hospital, Boston, MA 02114, USA
    J Am Diet Assoc 108:S66-72. 2008
    ....
  39. ncbi request reprint Clinical practice. Initial management of glycemia in type 2 diabetes mellitus
    David M Nathan
    Diabetes Center and the Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston 02114 2517, USA
    N Engl J Med 347:1342-9. 2002
  40. pmc Inflammation and progressive nephropathy in type 1 diabetes in the diabetes control and complications trial
    Julie Lin
    Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 31:2338-43. 2008
    ..Early albuminuria probably reflects vascular endothelial dysfunction, which may be mediated in part by chronic inflammation...
  41. pmc Effect of aging on A1C levels in individuals without diabetes: evidence from the Framingham Offspring Study and the National Health and Nutrition Examination Survey 2001-2004
    LYDIE N PANI
    Department of Medicine, Diabetes Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 31:1991-6. 2008
    ..We examined whether A1C was associated with age in nondiabetic subjects and in subjects with normal glucose tolerance (NGT) in two population-based cohorts...
  42. pmc Effects of the type 2 diabetes-associated PPARG P12A polymorphism on progression to diabetes and response to troglitazone
    Jose C Florez
    Center for Human Genetic Research and Department of Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston 02114, USA
    J Clin Endocrinol Metab 92:1502-9. 2007
    ..The common P12A polymorphism in PPARG (a target for thiazolidinedione medications) has been consistently associated with type 2 diabetes...
  43. ncbi request reprint Prevalence of hyper- and hypoglycemia among inpatients with diabetes: a national survey of 44 U.S. hospitals
    Deborah J Wexler
    Massachusetts General Hospital, Bulfinch 408, 55 Fruit Street, Boston, MA 02114, USA
    Diabetes Care 30:367-9. 2007
  44. ncbi request reprint How doctors choose medications to treat type 2 diabetes: a national survey of specialists and academic generalists
    Richard W Grant
    General Medicine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 30:1448-53. 2007
    ..However, the process by which physicians choose glucose-lowering medicines is poorly understood. We sought to study the means by which physicians choose medications for type 2 diabetic patients...
  45. pmc New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
    Josee Dupuis
    Department of Biostatistics, Boston University School of Public Health, Massachusetts, USA
    Nat Genet 42:105-16. 2010
    ....
  46. pmc Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
    Richa Saxena
    Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Nat Genet 42:142-8. 2010
    ..Of the three newly implicated loci (GIPR, ADCY5 and VPS13C), only ADCY5 was found to be associated with type 2 diabetes in collaborating studies (n = 35,869 cases, 89,798 controls, OR = 1.12, 95% CI 1.09-1.15, P = 4.8 x 10(-18))...
  47. pmc Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study
    Guillaume Pare
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    PLoS Genet 4:e1000312. 2008
    ..This observed genetic association between glycated hemoglobin levels and HK1 polymorphisms paves the way for further studies of the role of HK1 in hemoglobin glycation, glucose metabolism, and diabetes...
  48. doi request reprint Measuring psychological insulin resistance: barriers to insulin use
    Mary E Larkin
    Massachusetts General Hospital, Boston, MA 02114, USA
    Diabetes Educ 34:511-7. 2008
    ..The purpose of this study is to explore the attitudes that contribute to psychological insulin resistance (PIR) in insulin-naive patients with type 2 diabetes and to identify predictors of PIR...
  49. pmc Rapid identification of myocardial infarction risk associated with diabetes medications using electronic medical records
    John S Brownstein
    Children s Hospital Informatics Program at the Harvard MIT Division of Health Sciences and Technology, Boston, Massachusetts, USA
    Diabetes Care 33:526-31. 2010
    ..Our use of usual care electronic data sources from a large hospital network represents an innovative approach to rapid safety signal detection that may enable more effective postmarketing drug surveillance...
  50. pmc Prevalence of elevated hemoglobin A1c among patients admitted to the hospital without a diagnosis of diabetes
    Deborah J Wexler
    Massachusetts General Hospital Diabetes Center, Bulfinch 408, Massachusetts General Hospital, and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 93:4238-44. 2008
    ..One in four hospitalized patients has diagnosed diabetes. The prevalence of unrecognized, or undiagnosed, diabetes among hospitalized patients is not well established...
  51. pmc Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants
    Sekar Kathiresan
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Genet 41:334-41. 2009
    ..SNPs at nine loci were reproducibly associated with myocardial infarction, but tests of common and rare CNVs failed to identify additional associations with myocardial infarction risk...
  52. doi request reprint An algorithm for the care of type 2 diabetes
    Alan Cole
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Crit Pathw Cardiol 8:156-65. 2009
    ..Additional teaching is provided in the form of frequently asked questions answered by domain experts...
  53. ncbi request reprint Longitudinal association of glycemia and microalbuminuria: the Framingham Offspring Study
    James B Meigs
    General Medicine Division and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Diabetes Care 25:977-83. 2002
    ..To assess current and long-term associations of glycemia with microalbuminuria, a marker of generalized endothelial injury...
  54. ncbi request reprint A controlled trial of web-based diabetes disease management: the MGH diabetes primary care improvement project
    James B Meigs
    Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA
    Diabetes Care 26:750-7. 2003
    ..To test effects of a web-based decision support tool, the diabetes Disease Management Application (DMA), developed to improve evidence-based management of type 2 diabetes...
  55. ncbi request reprint A controlled trial of population management: diabetes mellitus: putting evidence into practice (DM-PEP)
    Richard W Grant
    General Medicine Division, Massachusetts General Hospital, Boston, MA, USA
    Diabetes Care 27:2299-305. 2004
    ..Population-level strategies to organize and deliver care may improve diabetes management. We conducted a multiclinic controlled trial of population management in patients with type 2 diabetes...
  56. ncbi request reprint Research navigating the course of clinical practice in diabetes
    Linda M Delahanty
    Nutrition and Behavioral Research, Massachusetts General Hospital, 50 Staniford Street, Boston, MA 02114, USA
    J Am Diet Assoc 104:1846-53. 2004
    ....
  57. ncbi request reprint Using metabolic syndrome traits for efficient detection of impaired glucose tolerance
    James B Meigs
    General Internal Medicine Unit, Massachusetts General Hospital, 50 Staniford St, 9th Floor, Boston, MA 02114, USA
    Diabetes Care 27:1417-26. 2004
    ..Efficient detection of impaired glucose tolerance (IGT) is needed to implement type 2 diabetes prevention interventions...
  58. ncbi request reprint Sex disparities in treatment of cardiac risk factors in patients with type 2 diabetes
    Deborah J Wexler
    Diabetes Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA
    Diabetes Care 28:514-20. 2005
    ..Diabetes eliminates the protective effect of female sex on the risk of coronary heart disease (CHD). We assessed sex differences in the treatment of CHD risk factors among patients with diabetes...
  59. ncbi request reprint Prevalence and characteristics of the metabolic syndrome in the San Antonio Heart and Framingham Offspring Studies
    James B Meigs
    Department of Medicine, General Medicine Division, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 52:2160-7. 2003
    ..S. By any criteria, subjects with the metabolic syndrome are more insulin resistant and at increased predicted risk for CHD versus those without the metabolic syndrome...
  60. ncbi request reprint The natural history of progression from normal glucose tolerance to type 2 diabetes in the Baltimore Longitudinal Study of Aging
    James B Meigs
    General Medicine Division and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, 50 Staniford Street, 9th Floor, Boston, MA 02114, USA
    Diabetes 52:1475-84. 2003
    ....
  61. ncbi request reprint Fasting and postchallenge glycemia and cardiovascular disease risk: the Framingham Offspring Study
    James B Meigs
    General Medicine Division and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Diabetes Care 25:1845-50. 2002
    ..To test the hypothesis that fasting hyperglycemia (FHG) and 2-h postchallenge glycemia (2hPG) independently increase the risk for cardiovascular disease (CVD)...
  62. ncbi request reprint Medical nutrition therapy for hypercholesterolemia positively affects patient satisfaction and quality of life outcomes
    Linda M Delahanty
    Massachusetts General Hospital, Diabetes Center, Boston 02114, USA
    Ann Behav Med 24:269-78. 2002
    ..Contrary to popular belief there is no apparent reduction but rather an improvement in some measures of QOL and patient satisfaction with MNT for hypercholesterolemia...
  63. pmc Psychological and behavioral correlates of baseline BMI in the diabetes prevention program (DPP)
    Linda M Delahanty
    Diabetes Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Diabetes Care 25:1992-8. 2002
    ..To determine psychological and behavioral correlates of baseline BMI in the Diabetes Prevention Program (DPP)...
  64. ncbi request reprint Report of the National Heart, Lung, and Blood Institute-National Institute of Diabetes and Digestive and Kidney Diseases Working Group on Cardiovascular Complications of Type 1 Diabetes Mellitus
    Peter Libby
    Brigham and Women s Hospital, Boston, Mass, USA
    Circulation 111:3489-93. 2005
  65. ncbi request reprint Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease
    James B Meigs
    General Medicine Division, Massachusetts General Hospital, 50 Staniford Street, 9th Floor, Boston, MA 02114, USA
    J Clin Endocrinol Metab 91:2906-12. 2006
    ..Metabolic risk conferred by adiposity may be due to associated risk factor clustering...
  66. ncbi request reprint Hemostatic markers of endothelial dysfunction and risk of incident type 2 diabetes: the Framingham Offspring Study
    James B Meigs
    General Medicine Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, USA
    Diabetes 55:530-7. 2006
    ..09-1.77). We conclude that in this community-based sample, plasma markers of endothelial dysfunction increased risk of incident diabetes independent of other diabetes risk factors including obesity, insulin resistance, and inflammation...
  67. pmc Psychological predictors of physical activity in the diabetes prevention program
    Linda M Delahanty
    Diabetes Center, Massachusetts General Hospital, Boston, MA 02114, USA
    J Am Diet Assoc 106:698-705. 2006
    ....
  68. ncbi request reprint Clinical and cost outcomes of medical nutrition therapy for hypercholesterolemia: a controlled trial
    L M Delahanty
    Massachusetts General Hospital, Diabetes Center, Boston 02114, USA
    J Am Diet Assoc 101:1012-23. 2001
    ..To compare the results and cost-effectiveness of a cholesterol lowering protocol implemented by registered dietitians with cholesterol lowering advice by physicians...
  69. ncbi request reprint The impact of diabetes mellitus on mortality from all causes and coronary heart disease in women: 20 years of follow-up
    F B Hu
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Arch Intern Med 161:1717-23. 2001
    ..Few data are available on the long-term impact of type 2 diabetes mellitus on total mortality and fatal coronary heart disease (CHD) in women...
  70. ncbi request reprint Effects of fasting and glucose infusion on basal and overnight leptin concentrations in normal-weight women
    S K Grinspoon
    Department of Pathology, Massachusetts General Hospital, Boston, USA
    Am J Clin Nutr 66:1352-6. 1997
    ..05). These data show the sensitivity of plasma leptin concentrations to small changes in energy supply and suggest a basic role of substrate metabolism in the short-term regulation of leptin...
  71. doi request reprint The clinical application of genetic testing in type 2 diabetes: a patient and physician survey
    R W Grant
    Division of General Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Diabetologia 52:2299-305. 2009
    ..Little is known about current physician and patient views regarding type 2 diabetes genetic testing. We hypothesised that physician and patient views would differ regarding the impact of genetic testing on motivation and adherence...
  72. doi request reprint Glycated albumin and direct low density lipoprotein cholesterol levels in type 2 diabetes mellitus
    Masumi Ai
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Clin Chim Acta 406:71-4. 2009
    ....
  73. ncbi request reprint Musculoskeletal disorders of the hand and shoulder in patients with diabetes mellitus
    Enrico Cagliero
    Massachusetts General Hospital Diabetes Center, Boston, Massachusetts 02114, USA
    Am J Med 112:487-90. 2002
  74. ncbi request reprint A prospective study of serum lipids and risk of diabetic macular edema in type 1 diabetes
    Biljana Miljanovic
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Ave East, Boston, MA 02215, USA
    Diabetes 53:2883-92. 2004
    ..Lipid-lowering treatment among type 1 diabetic subjects, recommended to prevent cardiovascular disease, may also decrease risk of CSME, an important cause of vision loss...
  75. doi request reprint Hyperglycemia on admission predicts larger infarct size in patients undergoing percutaneous coronary intervention for acute ST-segment elevation myocardial infarction
    Ignacio Cruz-Gonzalez
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Gray Bigelow 800, Boston, MA 02114, USA
    Diabetes Res Clin Pract 88:97-102. 2010
    ....
  76. pmc Retinal haemodynamics in individuals with well-controlled type 1 diabetes
    M Lorenzi
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, and Diabetes Center and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA
    Diabetologia 51:361-4. 2008
    ..Based on this, the aim of this study was to investigate whether patients with type 1 diabetes treated entirely or mostly in the post-DCCT era and tested in the absence of confounding factors show retinal haemodynamic abnormalities...
  77. pmc Insulin resistance influences the association of adiponectin levels with diabetes incidence in two population-based cohorts: the Cooperative Health Research in the Region of Augsburg (KORA) S4/F4 study and the Framingham Offspring Study
    M F Hivert
    Department of Medicine, Harvard Medical School, Boston, MA, USA
    Diabetologia 54:1019-24. 2011
    ..We tested the hypothesis that the association of adiponectin levels with incident type 2 diabetes differs between insulin-resistant and insulin-sensitive individuals...
  78. ncbi request reprint Clinical inertia in the management of Type 2 diabetes metabolic risk factors
    R W Grant
    General Medicine Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Diabet Med 21:150-5. 2004
    ..We assessed intensification of medical therapy over time, comparing the management of hyperglycaemia, hypertension, and hyperlipidaemia...
  79. ncbi request reprint Sample exchange to compare insulin measurements between the San Antonio Heart Study and the Framingham Offspring Study
    J B Meigs
    The General Medicine Division, Department of Medicine, Massachusetts Hospital and Harvard Medical School, Boston, MA, USA
    J Clin Epidemiol 54:1031-6. 2001
    ..Associated regression curves can be used to calibrate insulin levels to a common reference standard, allowing epidemiology studies to compare levels of insulin and associated risk factors...
  80. pmc Associations of adiponectin, resistin, and tumor necrosis factor-alpha with insulin resistance
    Marie France Hivert
    Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 93:3165-72. 2008
    ..Adipose tissue-derived adipokines may contribute to insulin resistance...
  81. doi request reprint A bihormonal closed-loop artificial pancreas for type 1 diabetes
    Firas H El-Khatib
    Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
    Sci Transl Med 2:27ra27. 2010
    ..These results demonstrate the feasibility of safe BG control by a bihormonal artificial endocrine pancreas...
  82. ncbi request reprint Coronary artery calcification in type 2 diabetes and insulin resistance: the framingham offspring study
    James B Meigs
    General Medicine Division and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Diabetes Care 25:1313-9. 2002
    ....
  83. pmc Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies
    Themistocles L Assimes
    Department of Medicine, Stanford University School of Medicine, Stanford, California 94304 1334, USA
    J Am Coll Cardiol 56:1552-63. 2010
    ..We sought to replicate the association between the kinesin-like protein 6 (KIF6) Trp719Arg polymorphism (rs20455), and clinical coronary artery disease (CAD)...
  84. ncbi request reprint Point-of-care testing for diabetes
    Deirdre R Blake
    Diabetes Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Mass, USA
    Crit Care Nurs Q 27:150-61. 2004
    ..The following review examines the role of various assays in the diagnosis and management of diabetes and discusses the role of point-of-care testing...
  85. pmc Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    William C Knowler
    Diabetes Prevention Program Coordinating Center, Biostatistics Center, George Washington University, 6110 Executive Blvd, Suite 750, Rockville, MD 20852, USA
    N Engl J Med 346:393-403. 2002
    ..We hypothesized that modifying these factors with a lifestyle-intervention program or the administration of metformin would prevent or delay the development of diabetes...
  86. ncbi request reprint Thiazolidinediones for initial treatment of type 2 diabetes?
    David M Nathan
    N Engl J Med 355:2477-80. 2006
  87. ncbi request reprint Screening for diabetes: can we afford not to screen?
    David M Nathan
    Ann Intern Med 140:756-8. 2004
  88. pmc Type 2 diabetes-associated missense polymorphisms KCNJ11 E23K and ABCC8 A1369S influence progression to diabetes and response to interventions in the Diabetes Prevention Program
    Jose C Florez
    Diabetes Prevention Program Coordinating Center, Biostatistics Center, George Washington University, 6110 Executive Blvd, Suite 750, Rockville, MD 20852, USA
    Diabetes 56:531-6. 2007
    ..We further hypothesize that the diabetes-preventive effect of metformin may interact with the impact of these variants on insulin regulation...
  89. pmc Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the look AHEAD trial
    Xavier Pi-Sunyer
    St Luke s Roosevelt Hospital Center, USA
    Diabetes Care 30:1374-83. 2007
    ..This report describes 1-year changes in CVD risk factors in a trial designed to examine the long-term effects of an intensive lifestyle intervention on the incidence of major CVD events...
  90. ncbi request reprint Trials that matter: rosiglitazone, ramipril, and the prevention of type 2 diabetes
    David M Nathan
    Ann Intern Med 146:461-3. 2007
  91. pmc Factors associated with diabetes onset during metformin versus placebo therapy in the diabetes prevention program
    John M Lachin
    d, Diabetes Prevention Program Coordinating Center, The Biostatistics Center, George Washington University, 6110 Executive Blvd, Suite 750, Rockville, MD 20852, USA
    Diabetes 56:1153-9. 2007
    ....
  92. ncbi request reprint Prediction of incident diabetes mellitus in middle-aged adults: the Framingham Offspring Study
    Peter W F Wilson
    Emory Program in Cardiovascular Outcomes Research and Epidemiology, Emory University School of Medicine, Atlanta, GA 30306, USA
    Arch Intern Med 167:1068-74. 2007
    ..Prediction rules for type 2 diabetes mellitus (T2DM) have been developed, but we lack consensus for the most effective approach...
  93. ncbi request reprint Rosiglitazone and cardiotoxicity--weighing the evidence
    David M Nathan
    N Engl J Med 357:64-6. 2007
  94. pmc Prevention of type 2 diabetes with troglitazone in the Diabetes Prevention Program
    William C Knowler
    George Washington University Biostatistics Center, Rockville, Maryland, USA
    Diabetes 54:1150-6. 2005
    ..Whether other thiazolidinedione drugs used for longer periods can safely prevent diabetes remains to be determined...
  95. ncbi request reprint Biological variation in HbA1c predicts risk of retinopathy and nephropathy in type 1 diabetes: response to McCarter et al
    Saul Genuth
    Diabetes Care 28:233; author reply 234-5. 2005
  96. doi request reprint Effect of glycemic exposure on the risk of microvascular complications in the diabetes control and complications trial--revisited
    John M Lachin
    The Biostatistics Center, The George Washington University, Rockville, MD 20852, USA
    Diabetes 57:995-1001. 2008
    ....
  97. pmc The prevention of type 2 diabetes
    JILL P CRANDALL
    Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Nat Clin Pract Endocrinol Metab 4:382-93. 2008
    ..Widespread application has, however, been limited by local financial considerations, even though cost-effectiveness might be achieved at the population level...
  98. ncbi request reprint The hemoglobin glycation index is not an independent predictor of the risk of microvascular complications in the Diabetes Control and Complications Trial
    John M Lachin
    The Biostatistics Center, George Washington University, Rockville, MD 20852, USA
    Diabetes 56:1913-21. 2007
    ..The HGI should not be used to estimate risk of complications or to guide therapy...
  99. pmc Health care resource utilization associated with a diabetes center and a general medicine clinic
    Elbert S Huang
    General Medicine Division, University of Chicago, Chicago, Illinoos 60637, USA
    J Gen Intern Med 19:28-35. 2004
    ..We compared the health care utilization associated with a diabetes center (DC) and a general medicine clinic (GMC)...
  100. pmc TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program
    Jose C Florez
    Diabetes Prevention Program Outcomes Study Coordinating Center, George Washington University, Rockville, MD 20852, USA
    N Engl J Med 355:241-50. 2006
    ....

Research Grants4

  1. Post-DPP Followup Study
    David Nathan; Fiscal Year: 2007
    ..women, and in older subjects in the DPP. The current application is for 5 years of funding, although the some of the goals of the projects described will require a 10-year study. ..
  2. Action for Health in Diabetes (Look AHEAD)
    David Nathan; Fiscal Year: 2007
    ..These procedures will enable us to analyze the effects of the intervention on serious cardiovascular- related factors and complications, and cost-effectiveness of the intervention. ..