Yaakov Nahmias

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. doi request reprint Apolipoprotein B-dependent hepatitis C virus secretion is inhibited by the grapefruit flavonoid naringenin
    Yaakov Nahmias
    Center for Engineering in Medicine, Shriners Burns Hospital, Boston, MA, USA
    Hepatology 47:1437-45. 2008
  2. pmc Naringenin inhibits the assembly and long-term production of infectious hepatitis C virus particles through a PPAR-mediated mechanism
    Jonathan Goldwasser
    Center for Engineering in Medicine, Shriners Burns Hospital, Boston, MA, USA
    J Hepatol 55:963-71. 2011
  3. pmc Activin alters the kinetics of endoderm induction in embryonic stem cells cultured on collagen gels
    Natesh Parashurama
    The Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Stem Cells 26:474-84. 2008
  4. pmc Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix
    Basak E Uygun
    Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 16:814-20. 2010
  5. pmc Oxygen-mediated enhancement of primary hepatocyte metabolism, functional polarization, gene expression, and drug clearance
    Srivatsan Kidambi
    Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 106:15714-9. 2009
  6. doi request reprint Mesenchymal stem cell-derived molecules directly modulate hepatocellular death and regeneration in vitro and in vivo
    Daan van Poll
    Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and Shriners Hospitals for Children, Boston, MA, USA
    Hepatology 47:1634-43. 2008
  7. pmc Amino acid-mediated heterotypic interaction governs performance of a hepatic tissue model
    Rohit Jindal
    Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    FASEB J 23:2288-98. 2009
  8. pmc Recovery of warm ischemic rat liver grafts by normothermic extracorporeal perfusion
    Herman Tolboom
    Center for Engineering in Medicine Surgical Services, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Transplantation 87:170-7. 2009
  9. pmc Reactive bone marrow stromal cells attenuate systemic inflammation via sTNFR1
    Hiroshi Yagi
    Department of Surgery, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and Shriners Hospitals for Children, Boston, Massachusetts, USA
    Mol Ther 18:1857-64. 2010
  10. pmc Transcriptional regulation of human and rat hepatic lipid metabolism by the grapefruit flavonoid naringenin: role of PPARalpha, PPARgamma and LXRalpha
    Jonathan Goldwasser
    Center for Engineering in Medicine, Shriners Burns Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 5:e12399. 2010

Collaborators

Detail Information

Publications19

  1. doi request reprint Apolipoprotein B-dependent hepatitis C virus secretion is inhibited by the grapefruit flavonoid naringenin
    Yaakov Nahmias
    Center for Engineering in Medicine, Shriners Burns Hospital, Boston, MA, USA
    Hepatology 47:1437-45. 2008
    ..CONCLUSION: These results suggest a novel therapeutic approach for the treatment of HCV infection...
  2. pmc Naringenin inhibits the assembly and long-term production of infectious hepatitis C virus particles through a PPAR-mediated mechanism
    Jonathan Goldwasser
    Center for Engineering in Medicine, Shriners Burns Hospital, Boston, MA, USA
    J Hepatol 55:963-71. 2011
    ..Recently, our group and others demonstrated that the HCV lifecycle is critically dependent on host lipid metabolism and that its production is metabolically modulated...
  3. pmc Activin alters the kinetics of endoderm induction in embryonic stem cells cultured on collagen gels
    Natesh Parashurama
    The Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Stem Cells 26:474-84. 2008
    ..In addition, our work suggests a new role for activin in induction of the precursors to endoderm and a new endoderm-enrichment technique using follistatin...
  4. pmc Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix
    Basak E Uygun
    Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 16:814-20. 2010
    ..These results provide a proof of principle for the generation of a transplantable liver graft as a potential treatment for liver disease...
  5. pmc Oxygen-mediated enhancement of primary hepatocyte metabolism, functional polarization, gene expression, and drug clearance
    Srivatsan Kidambi
    Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 106:15714-9. 2009
    ..These results are readily extendable to other culture configurations including three-dimensional culture, bioreactor studies, as well as microfabricated co-cultures...
  6. doi request reprint Mesenchymal stem cell-derived molecules directly modulate hepatocellular death and regeneration in vitro and in vivo
    Daan van Poll
    Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and Shriners Hospitals for Children, Boston, MA, USA
    Hepatology 47:1634-43. 2008
    ....
  7. pmc Amino acid-mediated heterotypic interaction governs performance of a hepatic tissue model
    Rohit Jindal
    Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    FASEB J 23:2288-98. 2009
    ..These findings suggest an important role for proline secretion by endothelial cells as a paracrine factor regulating hepatocyte function...
  8. pmc Recovery of warm ischemic rat liver grafts by normothermic extracorporeal perfusion
    Herman Tolboom
    Center for Engineering in Medicine Surgical Services, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Transplantation 87:170-7. 2009
    ..The rat model in this study is a useful platform to further optimize NELP as a method of recovery and preservation of DCD livers...
  9. pmc Reactive bone marrow stromal cells attenuate systemic inflammation via sTNFR1
    Hiroshi Yagi
    Department of Surgery, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and Shriners Hospitals for Children, Boston, Massachusetts, USA
    Mol Ther 18:1857-64. 2010
    ..These results suggest that improvements of inflammatory responses in animal models after local transplantation of MSCs are at least, in part, explained by the NFκB-dependent secretion of sTNFR1 by MSCs...
  10. pmc Transcriptional regulation of human and rat hepatic lipid metabolism by the grapefruit flavonoid naringenin: role of PPARalpha, PPARgamma and LXRalpha
    Jonathan Goldwasser
    Center for Engineering in Medicine, Shriners Burns Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 5:e12399. 2010
    ..Our findings explain the myriad effects of naringenin and support its continued clinical development. Of note, this is the first description of a non-toxic, naturally occurring LXRalpha inhibitor...
  11. ncbi request reprint Homogeneous differentiation of hepatocyte-like cells from embryonic stem cells: applications for the treatment of liver failure
    Cheul H Cho
    Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    FASEB J 22:898-909. 2008
    ..Incorporating the hepatocyte-like cells into a bioartificial liver device to treat fulminant hepatic failure improved animal survival, thereby underscoring the therapeutic potential of these cells...
  12. pmc In situ metabolic flux analysis to quantify the liver metabolic response to experimental burn injury
    Maria Louisa Izamis
    The Center for Engineering in Medicine, Massachusetts General Hospital Harvard Medical School Shriners Hospitals for Children, Boston, Massachusetts 02114, USA
    Biotechnol Bioeng 108:839-52. 2011
    ..These results suggest that increasing the severity of injury does not lead to a simple dose-dependent metabolic response, but rather leads to qualitatively different responses...
  13. ncbi request reprint Micropatterning of living cells by laser-guided direct writing: application to fabrication of hepatic-endothelial sinusoid-like structures
    Yaakov Nahmias
    Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, 51 Blossom Street, Boston, Massachusetts 02114, USA
    Nat Protoc 1:2288-96. 2006
    ..The total time required to carry out this protocol is typically 7 h...
  14. ncbi request reprint A novel formulation of oxygen-carrying matrix enhances liver-specific function of cultured hepatocytes
    Yaakov Nahmias
    Center for Engineering in Medicine Department of Surgery, Massachusetts General Hospital, Shriners Burns Hospital, Harvard Medical School, Boston, MA 02114, USA
    FASEB J 20:2531-3. 2006
    ..Culture of hepatocytes on oxygen-carrying matrix mimics the oxygen-rich environment of the liver and provides a simple method for enhanced long-term function...
  15. ncbi request reprint Integration of technologies for hepatic tissue engineering
    Yaakov Nahmias
    Center for Engineering in Medicine, Department of Surgery, Massachusetts General Hospital, Shriners Burns Hospital, Harvard Medical School, 51 Blossom St, Boston, MA 02114, USA
    Adv Biochem Eng Biotechnol 103:309-29. 2007
    ..Finally, we will review current opportunities and major challenges in integrating cell culture, bioreactor design, and microtechnology to develop new systems for novel applications...
  16. pmc Self-assembling elastin-like peptides growth factor chimeric nanoparticles for the treatment of chronic wounds
    Piyush Koria
    Center for Engineering in Medicine, Massachusetts General Hospital, Boston, MA 02129, USA
    Proc Natl Acad Sci U S A 108:1034-9. 2011
    ..The data strongly suggests that these self-assembled nanoparticles may be beneficial in the treatment of chronic wounds resulting from diabetes or other underlying circulatory conditions...
  17. ncbi request reprint Liver endothelial cells promote LDL-R expression and the uptake of HCV-like particles in primary rat and human hepatocytes
    Yaakov Nahmias
    Center for Engineering in Medicine Department of Surgery, Massachusetts General Hospital, Shriners Burns Hospital, Harvard Medical School, Boston, MA 02114, USA
    Hepatology 43:257-65. 2006
    ..In conclusion, our findings describe a novel model of polarized hepatocytes in vitro that can be used for the study of LDL metabolism and hepatitis C infection...
  18. pmc An orally delivered small-molecule formulation with antiangiogenic and anticancer activity
    Ofra Benny
    Vascular Biology Program and Department of Surgery, Children s Hospital Boston, Harvard Medical School, 1 Blackfan Circle, St Karp Research Building, Boston, Massachusetts 02215, USA
    Nat Biotechnol 26:799-807. 2008
    ..We show that Lodamin is an oral nontoxic antiangiogenic drug that can be chronically administered for cancer therapy or metastasis prevention...
  19. ncbi request reprint Cell patterning on biological gels via cell spraying through a mask
    Yaakov Nahmias
    Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Tissue Eng 11:701-8. 2005
    ....