Research Topics
| Yaakov NahmiasSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Detail Information
Publications
Apolipoprotein B-dependent hepatitis C virus secretion is inhibited by the grapefruit flavonoid naringeninYaakov Nahmias
Center for Engineering in Medicine, Shriners Burns Hospital, Boston, MA, USA
Hepatology 47:1437-45. 2008..CONCLUSION: These results suggest a novel therapeutic approach for the treatment of HCV infection...
Naringenin inhibits the assembly and long-term production of infectious hepatitis C virus particles through a PPAR-mediated mechanismJonathan Goldwasser
Center for Engineering in Medicine, Shriners Burns Hospital, Boston, MA, USA
J Hepatol 55:963-71. 2011..Recently, our group and others demonstrated that the HCV lifecycle is critically dependent on host lipid metabolism and that its production is metabolically modulated...- Activin alters the kinetics of endoderm induction in embryonic stem cells cultured on collagen gelsNatesh Parashurama
The Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Stem Cells 26:474-84. 2008..In addition, our work suggests a new role for activin in induction of the precursors to endoderm and a new endoderm-enrichment technique using follistatin... - Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrixBasak E Uygun
Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Nat Med 16:814-20. 2010..These results provide a proof of principle for the generation of a transplantable liver graft as a potential treatment for liver disease... - Oxygen-mediated enhancement of primary hepatocyte metabolism, functional polarization, gene expression, and drug clearanceSrivatsan Kidambi
Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02111, USA
Proc Natl Acad Sci U S A 106:15714-9. 2009..These results are readily extendable to other culture configurations including three-dimensional culture, bioreactor studies, as well as microfabricated co-cultures... - Mesenchymal stem cell-derived molecules directly modulate hepatocellular death and regeneration in vitro and in vivoDaan van Poll
Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and Shriners Hospitals for Children, Boston, MA, USA
Hepatology 47:1634-43. 2008.... - Amino acid-mediated heterotypic interaction governs performance of a hepatic tissue modelRohit Jindal
Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
FASEB J 23:2288-98. 2009..These findings suggest an important role for proline secretion by endothelial cells as a paracrine factor regulating hepatocyte function... - Recovery of warm ischemic rat liver grafts by normothermic extracorporeal perfusionHerman Tolboom
Center for Engineering in Medicine Surgical Services, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Transplantation 87:170-7. 2009..The rat model in this study is a useful platform to further optimize NELP as a method of recovery and preservation of DCD livers... - Reactive bone marrow stromal cells attenuate systemic inflammation via sTNFR1Hiroshi Yagi
Department of Surgery, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and Shriners Hospitals for Children, Boston, Massachusetts, USA
Mol Ther 18:1857-64. 2010..These results suggest that improvements of inflammatory responses in animal models after local transplantation of MSCs are at least, in part, explained by the NFκB-dependent secretion of sTNFR1 by MSCs... - Transcriptional regulation of human and rat hepatic lipid metabolism by the grapefruit flavonoid naringenin: role of PPARalpha, PPARgamma and LXRalphaJonathan Goldwasser
Center for Engineering in Medicine, Shriners Burns Hospital, Boston, Massachusetts, United States of America
PLoS ONE 5:e12399. 2010..Our findings explain the myriad effects of naringenin and support its continued clinical development. Of note, this is the first description of a non-toxic, naturally occurring LXRalpha inhibitor... 
Homogeneous differentiation of hepatocyte-like cells from embryonic stem cells: applications for the treatment of liver failureCheul H Cho
Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
FASEB J 22:898-909. 2008..Incorporating the hepatocyte-like cells into a bioartificial liver device to treat fulminant hepatic failure improved animal survival, thereby underscoring the therapeutic potential of these cells...- In situ metabolic flux analysis to quantify the liver metabolic response to experimental burn injuryMaria Louisa Izamis
The Center for Engineering in Medicine, Massachusetts General Hospital Harvard Medical School Shriners Hospitals for Children, Boston, Massachusetts 02114, USA
Biotechnol Bioeng 108:839-52. 2011..These results suggest that increasing the severity of injury does not lead to a simple dose-dependent metabolic response, but rather leads to qualitatively different responses... - Micropatterning of living cells by laser-guided direct writing: application to fabrication of hepatic-endothelial sinusoid-like structuresYaakov Nahmias
Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, 51 Blossom Street, Boston, Massachusetts 02114, USA
Nat Protoc 1:2288-96. 2006..The total time required to carry out this protocol is typically 7 h... - A novel formulation of oxygen-carrying matrix enhances liver-specific function of cultured hepatocytesYaakov Nahmias
Center for Engineering in Medicine/Department of Surgery, Massachusetts General Hospital, Shriners Burns Hospital, Harvard Medical School, Boston, MA 02114, USA
FASEB J 20:2531-3. 2006..Culture of hepatocytes on oxygen-carrying matrix mimics the oxygen-rich environment of the liver and provides a simple method for enhanced long-term function... - Integration of technologies for hepatic tissue engineeringYaakov Nahmias
Center for Engineering in Medicine, Department of Surgery, Massachusetts General Hospital, Shriners Burns Hospital, Harvard Medical School, 51 Blossom St, Boston, MA 02114, USA
Adv Biochem Eng Biotechnol 103:309-29. 2007..Finally, we will review current opportunities and major challenges in integrating cell culture, bioreactor design, and microtechnology to develop new systems for novel applications... - Self-assembling elastin-like peptides growth factor chimeric nanoparticles for the treatment of chronic woundsPiyush Koria
Center for Engineering in Medicine, Massachusetts General Hospital, Boston, MA 02129, USA
Proc Natl Acad Sci U S A 108:1034-9. 2011..The data strongly suggests that these self-assembled nanoparticles may be beneficial in the treatment of chronic wounds resulting from diabetes or other underlying circulatory conditions... - Liver endothelial cells promote LDL-R expression and the uptake of HCV-like particles in primary rat and human hepatocytesYaakov Nahmias
Center for Engineering in Medicine/Department of Surgery, Massachusetts General Hospital, Shriners Burns Hospital, Harvard Medical School, Boston, MA 02114, USA
Hepatology 43:257-65. 2006..In conclusion, our findings describe a novel model of polarized hepatocytes in vitro that can be used for the study of LDL metabolism and hepatitis C infection... - An orally delivered small-molecule formulation with antiangiogenic and anticancer activityOfra Benny
Vascular Biology Program and Department of Surgery, Children s Hospital Boston, Harvard Medical School, 1 Blackfan Circle, St Karp Research Building, Boston, Massachusetts 02215, USA
Nat Biotechnol 26:799-807. 2008..We show that Lodamin is an oral nontoxic antiangiogenic drug that can be chronically administered for cancer therapy or metastasis prevention... - Cell patterning on biological gels via cell spraying through a maskYaakov Nahmias
Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, USA
Tissue Eng 11:701-8. 2005....