G Musch

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Regional gas exchange and cellular metabolic activity in ventilator-induced lung injury
    Guido Musch
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Anesthesiology 106:723-35. 2007
  2. pmc Positron emission tomography imaging of regional pulmonary perfusion and ventilation
    Guido Musch
    Department of Anesthesia and Critical Care, CLN 309, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Proc Am Thorac Soc 2:522-7, 508-9. 2005
  3. pmc Relation between shunt, aeration, and perfusion in experimental acute lung injury
    Guido Musch
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Am J Respir Crit Care Med 177:292-300. 2008
  4. ncbi request reprint Positron emission tomography imaging of regional lung function
    G Musch
    Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Minerva Anestesiol 72:363-7. 2006
  5. ncbi request reprint Mechanism by which a sustained inflation can worsen oxygenation in acute lung injury
    Guido Musch
    Department of Anesthesia and Critical Care, CLN 309, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Anesthesiology 100:323-30. 2004
  6. ncbi request reprint Topographical distribution of pulmonary perfusion and ventilation, assessed by PET in supine and prone humans
    Guido Musch
    Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Appl Physiol 93:1841-51. 2002
  7. pmc Mild endotoxemia during mechanical ventilation produces spatially heterogeneous pulmonary neutrophilic inflammation in sheep
    Eduardo L V Costa
    Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Anesthesiology 112:658-69. 2010
  8. pmc Effect of prone position on regional shunt, aeration, and perfusion in experimental acute lung injury
    Torsten Richter
    Department of Anesthesia and Critical Care, CLN 309, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Am J Respir Crit Care Med 172:480-7. 2005
  9. ncbi request reprint Relationship between airway narrowing, patchy ventilation and lung mechanics in asthmatics
    N T Tgavalekos
    Department of Anesthesia and Critical Care CLN 237F, Massachusetts General Hospital, and Department of Biomedical Engineering, Boston University, Boston 02114, USA
    Eur Respir J 29:1174-81. 2007
  10. ncbi request reprint Modeling kinetics of infused 13NN-saline in acute lung injury
    K O'Neill
    Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Appl Physiol 95:2471-84. 2003

Research Grants

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Regional gas exchange and cellular metabolic activity in ventilator-induced lung injury
    Guido Musch
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Anesthesiology 106:723-35. 2007
    ....
  2. pmc Positron emission tomography imaging of regional pulmonary perfusion and ventilation
    Guido Musch
    Department of Anesthesia and Critical Care, CLN 309, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Proc Am Thorac Soc 2:522-7, 508-9. 2005
    ..This article describes insights into the pathophysiology of acute lung injury, pulmonary embolism, and asthma that have been gained by PET imaging of regional gas exchange...
  3. pmc Relation between shunt, aeration, and perfusion in experimental acute lung injury
    Guido Musch
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Am J Respir Crit Care Med 177:292-300. 2008
    ..In a pulmonary process characterized by spatially heterogeneous loss of aeration, the impairment of gas exchange is expected to depend on the regional distribution of perfusion relative to that of aeration...
  4. ncbi request reprint Positron emission tomography imaging of regional lung function
    G Musch
    Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Minerva Anestesiol 72:363-7. 2006
    ....
  5. ncbi request reprint Mechanism by which a sustained inflation can worsen oxygenation in acute lung injury
    Guido Musch
    Department of Anesthesia and Critical Care, CLN 309, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Anesthesiology 100:323-30. 2004
    ..However, RMs do not improve, and may even worsen, gas exchange in a fraction of these patients. In this study, the authors sought to determine the mechanism by which an RM can impair gas exchange in acute lung injury...
  6. ncbi request reprint Topographical distribution of pulmonary perfusion and ventilation, assessed by PET in supine and prone humans
    Guido Musch
    Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Appl Physiol 93:1841-51. 2002
    ....
  7. pmc Mild endotoxemia during mechanical ventilation produces spatially heterogeneous pulmonary neutrophilic inflammation in sheep
    Eduardo L V Costa
    Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Anesthesiology 112:658-69. 2010
    ..The authors tested whether mild endotoxemia combined with large tidal volume mechanical ventilation bounded by pressures within clinically acceptable limits could yield measurable and anatomically localized neutrophilic inflammation...
  8. pmc Effect of prone position on regional shunt, aeration, and perfusion in experimental acute lung injury
    Torsten Richter
    Department of Anesthesia and Critical Care, CLN 309, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Am J Respir Crit Care Med 172:480-7. 2005
    ..However, the regional mechanism by which the prone position improves gas exchange in acutely injured lungs is still incompletely defined...
  9. ncbi request reprint Relationship between airway narrowing, patchy ventilation and lung mechanics in asthmatics
    N T Tgavalekos
    Department of Anesthesia and Critical Care CLN 237F, Massachusetts General Hospital, and Department of Biomedical Engineering, Boston University, Boston 02114, USA
    Eur Respir J 29:1174-81. 2007
    ..The current data supports the concept that patchy ventilation is an expression of the integrated system and not just the sum of independent responses of individual airways...
  10. ncbi request reprint Modeling kinetics of infused 13NN-saline in acute lung injury
    K O'Neill
    Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Appl Physiol 95:2471-84. 2003
    ....
  11. ncbi request reprint Self-organized patchiness in asthma as a prelude to catastrophic shifts
    Jose G Venegas
    Massachusetts General Hospital, Department of Anesthesia and Critical Care, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Nature 434:777-82. 2005
    ..This work might have implications for the treatment of asthma, and might provide a model for studying diseases of other distributed organs...
  12. pmc Image-derived input function for assessment of 18F-FDG uptake by the inflamed lung
    Tobias Schroeder
    Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Nucl Med 48:1889-96. 2007
    ..This paper presents and validates a method to accurately derive an input function from a blood-pool region of interest (ROI) defined in dynamic PET images...
  13. pmc The prone position results in smaller ventilation defects during bronchoconstriction in asthma
    R Scott Harris
    Department of Medicine, Pulmonary and Critical Care Unit, Bulfinch 148, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Appl Physiol 107:266-74. 2009
    ..In asthma, the size and location of ventilation defects is affected by body position and likely affected by small differences in lung expansion during bronchoconstriction...
  14. doi request reprint Spatial heterogeneity of lung perfusion assessed with (13)N PET as a vascular biomarker in chronic obstructive pulmonary disease
    Marcos F Vidal Melo
    Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Nucl Med 51:57-65. 2010
    ....
  15. ncbi request reprint Changes in regional ventilation after autologous blood clot pulmonary embolism
    Marcos F Vidal Melo
    Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Anesthesiology 97:671-81. 2002
    ..This study aimed to directly assess changes in regional specific ventilation (sV(A)) due to autologous blood clot PE using positron emission tomography...
  16. pmc Regional pulmonary perfusion, inflation, and ventilation defects in bronchoconstricted patients with asthma
    R Scott Harris
    Department of Medicine Pulmonary and Critical Care Unit and General Medicine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Respir Crit Care Med 174:245-53. 2006
    ..However, the regional adaptations of pulmonary perfusion (Q) to such ventilation defects have not been well studied...
  17. ncbi request reprint Quantification of regional ventilation-perfusion ratios with PET
    Marcos F Vidal Melo
    Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, USA
    J Nucl Med 44:1982-91. 2003
    ..This study aims to present a PET-based method to estimate regional alveolar ventilation-to-perfusion ratios (V(A)/Q) predictive of arterial blood gases...
  18. pmc Measurement of regional specific lung volume change using respiratory-gated PET of inhaled 13N-nitrogen
    Tyler J Wellman
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts, USA
    J Nucl Med 51:646-53. 2010
    ....
  19. ncbi request reprint PET imaging of regional 18F-FDG uptake and lung function after cigarette smoke inhalation
    Tobias Schroeder
    Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Nucl Med 48:413-9. 2007
    ....
  20. pmc Modeling pulmonary kinetics of 2-deoxy-2-[18F]fluoro-D-glucose during acute lung injury
    Tobias Schroeder
    Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA
    Acad Radiol 15:763-75. 2008
    ..In the lungs, however, a high blood-to-parenchymal volume ratio and (18)F-FDG distribution in edematous injured tissue could require a modified model to properly describe (18)F-FDG kinetics...
  21. ncbi request reprint Identifying airways responsible for heterogeneous ventilation and mechanical dysfunction in asthma: an image functional modeling approach
    Nora T Tgavalekos
    Dept of Biomedical Engineering, Boston University, MA 02215, USA
    J Appl Physiol 99:2388-97. 2005
    ..Also, whereas larger airway constriction may contribute to mechanical dysfunction during asthma, degradation in ventilation function requires heterogeneous distribution of near closures confined to small airways...
  22. ncbi request reprint Repeated lung inflations and deterioration in gas exchange
    Giacomo Bellani
    Intensive Care Med 31:1295; author reply 1296. 2005

Research Grants3

  1. REGIONAL LUNG FUNCTION IN ACUTE LUNG INJURY
    Guido Musch; Fiscal Year: 2007
    ..End of Abstract) ..
  2. Effect of Prone Position on Ventilator-Induced Lung Injury
    Guido Musch; Fiscal Year: 2010
    ..In this research, we will test whether promoting uniform lung inflation and tidal expansion by prone positioning reduces neutrophil metabolic activation, an early and important event in the pathogenesis of VILI. ..