Affiliation: Massachusetts Institute of Technology
- Postsynaptic density scaffold SAP102 regulates cortical synapse development through EphB and PAK signaling pathwayYasunobu Murata
McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Neurosci 33:5040-52. 2013..Both SAP102 and PAKs are associated with X-linked mental retardation in humans; thus, synapse formation mediated by EphB/SAP102/PAK signaling in the early postnatal brain may be crucial for cognitive development...
- Eye opening and PSD95 are required for long-term potentiation in developing superior colliculusJian Ping Zhao
McGovern Institute for Brain Research and Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 110:707-12. 2013..These data indicate that young SC LTP arises from PSD95 unsilencing of silent synapses, that unsilencing is labile in young brain, and that even though SAP102 and PSD95 can bind the same NMDARs, only PSD95 enables SC synaptic maturation...
- TrkB and protein kinase Mζ regulate synaptic localization of PSD-95 in developing cortexAkira Yoshii
Departmens of Brain and Cognitive Science, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Neurosci 31:11894-904. 2011..These results also indicate that palmitoylation can be regulated by a trophic factor. Our findings have implications for neurodevelopmental disorders as well as aging brains...