Jason T Motz
Affiliation: Massachusetts General Hospital
- Model-based biological Raman spectral imagingKaren E Shafer-Peltier
Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, USA
J Cell Biochem Suppl 39:125-37. 2002..How to best extract meaningful chemical information using each imaging approach will be discussed and examples of images produced with each will be shown...
- Optical fiber probe for biomedical Raman spectroscopyJason T Motz
George R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Appl Opt 43:542-54. 2004..Performance has been tested through simulations and experiments with tissue models and several in vitro tissue types, demonstrating that this new design can advance Raman spectroscopy as a clinically practical technique...
- Spectral- and frequency-encoded fluorescence imagingJason T Motz
Harvard Medical School and the Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Opt Lett 30:2760-2. 2005..This method is applicable for developing submillimeter diameter endoscopes. The principles of the technique are validated by imaging indocyanine green fluorescence in microfluidic channels...
- Real-time Raman system for in vivo disease diagnosisJason T Motz
Massachusetts Institute of Technology, George R Harrison Spectroscopy Laboratory, Cambridge, Massachusetts 02138, USA
J Biomed Opt 10:031113. 2005..The real-time capabilities of the system were demonstrated in vivo during femoral bypass and breast lumpectomy surgeries. Such a system will greatly facilitate the adoption of Raman spectroscopy into clinical research and practice...
- In vivo Raman spectral pathology of human atherosclerosis and vulnerable plaqueJason T Motz
Massachusetts General Hospital, Harvard Medical School, Wellman Center for Photomedicine, Boston, Massachusetts 02114, USA
J Biomed Opt 11:021003. 2006..These initial findings indicate that Raman spectroscopy has the potential to be a clinically relevant diagnostic tool for studying cardiovascular disease...
- Detection of morphological markers of vulnerable atherosclerotic plaque using multimodal spectroscopyObrad R Scepanovic
Massachusetts Institute of Technology, G R Harrison Spectroscopy Laboratory, Cambridge, Massachusetts 02139, USA
J Biomed Opt 11:021007. 2006..The results indicate that MMS provides depth-sensitive and complementary morphological information about plaque composition. A prospective in vivo study will be conducted to validate these findings...
- Intrinsic fluorescence and diffuse reflectance spectroscopy identify superficial foam cells in coronary plaques prone to erosionGeorge O Angheloiu
Spectroscopy Laboratory, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA
Arterioscler Thromb Vasc Biol 26:1594-600. 2006..This is a key step in our ongoing program to develop a spectroscopic technique for real-time in vivo diagnosis of vulnerable atherosclerotic plaque...
- Intrinsic versus laser-induced fluorescence spectroscopy for coronary atherosclerosis: a generational comparison model for testing diagnostic accuracyGeorge O Angheloiu
Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Appl Spectrosc 66:1403-10. 2012..87 ± 0.025, superior to LIF(342) (84% ± 3% and 0.84 ± 0.016; P = 0.0002 and 0.02, respectively) in a generational comparison model...
- Characterization of atherosclerotic plaques by laser speckle imagingSeemantini K Nadkarni
Department of Dermatology, Harvard Medical School, Wellman Center for Photomedicine, Massachusetts General Hospital, 40 Blossom St, BAR 718, Boston, MA 02114, USA
Circulation 112:885-92. 2005..In this article, we describe a new optical technique, laser speckle imaging (LSI), that measures an index of plaque viscoelasticity. We evaluate the potential of LSI for characterizing atherosclerotic plaque...