Research Topics
Genomes and GenesSpecies | Samia MoraSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Publications
Association of high-density lipoprotein cholesterol with incident cardiovascular events in women, by low-density lipoprotein cholesterol and apolipoprotein B100 levels: a cohort studySamia Mora
Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
Ann Intern Med 155:742-50. 2011..Whether this observation is consistent across low-density lipoprotein cholesterol (LDL-C) levels or total atherogenic particle burden (apolipoprotein B100) is less well-studied, particularly in women...- On-treatment non-high-density lipoprotein cholesterol, apolipoprotein B, triglycerides, and lipid ratios in relation to residual vascular risk after treatment with potent statin therapy: JUPITER (justification for the use of statins in prevention: an inteSamia Mora
Center for Cardiovascular Disease Prevention, Divisions of Preventive and Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
J Am Coll Cardiol 59:1521-8. 2012.... - Determinants of residual risk in secondary prevention patients treated with high- versus low-dose statin therapy: the Treating to New Targets (TNT) studySamia Mora
Brigham and Women s Hospital, Boston, MA 02215, USA
Circulation 125:1979-87. 2012..Risk factors for this "residual risk" have not been studied comprehensively. We aimed to identify determinants of this risk above and beyond lipid-related risk factors... 
The clinical utility of high-sensitivity C-reactive protein in cardiovascular disease and the potential implication of JUPITER on current practice guidelinesSamia Mora
Divisions of Preventive and Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Clin Chem 55:219-28. 2009....- Lipoprotein particle profiles by nuclear magnetic resonance compared with standard lipids and apolipoproteins in predicting incident cardiovascular disease in womenSamia Mora
Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Avenue E, Boston, MA 02215, USA
Circulation 119:931-9. 2009..Nuclear magnetic resonance (NMR) spectroscopy measures the number and size of lipoprotein particles instead of their cholesterol or triglyceride content, but its clinical utility is uncertain... - Comparison of LDL cholesterol concentrations by Friedewald calculation and direct measurement in relation to cardiovascular events in 27,331 womenSamia Mora
Division of Preventive Medicine, Donald W Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Clin Chem 55:888-94. 2009.... - Statins for the primary prevention of cardiovascular events in women with elevated high-sensitivity C-reactive protein or dyslipidemia: results from the Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPSamia Mora
Center for Cardiovascular Disease Prevention, Divisions of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Circulation 121:1069-77. 2010..We analyzed sex-specific outcomes in the Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) and synthesized the results with prior trials... - Lipoprotein particle size and concentration by nuclear magnetic resonance and incident type 2 diabetes in womenSamia Mora
Division of Preventive Medicine, Brigham and Women s Hospital, Boston, Massachusett, USA
Diabetes 59:1153-60. 2010..We examined the association of lipoprotein particle size and concentration measured by nuclear magnetic resonance (NMR) spectroscopy with clinical type 2 diabetes... - Lipoprotein(a) and risk of type 2 diabetesSamia Mora
Center for Cardiovascular Disease Prevention, Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Clin Chem 56:1252-60. 2010..Previous studies have demonstrated that cardiovascular risk is higher with increased lipoprotein(a) [Lp(a)]. Whether Lp(a) concentration is related to type 2 diabetes is unclear... - Fasting compared with nonfasting lipids and apolipoproteins for predicting incident cardiovascular eventsSamia Mora
Donald W Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Circulation 118:993-1001. 2008..Whether fasting status alters associations of nontriglyceride lipids with CVD is unclear... - HDL cholesterol and residual risk of first cardiovascular events after treatment with potent statin therapy: an analysis from the JUPITER trialPaul M Ridker
Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Lancet 376:333-9. 2010..We addressed, using the JUPITER trial cohort, whether this association remains when LDL-cholesterol concentrations are reduced to the very low ranges with high-dose statin treatment... - Physical activity and reduced risk of cardiovascular events: potential mediating mechanismsSamia Mora
Donald W Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Circulation 116:2110-8. 2007..Although the precise mechanisms underlying this inverse association are unclear, differences in several cardiovascular risk factors may mediate this effect... 
Additive value of immunoassay-measured fibrinogen and high-sensitivity C-reactive protein levels for predicting incident cardiovascular eventsSamia Mora
Donald W Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215
Circulation 114:381-7. 2006..Whether other inflammatory biomarkers, such as fibrinogen, add further prognostic information is uncertain...- Fasting compared with nonfasting triglycerides and risk of cardiovascular events in womenSandeep Bansal
Donald W Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, Boston, MA 02215, USA
JAMA 298:309-16. 2007..Although triglyceride levels are typically obtained in the fasting state, postprandial hypertriglyceridemia may play an important role in atherosclerosis... - Exercise blood pressure and future cardiovascular death in asymptomatic individualsSandra A Weiss
Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
Circulation 121:2109-16. 2010..Individuals with exaggerated exercise blood pressure (BP) tend to develop future hypertension. It is controversial whether they have higher risk of death from cardiovascular disease (CVD)... - Lipoprotein subclass abnormalities and incident hypertension in initially healthy womenNina P Paynter
Divisions of Preventive Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
Clin Chem 57:1178-87. 2011..Whether lipoprotein particle size or subclass concentrations play a role in the development of hypertension is unknown... - Justification for the Use of Statins in Primary Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER)--can C-reactive protein be used to target statin therapy in primary prevention?Samia Mora
Center for Cardiovascular Disease Prevention and Division of Cardiovascular Disease, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
Am J Cardiol 97:33A-41A. 2006..Ongoing work will determine whether hs-CRP reduction, independent of LDL cholesterol reduction, results in a net clinical benefit... - Association of physical activity and body mass index with novel and traditional cardiovascular biomarkers in womenSamia Mora
Donald W Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02215, USA
JAMA 295:1412-9. 2006..There are few data directly comparing the effects of physical activity and body weight on cardiovascular biomarkers... - Homocysteine, 5,10-methylenetetrahydrofolate reductase 677C>T polymorphism, nutrient intake, and incident cardiovascular disease in 24,968 initially healthy womenRobert Y L Zee
Donald W Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Clin Chem 53:845-51. 2007..To address this apparent paradox, we explored whether interaction between genetic and dietary factors related to homocysteine metabolism contributes to CVD risk... - A national interactive web-based physical activity intervention in women, evaluation of the american heart association choose to move program 2006-2007Sarah B Lieber
Harvard Medical School, Boston, Massachusetts, USA
Am J Cardiol 109:1754-60. 2012..Increasing use of this simple Web-based tool could improve PA and promote disease prevention... - Blood pressure and risk of developing type 2 diabetes mellitus: the Women's Health StudyDavid Conen
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, USA
Eur Heart J 28:2937-43. 2007..To examine the relationship of blood pressure (BP) and BP progression with the subsequent development of type 2 diabetes... - LDL particle subclasses, LDL particle size, and carotid atherosclerosis in the Multi-Ethnic Study of Atherosclerosis (MESA)Samia Mora
Center for Cardiovascular Disease Prevention, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA, USA
Atherosclerosis 192:211-7. 2007..Previous studies showing that smaller low-density lipoprotein (LDL) size is associated with greater atherosclerotic risk did not adequately control for small and large LDL particle correlation... - Gender-specific prediction of cardiac disease: importance of risk factors and exercise variablesSamia Mora
Division of Preventive Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, Massachusetts 02215, USA
Cardiol Rev 14:281-5. 2006.... - Lifestyle interaction with fat mass and obesity-associated (FTO) genotype and risk of obesity in apparently healthy U.S. womenTariq Ahmad
Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
Diabetes Care 34:675-80. 2011..Variation in the fat mass and obesity-associated (FTO) gene is associated with obesity. The extent to which separate and combined effects of physical activity and caloric intake modify this association remains unclear... - Interaction of body mass index and framingham risk score in predicting incident coronary disease in familiesSamia Mora
Center for Cardiovascular Disease Prevention, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Ave East, 3rd Floor, Boston, MA 02215, USA
Circulation 111:1871-6. 2005..The aim of this study was to examine the effect of high BMI on incident CHD in white and black families with premature CHD and to estimate the heritability of BMI... - Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysisDaniel I Chasman
Donald W Reynolds Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
PLoS Genet 5:e1000730. 2009.... - Enhanced risk assessment in asymptomatic individuals with exercise testing and Framingham risk scoresSamia Mora
Center for Cardiovascular Disease Prevention, Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical Schoo, Boston, MA, USA
Circulation 112:1566-72. 2005..We hypothesized that risk prediction could be improved with 2 non-ECG exercise test measures, exercise capacity (metabolic equivalents, or METs) and heart rate recovery (HRR)... - Ability of exercise testing to predict cardiovascular and all-cause death in asymptomatic women: a 20-year follow-up of the lipid research clinics prevalence studySamia Mora
Ciccarone Preventive Cardiology Center, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
JAMA 290:1600-7. 2003..93; 95% CI, 5.62-29.73; P<.001). CONCLUSION: The prognostic value of exercise testing in asymptomatic women derives not from electrocardiographic ischemia but from fitness-related variables... - The metabolic syndrome in womenJ Gabriel Schneider
Ciccarone Center for the Prevention of Heart Disease, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Cardiol Rev 14:286-91. 2006..Appropriate treatment may also include managing individual cardiac risk factors with the use of antihypertensive and lipid-modifying agents among others... - Biomarkers for prediction of cardiovascular eventsDiane M Becker
N Engl J Med 356:1473; author reply 1474-5. 2007 - Glucose levels in the normal range predict incident diabetes in families with premature coronary heart diseaseStasia S Reynolds
Divisions of General Internal Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
Diabetes Res Clin Pract 74:267-73. 2006..867. CONCLUSION: Higher FPG levels within the designated "normal" range in high risk families are a potent independent risk factor for type 2 diabetes and may serve as a sentinel to trigger primary preventive interventions...