Gayatry Mohapatra

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Genome wide DNA copy number analysis of serous type ovarian carcinomas identifies genetic markers predictive of clinical outcome
    David A Engler
    Department of Statistics, Brigham Young University, Provo, Utah, United States of America
    PLoS ONE 7:e30996. 2012
  2. pmc Genome-wide comparison of paired fresh frozen and formalin-fixed paraffin-embedded gliomas by custom BAC and oligonucleotide array comparative genomic hybridization: facilitating analysis of archival gliomas
    Gayatry Mohapatra
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Acta Neuropathol 121:529-43. 2011
  3. pmc Genomic profiling of atypical meningiomas associates gain of 1q with poor clinical outcome
    Darlene Gabeau-Lacet
    Department of Pathology, Massachusetts General Hospital, 149 13th St, Charlestown, MA 02129, USA
    J Neuropathol Exp Neurol 68:1155-65. 2009
  4. pmc Glioma test array for use with formalin-fixed, paraffin-embedded tissue: array comparative genomic hybridization correlates with loss of heterozygosity and fluorescence in situ hybridization
    Gayatry Mohapatra
    Department of Pathology, Cancer Center and Neurosurgical Service, Massachusetts General Hospital and Harvard Medical School, Boston 02129, USA
    J Mol Diagn 8:268-76. 2006
  5. pmc In situ analysis of integrin and growth factor receptor signaling pathways in human glioblastomas suggests overlapping relationships with focal adhesion kinase activation
    Markus J Riemenschneider
    Department of Pathology, Molecular Neuro oncology Laboratory, 149 7151, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Am J Pathol 167:1379-87. 2005
  6. pmc Maintenance of primary tumor phenotype and genotype in glioblastoma stem cells
    Hiroaki Wakimoto
    Department of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, USA
    Neuro Oncol 14:132-44. 2012
  7. ncbi request reprint Array CGH in brain tumors
    Gayatry Mohapatra
    Department of Medicine, Massachusetts General Hospital, Boston, MA, USA
    Methods Mol Biol 973:325-38. 2013
  8. ncbi request reprint A pseudolikelihood approach for simultaneous analysis of array comparative genomic hybridizations
    David A Engler
    Department of Biostatistics, Harvard University, 655 Huntington Avenue, Boston, MA 02115, and Massachusetts General Hospital, Department of Pathology, Charlestown 02129, USA
    Biostatistics 7:399-421. 2006
  9. pmc Inhibition of Hedgehog signaling antagonizes serous ovarian cancer growth in a primary xenograft model
    Christopher K McCann
    Department of Vincent Obstetrics and Gynecology, Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 6:e28077. 2011
  10. pmc Application of signal processing techniques for estimating regions of copy number variations in human meningioma DNA
    Catherine Stamoulis
    Department of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:6973-6. 2009

Detail Information

Publications13

  1. pmc Genome wide DNA copy number analysis of serous type ovarian carcinomas identifies genetic markers predictive of clinical outcome
    David A Engler
    Department of Statistics, Brigham Young University, Provo, Utah, United States of America
    PLoS ONE 7:e30996. 2012
    ..We have identified a set of genetic alterations that could be used for stratification of high-grade serous tumors into clinically relevant treatment subgroups...
  2. pmc Genome-wide comparison of paired fresh frozen and formalin-fixed paraffin-embedded gliomas by custom BAC and oligonucleotide array comparative genomic hybridization: facilitating analysis of archival gliomas
    Gayatry Mohapatra
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Acta Neuropathol 121:529-43. 2011
    ..In combination, these advances should facilitate genome-wide analysis of rare, small and/or histologically heterogeneous gliomas from FFPE tissues...
  3. pmc Genomic profiling of atypical meningiomas associates gain of 1q with poor clinical outcome
    Darlene Gabeau-Lacet
    Department of Pathology, Massachusetts General Hospital, 149 13th St, Charlestown, MA 02129, USA
    J Neuropathol Exp Neurol 68:1155-65. 2009
    ..Given the heterogeneous treatment outcomes of atypical meningioma, investigation of large-scale and focal genomic alterations in multi-institutional efforts may help clarify molecular-genetic signatures of clinical use...
  4. pmc Glioma test array for use with formalin-fixed, paraffin-embedded tissue: array comparative genomic hybridization correlates with loss of heterozygosity and fluorescence in situ hybridization
    Gayatry Mohapatra
    Department of Pathology, Cancer Center and Neurosurgical Service, Massachusetts General Hospital and Harvard Medical School, Boston 02129, USA
    J Mol Diagn 8:268-76. 2006
    ..These results suggest that aCGH could offer an improved molecular diagnostic approach for gliomas because of its ability to detect clinically relevant molecular alterations in small FFPE specimens...
  5. pmc In situ analysis of integrin and growth factor receptor signaling pathways in human glioblastomas suggests overlapping relationships with focal adhesion kinase activation
    Markus J Riemenschneider
    Department of Pathology, Molecular Neuro oncology Laboratory, 149 7151, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Am J Pathol 167:1379-87. 2005
    ..Thus, FAK may act in glioblastoma as a downstream target of growth factor signaling, with integrins enhancing the impact of such signaling in the tumor microenvironment...
  6. pmc Maintenance of primary tumor phenotype and genotype in glioblastoma stem cells
    Hiroaki Wakimoto
    Department of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, USA
    Neuro Oncol 14:132-44. 2012
    ..These studies highlight the value of GSCs for preclinical modeling of clinically relevant, patient-specific GBM and, thus, pave the way for testing novel anti-GSC/GBM agents for personalized therapy...
  7. ncbi request reprint Array CGH in brain tumors
    Gayatry Mohapatra
    Department of Medicine, Massachusetts General Hospital, Boston, MA, USA
    Methods Mol Biol 973:325-38. 2013
    ..Lastly, novel technologies such as next-generation sequencing and multiplex digital gene counting technology such as NanoString will expand the -repertoire of techniques for assessing CNAs in brain tumors...
  8. ncbi request reprint A pseudolikelihood approach for simultaneous analysis of array comparative genomic hybridizations
    David A Engler
    Department of Biostatistics, Harvard University, 655 Huntington Avenue, Boston, MA 02115, and Massachusetts General Hospital, Department of Pathology, Charlestown 02129, USA
    Biostatistics 7:399-421. 2006
    ..Software for this approach is available at http://www.biostat.harvard.edu/ approximately betensky/papers.html...
  9. pmc Inhibition of Hedgehog signaling antagonizes serous ovarian cancer growth in a primary xenograft model
    Christopher K McCann
    Department of Vincent Obstetrics and Gynecology, Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 6:e28077. 2011
    ..This investigation was designed to determine if inhibition of this pathway could inhibit serous ovarian cancer growth...
  10. pmc Application of signal processing techniques for estimating regions of copy number variations in human meningioma DNA
    Catherine Stamoulis
    Department of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:6973-6. 2009
    ..The residual signals from this process were analyzed to identify disease-related copy number changes. We were able to identify distinct local changes at different chromosomes in patients with recurrent versus primary meningiomas...
  11. pmc Genomic profiling distinguishes familial multiple and sporadic multiple meningiomas
    Yiping Shen
    Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, 02114, USA
    BMC Med Genomics 2:42. 2009
    ....
  12. pmc Epigenetic regulation of CD133 and tumorigenicity of CD133 positive and negative endometrial cancer cells
    Anne M Friel
    Vincent Center for Reproductive Biology, Vincent Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA 02114, USA
    Reprod Biol Endocrinol 8:147. 2010
    ..Our objectives were to assess the relative level of CD133 expressing cells in primary human endometrial tumors, confirm their tumorigenic potential, and determine whether CD133 expression was epigenetically modified...
  13. ncbi request reprint Atypical extraventricular neurocytoma with oligodendroglioma-like spread and an unusual pattern of chromosome 1p and 19q loss
    Robert E Mrak
    Department of Pathology, University of Arkansas for Medical Sciences, Littlle Rock, AR 72205, USA
    Hum Pathol 35:1156-9. 2004
    ..This case also illustrates the limitations of relying exclusively on loss of heterozygosity analysis for tumor classification...