Affiliation: Massachusetts General Hospital
- Genome wide DNA copy number analysis of serous type ovarian carcinomas identifies genetic markers predictive of clinical outcomeDavid A Engler
Department of Statistics, Brigham Young University, Provo, Utah, United States of America
PLoS ONE 7:e30996. 2012..We have identified a set of genetic alterations that could be used for stratification of high-grade serous tumors into clinically relevant treatment subgroups...
- Genome-wide comparison of paired fresh frozen and formalin-fixed paraffin-embedded gliomas by custom BAC and oligonucleotide array comparative genomic hybridization: facilitating analysis of archival gliomasGayatry Mohapatra
Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Acta Neuropathol 121:529-43. 2011..In combination, these advances should facilitate genome-wide analysis of rare, small and/or histologically heterogeneous gliomas from FFPE tissues...
- Genomic profiling of atypical meningiomas associates gain of 1q with poor clinical outcomeDarlene Gabeau-Lacet
Department of Pathology, Massachusetts General Hospital, 149 13th St, Charlestown, MA 02129, USA
J Neuropathol Exp Neurol 68:1155-65. 2009..Given the heterogeneous treatment outcomes of atypical meningioma, investigation of large-scale and focal genomic alterations in multi-institutional efforts may help clarify molecular-genetic signatures of clinical use...
- Glioma test array for use with formalin-fixed, paraffin-embedded tissue: array comparative genomic hybridization correlates with loss of heterozygosity and fluorescence in situ hybridizationGayatry Mohapatra
Department of Pathology, Cancer Center and Neurosurgical Service, Massachusetts General Hospital and Harvard Medical School, Boston 02129, USA
J Mol Diagn 8:268-76. 2006..These results suggest that aCGH could offer an improved molecular diagnostic approach for gliomas because of its ability to detect clinically relevant molecular alterations in small FFPE specimens...
- In situ analysis of integrin and growth factor receptor signaling pathways in human glioblastomas suggests overlapping relationships with focal adhesion kinase activationMarkus J Riemenschneider
Department of Pathology, Molecular Neuro oncology Laboratory, 149 7151, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Am J Pathol 167:1379-87. 2005..Thus, FAK may act in glioblastoma as a downstream target of growth factor signaling, with integrins enhancing the impact of such signaling in the tumor microenvironment...
- Maintenance of primary tumor phenotype and genotype in glioblastoma stem cellsHiroaki Wakimoto
Department of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, USA
Neuro Oncol 14:132-44. 2012..These studies highlight the value of GSCs for preclinical modeling of clinically relevant, patient-specific GBM and, thus, pave the way for testing novel anti-GSC/GBM agents for personalized therapy...
- Array CGH in brain tumorsGayatry Mohapatra
Department of Medicine, Massachusetts General Hospital, Boston, MA, USA
Methods Mol Biol 973:325-38. 2013..Lastly, novel technologies such as next-generation sequencing and multiplex digital gene counting technology such as NanoString will expand the -repertoire of techniques for assessing CNAs in brain tumors...
- A pseudolikelihood approach for simultaneous analysis of array comparative genomic hybridizationsDavid A Engler
Department of Biostatistics, Harvard University, 655 Huntington Avenue, Boston, MA 02115, and Massachusetts General Hospital, Department of Pathology, Charlestown 02129, USA
Biostatistics 7:399-421. 2006..Software for this approach is available at http://www.biostat.harvard.edu/ approximately betensky/papers.html...
- Inhibition of Hedgehog signaling antagonizes serous ovarian cancer growth in a primary xenograft modelChristopher K McCann
Department of Vincent Obstetrics and Gynecology, Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
PLoS ONE 6:e28077. 2011..This investigation was designed to determine if inhibition of this pathway could inhibit serous ovarian cancer growth...
- Application of signal processing techniques for estimating regions of copy number variations in human meningioma DNACatherine Stamoulis
Department of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Conf Proc IEEE Eng Med Biol Soc 2009:6973-6. 2009..The residual signals from this process were analyzed to identify disease-related copy number changes. We were able to identify distinct local changes at different chromosomes in patients with recurrent versus primary meningiomas...
- Genomic profiling distinguishes familial multiple and sporadic multiple meningiomasYiping Shen
Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, 02114, USA
BMC Med Genomics 2:42. 2009....
- Epigenetic regulation of CD133 and tumorigenicity of CD133 positive and negative endometrial cancer cellsAnne M Friel
Vincent Center for Reproductive Biology, Vincent Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA 02114, USA
Reprod Biol Endocrinol 8:147. 2010..Our objectives were to assess the relative level of CD133 expressing cells in primary human endometrial tumors, confirm their tumorigenic potential, and determine whether CD133 expression was epigenetically modified...
- Atypical extraventricular neurocytoma with oligodendroglioma-like spread and an unusual pattern of chromosome 1p and 19q lossRobert E Mrak
Department of Pathology, University of Arkansas for Medical Sciences, Littlle Rock, AR 72205, USA
Hum Pathol 35:1156-9. 2004..This case also illustrates the limitations of relying exclusively on loss of heterozygosity analysis for tumor classification...