Madhusmita Misra

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Evaluation and treatment of low bone density in anorexia nervosa
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital, Harvard Medical School, USA
    Nutr Clin Care 5:298-308. 2002
  2. ncbi request reprint Serum osteoprotegerin in adolescent girls with anorexia nervosa
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 88:3816-22. 2003
  3. pmc Nutrient intake in community-dwelling adolescent girls with anorexia nervosa and in healthy adolescents
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Clin Nutr 84:698-706. 2006
  4. ncbi request reprint Long-term skeletal effects of eating disorders with onset in adolescence
    Madhusmita Misra
    Pediatric Endocine and Neuroendocrine Units, Massachusetts General Hospital, Boston, MA 02114, USA
    Ann N Y Acad Sci 1135:212-8. 2008
  5. pmc Increased bone marrow fat in anorexia nervosa
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital, Yawkey 6E, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 94:2129-36. 2009
  6. pmc Anorexia nervosa and bone
    Madhusmita Misra
    BUL 457Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USAPediatric Endocrine UnitMassachusetts General Hospital for Children and Harvard Medical School, Boston, Massachusetts 02114, USABUL 457Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USAPediatric Endocrine UnitMassachusetts General Hospital for Children and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Endocrinol 221:R163-76. 2014
  7. pmc Anorexia nervosa, obesity and bone metabolism
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Pediatr Endocrinol Rev 11:21-33. 2013
  8. pmc Impact of physiologic estrogen replacement on anxiety symptoms, body shape perception, and eating attitudes in adolescent girls with anorexia nervosa: data from a randomized controlled trial
    Madhusmita Misra
    BUL 457, Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114
    J Clin Psychiatry 74:e765-71. 2013
  9. pmc Hip structural analysis in adolescent boys with anorexia nervosa and controls
    Madhusmita Misra
    Neuroendocrine and Pediatric Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 98:2952-8. 2013
  10. doi request reprint Effects of hypogonadism on bone metabolism in female adolescents and young adults
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, BUL 457, 55 Fruit Street, Boston, MA 02114, USA
    Nat Rev Endocrinol 8:395-404. 2012

Detail Information

Publications92

  1. ncbi request reprint Evaluation and treatment of low bone density in anorexia nervosa
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital, Harvard Medical School, USA
    Nutr Clin Care 5:298-308. 2002
    ..To do this, it is necessary to understand the mechanisms underlying low bone density in anorexia nervosa. This article discusses current concepts related to bone loss associated with anorexia nervosa, including how to prevent it...
  2. ncbi request reprint Serum osteoprotegerin in adolescent girls with anorexia nervosa
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 88:3816-22. 2003
    ..OPG values correlate negatively with markers of nutritional status and lumbar bone density z-scores and may be a compensatory response to the bone loss seen in this population...
  3. pmc Nutrient intake in community-dwelling adolescent girls with anorexia nervosa and in healthy adolescents
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Clin Nutr 84:698-706. 2006
    ..Adolescence is a common time for the onset of anorexia nervosa (AN), a condition associated with long-term medical and hormonal consequences...
  4. ncbi request reprint Long-term skeletal effects of eating disorders with onset in adolescence
    Madhusmita Misra
    Pediatric Endocine and Neuroendocrine Units, Massachusetts General Hospital, Boston, MA 02114, USA
    Ann N Y Acad Sci 1135:212-8. 2008
    ..This remaining growth potential may be impaired as a consequence of low levels of insulin-like growth factor-I (IGF-I) levels from persistent undernutrition...
  5. pmc Increased bone marrow fat in anorexia nervosa
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital, Yawkey 6E, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 94:2129-36. 2009
    ..Recent data suggest that marrow fat measured by 1H-magnetic resonance spectroscopy (MRS) in combination with bone mineral density (BMD) may be more valuable than either parameter alone in detecting bone weakness...
  6. pmc Anorexia nervosa and bone
    Madhusmita Misra
    BUL 457Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USAPediatric Endocrine UnitMassachusetts General Hospital for Children and Harvard Medical School, Boston, Massachusetts 02114, USABUL 457Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USAPediatric Endocrine UnitMassachusetts General Hospital for Children and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Endocrinol 221:R163-76. 2014
    ..Further studies are necessary to determine the best therapeutic strategies for low bone density in AN. ..
  7. pmc Anorexia nervosa, obesity and bone metabolism
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Pediatr Endocrinol Rev 11:21-33. 2013
    ..In this review, we discuss bone metabolism in anorexia nervosa and obesity in relation to adipose tissue distribution and hormones secreted or regulated by body fat content...
  8. pmc Impact of physiologic estrogen replacement on anxiety symptoms, body shape perception, and eating attitudes in adolescent girls with anorexia nervosa: data from a randomized controlled trial
    Madhusmita Misra
    BUL 457, Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114
    J Clin Psychiatry 74:e765-71. 2013
    ..We hypothesized that physiologic estrogen replacement would ameliorate anxiety and improve eating attitudes without affecting body image in anorexia nervosa...
  9. pmc Hip structural analysis in adolescent boys with anorexia nervosa and controls
    Madhusmita Misra
    Neuroendocrine and Pediatric Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 98:2952-8. 2013
    ..Hip structural analysis (HSA) using dual-energy x-ray absorptiometry is a validated technique to assess hip geometry and strength while avoiding radiation associated with quantitative computed tomography...
  10. doi request reprint Effects of hypogonadism on bone metabolism in female adolescents and young adults
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, BUL 457, 55 Fruit Street, Boston, MA 02114, USA
    Nat Rev Endocrinol 8:395-404. 2012
    ....
  11. pmc State of the Art Review: Emerging Therapies: The Use of Insulin Sensitizers in the Treatment of Adolescents with Polycystic Ovary Syndrome (PCOS)
    David H Geller
    Division of Pediatric Endocrinology, Cedars Sinai Medical Center, David Geffen UCLA School of Medicine 8700 Beverly Blvd, Rm 4220, Los Angeles, CA 90048, USA
    Int J Pediatr Endocrinol 2011:9. 2011
    ....
  12. ncbi request reprint Relationships between serum adipokines, insulin levels, and bone density in girls with anorexia nervosa
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Endocrinol Metab 92:2046-52. 2007
    ..Adolescents with anorexia nervosa (AN) have low bone mineral density (BMD). Adipokines and insulin play an important role in bone metabolism in healthy individuals. However, their association with bone metabolism in AN is unknown...
  13. ncbi request reprint Role of cortisol in menstrual recovery in adolescent girls with anorexia nervosa
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Pediatr Res 59:598-603. 2006
    ..Baseline cortisol level strongly predicted increases in the percentage of body fat. We demonstrate that 1) high baseline cortisol level predicts increases in body fat and 2) increases in body fat predict menses recovery in AN...
  14. ncbi request reprint Growth hormone suppression after an oral glucose load in children
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 92:4623-9. 2007
    ..Adult data cannot be extrapolated to children given the pubertal increase in GH concentration. In addition, because GH levels are higher in pubertal girls than boys, nadir GH may differ across gender...
  15. pmc Prognostic indicators of changes in bone density measures in adolescent girls with anorexia nervosa-II
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 93:1292-7. 2008
    ..We hypothesized that baseline levels of nutritionally regulated hormones and of bone turnover markers would predict DeltaBMD overall...
  16. pmc Weight gain and restoration of menses as predictors of bone mineral density change in adolescent girls with anorexia nervosa-1
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 93:1231-7. 2008
    ..We hypothesized that menstrual recovery and weight gain (> or =10% increase in body mass index) would predict an increase in these measures of bone density...
  17. pmc Neuroendocrine consequences of anorexia nervosa in adolescents
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Endocr Dev 17:197-214. 2010
    ..Weight gain is associated with a stabilization of bone density, although residual deficits persist in the short term, and in some cases, long term...
  18. doi request reprint Bone density in the adolescent athlete
    Madhusmita Misra
    Neuroendocrine and Pediatric Endocrine Units, Massachusetts General Hospital, Boston, MA 02114, USA
    Rev Endocr Metab Disord 9:139-44. 2008
    ..Beneficial effects of increased mechanical loading from athletic activity do not appear to protect against the deleterious effects of hypogonadism in adolescent athletes...
  19. pmc Effects of rhIGF-1 administration on surrogate markers of bone turnover in adolescents with anorexia nervosa
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Bone 45:493-8. 2009
    ..Although IGF-1 is key to pubertal bone accretion, and effects have been demonstrated in adults, there are no data regarding the effect of recombinant human (rh) IGF-1 administration in adolescents with AN...
  20. pmc Bone metabolism in adolescent boys with anorexia nervosa
    Madhusmita Misra
    BUL 457, Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 93:3029-36. 2008
    ..Although primarily a disease in females, AN is increasingly being recognized in males. However, there are few or no data regarding BMD, bone turnover markers or their predictors in adolescent AN boys...
  21. pmc Lower growth hormone and higher cortisol are associated with greater visceral adiposity, intramyocellular lipids, and insulin resistance in overweight girls
    Madhusmita Misra
    Neuroendocrine Unit and Pediatric Endocrine Unit, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    Am J Physiol Endocrinol Metab 295:E385-92. 2008
    ..Our data indicate that lower peak GH and higher UFC in overweight girls are associated with visceral adiposity, insulin resistance, and lipids...
  22. ncbi request reprint Vitamin D deficiency in children and its management: review of current knowledge and recommendations
    Madhusmita Misra
    Pediatric Endocrine and Neuroendocrine Units, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Pediatrics 122:398-417. 2008
    ....
  23. pmc Increased carbohydrate induced ghrelin secretion in obese vs. normal-weight adolescent girls
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Obesity (Silver Spring) 17:1689-95. 2009
    ..Changes in anorexigenic and orexigenic hormones in obese vs. normal-weight adolescents following high-carbohydrate and high-fat meals may influence hunger and satiety signals and subsequent food intake...
  24. ncbi request reprint Intermittent growth attenuation: is this a sign of craniopharyngioma?
    Madhusmita Misra
    Pediatric Endocrine Unit, MassGeneral Hospital for Children and Harvard Medical School, Boston, USA
    J Pediatr Endocrinol Metab 19:1033-8. 2006
    ..These cases suggest the need for a low threshold to undertake hormonal evaluation of patients who present with a past history of growth attenuation...
  25. pmc The neuroendocrine basis of anorexia nervosa and its impact on bone metabolism
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Neuroendocrinology 93:65-73. 2011
    ..In addition, the review discusses low bone mineral density and altered bone microarchitecture in AN, the pathophysiology underlying impaired bone metabolism, and possible therapeutic strategies to optimize bone health...
  26. pmc Bone health in anorexia nervosa
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Curr Opin Endocrinol Diabetes Obes 18:376-82. 2011
    ..This review discusses causes of impaired bone health in anorexia nervosa and potential therapeutic strategies...
  27. pmc Bone metabolism in adolescents with anorexia nervosa
    M Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    J Endocrinol Invest 34:324-32. 2011
    ..Bisphosphonates act by decreasing bone resorption, and are not optimal for use in adolescents with AN, in whom the primary defect is low bone formation...
  28. ncbi request reprint Uncoupling of cardiovascular risk markers in adolescent girls with anorexia nervosa
    Madhusmita Misra
    Neuroendocrine Unit, and the Eating Disorders Unit, Child Psychiatry Service, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Pediatr 149:763-769. 2006
    ..We hypothesized that in AN, growth hormone (GH) resistance and hypercortisolemia would increase CV risk through effects on pro-inflammatory cytokines and lipid status despite low weight...
  29. pmc Physiologic estrogen replacement increases bone density in adolescent girls with anorexia nervosa
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Bone Miner Res 26:2430-8. 2011
    ..It is concluded that physiologic estradiol replacement increases spine and hip BMD in girls with AN...
  30. pmc Percentage extremity fat, but not percentage trunk fat, is lower in adolescent boys with anorexia nervosa than in healthy adolescents
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Clin Nutr 88:1478-84. 2008
    ..However, the effect of low testosterone and other hormonal alterations on body composition in boys with AN is not known...
  31. pmc Waist to hip ratio and trunk to extremity fat (DXA) are better surrogates for IMCL and for visceral fat respectively than for subcutaneous fat in adolescent girls
    Eray Savgan-Gurol
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA
    Nutr Metab (Lond) 7:86. 2010
    ..abstract:..
  32. pmc Bone density characteristics and major depressive disorder in adolescents
    Pouneh K Fazeli
    Neuroendocrine Unit, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, BUL 457, 55 Fruit St, Boston, MA 02114, USA
    Psychosom Med 75:117-23. 2013
    ..MDD has recently been associated with lower bone mineral density (BMD) in adults. Our objective was to determine whether MDD is associated with BMD, bone turnover markers, vitamin D, and gonadal steroids in adolescents...
  33. ncbi request reprint Effects of anorexia nervosa on clinical, hematologic, biochemical, and bone density parameters in community-dwelling adolescent girls
    Madhusmita Misra
    Neuroendocrine Unit, and Harvard Medical School, Boston, Massachusetts 02114, USA
    Pediatrics 114:1574-83. 2004
    ..The prevalence of AN is increasing in adolescents, and it is the third most common chronic disease in adolescent girls. Therefore, it is important to determine the medical effects of this disorder in this young population...
  34. ncbi request reprint Ghrelin and bone metabolism in adolescent girls with anorexia nervosa and healthy adolescents
    Madhusmita Misra
    BUL 457, Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 90:5082-7. 2005
    ..Anorexia nervosa (AN) in adolescents is associated with low bone mineral density (BMD) and increases in ghrelin secretion, an orexigenic GH secretagogue that stimulates osteoblast proliferation in vitro...
  35. ncbi request reprint Secretory dynamics of leptin in adolescent girls with anorexia nervosa and healthy adolescents
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Physiol Endocrinol Metab 289:E373-81. 2005
    ..Leptin predicts GH and cortisol parameters and with ghrelin predicts GH burst frequency. Low leptin and high ghrelin may be dual stimuli for high GH concentrations in undernutrition...
  36. pmc Effects of recombinant human growth hormone in anorexia nervosa: a randomized, placebo-controlled study
    Pouneh K Fazeli
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 95:4889-97. 2010
    ..The effects of supraphysiological recombinant human GH (rhGH) on GH resistance in AN are not currently known...
  37. pmc Inhibition of Pref-1 (preadipocyte factor 1) by oestradiol in adolescent girls with anorexia nervosa is associated with improvement in lumbar bone mineral density
    Alexander T Faje
    Neuroendocrine Unit, Massachusetts General Hospital for Children and Harvard Medical School, Boston, MA 02114, USA
    Clin Endocrinol (Oxf) 79:326-32. 2013
    ..In this study, we aim to (i) investigate effects of transdermal oestradiol on Pref-1 in adolescent girls with AN, and (ii) examine associations of changes in Pref-1 with changes in lumbar BMD and bone turnover markers...
  38. pmc Nocturnal oxytocin secretion is lower in amenorrheic athletes than nonathletes and associated with bone microarchitecture and finite element analysis parameters
    Elizabeth A Lawson
    Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Eur J Endocrinol 168:457-64. 2013
    ..We therefore investigated oxytocin secretion and its association with bone microarchitecture and strength in young female athletes...
  39. ncbi request reprint Hormonal and body composition predictors of soluble leptin receptor, leptin, and free leptin index in adolescent girls with anorexia nervosa and controls and relation to insulin sensitivity
    Madhusmita Misra
    BUL 457B, Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    J Clin Endocrinol Metab 89:3486-95. 2004
    ..Resumption of menses is associated with significant increases in the FLI, suggesting that free leptin may be an important determinant of menstrual recovery...
  40. pmc Sclerostin levels and bone turnover markers in adolescents with anorexia nervosa and healthy adolescent girls
    Alexander T Faje
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Bone 51:474-9. 2012
    ..The relationship between sclerostin and bone turnover markers is disrupted in adolescent girls with AN. Despite an increase in BMD with estradiol administration in AN, estrogen does not impact sclerostin levels in this group...
  41. ncbi request reprint Elevated peptide YY levels in adolescent girls with anorexia nervosa
    Madhusmita Misra
    BUL 457, Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 91:1027-33. 2006
    ..In addition, known regulators of bone turnover, such as GH, cortisol, and estrogen, explain only a fraction of the variability in bone turnover marker levels...
  42. pmc Fracture risk and areal bone mineral density in adolescent females with anorexia nervosa
    Alexander T Faje
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts
    Int J Eat Disord 47:458-66. 2014
    ..To (i) compare fracture prevalence in adolescent females with anorexia nervosa (AN) versus normal-weight controls and (ii) examine whether reductions in areal bone mineral density (aBMD) predict fracture risk in females with AN...
  43. pmc Appetite-regulating hormones cortisol and peptide YY are associated with disordered eating psychopathology, independent of body mass index
    Elizabeth A Lawson
    Neuroendocrine Unit, Bulfinch 457B Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Eur J Endocrinol 164:253-61. 2011
    ..We therefore studied the relationship between orexigenic and anorexigenic hormones and disordered eating psychopathology in women across a range of weights...
  44. ncbi request reprint Anorexia nervosa and osteoporosis
    Madhusmita Misra
    Pediatric Endocrine Unit, Massachusetts General Hospital for Children, Boston, MA, USA
    Rev Endocr Metab Disord 7:91-9. 2006
    ..This is particularly so for adolescents, who are in the process of accruing peak bone mass, and in whom a failure to attain peak bone mass may occur in AN in addition to loss of established bone...
  45. pmc Peptide YY in adolescent athletes with amenorrhea, eumenorrheic athletes and non-athletic controls
    Melissa Russell
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Bone 45:104-9. 2009
    ..The role of other nutritionally regulated hormones such as peptide YY (PYY) and adiponectin in mediating gonadal status and bone metabolism remains to be determined...
  46. pmc Adolescent girls with anorexia nervosa have impaired cortical and trabecular microarchitecture and lower estimated bone strength at the distal radius
    Alexander T Faje
    Neuroendocrine Unit, Massachusetts General Hospital for Children, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 98:1923-9. 2013
    ..Because microarchitectural abnormalities and FEA may predict fracture risk independent of aBMD, these data are important to obtain...
  47. pmc Visceral fat is a negative predictor of bone density measures in obese adolescent girls
    Melissa Russell
    M P H, BUL 457, Neuroendocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 95:1247-55. 2010
    ....
  48. pmc Higher ghrelin and lower leptin secretion are associated with lower LH secretion in young amenorrheic athletes compared with eumenorrheic athletes and controls
    Kathryn E Ackerman
    Neuroendocrine Unit, Massachusetts General Hospital, Boston, 02114, USA
    Am J Physiol Endocrinol Metab 302:E800-6. 2012
    ..We conclude that higher ghrelin and lower leptin secretion in AA related to lower fat mass may contribute to altered LH pulsatility and amenorrhea...
  49. pmc Leptin levels are associated with decreased depressive symptoms in women across the weight spectrum, independent of body fat
    Elizabeth A Lawson
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Clin Endocrinol (Oxf) 76:520-5. 2012
    ..We investigated the relationship between leptin and ghrelin levels and symptoms of depression, anxiety and perceived stress in women across the weight spectrum...
  50. pmc Acylated ghrelin and leptin in adolescent athletes with amenorrhea, eumenorrheic athletes and controls: a cross-sectional study
    Karla Christo
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Clin Endocrinol (Oxf) 69:628-33. 2008
    ..We hypothesized that adolescent athletes with amenorrhea (AA) would have higher ghrelin and lower leptin levels than eumenorrheic athletes (EA) and would predict levels of gonadal steroids...
  51. pmc Cortical microstructure and estimated bone strength in young amenorrheic athletes, eumenorrheic athletes and non-athletes
    Kathryn E Ackerman
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Bone 51:680-7. 2012
    ..Finite element analysis (FEA) is a unique tool to estimate bone strength in vivo, and the contribution of cortical microstructure to bone strength in young athletes is not well understood...
  52. ncbi request reprint Alterations in cortisol secretory dynamics in adolescent girls with anorexia nervosa and effects on bone metabolism
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:4972-80. 2004
    ..Therefore, high cortisol values in AN may contribute to the low bone density observed in adolescents with this disorder by decreasing bone formation...
  53. pmc Hormonal and nutritional effects on cardiovascular risk markers in young women
    Elizabeth A Lawson
    Neuroendocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 92:3089-94. 2007
    ..Moreover, oral estrogens, known to increase hsCRP in other populations, are commonly prescribed in AN. To date, hsCRP levels and their physiological determinants have not been reported in women with AN...
  54. pmc Fibroblast growth factor-21 may mediate growth hormone resistance in anorexia nervosa
    Pouneh K Fazeli
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 95:369-74. 2010
    ..In a transgenic mouse model, FGF-21 reduces IGF-I levels by inhibiting signal transducer and activator of transcription-5, a mediator of the intracellular effects of GH...
  55. pmc Hypercortisolemia is associated with severity of bone loss and depression in hypothalamic amenorrhea and anorexia nervosa
    Elizabeth A Lawson
    Neuroendocrine Unit, Bulfinch 457B, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 94:4710-6. 2009
    ..Significant hypercortisolemia, as in Cushing's disease, causes bone loss. It is unknown whether anxiety and depression and/or cortisol dysregulation contribute to low bone density in AN or HA...
  56. pmc Preadipocyte factor-1 is associated with marrow adiposity and bone mineral density in women with anorexia nervosa
    Pouneh K Fazeli
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 95:407-13. 2010
    ..Adipocytes and osteoblasts differentiate from a common progenitor cell, the human mesenchymal stem cell. Therefore, understanding factors that regulate this differentiation process may provide insight into bone loss in AN...
  57. pmc Hip structural analysis in adolescent and young adult oligoamenorrheic and eumenorrheic athletes and nonathletes
    Kathryn E Ackerman
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Clin Endocrinol Metab 98:1742-9. 2013
    ..Hip structural analysis (HSA) using dual-energy x-ray absorptiometry is a validated technique to assess hip bone structure...
  58. pmc Growth hormone is positively associated with surrogate markers of bone turnover during puberty
    Melissa Russell
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Clin Endocrinol (Oxf) 75:482-8. 2011
    ..Puberty is characterized by increases in growth hormone (GH) and insulin-like growth factor-1 (IGF-1) and the pubertal growth spurt. Bone formation and resorption also increase, consistent with increased bone metabolism...
  59. pmc Bone microarchitecture is impaired in adolescent amenorrheic athletes compared with eumenorrheic athletes and nonathletic controls
    Kathryn E Ackerman
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 96:3123-33. 2011
    ..Abnormal bone microarchitecture is an independent determinant of fracture risk and has not been assessed in young athletes and nonathletes...
  60. ncbi request reprint Growth hormone and ghrelin responses to an oral glucose load in adolescent girls with anorexia nervosa and controls
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:1605-12. 2004
    ..Further studies are needed to define GH suppression in an adolescent population...
  61. pmc Effects of risedronate and low-dose transdermal testosterone on bone mineral density in women with anorexia nervosa: a randomized, placebo-controlled study
    Karen K Miller
    Neuroendocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 96:2081-8. 2011
    ..Estrogen administration has not been shown to prevent bone loss in this population, and to date, there are no approved, effective therapies for this comorbidity...
  62. pmc Peptide YY (PYY) levels and bone mineral density (BMD) in women with anorexia nervosa
    Andrea L Utz
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Bone 43:135-9. 2008
    ..Y2 receptor knockout mice have increased bone mineral density (BMD) and thus PYY may play a role in regulating bone mass. We hypothesized that PYY levels would be inversely associated with BMD in women with AN...
  63. pmc Bone metabolism in adolescent athletes with amenorrhea, athletes with eumenorrhea, and control subjects
    Karla Christo
    Massachusetts General Hospital, Neuroendocrine Unit, BUL 457, 55 Fruit St, Boston, MA 02114, USA
    Pediatrics 121:1127-36. 2008
    ....
  64. pmc Determinants of skeletal loss and recovery in anorexia nervosa
    Karen K Miller
    Neuroendocrine Unit, Bulfinch 457B, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Endocrinol Metab 91:2931-7. 2006
    ..Anorexia nervosa (AN) is complicated by severe bone loss. The effects of persistent undernutrition and consequent neuroendocrine dysfunction on bone mass and the factors influencing skeletal recovery have not been well characterized...
  65. pmc Cortisol secretory parameters in young exercisers in relation to LH secretion and bone parameters
    Kathryn E Ackerman
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Clin Endocrinol (Oxf) 78:114-9. 2013
    ..We hypothesized that higher cortisol secretion in young endurance weight-bearing AE compared with EE and nonexercisers predicts lower LH secretion, lower levels of a bone formation marker and higher levels of a bone resorption marker...
  66. pmc Validation of a food frequency questionnaire for determining calcium and vitamin D intake by adolescent girls with anorexia nervosa
    Catherine Taylor
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Am Diet Assoc 109:479-85, 485.e1-3. 2009
    ..78, P<0.0001). Less robust correlations were observed for calcium intake (r=0.65, P<0.0001). The FFQ used in this study can be effectively used to assess daily calcium and vitamin D intake in adolescent girls with anorexia nervosa...
  67. pmc Decreased nocturnal oxytocin levels in anorexia nervosa are associated with low bone mineral density and fat mass
    Elizabeth A Lawson
    Neuroendocrine Unit, Bulfinch 457B, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 72:1546-51. 2011
    ..Our objective was to investigate the relationship between oxytocin levels, bone mineral density, and body composition in women with anorexia nervosa...
  68. ncbi request reprint Hormonal determinants of regional body composition in adolescent girls with anorexia nervosa and controls
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, BUL 457, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 90:2580-7. 2005
    ..High cortisol levels in AN predict a redistribution of lean body mass such that extremity lean mass decreases. Further studies are necessary to better understand the implications of these data...
  69. ncbi request reprint Regional body composition in adolescents with anorexia nervosa and changes with weight recovery
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Am J Clin Nutr 77:1361-7. 2003
    ..Little is known about fat distribution in adolescents with AN, especially with weight recovery...
  70. pmc Effect of body mass index on peak growth hormone response to provocative testing in children with short stature
    Takara L Stanley
    Pediatric Endocrine Unit, Massachusetts General Hospital for Children and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 94:4875-81. 2009
    ..Obesity is associated with decreased spontaneous and stimulated GH secretion, but the effect of body mass index (BMI) on results of GH stimulation testing in children with short stature is not known...
  71. pmc Peptide YY levels across pubertal stages and associations with growth hormone
    Benjamin Lloyd
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 95:2957-62. 2010
    ..Peptide YY (PYY) is an anorexigenic hormone that is high in anorexia nervosa and low in obesity, inhibits GnRH secretion, and is suppressed by GH administration. The relationship between PYY and GH has not been examined across puberty...
  72. ncbi request reprint Secretory dynamics of ghrelin in adolescent girls with anorexia nervosa and healthy adolescents
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    Am J Physiol Endocrinol Metab 289:E347-56. 2005
    ..The most important predictor of ghrelin concentration is insulin resistance, and ghrelin in turn predicts GH and cortisol burst frequency...
  73. pmc Comparison of DXA and CT in the assessment of body composition in premenopausal women with obesity and anorexia nervosa
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Obesity (Silver Spring) 18:2227-33. 2010
    ..The level of hydration does not significantly affect most DXA body composition measurements, with the exceptions of thigh fat...
  74. pmc Hormone predictors of abnormal bone microarchitecture in women with anorexia nervosa
    Elizabeth A Lawson
    Neuroendocrine Unit, Bulfinch 457B, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Bone 46:458-63. 2010
    ..We concluded that bone microarchitecture is abnormal in women with AN. Endogenous IGF-I, leptin, and androgen levels predict bone microarchitecture independent of BMI...
  75. pmc Influence of ghrelin and adipocytokines on bone mineral density in adolescent female athletes with amenorrhea and eumenorrheic athletes
    Melissa Russell
    Pediatric Endocrine and Neuroendocrine Units, Massachusetts General Hospital, Boston, Mass 02114, USA
    Med Sport Sci 55:103-13. 2010
    ..A better understanding of pathways linking low energy availability with functional hypothalamic amenorrhea and low BMD is critical for the development of future therapeutic strategies addressing these issues in amenorrheic athletes...
  76. ncbi request reprint Androgen deficiency: association with increased anxiety and depression symptom severity in anorexia nervosa
    Karen K Miller
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychiatry 68:959-65. 2007
    ..Because androgens are known to affect mood and behavior, we hypothesized that low endogenous androgen production in anorexia nervosa would predict anxiety and depression severity...
  77. doi request reprint Determinants of height in adolescent girls with anorexia nervosa
    Rajani Prabhakaran
    BUL 457, MassGeneral Hospital, Neuroendocrine Unit, 55 Fruit St, Boston, MA 02114, USA
    Pediatrics 121:e1517-23. 2008
    ..In addition, growth hormone may have direct effects on the growth plate independent of insulin-like growth factor 1 to increase statural growth...
  78. pmc Reduced amylin levels are associated with low bone mineral density in women with anorexia nervosa
    Monica H Wojcik
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Bone 46:796-800. 2010
    ..Peptide hormones, including amylin, GIP, and GLP2, are released immediately after nutrient intake and may be involved in the regulation of bone turnover...
  79. ncbi request reprint Alterations in growth hormone secretory dynamics in adolescent girls with anorexia nervosa and effects on bone metabolism
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 88:5615-23. 2003
    ..Acquired GH resistance may play a role in the osteopenia and decreased peak bone mass frequently associated with AN...
  80. ncbi request reprint The role of Müllerian inhibiting substance in the evaluation of phenotypic female patients with mild degrees of virilization
    Madhusmita Misra
    Pediatric Endocrine Unit, MassGeneral Hospital for Children and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 88:787-92. 2003
    ..A value within the normal female range in a virilized patient did not exclude dysgenetic testicular tissue or ovotestis, whereas undetectable values were consistent with the absence of testicular tissue...
  81. doi request reprint Case records of the Massachusetts General Hospital. Case 29-2008. A 19-year-old man with weight loss and abdominal pain
    Mark A Goldstein
    Department of Pediatrics, Massachusetts General Hospital and Harvard Medical School, USA
    N Engl J Med 359:1272-83. 2008
  82. pmc Distal radius in adolescent girls with anorexia nervosa: trabecular structure analysis with high-resolution flat-panel volume CT
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital, 55 Fruit St, Yawkey 6E, Boston, MA 02114, USA
    Radiology 249:938-46. 2008
    ....
  83. ncbi request reprint Effects of psychiatric disorders and psychotropic medications on prolactin and bone metabolism
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 65:1607-18; quiz 1590, 1760-1. 2004
    ..Few reviews have thus far addressed this issue. We have consolidated information from studies that examined effects of psychiatric conditions and their treatment on bone metabolism...
  84. doi request reprint Adolescent obesity and bariatric surgery
    Lynne L Levitsky
    Pediatric Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Curr Opin Endocrinol Diabetes Obes 16:37-44. 2009
    ..Examines the effects of bariatric surgery on adolescent obesity...
  85. doi request reprint Polycystic ovary syndrome in obese adolescents
    Takara Stanley
    MassGeneral Hospital for Children and Harvard Medical School, Boston, Massachusetts 02114, USA
    Curr Opin Endocrinol Diabetes Obes 15:30-6. 2008
    ..This review describes recent insights into the pathophysiology and treatment of polycystic ovary syndrome, with special attention given to the relationship between polycystic ovary syndrome and obesity...
  86. ncbi request reprint Corticotropin-independent cushing syndrome in a child with an ovarian tumor misdiagnosed as nonclassic congenital adrenal hyperplasia
    Punkaj Gupta
    Division of Pediatric Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Endocr Pract 14:875-9. 2008
    ..To describe a patient with corticotropin-independent Cushing syndrome previously diagnosed and treated as congenital adrenal hyperplasia (CAH)...
  87. ncbi request reprint Measurement of Mullerian inhibiting substance facilitates management of boys with microphallus and cryptorchidism
    Madhusmita Misra
    Pediatric Endocrine Unit, Massachusetts General Hospital for Children and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 87:3598-602. 2002
    ..We conclude that preoperative measurement of MIS facilitates the management of children with cryptorchidism and intersex disorders and offers a measure of Sertoli cell function...
  88. ncbi request reprint Predictors and growth consequences of central hypothyroidism in pediatric patients receiving recombinant human growth hormone
    Kara Wong
    Harvard Medical School, Boston, MA, USA
    J Pediatr Endocrinol Metab 23:451-61. 2010
    ..We hypothesized that children with GH deficiency (GHD) and greatest severity of GHD would be most likely to develop central hypothyroidism and decreased growth velocity (GV)...
  89. doi request reprint Transitioning of children with GH deficiency to adult dosing: changes in body composition
    Vi Thuy Nguyen
    Pediatric Endocrine Unit, MassGeneral Hospital for Children and Harvard Medical School, Boston, MA, 02114, USA
    Pituitary 12:125-35. 2009
    ..We also review data regarding who should receive GHRT, the criteria for diagnosing persistent GHD, dosing of GHRT and the possibility of a GH 'holiday'...
  90. ncbi request reprint The role of recombinant human insulin-like growth factor-I in treating children with short stature
    Paulo F Collett-Solberg
    Instituto Estadual de Diabetes e Endocrinologia, Rio de Janeiro, RJ, Brazil 22470 030
    J Clin Endocrinol Metab 93:10-8. 2008
    ....
  91. doi request reprint Use of aromatase inhibitors in children and adolescents with disorders of growth and adolescent development
    Dorothy I Shulman
    All Children s Hospital, St Petersburg, Florida 33701, USA
    Pediatrics 121:e975-83. 2008
    ..In this report, we summarize the published data regarding the use of aromatase inhibitors in these conditions, and review known and potential benefits, safety concerns, and shortcomings of the available information...
  92. ncbi request reprint Abnormal bone mineral accrual in adolescent girls with anorexia nervosa
    Leslie A Soyka
    Department of Pediatrics, University of Massachusetts Medical School, Worcester 01655, USA
    J Clin Endocrinol Metab 87:4177-85. 2002
    ..A rise in bone turnover markers may be an early indicator of increase in BMD in recovering girls with AN...

Research Grants7

  1. Nutritional and Hormonal Determinants of Peak Bone Mass
    Madhusmita Misra; Fiscal Year: 2004
    ..The effects of estrogen in weight recovered vs. non-weight recovered AN will also be studied. ..
  2. Nutritional and Hormonal Determinants of Peak Bone Mass
    Madhusmita Misra; Fiscal Year: 2005
    ..The effects of estrogen in weight recovered vs. non-weight recovered AN will also be studied. ..
  3. Nutritional and Hormonal Determinants of Peak Bone Mass
    Madhusmita Misra; Fiscal Year: 2006
    ..The effects of estrogen in weight recovered vs. non-weight recovered AN will also be studied. ..
  4. Nutritional and Hormonal Determinants of Peak Bone Mass
    Madhusmita Misra; Fiscal Year: 2007
    ..The effects of estrogen in weight recovered vs. non-weight recovered AN will also be studied. ..
  5. Fat Mediated Modulation of Reproductive and Endocrine Function in Young Athletes
    Madhusmita Misra; Fiscal Year: 2009
    ..This research proposal will examine the impact of low fat mass and related hormones on absence of periods in these young women, and strategies to increase bone density at this critical time. ..
  6. Fat Mediated Modulation of Reproductive and Endocrine Function in Young Athletes
    Madhusmita Misra; Fiscal Year: 2010
    ..This research proposal will examine the impact of low fat mass and related hormones on absence of periods in these young women, and strategies to increase bone density at this critical time. ..