Mari Mino-Kenudson

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Prognosis of invasive intraductal papillary mucinous neoplasm depends on histological and precursor epithelial subtypes
    Mari Mino-Kenudson
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Gut 60:1712-20. 2011
  2. doi request reprint Reflex testing for epidermal growth factor receptor mutation and anaplastic lymphoma kinase fluorescence in situ hybridization in non-small cell lung cancer
    Mari Mino-Kenudson
    Department of Pathology, Massachusetts General Hospital, 55 Fruit St, Warren 122, Boston, MA 02114, USA
    Arch Pathol Lab Med 135:655-64. 2011
  3. doi request reprint Histologic and cytomorphologic features of ALK-rearranged lung adenocarcinomas
    Michiya Nishino
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Mod Pathol 25:1462-72. 2012
  4. doi request reprint The dichotomy in carcinogenesis of the distal esophagus and esophagogastric junction: intestinal-type vs cardiac-type mucosa-associated adenocarcinoma
    Elizabeth G Demicco
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Mod Pathol 24:1177-90. 2011
  5. ncbi request reprint EMR for Barrett's esophagus-related superficial neoplasms offers better diagnostic reproducibility than mucosal biopsy
    Mari Mino-Kenudson
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Gastrointest Endosc 66:660-6; quiz 767, 769. 2007
  6. doi request reprint Branch duct intraductal papillary mucinous neoplasms: does cyst size change the tip of the scale? A critical analysis of the revised international consensus guidelines in a large single-institutional series
    Klaus Sahora
    Departments of Surgery Pathology Gastroenterology and Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
    Ann Surg 258:466-75. 2013
  7. pmc Tumor islands in resected early-stage lung adenocarcinomas are associated with unique clinicopathologic and molecular characteristics and worse prognosis
    Maristela L Onozato
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Surg Pathol 37:287-94. 2013
  8. doi request reprint Role of computed tomography perfusion in the evaluation of pancreatic necrosis and pancreatitis after endoscopic ultrasound-guided ablation of the pancreas in a porcine model
    Dushyant V Sahani
    Department of Radiology, Massachusetts General Hospital, Boston, 02114, USA
    Pancreas 38:775-81. 2009
  9. doi request reprint Feasibility of EUS-guided injection of irinotecan-loaded microspheres into the swine pancreas
    Cetin Karaca
    Massachusetts General Hospital, Boston, Massachusetts, USA
    Gastrointest Endosc 73:603-6. 2011
  10. doi request reprint CDX2 expression in the intestinal-type gastric epithelial neoplasia: frequency and significance
    Do Youn Park
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114 2696, USA
    Mod Pathol 23:54-61. 2010

Detail Information

Publications86

  1. pmc Prognosis of invasive intraductal papillary mucinous neoplasm depends on histological and precursor epithelial subtypes
    Mari Mino-Kenudson
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Gut 60:1712-20. 2011
    ..The authors investigate the clinicopathological characteristics and the impact on survival of both the invasive component and its background IPMN...
  2. doi request reprint Reflex testing for epidermal growth factor receptor mutation and anaplastic lymphoma kinase fluorescence in situ hybridization in non-small cell lung cancer
    Mari Mino-Kenudson
    Department of Pathology, Massachusetts General Hospital, 55 Fruit St, Warren 122, Boston, MA 02114, USA
    Arch Pathol Lab Med 135:655-64. 2011
    ....
  3. doi request reprint Histologic and cytomorphologic features of ALK-rearranged lung adenocarcinomas
    Michiya Nishino
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Mod Pathol 25:1462-72. 2012
    ..However, morphologic screening alone will not detect a minority of ALK+ lung adenocarcinomas, and the routine use of ancillary studies may be warranted to identify all patients who may benefit from crizotinib treatment...
  4. doi request reprint The dichotomy in carcinogenesis of the distal esophagus and esophagogastric junction: intestinal-type vs cardiac-type mucosa-associated adenocarcinoma
    Elizabeth G Demicco
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Mod Pathol 24:1177-90. 2011
    ..Additional studies are warranted to further clarify their pathogenesis and the molecular mechanisms involved...
  5. ncbi request reprint EMR for Barrett's esophagus-related superficial neoplasms offers better diagnostic reproducibility than mucosal biopsy
    Mari Mino-Kenudson
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Gastrointest Endosc 66:660-6; quiz 767, 769. 2007
    ..It also allows for better pathologic grading compared with mucosal biopsy specimens. However, the interobserver variation in the interpretation of EMR specimens has not been tested...
  6. doi request reprint Branch duct intraductal papillary mucinous neoplasms: does cyst size change the tip of the scale? A critical analysis of the revised international consensus guidelines in a large single-institutional series
    Klaus Sahora
    Departments of Surgery Pathology Gastroenterology and Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
    Ann Surg 258:466-75. 2013
    ..The aim of this study was to critically analyze the safety of the revised guidelines, with focus on cyst size and worrisome features in the management of BD-IPMN...
  7. pmc Tumor islands in resected early-stage lung adenocarcinomas are associated with unique clinicopathologic and molecular characteristics and worse prognosis
    Maristela L Onozato
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Surg Pathol 37:287-94. 2013
    ..Thus, aggressive surveillance and/or further intervention may be indicated for patients whose tumors exhibit tumor islands...
  8. doi request reprint Role of computed tomography perfusion in the evaluation of pancreatic necrosis and pancreatitis after endoscopic ultrasound-guided ablation of the pancreas in a porcine model
    Dushyant V Sahani
    Department of Radiology, Massachusetts General Hospital, Boston, 02114, USA
    Pancreas 38:775-81. 2009
    ..To evaluate the role of computed tomography (CT) perfusion in detection of pancreatic necrosis and pancreatitis after endoscopic ultrasound-guided ethanol ablation of porcine pancreas and to correlate the evaluation with histopathology...
  9. doi request reprint Feasibility of EUS-guided injection of irinotecan-loaded microspheres into the swine pancreas
    Cetin Karaca
    Massachusetts General Hospital, Boston, Massachusetts, USA
    Gastrointest Endosc 73:603-6. 2011
    ..LC beads (Biocompatibles International plc) are designed for the time-released delivery of the chemotherapeutic agent irinotecan into focal, hypervascularized, hepatic tumors...
  10. doi request reprint CDX2 expression in the intestinal-type gastric epithelial neoplasia: frequency and significance
    Do Youn Park
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114 2696, USA
    Mod Pathol 23:54-61. 2010
    ....
  11. ncbi request reprint Buried dysplasia and early adenocarcinoma arising in barrett esophagus after porfimer-photodynamic therapy
    Mari Mino-Kenudson
    Department of Pathology, Gastrointestinal Pathology Service, Massachusetts General Hospital, Boston, MA 02114 2696, USA
    Am J Surg Pathol 31:403-9. 2007
    ..Thorough endoscopic surveillance with extensive biopsies, especially of the sites previously positive for neoplasia is important to avoid overlooking buried neoplasms that may progress...
  12. doi request reprint Leaks and endoscopic assessment of break of integrity after NOTES gastrotomy: the LEAKING study, a prospective, randomized, controlled trial
    Field F Willingham
    Department of Medicine, Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Gastrointest Endosc 71:1018-24. 2010
    ..Gastric leak testing after natural orifice transluminal endoscopic surgery (NOTES) gastrotomy closure may help reduce the risk of leaks after transgastric procedures...
  13. doi request reprint A prospective, randomized trial of esophageal submucosal tunnel closure with a stent versus no closure to secure a transesophageal natural orifice transluminal endoscopic surgery access site
    Brian G Turner
    Gastroenterology Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Gastrointest Endosc 73:785-90. 2011
    ..Secure esophagotomy closure methods are a critical element in the advancement of transesophageal natural orifice transluminal endoscopic surgery (NOTES) procedures...
  14. pmc A novel, highly sensitive antibody allows for the routine detection of ALK-rearranged lung adenocarcinomas by standard immunohistochemistry
    Mari Mino-Kenudson
    Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts
    Clin Cancer Res 16:1561-71. 2010
    ..In the present study, we used novel antibodies to compare ALK protein expression in genetically defined lung cancers and anaplastic large cell lymphomas...
  15. pmc Image-guided biopsy in the esophagus through comprehensive optical frequency domain imaging and laser marking: a study in living swine
    Melissa J Suter
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Gastrointest Endosc 71:346-53. 2010
    ..When deployed through a balloon-centering catheter, OFDI can automatically image the entire distal esophagus (6.0 cm length) in approximately 2 minutes...
  16. doi request reprint Survival study of natural orifice translumenal endoscopic surgery for rectosigmoid resection using transanal endoscopic microsurgery with or without transgastric endoscopic assistance in a swine model
    Patricia Sylla
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, WACC 460, Boston, MA 02114, USA
    Surg Endosc 24:2022-30. 2010
    ....
  17. pmc Stent placement provides safe esophageal closure in thoracic NOTES(TM) procedures
    Brian G Turner
    Massachusetts General Hospital, Boston, MA 02114, USA
    Surg Endosc 25:913-8. 2011
    ..Previously described methods, such as suturing devices, clips, or submucosal tunneling, all have weaknesses. In this survival animal series, we demonstrate safe esophageal closure with a prototype retrievable, antimigration stent...
  18. pmc Optical coherence tomography to identify intramucosal carcinoma and high-grade dysplasia in Barrett's esophagus
    John A Evans
    Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Clin Gastroenterol Hepatol 4:38-43. 2006
    ..The purpose of this study was to establish OCT image characteristics of IMC and HGD in Barrett's esophagus...
  19. pmc Branch-duct intraductal papillary mucinous neoplasms: observations in 145 patients who underwent resection
    J Ruben Rodriguez
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Gastroenterology 133:72-9; quiz 309-10. 2007
    ..This study describes the combined experience of 2 tertiary centers with branch-duct IPMNs aiming to validate these recommendations...
  20. doi request reprint Cyclooxygenase-2 expression in esophageal epithelium before and after photodynamic therapy for Barrett's esophagus with high-grade dysplasia or intramucosal carcinoma
    Patrick Yachimski
    Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Virchows Arch 459:581-6. 2011
    ..Prospective studies should determine whether cyclooxygenase inhibitors have a role as adjuvant therapy to prevent recurrence of Barrett's esophagus following endoscopic therapy...
  21. pmc Cytology adds value to imaging studies for risk assessment of malignancy in pancreatic mucinous cysts
    Muriel Genevay
    Department of Pathology, The James Homer Wright Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Ann Surg 254:977-83. 2011
    ..Evaluate the value of cytology relative to imaging features in risk assessment for malignancy as defined in the Sendai Guidelines...
  22. pmc Novel xenograft and cell line derived from an invasive intraductal papillary mucinous neoplasm of the pancreas give new insights into molecular mechanisms
    Stefan Fritz
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Pancreas 39:308-14. 2010
    ..Little is known about the genetic signature of IPMC. In this study, we describe a novel xenograft model and cell culture created to biologically and genetically characterize these tumors...
  23. pmc Lymphocytic reaction to colorectal cancer is associated with longer survival, independent of lymph node count, microsatellite instability, and CpG island methylator phenotype
    Shuji Ogino
    Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Clin Cancer Res 15:6412-20. 2009
    ....
  24. doi request reprint Effect of tumor characteristics and duplication of the muscularis mucosae on the endoscopic staging of superficial Barrett esophagus-related neoplasia
    Rajni V Mandal
    Department of Pathology, Gastrointestinal Pathology Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Surg Pathol 33:620-5. 2009
    ..EUS alone is not sufficient for staging these neoplasms precisely, and to accurately stratify patients into different treatment arms, EMR should play a role as a complementary staging modality...
  25. ncbi request reprint Endoscopic ultrasound guided fine needle aspiration biopsy of autoimmune pancreatitis: diagnostic criteria and pitfalls
    Vikram Deshpande
    Department of Pathology, Massachusetts General Hospital, Boston, MA, USA
    Am J Surg Pathol 29:1464-71. 2005
    ....
  26. pmc Endoscopic transesophageal mediastinal lymph node dissection and en bloc resection by using mediastinal and thoracic approaches (with video)
    Brian G Turner
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Gastrointest Endosc 72:831-5. 2010
    ..The criterion standard for sampling mediastinal lymph nodes is cervical mediastinoscopy. Current methods that require transthoracic or cervical incisions can result in significant postoperative pain...
  27. pmc Comprehensive imaging of gastroesophageal biopsy samples by spectrally encoded confocal microscopy
    DongKyun Kang
    Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Gastrointest Endosc 71:35-43. 2010
    ....
  28. pmc Volumetric optical frequency domain imaging of pulmonary pathology with precise correlation to histopathology
    Lida P Hariri
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Chest 143:64-74. 2013
    ..Bronchoscopic OFDI has been evaluated in vivo, but a lack of correlated histopathology has limited the ability to develop accurate image interpretation criteria...
  29. pmc Pancreatic ductal adenocarcinoma: long-term survival does not equal cure
    Cristina R Ferrone
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Surgery 152:S43-9. 2012
    ..Our aim was to identify the prognostic factors for long-term survival after resection of pancreatic ductal adenocarcinoma related to patients, treatments, and tumor biology...
  30. pmc Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
    Eunice L Kwak
    Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA
    N Engl J Med 363:1693-703. 2010
    ..We explored the therapeutic efficacy of inhibiting ALK in such tumors in an early-phase clinical trial of crizotinib (PF-02341066), an orally available small-molecule inhibitor of the ALK tyrosine kinase...
  31. doi request reprint Prospective analysis of atypical epithelial cells as a high-risk cytologic feature for malignancy in pancreatic cysts
    Martha B Pitman
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 01907, USA
    Cancer Cytopathol 121:29-36. 2013
    ..The objective of the current study was to assess the accuracy of AECs in predicting malignancy in pancreatic cysts...
  32. doi request reprint Natural orifice versus conventional laparoscopic distal pancreatectomy in a porcine model: a randomized, controlled trial
    Field F Willingham
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Gastrointest Endosc 70:740-7. 2009
    ..Distal pancreatectomy has significant postoperative morbidity and would permit rigorous examination in a controlled trial setting...
  33. pmc The Cables gene on chromosome 18q is silenced by promoter hypermethylation and allelic loss in human colorectal cancer
    Do Youn Park
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Pathol 171:1509-19. 2007
    ..Loss of Cables expression in 65% of CRCs suggests that it is a common event in colonic carcinogenesis, with promoter methylation and LOH appearing to be important mechanisms of Cables gene inactivation...
  34. doi request reprint Feasibility of endoscopic transesophageal thoracic sympathectomy (with video)
    Brian G Turner
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Gastrointest Endosc 71:171-5. 2010
    ..Thoracoscopic sympathectomy is the preferred surgical treatment for patients with disabling palmar hyperhidrosis. Current methods require a transthoracic approach to permit ablation of the thoracic sympathetic chain...
  35. pmc Plectin-1 as a novel biomarker for pancreatic cancer
    Dirk Bausch
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114 2622, USA
    Clin Cancer Res 17:302-9. 2011
    ..Plectin-1 (Plec1) was recently identified as one such biomarker. However, its suitability as a specific biomarker for human pancreatic cancer, and its usability as an imaging target, remain to be assessed...
  36. pmc Negative lymph node count is associated with survival of colorectal cancer patients, independent of tumoral molecular alterations and lymphocytic reaction
    Shuji Ogino
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Gastroenterol 105:420-33. 2010
    ....
  37. ncbi request reprint Autoimmune pancreatitis: more than just a pancreatic disease? A contemporary review of its pathology
    Vikram Deshpande
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Arch Pathol Lab Med 129:1148-54. 2005
    ..Autoimmune pancreatitis (AIP) is a chronic inflammatory condition of the pancreas constituting one quarter of Whipple resections performed for benign conditions in North America...
  38. ncbi request reprint Mucin expression in reactive gastropathy: an immunohistochemical analysis
    Mari Mino-Kenudson
    Massachusetts General Hospital Department of Pathology, Boston, MA 02114 2696, USA
    Arch Pathol Lab Med 131:86-90. 2007
    ..However, the evaluation of mucins, important components of the protective mucosal mucous layer, has not been reported...
  39. doi request reprint Novel endoscopic therapeutic modalities for superficial neoplasms arising in Barrett's esophagus: a primer for surgical pathologists
    Gregory Y Lauwers
    Gastrointestinal Pathology Unit, Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114 USA
    Mod Pathol 22:489-98. 2009
    ....
  40. ncbi request reprint Concentration-dependent ablation of pancreatic tissue by EUS-guided ethanol injection
    Kai Matthes
    Gastrointestinal Unit, Gastrointestinal Pathology Service, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Gastrointest Endosc 65:272-7. 2007
    ..Ethanol is a commonly available agent and has been used to successfully and safely ablate cystic lesions of various organs...
  41. ncbi request reprint Sessile serrated adenoma: challenging discrimination from other serrated colonic polyps
    Alton B Farris
    Department of Pathology, Biostatistics Center, Massachusetts General Hospital, Boston, MA, USA
    Am J Surg Pathol 32:30-5. 2008
    ..However, this level of variability is acceptable because the presence of SSA indicates increased risk of developing additional serrated polyps and carcinoma, and surveillance is appropriate...
  42. pmc FGFR1 amplification in squamous cell carcinoma of the lung
    Rebecca S Heist
    Department or Thoracic Oncology, Massachusetts General Hospital Cancer Center, Boston, Massachusetts 02114, USA
    J Thorac Oncol 7:1775-80. 2012
    ..Little is known, however, about the clinical and demographic correlates of FGFR1 amplification...
  43. pmc Intraductal papillary mucinous neoplasms: does a family history of pancreatic cancer matter?
    Deepika Nehra
    Department of Surgery, Massachusetts General Hospital, Boston MA, USA
    Pancreatology 12:358-63. 2012
    ....
  44. pmc ROS1 rearrangements define a unique molecular class of lung cancers
    Kristin Bergethon
    Massachusetts General Hospital, Boston, MA 02114 2696, USA
    J Clin Oncol 30:863-70. 2012
    ..Because little is known about these tumors, we examined the clinical characteristics and treatment outcomes of patients with NSCLC with ROS1 rearrangement...
  45. ncbi request reprint Buried Barrett's epithelium following photodynamic therapy shows reduced crypt proliferation and absence of DNA content abnormalities
    Jason L Hornick
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Gastroenterol 103:38-47. 2008
    ..The neoplastic potential of buried BE is poorly understood. The aim of this study was to evaluate the biological characteristics of nonburied and buried BE in patients treated with PDT...
  46. doi request reprint Immunohistochemistry for cell polarity protein lethal giant larvae 2 differentiates pancreatic intraepithelial neoplasia-3 and ductal adenocarcinoma of the pancreas from lower-grade pancreatic intraepithelial neoplasias
    Mikhail Lisovsky
    The James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Hum Pathol 41:902-9. 2010
    ..Loss or abnormal lethal giant larvae 2 expression is seen in pancreatic intraepithelial neoplasia-3 and adenocarcinoma and might be useful in separating them from lower-grade pancreatic intraepithelial neoplasias...
  47. ncbi request reprint EUS-guided injection of paclitaxel (OncoGel) provides therapeutic drug concentrations in the porcine pancreas (with video)
    Kai Matthes
    Gastrointestinal Unit, Gastrointestinal Pathology Service, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Gastrointest Endosc 65:448-53. 2007
    ..OncoGel (ReGel/paclitaxel) is an intralesional injectable formulation of the chemotherapeutic drug, paclitaxel, for local tumor management...
  48. doi request reprint Global genomic analysis of intraductal papillary mucinous neoplasms of the pancreas reveals significant molecular differences compared to ductal adenocarcinoma
    Stefan Fritz
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Ann Surg 249:440-7. 2009
    ..To determine whether intraductal papillary mucinous neoplasms of the pancreas (IPMNs) have a different genetic background compared with ductal adenocarcinoma (PDAC)...
  49. pmc Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models
    Ryan B Corcoran
    Massachusetts General Hospital Cancer Center, Boston, MA 02129, USA
    Cancer Cell 23:121-8. 2013
    ....
  50. pmc Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers
    Ryohei Katayama
    Massachusetts General Hospital Cancer Center, Boston, MA 02129, USA
    Sci Transl Med 4:120ra17. 2012
    ....
  51. doi request reprint Distinct histopathology of acute onset or abrupt exacerbation of hypersensitivity pneumonitis
    Lida P Hariri
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Hum Pathol 43:660-8. 2012
    ....
  52. pmc Chitinase 3-like-1 expression in colonic epithelial cells as a potentially novel marker for colitis-associated neoplasia
    Chun Chuan Chen
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Pathol 179:1494-503. 2011
    ..In summary, CHI3L1 may contribute to the proliferation, migration, and neoplastic progression of CECs under inflammatory conditions and could be a useful biomarker for neoplastic changes in patients with IBD...
  53. pmc Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors
    Lecia V Sequist
    Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA
    Sci Transl Med 3:75ra26. 2011
    ..Collectively, these results deepen our understanding of resistance to EGFR inhibitors and underscore the importance of repeatedly assessing cancers throughout the course of the disease...
  54. ncbi request reprint Feasibility of endoscopic transgastric distal pancreatectomy in a porcine animal model
    Kai Matthes
    Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Gastrointest Endosc 66:762-6. 2007
    ..In contrast to laparoscopic tubal ligation, oophorectomy, and appendectomy, laparoscopic distal pancreatectomy is associated with a morbidity rate of more than 50% and a mortality rate of more than 3%...
  55. doi request reprint Multidisciplinary approach to diagnosis and management of intraductal papillary mucinous neoplasms of the pancreas
    Dushyant V Sahani
    Department of Radiology, Division of Abdominal Imaging and Intervention, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Clin Gastroenterol Hepatol 7:259-69. 2009
    ..Furthermore, issues of multifocality and increased predisposition of the pancreas to ductal adenocarcinoma must be addressed at follow-up evaluation. A follow-up management algorithm also is proposed in this review...
  56. doi request reprint Clinicopathologic and molecular profiles of microsatellite unstable Barrett Esophagus-associated adenocarcinoma
    Alton B Farris
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Am J Surg Pathol 35:647-55. 2011
    ..Given the growing evidence that indicates lack of benefits from adjuvant therapy with fluorouracil in the colonic counterpart, it may be important to identify MSI-H in BE-associated adenocarcinomas...
  57. doi request reprint Adenomatous and foveolar gastric dysplasia: distinct patterns of mucin expression and background intestinal metaplasia
    Do Youn Park
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114 2696, USA
    Am J Surg Pathol 32:524-33. 2008
    ..4%) of GED (P = 0.005 for both comparisons). In conclusion, our study indicates that foveolar and adenomatous types of GED have distinct clinicopathologic features, mucin profiles, and association with different types of IM...
  58. pmc Unique clinicopathologic features characterize ALK-rearranged lung adenocarcinoma in the western population
    Scott J Rodig
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Clin Cancer Res 15:5216-23. 2009
    ..We evaluated the incidence and the characteristics of ALK-rearranged lung adenocarcinomas within the western population and the optimal diagnostic modality to detect ALK rearrangements in routine clinical practice...
  59. doi request reprint IgG4+ to IgG+ plasma cells ratio of ampulla can help differentiate autoimmune pancreatitis from other "mass forming" pancreatic lesions
    Alireza Sepehr
    Department of Pathology, Gastrointestinal Pathology Service, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Surg Pathol 32:1770-9. 2008
    ..In conclusion, evaluation of ampullary histology and IgG4/IgG ratio might be proven beneficial in discriminating AIP from other mass forming pancreatic lesions...
  60. pmc Acquired resistance to crizotinib from a mutation in CD74-ROS1
    Mark M Awad
    Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA
    N Engl J Med 368:2395-401. 2013
    ..Funded by Pfizer and others; ClinicalTrials.gov number, NCT00585195.)...
  61. pmc Dedifferentiation in gastrointestinal stromal tumor to an anaplastic KIT-negative phenotype: a diagnostic pitfall: morphologic and molecular characterization of 8 cases occurring either de novo or after imatinib therapy
    Cristina R Antonescu
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Am J Surg Pathol 37:385-92. 2013
    ..This phenomenon is not related to additional KIT mutations, but might be secondary to genetic instability, either represented by loss of heterozygosity or low level of KIT amplification...
  62. ncbi request reprint A role of three-dimensional (3D) reconstruction in the classification of lung adenocarcinoma
    Maristela L Onozato
    Department of Pathology Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Stud Health Technol Inform 179:250-6. 2012
    ....
  63. pmc Prognostic significance and molecular associations of tumor growth pattern in colorectal cancer
    Teppei Morikawa
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
    Ann Surg Oncol 19:1944-53. 2012
    ..However, little is known about the prognostic significance of tumor growth pattern, independent of tumoral molecular alterations and other histologic features...
  64. doi request reprint Molecular characteristics and biological behaviours of the oncocytic and pancreatobiliary subtypes of intraductal papillary mucinous neoplasms
    Hong D Xiao
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    J Pathol 224:508-16. 2011
    ..However, the less frequent TP53 overexpression associated with the significantly lower rates of invasion and nodal disease in the oncocytic type correlates with better outcomes compared to the pancreatobiliary type...
  65. pmc Plectin-1 is a biomarker of malignant pancreatic intraductal papillary mucinous neoplasms
    Dirk Bausch
    Department of Surgery, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114 2622, USA
    J Gastrointest Surg 13:1948-54; discussion 1954. 2009
    ..Improved detection of malignancy using novel biomarkers may therefore improve diagnostic accuracy. One such promising novel biomarker is Plectin-1 (Plec-1)...
  66. doi request reprint Gastroduodenitis associated with yttrium 90-microsphere selective internal radiation: an iatrogenic complication in need of recognition
    Fumihiro Ogawa
    Gastrointestinal Pathology Service, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, MA 02114 2696, USA
    Arch Pathol Lab Med 132:1734-8. 2008
    ..During administration of microspheres via the hepatic artery branches, some may on occasion be misdirected and be caught in the capillary bed of the duodenal and/or stomach...
  67. pmc Sensitive sequencing method for KRAS mutation detection by Pyrosequencing
    Shuji Ogino
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    J Mol Diagn 7:413-21. 2005
    ..In addition, the applicability of this assay for DNA amplified by whole-genome amplification technique provides an expanded source of DNA for large-scale studies...
  68. pmc Identifying intestinal metaplasia at the squamocolumnar junction by using optical coherence tomography
    John A Evans
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
    Gastrointest Endosc 65:50-6. 2007
    ..The accuracy of OCT for differentiating tissue types at the squamocolumnar junction (SCJ) has not been established...
  69. doi request reprint Prospective evaluation of reader performance on MDCT in characterization of cystic pancreatic lesions and prediction of cyst biologic aggressiveness
    Dushyant V Sahani
    Department of Radiology, Division of Abdominal Imaging and Interventional Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, USA
    AJR Am J Roentgenol 197:W53-61. 2011
    ..Our objective was to evaluate the accuracy of MDCT features of pancreatic cystic lesions in cyst characterization and in predicting cyst biologic aggressiveness...
  70. doi request reprint Pancreatic mucinous cystic neoplasm of the main pancreatic duct
    Ricard Masia
    Department of Pathology and Laboratory Medicine, Massachusetts General Hospital, Boston, 02114 2696, USA
    Arch Pathol Lab Med 135:264-7. 2011
    ..Pancreatic mucinous cystic neoplasm involving the entire main pancreatic duct has not, to our knowledge, been previously reported...
  71. doi request reprint Alpha-CTLA-4 mAb-associated panenteritis: a histologic and immunohistochemical analysis
    Darryl A Oble
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114 2696, USA
    Am J Surg Pathol 32:1130-7. 2008
    ....
  72. doi request reprint High-grade atypical epithelial cells in pancreatic mucinous cysts are a more accurate predictor of malignancy than "positive" cytology
    Martha Bishop Pitman
    Department of Pathology, The James Homer Wright Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Cytopathol 118:434-40. 2010
    ..In the current study, the authors hypothesized that a cytological threshold of high-grade atypical epithelial cells (AEC) is a more accurate predictor of malignancy...
  73. doi request reprint Intrathoracic hibernoma: a case with multimodality imaging correlation
    Brent P Little
    Division of Thoracic Radiology, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Thorac Imaging 26:W20-2. 2011
    ..Chest radiography, computed tomography, fluorodeoxyglucose positron emission tomography, and angiography are presented. A short review of the literature and discussion of imaging and histologic diagnosis of hibernomas are provided...
  74. pmc Prospective evaluation of MR enterography as the primary imaging modality for pediatric Crohn disease assessment
    Michael S Gee
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, USA
    AJR Am J Roentgenol 197:224-31. 2011
    ....
  75. pmc Cytological analysis of small branch-duct intraductal papillary mucinous neoplasms provides a more accurate risk assessment of malignancy than symptoms
    Jill Ono
    Department of Pathology, Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States
    Cytojournal 8:21. 2011
    ..We have assessed the value of cytology relative to symptom for predicting malignancy in IPMNs without high-risk imaging features...
  76. ncbi request reprint Management of superficial Barrett's epithelium-related neoplasms by endoscopic mucosal resection: clinicopathologic analysis of 27 cases
    Mari Mino-Kenudson
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Surg Pathol 29:680-6. 2005
    ..This is a significant advantage since it can modify patients' management. However, frequent incompleteness of resection and high persistence/recurrence are significant pitfalls that dictate continued endoscopic surveillance...
  77. ncbi request reprint Autoimmune pancreatitis: a systemic immune complex mediated disease
    Vikram Deshpande
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Surg Pathol 30:1537-45. 2006
    ..Documentation of increased numbers of tissue IgG4 positive plasma cells, although not an entirely specific marker for AIP, may provide ancillary evidence for the diagnosis of a IgG4-related systemic disease...
  78. ncbi request reprint Endoscopic mucosal resection: an improved diagnostic procedure for early gastroesophageal epithelial neoplasms
    Mindy J Hull
    Department of Pathology, Gastrointestinal Pathology Service, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Am J Surg Pathol 30:114-8. 2006
    ..EMR can substantially modify the diagnostic grade of a lesion and therefore facilitate optimal therapeutic decisions by avoiding undertreatment and overtreatment based on inaccurate grading and staging...
  79. pmc Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK
    Alice T Shaw
    Department of Pathology, Massachusetts General Hospital, Warren 501c, 55 Fruit St, Boston, MA 02114, USA
    J Clin Oncol 27:4247-53. 2009
    ..To aid in identification and treatment of these patients, we examined the clinical characteristics and treatment outcomes of patients who had NSCLC with and without EML4-ALK...
  80. pmc Whole-slide imaging digital pathology as a platform for teleconsultation: a pilot study using paired subspecialist correlations
    David C Wilbur
    Department of Pathology, James Homer Wright Pathology Laboratories, Massachusetts General Hospital, and the Department of Pathology, Harvard Medical School, Boston, MA 02114, USA
    Arch Pathol Lab Med 133:1949-53. 2009
    ..Before implementation, technical issues, pathologist adaptability, and morphologic pitfalls must be well characterized...
  81. doi request reprint Phase I study of preoperative short-course chemoradiation with proton beam therapy and capecitabine for resectable pancreatic ductal adenocarcinoma of the head
    Theodore S Hong
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 79:151-7. 2011
    ..To evaluate the safety of 1 week of chemoradiation with proton beam therapy and capecitabine followed by early surgery...
  82. doi request reprint Acute fibrinous and organizing pneumonia in systemic lupus erythematosus: a case report and review of the literature
    Lida P Hariri
    Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Pathol Int 60:755-9. 2010
    ....
  83. pmc Cyclooxygenase-2 overexpression is common in serrated and non-serrated colorectal adenoma, but uncommon in hyperplastic polyp and sessile serrated polyp/adenoma
    Takako Kawasaki
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA
    BMC Cancer 8:33. 2008
    ..Therefore, we hypothesized that COX-2 may play a less important role in the serrated pathway...
  84. pmc Imaging of acute mesenteric ischemia using multidetector CT and CT angiography in a porcine model
    David E Rosow
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Gastrointest Surg 9:1262-74; discussion 1274-5. 2005
    ..These results indicate that M.D.CT-CTA holds great promise for the early detection necessary for successful treatment of acute mesenteric ischemia...
  85. doi request reprint Imaging-based quantification of hepatic fat: methods and clinical applications
    Xiaozhou Ma
    Division of Abdominal Imaging and Intervention Radiology, Massachusetts General Hospital, 55 Fruit St, White 270, Boston, MA 02114, USA
    Radiographics 29:1253-77. 2009
    ..However, both are expensive and too complex to be used to monitor steatosis...
  86. ncbi request reprint Histopathology of autoimmune pancreatitis: recognized features and unsolved issues
    Mari Mino-Kenudson
    Gastrointestinal Pathology Service, Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Gastrointest Surg 9:6-10. 2005