Karen Miller

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Endocrine effects of anorexia nervosa
    Karen Klahr Miller
    Harvard Medical School and Neuroendocrine Unit, BUL 457B, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Endocrinol Metab Clin North Am 42:515-28. 2013
  2. ncbi request reprint Effects of testosterone therapy on cardiovascular risk markers in androgen-deficient women with hypopituitarism
    K K Miller
    Neuroendocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 92:2474-9. 2007
  3. ncbi request reprint Preservation of neuroendocrine control of reproductive function despite severe undernutrition
    K K Miller
    Neuroendocrine Unit, BUL 457B, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:4434-8. 2004
  4. ncbi request reprint Truncal adiposity, relative growth hormone deficiency, and cardiovascular risk
    K K Miller
    Neuroendocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 90:768-74. 2005
  5. doi request reprint Androgen deficiency: effects on body composition
    Karen K Miller
    Neuroendocrine Unit, Massachusetts General Hospital, Harvard Medical School, Bulfinch 457B, Boston, MA, 02114, USA
    Pituitary 12:116-24. 2009
  6. ncbi request reprint Testosterone administration attenuates regional brain hypometabolism in women with anorexia nervosa
    Karen K Miller
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, BUL 457B, Boston, MA 02114, USA
    Psychiatry Res 132:197-207. 2004
  7. pmc Growth hormone deficiency after treatment of acromegaly: a randomized, placebo-controlled study of growth hormone replacement
    Karen K Miller
    Neuroendocrine Unit, Bulfinch 457B, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 95:567-77. 2010
  8. ncbi request reprint Medical findings in outpatients with anorexia nervosa
    Karen K Miller
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Arch Intern Med 165:561-6. 2005
  9. ncbi request reprint Effects of testosterone replacement in androgen-deficient women with hypopituitarism: a randomized, double-blind, placebo-controlled study
    K K Miller
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 91:1683-90. 2006
  10. ncbi request reprint Androgen deficiency: association with increased anxiety and depression symptom severity in anorexia nervosa
    Karen K Miller
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychiatry 68:959-65. 2007

Research Grants

Collaborators

Detail Information

Publications82

  1. pmc Endocrine effects of anorexia nervosa
    Karen Klahr Miller
    Harvard Medical School and Neuroendocrine Unit, BUL 457B, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Endocrinol Metab Clin North Am 42:515-28. 2013
    ..In addition, therapies directed at specific complications have been a particular focus of research. ..
  2. ncbi request reprint Effects of testosterone therapy on cardiovascular risk markers in androgen-deficient women with hypopituitarism
    K K Miller
    Neuroendocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 92:2474-9. 2007
    ..However, the safety of chronic testosterone administration on cardiovascular risk and insulin resistance is unknown...
  3. ncbi request reprint Preservation of neuroendocrine control of reproductive function despite severe undernutrition
    K K Miller
    Neuroendocrine Unit, BUL 457B, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:4434-8. 2004
    ..In addition, nutritional intake and normal hormonal function may be independent contributors to maintenance of trabecular bone mass in low-weight women...
  4. ncbi request reprint Truncal adiposity, relative growth hormone deficiency, and cardiovascular risk
    K K Miller
    Neuroendocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 90:768-74. 2005
    ....
  5. doi request reprint Androgen deficiency: effects on body composition
    Karen K Miller
    Neuroendocrine Unit, Massachusetts General Hospital, Harvard Medical School, Bulfinch 457B, Boston, MA, 02114, USA
    Pituitary 12:116-24. 2009
    ..Further research is needed to establish the effects of endogenous androgens on the regulation of body composition in women...
  6. ncbi request reprint Testosterone administration attenuates regional brain hypometabolism in women with anorexia nervosa
    Karen K Miller
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, BUL 457B, Boston, MA 02114, USA
    Psychiatry Res 132:197-207. 2004
    ..Further study is warranted to replicate these findings, as well as to determine their physiological and clinical significance...
  7. pmc Growth hormone deficiency after treatment of acromegaly: a randomized, placebo-controlled study of growth hormone replacement
    Karen K Miller
    Neuroendocrine Unit, Bulfinch 457B, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 95:567-77. 2010
    ....
  8. ncbi request reprint Medical findings in outpatients with anorexia nervosa
    Karen K Miller
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Arch Intern Med 165:561-6. 2005
    ..However, few clinical data exist regarding community-dwelling women with anorexia nervosa. The objective of this study was to determine the prevalences of common medical findings for these women...
  9. ncbi request reprint Effects of testosterone replacement in androgen-deficient women with hypopituitarism: a randomized, double-blind, placebo-controlled study
    K K Miller
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 91:1683-90. 2006
    ..Hypopituitarism in women is characterized by profound androgen deficiency due to a loss of adrenal and/or ovarian function. The effects of testosterone replacement in this population have not been reported...
  10. ncbi request reprint Androgen deficiency: association with increased anxiety and depression symptom severity in anorexia nervosa
    Karen K Miller
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychiatry 68:959-65. 2007
    ..Because androgens are known to affect mood and behavior, we hypothesized that low endogenous androgen production in anorexia nervosa would predict anxiety and depression severity...
  11. pmc Determinants of skeletal loss and recovery in anorexia nervosa
    Karen K Miller
    Neuroendocrine Unit, Bulfinch 457B, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Endocrinol Metab 91:2931-7. 2006
    ..Anorexia nervosa (AN) is complicated by severe bone loss. The effects of persistent undernutrition and consequent neuroendocrine dysfunction on bone mass and the factors influencing skeletal recovery have not been well characterized...
  12. pmc Androgens in women with anorexia nervosa and normal-weight women with hypothalamic amenorrhea
    K K Miller
    Neuroendocrine Unit, Harris Center, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 92:1334-9. 2007
    ....
  13. ncbi request reprint Low-dose transdermal testosterone augmentation therapy improves depression severity in women
    Karen K Miller
    Neurendocrine Research Program in Women s Health, Neuendocrine Unit, Massachusetts General Hospital, Boston, MA, USA
    CNS Spectr 14:688-94. 2009
    ..However, the effects of low-dose testosterone as augmentation therapy in women with treatment-resistant depression have not been studied...
  14. ncbi request reprint Effects of risedronate on bone density in anorexia nervosa
    Karen K Miller
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:3903-6. 2004
    ..S. for premenopausal women other than those receiving glucocorticoids. Further studies are needed to establish the efficacy and safety of bisphosphonate therapy in this population...
  15. ncbi request reprint Measurement of free testosterone in normal women and women with androgen deficiency: comparison of methods
    Karen K Miller
    Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:525-33. 2004
    ..0001), but is a unitless number without reference to the physical reality of free T. We conclude that the mass action equation and equilibrium dialysis are the preferred methods for use in diagnosing androgen deficiency in women...
  16. pmc Effects of risedronate and low-dose transdermal testosterone on bone mineral density in women with anorexia nervosa: a randomized, placebo-controlled study
    Karen K Miller
    Neuroendocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 96:2081-8. 2011
    ..Estrogen administration has not been shown to prevent bone loss in this population, and to date, there are no approved, effective therapies for this comorbidity...
  17. ncbi request reprint Androgen deficiency in women
    K K Miller
    Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 86:2395-401. 2001
    ..Therefore, although widespread screening and hormone replacement for androgen deficiency cannot be recommended yet, increasing interest in this topic makes consideration of the available data important...
  18. ncbi request reprint Androgens and bone density in women with hypopituitarism
    Karen K Miller
    Department of Medicine, Neuroendocrine Unit, Clinical Research Center, Bulfinch 457B, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Endocrinol Metab 87:2770-6. 2002
    ..It remains to be determined whether androgen replacement therapy itself or an increase in lean body mass achieved as a result of androgen administration will result in an improvement in BMD in this population...
  19. ncbi request reprint Testosterone administration in women with anorexia nervosa
    K K Miller
    Neuroendocrine Unit, BUL 457B, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 90:1428-33. 2005
    ..Low-dose testosterone may also prevent decreased bone formation in AN, but because testosterone did not affect all markers of bone formation studied, further data are needed...
  20. ncbi request reprint Mechanisms by which nutritional disorders cause reduced bone mass in adults
    Karen K Miller
    Neuroendocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Womens Health (Larchmt) 12:145-50. 2003
    ..This review discusses nutritional causes of reduced bone mass in adults and how nutritional disorders exert deleterious effects on the skeleton...
  21. pmc Endocrine dysregulation in anorexia nervosa update
    K K Miller
    Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 96:2939-49. 2011
    ..This Update reviews recent advances in the understanding of the endocrine dysregulation observed in this state of chronic starvation, as well as the mechanisms underlying the disease itself...
  22. pmc Effects of recombinant human growth hormone in anorexia nervosa: a randomized, placebo-controlled study
    Pouneh K Fazeli
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 95:4889-97. 2010
    ..The effects of supraphysiological recombinant human GH (rhGH) on GH resistance in AN are not currently known...
  23. ncbi request reprint Ghrelin and bone metabolism in adolescent girls with anorexia nervosa and healthy adolescents
    Madhusmita Misra
    BUL 457, Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 90:5082-7. 2005
    ..Anorexia nervosa (AN) in adolescents is associated with low bone mineral density (BMD) and increases in ghrelin secretion, an orexigenic GH secretagogue that stimulates osteoblast proliferation in vitro...
  24. ncbi request reprint Effects of anorexia nervosa on clinical, hematologic, biochemical, and bone density parameters in community-dwelling adolescent girls
    Madhusmita Misra
    Neuroendocrine Unit, and Harvard Medical School, Boston, Massachusetts 02114, USA
    Pediatrics 114:1574-83. 2004
    ..The prevalence of AN is increasing in adolescents, and it is the third most common chronic disease in adolescent girls. Therefore, it is important to determine the medical effects of this disorder in this young population...
  25. pmc Growth hormone decreases visceral fat and improves cardiovascular risk markers in women with hypopituitarism: a randomized, placebo-controlled study
    Catherine Beauregard
    Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Endocrinol Metab 93:2063-71. 2008
    ..Data regarding gender-specific efficacy of GH on critical endpoints are lacking. There are no randomized, placebo-controlled studies of physiological GH therapy solely in women...
  26. pmc Hormonal and nutritional effects on cardiovascular risk markers in young women
    Elizabeth A Lawson
    Neuroendocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 92:3089-94. 2007
    ..Moreover, oral estrogens, known to increase hsCRP in other populations, are commonly prescribed in AN. To date, hsCRP levels and their physiological determinants have not been reported in women with AN...
  27. pmc Visceral fat is a negative predictor of bone density measures in obese adolescent girls
    Melissa Russell
    M P H, BUL 457, Neuroendocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 95:1247-55. 2010
    ..Conclusion: VAT is an independent inverse determinant of bone density in obesity. This association may be mediated by adipokines and a chronic inflammatory state...
  28. ncbi request reprint Effects of recombinant human insulin-like growth factor (IGF)-I and estrogen administration on IGF-I, IGF binding protein (IGFBP)-2, and IGFBP-3 in anorexia nervosa: a randomized-controlled study
    Steven Grinspoon
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 88:1142-9. 2003
    ..In conclusion, our data suggest that chronic rhIGF-I administration increases IGF-I and IGFBP-2 and decreases IGFBP-3 in women with anorexia nervosa. IGFBP-2 and IGFBP-3 may be important determinants of bone density in this population...
  29. ncbi request reprint Effects of recombinant human IGF-I and oral contraceptive administration on bone density in anorexia nervosa
    Steven Grinspoon
    Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Endocrinol Metab 87:2883-91. 2002
    ..Further long-term studies are needed to investigate the effects of rhIGF-I and combined anabolic/antiresorptive strategies on bone in women with anorexia nervosa...
  30. ncbi request reprint Hormonal and body composition predictors of soluble leptin receptor, leptin, and free leptin index in adolescent girls with anorexia nervosa and controls and relation to insulin sensitivity
    Madhusmita Misra
    BUL 457B, Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    J Clin Endocrinol Metab 89:3486-95. 2004
    ..Resumption of menses is associated with significant increases in the FLI, suggesting that free leptin may be an important determinant of menstrual recovery...
  31. pmc Fibroblast growth factor-21 may mediate growth hormone resistance in anorexia nervosa
    Pouneh K Fazeli
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 95:369-74. 2010
    ..In a transgenic mouse model, FGF-21 reduces IGF-I levels by inhibiting signal transducer and activator of transcription-5, a mediator of the intracellular effects of GH...
  32. ncbi request reprint Elevated peptide YY levels in adolescent girls with anorexia nervosa
    Madhusmita Misra
    BUL 457, Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 91:1027-33. 2006
    ..In addition, known regulators of bone turnover, such as GH, cortisol, and estrogen, explain only a fraction of the variability in bone turnover marker levels...
  33. ncbi request reprint Secretory dynamics of leptin in adolescent girls with anorexia nervosa and healthy adolescents
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Physiol Endocrinol Metab 289:E373-81. 2005
    ..Leptin predicts GH and cortisol parameters and with ghrelin predicts GH burst frequency. Low leptin and high ghrelin may be dual stimuli for high GH concentrations in undernutrition...
  34. pmc Growth hormone deficiency by growth hormone releasing hormone-arginine testing criteria predicts increased cardiovascular risk markers in normal young overweight and obese women
    Andrea L Utz
    Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Endocrinol Metab 93:2507-14. 2008
    ..Little is known about the relationship between GH and cardiovascular risk markers in women without organic hypothalamic/pituitary disease...
  35. pmc Peptide YY in adolescent athletes with amenorrhea, eumenorrheic athletes and non-athletic controls
    Melissa Russell
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Bone 45:104-9. 2009
    ..The role of other nutritionally regulated hormones such as peptide YY (PYY) and adiponectin in mediating gonadal status and bone metabolism remains to be determined...
  36. ncbi request reprint Serum osteoprotegerin in adolescent girls with anorexia nervosa
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 88:3816-22. 2003
    ..OPG values correlate negatively with markers of nutritional status and lumbar bone density z-scores and may be a compensatory response to the bone loss seen in this population...
  37. ncbi request reprint Alterations in growth hormone secretory dynamics in adolescent girls with anorexia nervosa and effects on bone metabolism
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 88:5615-23. 2003
    ..Acquired GH resistance may play a role in the osteopenia and decreased peak bone mass frequently associated with AN...
  38. pmc Preadipocyte factor-1 is associated with marrow adiposity and bone mineral density in women with anorexia nervosa
    Pouneh K Fazeli
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 95:407-13. 2010
    ..Adipocytes and osteoblasts differentiate from a common progenitor cell, the human mesenchymal stem cell. Therefore, understanding factors that regulate this differentiation process may provide insight into bone loss in AN...
  39. pmc Acylated ghrelin and leptin in adolescent athletes with amenorrhea, eumenorrheic athletes and controls: a cross-sectional study
    Karla Christo
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Clin Endocrinol (Oxf) 69:628-33. 2008
    ..We hypothesized that adolescent athletes with amenorrhea (AA) would have higher ghrelin and lower leptin levels than eumenorrheic athletes (EA) and would predict levels of gonadal steroids...
  40. ncbi request reprint Regional body composition in adolescents with anorexia nervosa and changes with weight recovery
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Am J Clin Nutr 77:1361-7. 2003
    ..Little is known about fat distribution in adolescents with AN, especially with weight recovery...
  41. ncbi request reprint Growth hormone and ghrelin responses to an oral glucose load in adolescent girls with anorexia nervosa and controls
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:1605-12. 2004
    ..Further studies are needed to define GH suppression in an adolescent population...
  42. pmc Bone metabolism in adolescent athletes with amenorrhea, athletes with eumenorrhea, and control subjects
    Karla Christo
    Massachusetts General Hospital, Neuroendocrine Unit, BUL 457, 55 Fruit St, Boston, MA 02114, USA
    Pediatrics 121:1127-36. 2008
    ....
  43. ncbi request reprint Secretory dynamics of ghrelin in adolescent girls with anorexia nervosa and healthy adolescents
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    Am J Physiol Endocrinol Metab 289:E347-56. 2005
    ..The most important predictor of ghrelin concentration is insulin resistance, and ghrelin in turn predicts GH and cortisol burst frequency...
  44. ncbi request reprint Hormonal determinants of regional body composition in adolescent girls with anorexia nervosa and controls
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, BUL 457, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 90:2580-7. 2005
    ..High cortisol levels in AN predict a redistribution of lean body mass such that extremity lean mass decreases. Further studies are necessary to better understand the implications of these data...
  45. ncbi request reprint Alterations in cortisol secretory dynamics in adolescent girls with anorexia nervosa and effects on bone metabolism
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:4972-80. 2004
    ..Therefore, high cortisol values in AN may contribute to the low bone density observed in adolescents with this disorder by decreasing bone formation...
  46. ncbi request reprint Diagnostic errors after inferior petrosal sinus sampling
    Brooke Swearingen
    Neuroendocrine Clinical Center, Division of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:3752-63. 2004
    ....
  47. pmc Hypercortisolemia is associated with severity of bone loss and depression in hypothalamic amenorrhea and anorexia nervosa
    Elizabeth A Lawson
    Neuroendocrine Unit, Bulfinch 457B, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 94:4710-6. 2009
    ..Significant hypercortisolemia, as in Cushing's disease, causes bone loss. It is unknown whether anxiety and depression and/or cortisol dysregulation contribute to low bone density in AN or HA...
  48. pmc Hormone predictors of abnormal bone microarchitecture in women with anorexia nervosa
    Elizabeth A Lawson
    Neuroendocrine Unit, Bulfinch 457B, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Bone 46:458-63. 2010
    ..We concluded that bone microarchitecture is abnormal in women with AN. Endogenous IGF-I, leptin, and androgen levels predict bone microarchitecture independent of BMI...
  49. pmc Peak growth hormone-releasing hormone-arginine-stimulated growth hormone is inversely associated with intramyocellular and intrahepatic lipid content in premenopausal women with obesity
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 94:3995-4002. 2009
    ..Little is known about the role of decreased endogenous GH secretion in the pathogenesis of insulin resistance in obesity...
  50. pmc Effects of rhIGF-1 administration on surrogate markers of bone turnover in adolescents with anorexia nervosa
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Bone 45:493-8. 2009
    ..Although IGF-1 is key to pubertal bone accretion, and effects have been demonstrated in adults, there are no data regarding the effect of recombinant human (rh) IGF-1 administration in adolescents with AN...
  51. ncbi request reprint Role of cortisol in menstrual recovery in adolescent girls with anorexia nervosa
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Pediatr Res 59:598-603. 2006
    ..Baseline cortisol level strongly predicted increases in the percentage of body fat. We demonstrate that 1) high baseline cortisol level predicts increases in body fat and 2) increases in body fat predict menses recovery in AN...
  52. ncbi request reprint Growth hormone suppression after an oral glucose load in children
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 92:4623-9. 2007
    ..Adult data cannot be extrapolated to children given the pubertal increase in GH concentration. In addition, because GH levels are higher in pubertal girls than boys, nadir GH may differ across gender...
  53. ncbi request reprint Regional cerebral brain metabolism correlates of neuroticism and extraversion
    Thilo Deckersbach
    Department of Psychiatry, Massachusetts General Hospital, Boston, USA
    Depress Anxiety 23:133-8. 2006
    ..No significant correlations were found involving anterior cingulate, amygdala, or ventral striatum. Neuroticism and Extraversion are associated with activity in insular cortex and orbitofrontal cortex, respectively...
  54. pmc Reduced amylin levels are associated with low bone mineral density in women with anorexia nervosa
    Monica H Wojcik
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Bone 46:796-800. 2010
    ..Peptide hormones, including amylin, GIP, and GLP2, are released immediately after nutrient intake and may be involved in the regulation of bone turnover...
  55. pmc Comparison of DXA and CT in the assessment of body composition in premenopausal women with obesity and anorexia nervosa
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Obesity (Silver Spring) 18:2227-33. 2010
    ..The level of hydration does not significantly affect most DXA body composition measurements, with the exceptions of thigh fat...
  56. pmc Breath-hold 1H-magnetic resonance spectroscopy for intrahepatic lipid quantification at 3 Tesla
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Comput Assist Tomogr 34:372-6. 2010
    ..To compare breath-hold 1H-magnetic resonance spectroscopy (1H-MRS) with respiratory-gated 1H-MRS and computed tomography (CT) for quantification of hepatic lipid content...
  57. ncbi request reprint Effects of estrogen and recombinant human insulin-like growth factor-I on ghrelin secretion in severe undernutrition
    Steven Grinspoon
    Neuroendocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:3988-93. 2004
    ..The mechanisms of these effects are unknown and may relate to direct effects on ghrelin or changes in GH. Further studies are needed to determine the mechanisms by which rhIGF-I and E increase ghrelin in human physiology...
  58. pmc Comparison of 3.0 T proton magnetic resonance spectroscopy short and long echo-time measures of intramyocellular lipids in obese and normal-weight women
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Magn Reson Imaging 32:388-93. 2010
    ..To compare correlations of intramyocellular lipids (IMCL) measured by short and long echo-time proton magnetic resonance spectroscopy (1H-MRS) with indices of body composition and insulin resistance in obese and normal-weight women...
  59. pmc Growth hormone deficiency is associated with decreased quality of life in patients with prior acromegaly
    Tamara Wexler
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 94:2471-7. 2009
    ..However, it is unknown whether patients with GHD after treatment for acromegaly have a poorer quality of life than those with normal GH levels after cure of acromegaly...
  60. ncbi request reprint Serum prolactin levels among outpatients with major depressive disorder during the acute phase of treatment with fluoxetine
    George I Papakostas
    Depression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychiatry 67:952-7. 2006
    ..To determine changes in serum prolactin levels in outpatients with DSM-IV-diagnosed major depressive disorder (MDD) following a 12-week open-label trial of fluoxetine...
  61. pmc Increased carbohydrate induced ghrelin secretion in obese vs. normal-weight adolescent girls
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Obesity (Silver Spring) 17:1689-95. 2009
    ..Changes in anorexigenic and orexigenic hormones in obese vs. normal-weight adolescents following high-carbohydrate and high-fat meals may influence hunger and satiety signals and subsequent food intake...
  62. pmc Prognostic indicators of changes in bone density measures in adolescent girls with anorexia nervosa-II
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 93:1292-7. 2008
    ..We hypothesized that baseline levels of nutritionally regulated hormones and of bone turnover markers would predict DeltaBMD overall...
  63. pmc Weight gain and restoration of menses as predictors of bone mineral density change in adolescent girls with anorexia nervosa-1
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 93:1231-7. 2008
    ..We hypothesized that menstrual recovery and weight gain (> or =10% increase in body mass index) would predict an increase in these measures of bone density...
  64. ncbi request reprint Relationships between serum adipokines, insulin levels, and bone density in girls with anorexia nervosa
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Endocrinol Metab 92:2046-52. 2007
    ..Adolescents with anorexia nervosa (AN) have low bone mineral density (BMD). Adipokines and insulin play an important role in bone metabolism in healthy individuals. However, their association with bone metabolism in AN is unknown...
  65. ncbi request reprint Uncoupling of cardiovascular risk markers in adolescent girls with anorexia nervosa
    Madhusmita Misra
    Neuroendocrine Unit, and the Eating Disorders Unit, Child Psychiatry Service, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Pediatr 149:763-769. 2006
    ..We hypothesized that in AN, growth hormone (GH) resistance and hypercortisolemia would increase CV risk through effects on pro-inflammatory cytokines and lipid status despite low weight...
  66. pmc Nutrient intake in community-dwelling adolescent girls with anorexia nervosa and in healthy adolescents
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Clin Nutr 84:698-706. 2006
    ..Adolescence is a common time for the onset of anorexia nervosa (AN), a condition associated with long-term medical and hormonal consequences...
  67. pmc Peptide YY (PYY) levels and bone mineral density (BMD) in women with anorexia nervosa
    Andrea L Utz
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Bone 43:135-9. 2008
    ..Y2 receptor knockout mice have increased bone mineral density (BMD) and thus PYY may play a role in regulating bone mass. We hypothesized that PYY levels would be inversely associated with BMD in women with AN...
  68. doi request reprint Gender effects on cardiac valvular function in hyperprolactinaemic patients receiving cabergoline: a retrospective study
    Lisa B Nachtigall
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Clin Endocrinol (Oxf) 72:53-8. 2010
    ..Ergot-derived dopamine agonists are associated with increased risk of valvular dysfunction in Parkinson's disease. The risk of valvular disease associated with lower doses of cabergoline used to treat prolactinomas remains controversial...
  69. pmc Increased bone marrow fat in anorexia nervosa
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital, Yawkey 6E, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 94:2129-36. 2009
    ..Recent data suggest that marrow fat measured by 1H-magnetic resonance spectroscopy (MRS) in combination with bone mineral density (BMD) may be more valuable than either parameter alone in detecting bone weakness...
  70. pmc Anthropometry, CT, and DXA as predictors of GH deficiency in premenopausal women: ROC curve analysis
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospita, Boston, MA 02114, USA
    J Appl Physiol (1985) 106:418-22. 2009
    ..It can be used to identify women in whom GH deficiency is likely and therefore in whom formal GH stimulation testing might be indicated...
  71. pmc Percentage extremity fat, but not percentage trunk fat, is lower in adolescent boys with anorexia nervosa than in healthy adolescents
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Clin Nutr 88:1478-84. 2008
    ..However, the effect of low testosterone and other hormonal alterations on body composition in boys with AN is not known...
  72. pmc Distal radius in adolescent girls with anorexia nervosa: trabecular structure analysis with high-resolution flat-panel volume CT
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital, 55 Fruit St, Yawkey 6E, Boston, MA 02114, USA
    Radiology 249:938-46. 2008
    ....
  73. pmc Lower growth hormone and higher cortisol are associated with greater visceral adiposity, intramyocellular lipids, and insulin resistance in overweight girls
    Madhusmita Misra
    Neuroendocrine Unit and Pediatric Endocrine Unit, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    Am J Physiol Endocrinol Metab 295:E385-92. 2008
    ..Our data indicate that lower peak GH and higher UFC in overweight girls are associated with visceral adiposity, insulin resistance, and lipids...
  74. pmc Bone metabolism in adolescent boys with anorexia nervosa
    Madhusmita Misra
    BUL 457, Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 93:3029-36. 2008
    ..Although primarily a disease in females, AN is increasingly being recognized in males. However, there are few or no data regarding BMD, bone turnover markers or their predictors in adolescent AN boys...
  75. pmc Appetite-regulating hormones cortisol and peptide YY are associated with disordered eating psychopathology, independent of body mass index
    Elizabeth A Lawson
    Neuroendocrine Unit, Bulfinch 457B Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Eur J Endocrinol 164:253-61. 2011
    ..We therefore studied the relationship between orexigenic and anorexigenic hormones and disordered eating psychopathology in women across a range of weights...
  76. pmc Vertebral bone marrow fat is positively associated with visceral fat and inversely associated with IGF-1 in obese women
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Obesity (Silver Spring) 19:49-53. 2011
    ..This suggests that the detrimental effect of visceral fat on bone health may be mediated in part by IGF-1 as an important regulator of the fat and bone lineage...
  77. pmc Determinants of bone mineral density in obese premenopausal women
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Yawkey 6E, 55 Fruit Street, Boston, MA 02114, USA
    Bone 48:748-54. 2011
    ..Moreover, our findings suggest that IGF-1 may be a mediator of the deleterious effects of VAT on bone health through effects on bone formation...
  78. doi request reprint Determinants of height in adolescent girls with anorexia nervosa
    Rajani Prabhakaran
    BUL 457, MassGeneral Hospital, Neuroendocrine Unit, 55 Fruit St, Boston, MA 02114, USA
    Pediatrics 121:e1517-23. 2008
    ..In addition, growth hormone may have direct effects on the growth plate independent of insulin-like growth factor 1 to increase statural growth...
  79. ncbi request reprint Perceived loss of memory ability and cerebral metabolic decline in persons with the apolipoprotein E-IV genetic risk for Alzheimer disease
    Linda Ercoli
    Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, 90024, USA
    Arch Gen Psychiatry 63:442-8. 2006
    ..Concerns about age-related memory loss are greater in persons who have the apolipoprotein E-IV (APOE4) genetic risk for Alzheimer disease, but the correlation between the degree of concerns and future cerebral metabolic decline is unknown...
  80. ncbi request reprint Androgen therapy in women: an Endocrine Society Clinical Practice guideline
    Margaret E Wierman
    University of Colorado at Denver and Health Sciences Center, Aurora, CO 80010, USA
    J Clin Endocrinol Metab 91:3697-710. 2006
    ..The objective was to provide guidelines for the therapeutic use of androgens in women...
  81. ncbi request reprint Abnormal bone mineral accrual in adolescent girls with anorexia nervosa
    Leslie A Soyka
    Department of Pediatrics, University of Massachusetts Medical School, Worcester 01655, USA
    J Clin Endocrinol Metab 87:4177-85. 2002
    ..A rise in bone turnover markers may be an early indicator of increase in BMD in recovering girls with AN...
  82. ncbi request reprint Management of hyperprolactinemia in patients receiving antipsychotics
    Karen K Miller
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    CNS Spectr 9:28-32. 2004
    ..Hormone-replacement therapy, which involves estrogen/progestogen in women and testosterone in men, can often prevent modification and interruption of successful psychiatric medication regimens...

Research Grants6

  1. GH, Cardiovascular Risk and Visceral Adiposity in Women
    Karen K Miller; Fiscal Year: 2010
    ....
  2. Androgen deficiency and Osteopenia in Anorexia Nervosa
    Karen Miller; Fiscal Year: 2002
    ..In the third phase of the study, we will examine the effects of administering testosterone on bone density and body mass. ..
  3. GH, Cardiovascular Risk and Visceral Adiposity in Women
    Karen Miller; Fiscal Year: 2009
    ....