Research Topics
| E K MillerSummaryAffiliation: Massachusetts Institute of Technology Country: USA Publications
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Publications
Neural correlates of categories and conceptsEarl K Miller
Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Curr Opin Neurobiol 13:198-203. 2003..Recent studies have revealed their neural correlates in various cortical areas of the non-human primate brain...- The prefrontal cortex and cognitive controlE K Miller
Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Nat Rev Neurosci 1:59-65. 2000..Studies indicate that the prefrontal cortex is central in this process. It provides an infrastructure for synthesizing a diverse range of information that lays the foundation for the complex forms of behaviour observed in primates... - An integrative theory of prefrontal cortex functionE K Miller
Center for Learning and Memory, RIKEN MIT Neuroscience Research Center and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Annu Rev Neurosci 24:167-202. 2001..We review neurophysiological, neurobiological, neuroimaging, and computational studies that support this theory and discuss its implications as well as further issues to be addressed.. 
The prefrontal cortex: categories, concepts and cognitionEarl K Miller
Center for Learning and Memory, RIKEN MIT Neuroscience Research Center and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Philos Trans R Soc Lond B Biol Sci 357:1123-36. 2002..In short, the prefrontal cortex seems to underlie our internal representations of the 'rules of the game'. This may provide the necessary foundation for the complex behaviour of primates, in whom this structure is most elaborate...- Experience-dependent sharpening of visual shape selectivity in inferior temporal cortexDavid J Freedman
The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Cereb Cortex 16:1631-44. 2006..We again found that ITC stimulus selectivity was sharper for familiar than novel stimuli, suggesting that enhanced shape tuning in ITC can arise for both passively experienced and explicitly trained stimuli... - Analog numerical representations in rhesus monkeys: evidence for parallel processingAndreas Nieder
Massachusetts Institute of Technology, USA
J Cogn Neurosci 16:889-901. 2004..The behavioral results are compared to single-cell recordings from the prefrontal cortex in the same subjects. Models for numerosity discrimination that may account for these results are discussed... - A comparison of abstract rules in the prefrontal cortex, premotor cortex, inferior temporal cortex, and striatumRahmat Muhammad
The Picower Institute for Learning and Memory, RIKEN-MIT Neuroscience Research Center, and Department of Brain and Cognitive Sciences, Massachusets Institute of Technology, MA 02139, USA
J Cogn Neurosci 18:974-89. 2006..These findings are discussed in the context of the anatomy and posited functions of these areas... - The representation of multiple objects in prefrontal neuronal delay activityMelissa R Warden
The Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Cereb Cortex 17:i41-50. 2007..This is a potential mechanism for representing the temporal order of objects... 
Prefrontal cortex activity during flexible categorizationJefferson E Roy
The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Neurosci 30:8519-28. 2010..We suggest that the PFC represents competing category representations independently to reduce interference between them...- Top-down versus bottom-up control of attention in the prefrontal and posterior parietal corticesTimothy J Buschman
Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, and Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Science 315:1860-2. 2007..This result indicates that top-down and bottom-up signals arise from the frontal and sensory cortex, respectively, and different modes of attention may emphasize synchrony at different frequencies... - Timecourse of object-related neural activity in the primate prefrontal cortex during a short-term memory taskGregor Rainer
Center for Learning and Memory, RIKEN MIT Neuroscience Center, and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Eur J Neurosci 15:1244-54. 2002..These results suggest that PF delay activity does not merely maintain recent sensory input, but is subject to more complex experience-dependent dynamics. This has implications for how delay activity is generated and maintained... - Learning substrates in the primate prefrontal cortex and striatum: sustained activity related to successful actionsMark H Histed
The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Neuron 63:244-53. 2009..These long-lasting signals about trial outcome provide a way to link one action to the next and may allow reward signals to be combined over time to implement successful learning... - Representation of multiple, independent categories in the primate prefrontal cortexJason A Cromer
The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Neuron 66:796-807. 2010..We suggest that cognitive demands determine whether PFC neurons function as category "multitaskers.".. - Effects of visual experience on the representation of objects in the prefrontal cortexG Rainer
Center for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139, USA
Neuron 27:179-89. 2000..These results demonstrate a neural correlate of visual learning in the PF cortex of adult monkeys... - Visual categorization and the primate prefrontal cortex: neurophysiology and behaviorDavid J Freedman
Center for Learning and Memory, Massachusetts Institute of Technology, Cambridge 02139, USA
J Neurophysiol 88:929-41. 2002..These results suggest that the lateral prefrontal cortex is an important part of the neuronal circuitry underlying category learning and category-based behaviors... - Categorical representation of visual stimuli in the primate prefrontal cortexD J Freedman
Center for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Science 291:312-6. 2001..Neural activity in the lateral prefrontal cortex reflected the category of visual stimuli, even when a monkey was retrained with the stimuli assigned to new categories... - All my circuits: using multiple electrodes to understand functioning neural networksEarl K Miller
The Picower Institute for Learning and Memory and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Neuron 60:483-8. 2008..This allows the study of the activity of many neurons simultaneously, which in turn has provided insight into how different neuron populations interact and collaborate to produce thought and action... - Task-dependent changes in short-term memory in the prefrontal cortexMelissa R Warden
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
J Neurosci 30:15801-10. 2010..In addition, most of the neurons encoded both the task and the objects, evidence for a single population responsible for these two critical prefrontal functions... - V1 neurons signal acquisition of an internal representation of stimulus locationJitendra Sharma
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Science 300:1758-63. 2003..We propose that the representation arises in a distributed cortical network and is associated with systematic changes in response selectivity and dynamics at the earliest stages of cortical visual processing... - Phase-dependent neuronal coding of objects in short-term memoryMarkus Siegel
The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 106:21341-6. 2009..Encoding at distinct phases may play a role for disambiguating information about multiple objects in short-term memory... - Serial, covert shifts of attention during visual search are reflected by the frontal eye fields and correlated with population oscillationsTimothy J Buschman
The Picower Institute for Learning and Memory and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Neuron 63:386-96. 2009..It also suggests that neuron population oscillations may regulate the timing of cognitive processing... - Dynamics of neuronal sensitivity in visual cortex and local feature discriminationValentin Dragoi
Department of Brain and Cognitive Sciences, Picower Center for Learning and Memory, 45 Carleton Street, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Nat Neurosci 5:883-91. 2002..Hence, successive exposure to image patches of dissimilar spatial structure enhances both the ability to discriminate local features and the encoding of these features by V1 neurons... - Neuronal activity in primate dorsolateral and orbital prefrontal cortex during performance of a reward preference taskJonathan D Wallis
The Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center and Department of Brain and Cognitive Sciences, E25 236, 45 Carleton Street, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Eur J Neurosci 18:2069-81. 2003..Further, reward selectivity arose more rapidly in the OFC than the DLPFC. These results are consistent with reward information entering the PFC via the OFC, where it is passed to the DLPFC and used to control behaviour... - Dynamic population coding of category information in inferior temporal and prefrontal cortexEthan M Meyers
Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA
J Neurophysiol 100:1407-19. 2008.... - A comparison of primate prefrontal and inferior temporal cortices during visual categorizationDavid J Freedman
The Picower Center for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Neurosci 23:5235-46. 2003.... - Microstimulation of frontal cortex can reorder a remembered spatial sequenceMark H Histed
The Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Massachusetts, USA
PLoS Biol 4:e134. 2006.... - Different time courses of learning-related activity in the prefrontal cortex and striatumAnitha Pasupathy
The Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 USA
Nature 433:873-6. 2005..These results support the hypothesis that rewarded associations are first identified by the basal ganglia, the output of which 'trains' slower learning mechanisms in the frontal cortex... - From rule to response: neuronal processes in the premotor and prefrontal cortexJonathan D Wallis
Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Massachusetts Institute of Technology, Cambridge, 02139, USA
J Neurophysiol 90:1790-806. 2003..In contrast, neurons encoding the behavioral response were more prevalent in the PMC, and the selectivity was stronger and appeared earlier in the PMC than in the PFC... - Representation of the quantity of visual items in the primate prefrontal cortexAndreas Nieder
Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Science 297:1708-11. 2002..A mechanism that extracts the quantity of visual field items could contribute to general numerical ability... - Coding of cognitive magnitude: compressed scaling of numerical information in the primate prefrontal cortexAndreas Nieder
Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Neuron 37:149-57. 2003..These results suggest that certain cognitive and perceptual/sensory representations share the same fundamental mechanisms and neural coding schemes... - A parieto-frontal network for visual numerical information in the monkeyAndreas Nieder
Picower Center for Learning and Memory, and Department of Brain and Cognitive Sciences, RIKEN Massachusetts Institute of Technology Neuroscience Research Center, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 101:7457-62. 2004..This finding suggests a parieto-frontal network for numerosity in monkeys and establishes homologies between the monkey and human brain... - Single neurons in prefrontal cortex encode abstract rulesJ D Wallis
Center for Learning and Memory, RIKEN-MIT Neuroscience Research Center, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139, USA
Nature 411:953-6. 2001..The most prevalent neuronal activity observed in the PFC reflected the coding of these abstract rules... - A neural circuit model of flexible sensorimotor mapping: learning and forgetting on multiple timescalesStefano Fusi
Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Neuron 54:319-33. 2007..This model prediction is confirmed by monkey data. Therefore, our work reveals a scenario for conditional associative learning that is distinct from instant switching between sets of well-established sensorimotor associations... - Neural circuits subserving the retrieval and maintenance of abstract rulesSilvia A Bunge
Psychology Department and Center for Mind and Brain, University of California Davis, California 95616, USA
J Neurophysiol 90:3419-28. 2003..Future investigations of cross-regional interactions will enable full assessment of this account. Collectively, these results demonstrate that multiple, neurally separable processes are recruited during abstract rule representation... - Neurodynamics of the prefrontal cortex during conditional visuomotor associationsMarco Loh
Universitat Pompeu Fabra, Passeig de Circumval lació 8, Barcelona, Spain
J Cogn Neurosci 20:421-31. 2008..We find that a linear change in network parameters relates to the changes in neural activity in consecutive correct trials during learning, which is important evidence for the underlying learning mechanisms... - Neural mechanisms of visual categorization: insights from neurophysiologyDavid J Freedman
Department of Neurobiology, Harvard Medical School, Boston, MA, USA
Neurosci Biobehav Rev 32:311-29. 2008....